Generic Name: nadolol, Oral tablet

Generic Name:

nadolol, Oral tablet

Corgard

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Highlights for nadolol

Oral tablet
1

Nadolol is an oral medication used to treat high blood pressure (hypertension) and angina.

2

Common side effects include dry and itching skin, headache, and change in sex drive or performance.

3

If you’re taking nadolol, don’t take cough, cold, or pain medications before asking your doctor or pharmacist. Some ingredients in these medications can increase your blood pressure.

4

You may get drowsy or dizzy after taking nadolol. Don’t drive, operate heavy machinery, or do anything that requires being mentally alert until you know how it affects you.

5

Suddenly stopping nadolol can cause a heart attack, stroke, irregular heartbeat, or severe high blood pressure. Your dose will be slowly lowered, and you’ll be carefully monitored by a doctor or nurse.

IMPORTANT INFORMATION

FDA Warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

Suddenly stopping warning. Suddenly stopping treatment with nadolol can cause a heart attack, stroke, irregular heartbeat, or severe high blood pressure. Your doctor will decide if you need to stop taking nadolol. The dose will be slowly lowered over a 1–2 week period, and you’ll be carefully monitored by your doctor or nurse.

Don’t stop nadolol suddenly if you’re taking catecholamine medications. Suddenly stopping treatment with nadolol while on catecholamines may cause chest pain or a heart attack.

Surgery warning

Tell your doctor if you’re having a major surgery. You may still take the drug, but taking it may increase your risks of low blood pressure and heart failure when receiving general anesthesia and undergoing major surgery. Your doctor will decide if you should be slowly taken off nadolol before the surgery.

Drug interactions warning

Many medications interact with nadolol. Don’t start or stop taking any medications (prescription or over-the-counter) without talking to your doctor or pharmacist.

Drug Features

Nadolol is a prescription drug. It’s available as an oral tablet.

It’s also available in a generic version. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand. Talk to your healthcare provider to see if the generic will work for you.

This drug may be used as part of a combination therapy. That means you may need to take it with other drugs.

Why It's Used

Nadolol is used to treat high blood pressure and chest pain (angina) in people with high blood pressure, a previous heart attack, or heart failure.

How It Works

Nadolol is in a class of medications called beta blockers.

More Details

How It Works

Nadolol is in a class of medications called beta blockers. It works to reduce your heart’s workload, which can lower blood pressure and help your heart beat more regularly.

Beta blockers prevent epinephrine (adrenaline) and norepinephrine (noradrenaline) from acting on beta receptors in blood vessels and in your heart. This causes blood vessels to relax. By relaxing the vessels, beta blockers help to lower blood pressure and reduce chest pain. Blood pressure is often raised because vessels are tightened. That puts a strain on the heart and increases the body's oxygen demand. Beta blockers help to lower the heart rate and the heart's demand for oxygen.

Beta blockers don’t permanently change blood pressure and chest pain. Instead, they help to manage the symptoms.

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nadolol Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with nadolol include:

  • dry, itching skin

  • headache

  • change in sex drive or performance

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • allergic reactions, such as:

    • skin rash
    • itching
    • hives
  • tingling, numbness, or cold feeling in your hands or feet

  • difficulty breathing or wheezing

  • irregular heart beat

  • slow heart rate

  • swelling of your ankles or legs

Pharmacist's Advice
Healthline Pharmacist Editorial Team

You may get drowsy or dizzy after taking nadolol. Don’t drive, operate heavy machinery, or do anything that requires being mentally alert until you know how it affects you.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
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nadolol May Interact with Other Medications

Oral tablet

Nadolol can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Food Interactions

Green tea may interfere with how well nadolol works in your body. You may need to lower the amount of green tea you drink while taking nadolol.

Alcohol Interaction

Consuming alcohol while taking nadolol can make you feel more dizzy or sleepy. Don’t drink alcoholic beverages while being treated with nadolol.

Medications That Might Interact with This Drug

Heart medications

Talk to your doctor about other medications you’re taking to control your blood pressure, heartbeat, or heart rate. Starting, stopping, or taking other medications for blood pressure, heartbeat, or heart rate with nadolol can cause serious side effects, such as rebound high blood pressure, heart failure, low blood pressure, slow heartbeat, or irregular heartbeat.

Examples are:

  • clonidine
  • digoxin
  • propranolol
  • sotalol
  • flecainide
  • amiodarone
  • nifedipine
  • verapamil

Diabetes medications

Nadolol may not allow your body to control blood sugar. Tell your doctor if you’re taking medications for diabetes. Your doctor will monitor you more closely to see how your body responds to nadolol.

Examples are:

  • glucagon
  • metformin
  • glipizide
  • glyburide

Asthma/COPD medications

Don’t take nadolol if you have asthma, chronic obstructive pulmonary disease (COPD), or any other chronic airway disease. Nadolol can cause medications that treat these conditions to not work as well as they should.

Examples are:

  • albuterol
  • theophylline
  • formoterol
  • salmeterol

Parkinson’s disease medications

Tell your doctor if you’re taking medications to treat Parkinson’s disease. Taking certain medications for Parkinson’s disease with nadolol can cause your blood pressure to lower too much.

Examples are:

  • levodopa
  • selegiline
  • rasagiline

Mood disorder drug
  • haloperidol

Avoid taking nadolol with haloperidol. This can cause your blood pressure to lower too much.

Migraine drugs
  • Ergot alkaloids. Examples are:
    • ergotamine
    • dihyrdoergotamine
    • methylergonovine
    • methysergide

Avoid taking nadolol with ergot alkaloids. Nadolol can increase the effect of ergot alkaloids in your body causing less oxygen to go to your arms and legs.

Dementia drug
  • rivastigmine

Avoid taking nadolol with rivastigmine, which is commonly used for Alzheimer’s disease. Taking these medications together can cause your heart rate to slow and possibly cause you to faint.

Allergy drug
  • epinephrine

Tell your doctor if you use epinephrine to treat allergic reactions. Treatment with nadolol may not allow the usual dose of epinephrine you use for allergic reactions to work as well.

Non-steroidal anti-inflammatory drugs (NSAIDs)

Tell your doctor if you’re using NSAIDs to treat pain or any other condition. These medications are available as a prescription or over the counter. Taking NSAIDs with nadolol can lower the effect of nadolol in your body, which won’t control your blood pressure like it should.

Examples are:

  • ibuprofen
  • naproxen
  • indomethacin
  • meloxicam

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with heart failure

Don’t take nadolol if you have active congestive heart failure. Nadolol may make heart failure worse. If you don’t have a history of heart failure, your doctor may still treat you with nadolol, but you’ll be closely monitored for signs or symptoms of heart failure.

People with chronic airway disease

Don’t use nadolol if you have chronic bronchitis or emphysema. Nadolol may interfere with how well medications used to treat these conditions work.

People with diabetes

You may not able to take nadolol if you have diabetes. Nadolol can cause your body to become less sensitive to high levels of sugar in your bloodstream. This can hide the signs of high blood sugar, such as a fast heartbeat or changes in blood pressure.

People with thyroid disease

You may not be able to take nadolol if you have problems with your thyroid. Nadolol can hide the signs of too much thyroid hormone in your body, such as a fast heart rate.

People with kidney disease

Your doctor may monitor you closely if you have kidney damage or kidney disease and are being treated with nadolol. They may also change your dose.

People with Raynaud’s phenomenon

Don’t use nadolol if you have Raynaud’s phenomenon or peripheral vascular disease (a disease affecting the blood vessels in your arms and legs). Taking nadolol if you have Raynaud’s or peripheral vascular disease can cause your heart not to work as well. This may cause the symptoms of Raynaud’s or peripheral vascular disease to get worse.

People with psoriasis

Nadolol can make your psoriasis worse. It is unclear why this happens. Researchers believe it may be due to the effects of beta blockers on immune cells.

People with myasthenia gravis

Nadolol can cause increased muscle weakness or double vision.

Pregnant women

Nadolol is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus .

Tell your doctor if you’re pregnant or plan to become pregnant. Nadolol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Women who are nursing

Nadolol is passed through breast milk and may cause side effects in a breastfeeding child. You and your doctor may decide if you’ll take nadolol or breastfeed.

For Seniors

People aged 65 years and older might have unpredictable responses to nadolol and other beta blockers. If you’re 65 or older, you may start with the normal adult dose and see how the medication affects you.

For Children

The effectiveness and safety of nadolol haven’t been established in people younger than 18 years old.

When to call the doctor

Call your doctor or go to the emergency room if you have chest pain, a headache, jaw pain, upper back pain, nausea or vomiting, or trouble breathing. These may be symptoms of a heart attack.

Allergies

Nadolol can cause a severe allergic reaction. Symptoms may include:

  • trouble breathing
  • swelling of your throat or tongue
  • fever

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal.

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How to Take nadolol (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Angina
Form: Oral tablet
Strengths: 20 mg, 40 mg, and 80 mg
Adult Dosage (ages 18 years and older)
  • The starting dose may be 40 mg taken once per day.
  • This dose can be increased by 40–80 mg per day every 3 to 7 days.
  • The maximum dose is 240 mg per day.
Child Dosage (ages 0–17 years)

A safe and effective dose hasn’t been established for this age group.

Special Considerations

Kidney disease: Your dose will be lowered if you have kidney damage or kidney disease.

Hypertension
Form: Oral tablet
Strengths: 20 mg, 40 mg, and 80 mg
Adult Dosage (ages 18 years and older)
  • The starting dose may be 40 mg taken once per day.
  • This dose can be increased by 40–80 mg per day every 2 to 14 days.
  • Doses of 240–320 mg per day may be needed to control blood pressure in certain people.
Child Dosage (ages 0–17 years)

A safe and effective dose hasn’t been established for this age group.

Special Considerations

Kidney disease: Your dose will be lowered if you have kidney damage or kidney disease.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Nadolol comes with risks if you don’t take it as prescribed.

If You Don't Take It At All

If you don’t take nadolol, your blood pressure won’t be lowered and you may be at risk for serious heart problems, such as heart attack or stroke.

If You Stop Taking It

Don’t stop taking nadolol without talking to your doctor. Stopping suddenly can cause serious heart problems, such as a heart attack, stroke, or irregular heartbeat.

If You Take Too Much

Go to the nearest emergency room as soon as possible or contact a poison control center. Taking too much nadolol can lead to severe low blood pressure, severe slowing of the heart, and even heart failure.

What to Do If You Miss a Dose

If you miss a dose, take it as soon as you can. However, if it’s almost time for your next dose, take only the next dose. Don’t take extra doses or double doses to make up for any doses that you missed.

How to Tell If the Drug Is Working

This medication may not make you feel any different. But you may be able to tell it’s working if your blood pressure goes down. Your doctor will check your blood pressure and heart rate regularly.

Nadolol is a long-term drug treatment.

Store in temperatures from 59–86°F (15–30°C)

Don’t freeze nadolol. Keep it away from light and high temperature.

Note: Keep this medication away from areas where they could get wet, such as bathrooms. Store it away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry it with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt this medication.
  • You may need to show your pharmacy’s preprinted label to identify the medication. Keep the original prescription-labeled box with you when traveling.

Clinical Monitoring

Your doctor will monitor your blood pressure and heart rate regularly. Make sure to ask your doctor or nurse what your blood pressure and pulse should be if you’re checking those yourself. You may also have to get blood tests done so your doctor can see how well your kidneys and liver are working.

Are There Any Alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

What does the pill look like?

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How Much Does nadolol Cost?

Oral tablet
We've partnered with GoodRX so you can compare prices and save money on your next prescription. Check out the lowest cash prices below and enter your zip code to find the best deal near you.

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Lowest price for nadolol

CVS Pharmacy $11.99
Walgreens $27.05
Walmart $33.95
These represent the lowest cash prices for nadolol and may be lower than your insurance.

Find the lowest prices of nadolol near you

These represent the lowest cash prices for nadolol and may be lower than your insurance.

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on June 25, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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