Mirabegron | Side Effects, Dosage, Uses & More
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Generic Name:

mirabegron, Oral tablet

All Brands

  • Myrbetriq
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Highlights for mirabegron

Oral tablet
1

Mirabegron is an oral drug that’s used to treat the symptoms of overactive bladder (OAB). Symptoms can include a strong need to urinate, with leaking or wetting accidents (urge urinary incontinence). They can also include a strong need to urinate right away (urgency), and urinating often (frequency). 

2

The standard starting dose for adults is 25 mg taken by mouth once per day. If your symptoms don’t improve after 8 weeks of treatment, your doctor may change your dose to 50 mg taken once per day. 

3

Common side effects can include high blood pressure, common cold symptoms, urinary tract infection, or headache.

4

This drug can change the way your body processes other drugs. Certain drugs, such as thioridazine, flecainide, propafenone, or digoxin, can become toxic in your body if too much builds up. Tell your doctor about any other medications you’re taking before you start treatment with mirabegron. 

IMPORTANT INFORMATION

High blood pressure

This drug may cause your blood pressure to increase. If you already have high blood pressure, this drug can make it worse. Your doctor should check your blood pressure regularly while you’re taking this drug.

Urinary retention

This drug may make it harder to empty your bladder if you have bladder obstruction or if you’re taking other medications to treat overactive bladder. Tell your doctor right away if you’re unable to empty your bladder.

Swelling (edema)

In rare cases, this drug may cause swelling of the face, lips, tongue, or throat. If swelling occurs and makes it hard for you to breathe, call 9-1-1 or go to the emergency room right away.

What is mirabegron?

This drug is a prescription drug. It comes in the form of an extended-release tablet you take by mouth.

This drug is a brand-name drug. It’s not available as a generic drug. 

Why it's used

This drug is used to treat the following symptoms of overactive bladder (OAB) in adults:

  • Urge urinary incontinence: a strong need to urinate, with leaking or wetting accidents
  • Urgency: a strong need to urinate right away
  • Frequency: urinating more often than usual

How it works

This drug belongs to a class of drugs called beta-3 adrenergic agonists. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

This drug works by relaxing the muscle that surrounds your bladder. It may increase your bladder’s ability to store urine. This reduces your symptoms of overactive bladder.

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mirabegron Side Effects

Oral tablet

Most Common Side Effects

The more common side effects that can occur with mirabegron include:

  • high blood pressure

  • common cold symptoms, such as nasal congestion, runny nose, or sneezing

  • urinary tract infection

  • headache

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

Call your doctor right away if you have serious side effects. Call 9-1-1 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • High blood pressure

  • Urinary retention (not being able to empty your bladder)

  • Swelling of your face, lips, tongue, or throat that makes it hard to breathe

Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug does not cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
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mirabegron May Interact with Other Medications

Oral tablet

Mirabegron can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Medications that might interact with this drug

Antipsychotic drugs

Mirabegron increases the level of these drugs in your body. This can raise your risk of side effects.

These drugs include:

  • thioridazine

Blood thinners

Mirabegron increases the level of these drugs in your body. This can raise your risk of side effects.

These drugs include:

  • warfarin

Heart drugs

Mirabegron increases the level of these drugs in your body. This can raise your risk of side effects.

These drugs include:

  • flecainide
  • propafenone
  • digoxin

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
liver problems
People with liver problems

This drug is processed by your liver. If your liver isn’t working well, more of this drug may stay in your body. This puts you at risk for more side effects. You shouldn’t take this drug if you have severe liver disease. If you have moderate liver disease, your doctor may adjust your dose of this drug.

kidney problems
People with kidney problems

This drug is cleared from your body by your kidneys. If your kidneys aren’t working well, more of this drug may stay in your body. This puts you at risk for more side effects. If you have end-stage kidney disease, you shouldn’t take this drug. If you have severe kidney disease, your doctor may adjust your dose of this drug.

high blood pressure
People with high blood pressure

If you have a history of high blood pressure, this drug may make your condition worse. Your doctor should check your blood pressure regularly while you’re taking this drug. If your high blood pressure is severe, you shouldn’t take this drug.

bladder outlet obstruction
People with bladder outlet obstruction

This drug may make it harder to empty your bladder if you have bladder obstruction or if you’re taking other medications to treat overactive bladder. Tell your doctor right away if you’re not able to empty your bladder.

pregnant women
Pregnant women

This drug is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk to the fetus.

breastfeeding
Women who are breast-feeding

It isn’t known if this drug passes into breast milk. If it does, it may cause side effects in a child who is breast-fed.

Talk to your doctor if you breast-feed your baby. You may need to decide whether to stop breast-feeding or stop taking this medication.

for children
For children

The safety and effectiveness of this drug in children younger than 18 years haven’t been established.

call doctor
When to call the doctor

Call your doctor if you become pregnant while taking this drug.

allergies
Allergies

This drug may cause a severe allergic reaction called angioedema. Symptoms can include:

  • swelling of your face, lips, tongue, or throat
  • trouble breathing

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

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How to Take mirabegron (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Overactive bladder (OAB)

Brand: Myrbetriq

Form: Oral extended-release tablet
Strengths: 25 mg, 50 mg
Adult dosage (ages 18 years and older)

The typical starting dose is 25 mg taken by mouth once per day. If your symptoms don’t improve within 8 weeks of taking this drug, your doctor may increase your dose to 50 mg taken once per day. The maximum dose is 50 mg taken once per day.

Child dosage (ages 0–17 years)

This medication hasn’t been studied in children. It shouldn’t be used in people younger than 18 years.

Special considerations

Kidney disease: If you have severe kidney disease, your dose of mirabegron shouldn’t be more than 25 mg per day.

Liver disease: If you have moderate liver disease, your dose of mirabegron shouldn’t be more than 25 mg per day.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all

Your symptoms of overactive bladder won’t get better. You may still have a strong urge to urinate, along with leaking or wetting accidents. You may also urinate more often than usual.

If you miss doses or don’t take the drug on schedule

Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much

You could have dangerous levels of the drug in your body. You may have the following symptoms:

  • heart rhythm problems (palpitations)
  • increased heart rate
  • high blood pressure

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room right away. 

What to do if you miss a dose

If you miss a dose of this drug, skip the dose and start taking this drug again the next day. Don’t take two doses of this drug on the same day. This could cause dangerous side effects.

How to tell if the drug is working

Your symptoms caused by overactive bladder should get better.

This drug is used for long-term treatment.

Don’t crush, cut, or chew the tablet

Each tablet should be swallowed whole with a glass of water.

Store this drug carefully

  • Keep this drug at room temperature at 77°F (25°C). It can be stored briefly between 59°F (15°C) and 86°F (30°C).
  • Keep the medication bottle closed.
  • Keep your drugs away from areas where they could get wet, such as bathrooms. Store this drug away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry your medication with you, such as in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

During your treatment with this drug, your doctor will monitor your:

  • symptoms of overactive bladder
  • blood pressure

Insurance

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

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How Much Does mirabegron Cost?

Oral tablet

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Lowest price for mirabegron

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Kroger Pharmacy $304.45
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These prices represent the lowest priced national pharmacies for mirabegron on GoodRx. They may be lower than your insurance.

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on September 8, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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