Advertisement

Generic Name:

mitoxantrone, Injectable solution

All Brands

  • Novantrone (Discontinued)
A discontinued drug is a drug that has been taken off the market due to safety issues, shortage of raw materials, or low market demand.
SECTION 1 of 5

Highlights for mitoxantrone

Injectable solution
1

Mitoxantrone is an injection chemotherapy drug. It’s used to treat multiple sclerosis and certain types of cancer.

2

Mitoxantrone is given by a healthcare provider. It’s usually given once every three months for about 2 to 3 years, but this can be different for each person.

3

This drug can cause heart damage during therapy and even years after therapy is over. Talk to your doctor about evaluating your risk factors.

4

Mitoxantrone may harm a fetus or breastfeeding baby. You should not become pregnant or breastfeed while taking the drug.

5

The most common side effects of mitoxantrone are nausea, constipation, diarrhea, stomach pain, hair loss, fever, chills, cough, sore throat, mouth sores, and loss of menstrual periods.

IMPORTANT INFORMATION

FDA Warning

This drug has some Black Box Warnings. A Black Box Warning is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

Heart failure. Mitoxantrone may cause heart failure, which can lead to death. This can happen during therapy or months to years after therapy.

Lowered immunity. This drug lowers your immunity. Typically this drug isn’t given if your neutrophil count is less than 1,500. However, if you have acute nonlymphocytic leukemia, it’s still okay to take this drug even if your neutrophil count is below 1,500.

Increased infection risk

Mitoxantrone may cause your white blood cell count to go down. This increases your chance of getting an infection. The drug may also cause your platelet count to go down, which increases your chance of bleeding. Call your doctor right away if you experience:

  • fever
  • chills
  • sore throat
  • cough
  • pain with urination
  • urinating more often
  • unusual bleeding or bruising

May discolor urine or eyes

Mitoxantrone is dark blue, and it may turn your urine blue-green for a few days after each dose. It may also make the whites of your eyes a little blue. This will go away.

What is mitoxantrone?

Mitoxantrone is an injected drug. It is only given by a healthcare provider in a clinical setting.

When treating prostate cancer and nonlymphocytic leukemia, this drug is used as a combination therapy. For advanced prostate cancer, it’s used with steroids as initial chemotherapy. It’s used together with other drugs to treat acute nonlymphocytic leukemia in people older than 18 years.

Why it's used

Mitoxantrone is used to reduce problems associated with secondary (chronic) progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. It’s also used to reduce pain related to advanced hormone refractory prostate cancer and to treat acute nonlymphocytic leukemia.

How it works

This medication works in different ways to treat multiple sclerosis (MS) and acute nonlymphocytic leukemia and prostate cancer.

In MS, immune cells damage the protective covering of nerves.

More Details

How It Works

This medication works in different ways to treat multiple sclerosis (MS) and acute nonlymphocytic leukemia and prostate cancer.

In MS, immune cells damage the protective covering of nerves. Mitoxantrone limits the ability of these cells to damage the protective nerve covering.

For acute nonlymphocytic leukemia and prostate cancer, mitoxantrone targets cells that divide quickly. These include cancer cells. Mitoxantrone causes these cells to die.

Advertisement
SECTION 2 of 5

mitoxantrone Side Effects

Injectable solution

Most Common Side Effects

The most common side effects of mitoxantrone include:

  • nausea

  • sudden hair loss

  • loss of menstrual periods

  • bladder infections

  • mouth sores

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

  • decreased ability to make blood cells. Symptoms may include:

    • fatigue
    • fever
    • chills
    • sore throat
    • cough
    • unusual bleeding or bruising
  • congestive heart failure. Symptoms may include:

    • trouble breathing
    • swelling of your legs or ankles
    • sudden weight gain
    • uneven or fast heartbeat
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Mitoxantrone does not cause drowsiness.

Common side effects can normally be treated by your doctor.

Mitoxantrone is dark blue in color, and it may turn your urine a blue-green color. It may also turn the whites of your eyes a little blue for a few days after each dose. This effect will go away.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

mitoxantrone May Interact with Other Medications

Injectable solution

Mitoxantrone can interact with other medications, herbs, or vitamins you might be taking. Your healthcare provider will look out for interactions with your current medications. Always be sure to tell your doctor about all medications, herbs, or vitamins you’re taking.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Mitoxantrone Warnings
low immunity
People with low immunity

Taking this drug can lower your immunity. You shouldn’t take it if your doctor finds you have a low immunity. Mitoxantrone can lower your immunity even further.

heart conditions
People with heart conditions

You shouldn’t take mitoxantrone if your doctor finds your heart is not working normally. This drug can decrease your heart’s ability to pump blood.

pregnant woman
Pregnant women

Mitoxantrone is a category D pregnancy drug. That means two things:

  1. Studies show a risk of adverse effects to the fetus when the mother takes the drug.
  2. This drug should only be used during pregnancy in serious cases where it's needed to treat a dangerous condition in the mother.

Mitoxantrone can harm a developing baby, so your doctor may give you a pregnancy test before each dose.

If you plan on getting pregnant, talk with your doctor about stopping mitoxantrone. If you become pregnant, contact your doctor right away.

breastfeeding
Women who are nursing

You shouldn’t breastfeed if you’re taking mitoxantrone. The drug may be passed to your baby through your breast milk, which can be harmful to your baby.

SECTION 4 of 5

How to Take mitoxantrone (Dosage)

Injectable solution

Your doctor will determine a dose that’s right for you based on your individual needs. Your general health may affect your dose. Tell your doctor about all health conditions you have before your doctor or nurse administers the drug to you. 

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with risks if you don’t take it as prescribed by your doctor.

If You Stop Receiving this Drug

Your disease may become worse and your symptoms may return.

If You Miss a Dose

If you miss a dose, your symptoms can return and your disease could get worse. It’s important not to miss your dose. Call your doctor if you’re unable to keep an appointment.

If You Take Too Much

If you take too much, you can experience more side effects, including more serious infections, heart problems, and even death.

What to Do If You Miss a Dose

It’s important not to miss your dose. If you’re unable to keep a dosing appointment, call your doctor.

How to Tell the Drug Is Working

You may be able to tell the drug is working for MS if your symptoms don’t get worse and you have fewer flare-ups.

You’re doctor will do tests to see how well the drug is working for cancer treatment.

This is a long-term treatment.

It’s important not to miss your dose

Call your doctor or healthcare professional if you are unable to keep an appointment.

How Long Does It Take?

How long it takes depends on the condition. For treating multiple sclerosis and prostate cancer, it usually takes 5–15 minutes. For nonlymphocytic leukemia, you may need to stay in the hospital because it’s part of a chemo combination therapy.

Travel

Mitoxantrone is only given by a healthcare provider. It’s important to discuss your travel plans with your healthcare provider to arrange for a place to receive mitoxantrone where you’ll be staying.

Clinical Monitoring

Your doctor may perform these tests to monitor you as you take mitoxantrone:

  • complete blood count
  • chest X-ray
  • heart function tests:
    • electrocardiography
    • echocardiography
    • ejection fraction
  • cholesterol level tests
  • liver function and bile tests
  • pregnancy tests

Insurance

Many insurance companies will require a prior authorization before they approve the payment for mitoxantrone.

SECTION 5 of 5

How Much Does mitoxantrone Cost?

Injectable solution

We've partnered with GoodRx so you can compare prices, find discounts and save up to 80% on your next prescription. Check out the low coupon prices below — no insurance required.

Compare prices and save up to 80% on your next refill!

Lowest price for mitoxantrone

Membership warehouse $252.75
Safeway $252.75
Kroger Pharmacy $256.55
These prices represent the lowest priced national pharmacies for mitoxantrone on GoodRx. They may be lower than your insurance.

Enter your zip code to find the best deal near you.

These prices represent the lowest priced national pharmacies for mitoxantrone on GoodRx. They may be lower than your insurance.

Show Sources

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on May 29, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
Advertisement
Advertisement
Advertisement