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Generic Name:

methyltestosterone, Oral capsule

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  • Android
  • Testred
SECTION 1 of 5

Highlights for methyltestosterone

Oral capsule
1

Methyltestosterone is an oral drug used to stimulate the development of the male sex organ and to maintain secondary sex characteristics in males who have low organ function.

2

This drug is used in women as a secondary treatment in women with advanced, androgen-responsive, inoperable, metastatic (skeletal) breast cancer who went through menopause within the past 1–5 years. It’s also used in premenopausal women with breast cancer who have benefited from ovary removal and have a hormone-responsive tumor.

3

The standard dosage depends on your age, sex, and the condition that’s being treated. Your doctor will decide a dose that’s right for you.

4

Common side effects include nausea, vomiting, yellowing of your skin, and ankle swelling.

5

You shouldn’t use this drug if you’re pregnant or plan to become pregnant. Methyltestosterone can harm the fetus. Use effective birth control while you take this medication.

IMPORTANT INFORMATION

High calcium levels

If you have breast cancer, this drug may cause high calcium levels in your blood (hypercalcemia). This condition can be serious. If this happens, your doctor may stop treatment with the drug.

Risk of liver problems

Long-term use or high doses of this drug may cause liver problems. These include blood-filled cystic spaces on the liver (peliosis hepatis) and tumors on the liver that may be cancerous.

Hepatitis

Your doctor may have you stop taking this drug if you develop hepatitis with jaundice (yellowing of your skin or the whites of your eyes) or if your liver function becomes abnormal. If the drug caused these conditions, your jaundice may go away and your liver function may return to normal once you stop taking this drug.

Drug features

This drug is a controlled substance that’s only available by prescription. It’s available in these forms: oral capsules and oral tablets.

This product isn’t available as a generic drug. 

Why it's used

The use of this drug in males is different from the use in females.

More Details

How it works

This drug belongs to a class of drugs called androgens.

More Details

Why it's used

Males:

The effects of this drug on your body include:

  • growth and maturation of your prostate, seminal vesicles, penis, and scrotum
  • development of male hair in the beard, pubic area, chest, and underarm area
  • enlargement of the voice box (larynx)  
  • thickening of the vocal cords
  • changes in body muscle
  • fat redistribution

Females:

  • The goal of treatment with this drug includes removal (ablation) of the ovaries.
  • This drug has been used in premenopausal women with breast cancer who have benefitted from oophorectomy (removal of the ovaries) and have a hormone-responsive tumor.

How it works

This drug belongs to a class of drugs called androgens. It’s a class III synthetic derivative of testosterone. A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

Males:

The androgens are steroids that develop and maintain primary and secondary male sex characteristics. This drug stimulates receptors in organs and tissues to improve growth and development of male sex organs and maintain male secondary sex characteristics.

Females:

When you take this drug, your body prevents the release of testosterone by blocking of certain hormones.

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SECTION 2 of 5

methyltestosterone Side Effects

Oral capsule

More Common Side Effects

  • The most common side effects that occur with methyltestosterone include:

    • nausea
    • vomiting
    • yellowing of your skin
    • ankle swelling

    If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

  • The most common side effects that occur with methyltestosterone in males include:

    • acne
    • hair changes. Symptoms include:
      • abnormal hair growth on your face and body (hirsutism)
    • male pattern baldness
    • heart problems, including heart failure, heart attack, and stroke. Symptoms include:
      • sudden weakness, tingling, or numbness in your face, arm, or leg, especially on one side of your body
      • severe headache
      • confusion
      • trouble speaking or walking
      • sudden chest pain
    • liver problems. Symptoms include:
    • nausea
    • jaundice, including dark-colored urine and yellowing of your skin or the whites of your eyes
    • changes in liver function
      • nervous system problems. Symptoms include:
      • increased or decreased sex drive
      • headache
      • anxiety
      • depression
      • tingling, prickling, pins and needles sensation around the body
        • higher cholesterol levels
        • blood clots. Symptoms include:
          • sudden chest pain
          • shortness of breath
          • coughing up blood
          • pain, tenderness, or swelling in one or both of your legs
    • more frequent and longer lasting erections
  • The most common side effects that occur with methyltestosterone in females include:

    • hoarseness of your voice
    • acne
    • changes in your menstrual periods, such as less frequent menstrual periods
    • inhibition of gonadotropin (hormones secreted by gonadotrope cells of the anterior pituitary) secretion. Symptoms include:
    • hot flashes
    • sleep disturbance
    • mood swings
    • depression
    • vaginal dryness and painful sexual intercourse
    • urinary incontinence
    • urinary tract infections
      • development of male characteristics (virilization). These changes may not be reversible after you stop taking this drug. Symptoms include:
        • deepening of your voice
        • growth of your clitoris
        • more hair on your face

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life-threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • Serious side effects that occur with methyltestosterone in males include:

    • bleeding problems. Symptoms include:
    • bleeding that doesn’t stop
    • bruising more often than usual
    • weight gain (fluid and electrolyte disturbances)
  • Serious side effects that occur with methyltestosterone in females include:

    • development of male characteristics (virilization). These changes may not be reversible after you stop taking this drug. Symptoms include:
      • deepening of your voice
      • growth of your clitoris
      • deepening of your voice
      • abnormal hair growth on your face and body (hirsutism)
      • acne
      • menstrual changes, such as less frequent menstrual periods
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug doesn’t cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

methyltestosterone May Interact with Other Medications

Oral capsule

Methyltestosterone can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Alcohol interaction

You should limit alcohol while taking this drug. Using alcohol while taking methyltestosterone can have a sedative effect. It may cause slowed reflexes, poor judgment, and sleepiness, which can be dangerous.

Also, your body processes alcohol and this drug in similar ways. That means that if you drink alcohol, this drug might take longer to leave your body. You also could experience worse side effects.

Medications that might interact with this drug

Blood thinners
  • warfarin

Methyltestosterone can increase the amount of the blood thinner in your body. This may make it easier for you to bleed. Your doctor will monitor you closely if you take these two medicines together.

Pain drugs
  • oxyphenbutazone

Taking these drugs together may increase the levels of oxyphenbutazone in your body. This may increase your risk of side effects and toxicity.

Insulin

This drug may lower your blood sugar levels. Your doctor may adjust your dose of insulin while you’re taking methyltestosterone.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
heart disease
People with heart disease

This drug may increase the risk of heart failure, heart attack, and stroke, especially in men. These events may be fatal. People with heart disease may also have a higher risk of swelling (edema) with or without heart failure while taking this drug. If this happens, your doctor may stop methyltestosterone or prescribe a diuretic.

blood clots
People with a history of blood clots

If you have a history of blood clots, such as deep vein thrombosis (DVT) and pulmonary embolism (PE), talk to your doctor to evaluate your risk.

liver disease
People with liver disease

Tell your doctor if you have liver problems or had them in the past. Methyltestosterone may cause liver toxicity, jaundice, hepatitis, and liver cancer.

pregnant women
Pregnant women

This drug is a category X pregnancy drug. Category X drugs should never be used during pregnancy. 

If this drug is taken during pregnancy, it can cause serious effects in the fetus. This drug may cause abnormal sex organ development in a female fetus.

Tell your doctor if you’re pregnant or plan to become pregnant.

breast-feeding
Women who are breast-feeding

It isn’t known if this drug passes into breast milk. If it does, it may cause serious effects in a breast-feeding child.

You and your doctor may need to decide if you’ll take this drug or breast-feed.

for seniors
For seniors

Seniors who take this drug may have an increased risk of prostate enlargement and prostate cancer.

for children
For children

This drug should be used with caution in children. This drug may cause serious effects on bone growth when given to children. It may cause a child’s bones to mature without causing a child to grow in height. This drug may stop children from ever reaching their full height. Your child’s doctor will take x-rays of your child’s hands and wrists every 6 months while on this drug.

allergies
Allergies

This drug can cause a severe allergic reaction. Symptoms include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal.

SECTION 4 of 5

How to Take methyltestosterone (Dosage)

Oral capsule

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Hypogonadism

Brand: Android C-III

Form: Oral capsule
Strengths: 25 mg

Brand: Testred C-III

Form: Oral capsule
Strengths: 10 mg

Generic: methyltestosterone

Form: Oral capsule
Strengths: 10 mg
Form: Oral tablet
Strengths: 10 mg
Adult dosage (ages 18–64 years)
  • Dosage to treat hypogonadism: 10–50 mg taken by mouth 2–3 times per day
  • Dosage to induce puberty: Your doctor will decide your dose based on your age, bone structure, and other factors.
Child dosage (ages 13–17 years)
  • Dosage to treat hypogonadism: 10–50 mg taken by mouth 2–3 times per day
  • Dosage to induce puberty: Your doctor will decide your dose based on your age, bone structure, and other factors.
Child dosage (ages 0–12 years)

This drug should not be used in people younger than 12 years.

Senior dosage (ages 65 years and older)

Your body processes this drug more slowly. Your doctor may start you on a lowered dose so that too much of this drug doesn’t build up in your body. Too much of the drug in your body can be toxic.

Breast cancer

Brand: Android C-III

Form: Oral capsule
Strengths: 25 mg

Brand: Testred C-III

Form: Oral capsule
Strengths: 10 mg

Generic: methyltestosterone

Form: Oral capsule
Strengths: 10 mg
Form: Oral tablet
Strengths: 10 mg
Adult dosage (ages 18–64 years)

Breast cancer: 50–200 mg taken by mouth 2–3 times per day

Child dosage (ages 0–17 years)

This drug shouldn’t be used for treatment of breast cancer in people younger than 18 years.

Senior dosage (ages 65 years and older)

Your body processes this drug more slowly. Your doctor may start you on a lowered dose so that too much of this drug doesn’t build up in your body. Too much of the drug in your body can be toxic.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with serious risks if you don’t take it as prescribed.

If you don’t take it at all

If you don’t take it at all, you have a higher risk of reversing the benefits of the drug.

If you take too much

If you take too much, you have a higher risk of developing the most common symptoms (nausea, vomiting, changes in skin color, and ankle swelling). If you think that you’ve taken too much methyltestosterone, call your doctor or go to the emergency room right away.

If you miss a dose

Talk to your doctor right away if you miss a dose. If you forget to take your dose, take it as soon as you remember. If it’s just a few hours before the time for your next dose, take only one dose at that time.

Never try to catch up by taking two doses at once. This could result in toxic side effects.

How to tell if the drug is working

Males:
You may be able to tell if this drug is working if you have signs of puberty, such as growth of your testicles and scrotal sac, growth of your pubic hair, body growth, growth of your penis, facial and underarm hair, and acne. Your doctor will also monitor you for the appearance of puberty.

Females:
Your doctor will do tests to see if the drug is working.

This drug may be used for short-term or long-term treatment.

Important considerations for taking this drug
can crush tablet
The tablets can be crushed. The capsules can’t be crushed.
storage
Store the drug as close to 77°F (25°C) as possible
See Details
refillable
The prescription is refillable
travel
Travel
See Details
clinical monitoring
Clinical monitoring
See Details
not usually stocked
Not every pharmacy stocks this drug, so call ahead
prior authorization
Insurance
See Details

Store the drug as close to 77°F (25°C) as possible

  • It must be kept in temperatures from 59°F (15°C) to 86°F (30°C).
  • Don’t freeze this drug.
  • Keep it away from light and high temperatures.
  • Keep your drugs away from areas where they could get wet, such as bathrooms. Store this drug away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry your medication with you or in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t hurt this medication.
  • You may need to show airport staff your pharmacy’s label to clearly identify the medication. Keep the original prescription label with you when traveling.Don’t leave this medication in the car, especially when the temperature is hot or freezing.
  • Since this drug is a controlled substance, make sure that you have enough of it before you travel. You may not be able to fill your prescription on your trip. State laws differ about refilling controlled substances. Speak to your pharmacist.

Clinical monitoring

Your doctor will check the following to make sure that this medication is working and is safe for you:

  • kidney function
  • liver function
  • blood sugar levels
  • electrolyte levels (sodium, chloride, potassium, calcium, and inorganic phosphates)
  • symptoms of jaundice, such as yellowing of your skin or the whites of your eyes
  • cholesterol
  • symptoms of bleeding and bruising

Males with delayed puberty:

Your doctor will check the following to make sure that this medication is working and is safe for you:

  • x-rays to check your bone age every 6 months in males who haven’t gone through puberty

Females:

Your doctor will check the following to make sure that this medication is working and is safe for you:

  • urine and blood calcium levels

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for this drug.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

SECTION 5 of 5

How Much Does methyltestosterone Cost?

Oral capsule

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Lowest price for methyltestosterone

Walgreens $17.95
Rite-Aid $3,027.70
Membership warehouse $5,161.57
These prices represent the lowest priced national pharmacies for methyltestosterone on GoodRx. They may be lower than your insurance.

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These prices represent the lowest priced national pharmacies for methyltestosterone on GoodRx. They may be lower than your insurance.

Show Sources

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on September 15, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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