Metformin/pioglitazone | Side Effects, Dosage, Uses & More

Generic Name:

metformin-pioglitazone, Oral tablet

All Brands

  • Actoplus Met
SECTION 1 of 4

Highlights for metformin-pioglitazone

Oral tablet
1

Metformin/pioglitazone is a combination of two drugs in a single form that’s used to lower blood sugar levels in type 2 diabetes. It’s used along with diet and exercise.

2

This drug is given in divided doses with meals, usually twice per day. You should take this drug at the same time each day to keep your blood sugar levels steady.

3

Tell your doctor if you have heart failure, kidney problems, bladder cancer, liver problems, or the diabetic eye disease macular edema. You should also tell your doctor if you drink a lot of alcohol. This drug may not be safe for you to take.

4

Metformin/pioglitazone may cause you to ovulate, even if you don’t get regular menstrual periods. This can increase your risk of becoming pregnant. Ask your doctor about effective forms of birth control while taking this drug.

5

Common side effects include diarrhea, nausea, upset stomach, cold-like symptoms (upper respiratory tract infection), swelling in your legs, ankles, and feet, headache, and weight gain. These side effects usually happen during the first few weeks of treatment. Taking this drug with food may lower your risk of side effects.

IMPORTANT INFORMATION

FDA warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

Heart failure warning: Pioglitazone can cause heart failure or make existing heart problems worse. You shouldn’t use this drug if you have symptoms of heart failure. Symptoms include:

  • fast weight gain
  • shortness of breath or trouble breathing, especially when you lay down
  • swelling or fluid retention in your arms or legs
  • unusual tiredness

Lactic acidosis warning: Lactic acidosis is a rare but serious side effect of metformin. In this condition, lactic acid builds up in your blood. This is a medical emergency that requires treatment in the hospital. Lactic acidosis is fatal in about half of people who develop it.  You should stop taking metformin and call your doctor right away or go to the emergency room if you have signs of lactic acidosis. Symptoms include:

  • tiredness
  • weakness
  • unusual muscle pain
  • trouble breathing
  • unusual sleepiness
  • stomach pains, nausea, or vomiting
  • dizziness or lightheadedness
  • slow or irregular heart rate

Your risk of lactic acidosis may be higher if you drink a lot of alcohol or have the following conditions:

  • sepsis, a dangerous complication of an infection
  • dehydration
  • liver problems
  • kidney problems
  • congestive heart failure

Risk of pregnancy

Pioglitazone may cause you to ovulate (release of an egg from an ovary), which can lead to pregnancy. You may ovulate even if you don’t have regular menstrual periods. Ask your doctor about effective forms of birth control to use while you’re taking this medication.  

X-ray warning

You’ll need to stop taking this drug for a short time if you plan to have an injection of dye or contrast for an x-ray procedure. This can affect how your kidneys work and put you at risk for lactic acidosis.

Drug features

Metformin/pioglitazone is a prescription drug. It’s available in these forms: oral immediate-release tablet and oral extended-release tablet.

Metformin/pioglitazone is available as a generic drug. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand. Talk to your healthcare provider to see if the generic will work for you.

This is a combination of two or more drugs in a single form. It’s important to know about all the drugs in the combination because they each may have unique traits.

This drug may be used as part of a combination therapy. That means you need to take it with other drugs.

Why it's used

Metformin/pioglitazone is used to improve blood sugar control in adults with type 2 diabetes. It’s used along with diet and exercise.

This drug isn’t used to treat type 1 diabetes or diabetic ketoacidosis, a complication of diabetes that occurs when your body produces high levels of blood acids called ketones.

How it works

Metformin/pioglitazone is a combination of two diabetes medications that work in different ways.

Metformin belongs to a class of drugs called biguanides. A class of drugs refers to medications that work similarly.

More Details

How it works

Metformin/pioglitazone is a combination of two diabetes medications that work in different ways.

Metformin belongs to a class of drugs called biguanides. A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

Metformin reduces the amount of glucose (sugar) made by your liver, lowers the amount of glucose your body absorbs, and increases the effect of insulin on your body. Insulin is a hormone that helps your body remove extra sugar from your blood. This lowers your blood sugar levels.

Pioglitazone belongs to a class of drugs called thiazolidinediones. It works by helping you respond better to the insulin that your body makes. It helps insulin take the glucose from your bloodstream and move it into the cells, where it’s used to make fuel or energy. This lowers your blood sugar levels.

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SECTION 2 of 4

metformin-pioglitazone Side Effects

Oral tablet

More Common Side Effects

The more common side effects that occur with metformin/pioglitazone include: 

  • diarrhea

  • nausea

  • upset stomach

  • cold-like symptoms (upper respiratory tract infection)

  • swelling (edema)

  • headache

  • weight gain

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life-threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

  • low blood sugar (hypoglycemia). Symptoms include: 

    • mood changes, such as irritability, impatience, anger, stubbornness, or sadness
    • confusion
    • lightheadedness
    • dizziness
    • sleepiness
    • blurred vision
    • tingling or numbness in your lips or tongue
    • headaches
    • weakness
    • tiredness
    • lack of coordination
    • nightmares or crying out during your sleep
    • seizures
    • loss of consciousness
  • lactic acidosis. Symptoms include:

    • weakness or tiredness
    • unusual muscle pain
    • stomach pains, nausea, or vomiting
    • trouble breathing
    • dizziness or lightheadedness
    • slow or irregular heart rate
  • heart failure. Symptoms include: 

    • swelling or fluid retention, especially in the ankles or legs
    • shortness of breath or trouble breathing, especially when you lie down
    • unusually fast weight gain
    • unusual tiredness
  • swelling in the back of your eye (macular edema). Symptoms include:

    • blurred vision
  • low red blood cell count (anemia). Symptoms include:

    • pale skin
    • shortness of breath
    • tiredness
    • chest pain
  • bladder cancer. Symptoms include:

    • blood or a red color in your urine
    • needing to urinate more often than normal
    • pain in your bladder when you urinate
  • broken bones (fractures)

  • ovulation, which may lead to pregnancy

Pharmacist's Advice
Healthline Pharmacist Editorial Team

Metformin/pioglitazone doesn’t cause drowsiness. However, it may cause a low blood sugar reaction.

If you have a low blood sugar reaction, you need to treat it.

  • For mild hypoglycemia (55–70 mg/dL), treatment is 15–20 grams of glucose (a type of sugar). You need to eat or drink one of the following:
    • 3–4 glucose tablets
    • a tube of glucose gel
    • ½ cup of juice or regular, non-diet soda
    • 1 cup of nonfat or 1% cow’s milk
    • 1 tablespoon of sugar, honey, or corn syrup
    • 8–10 pieces of hard candy, such as lifesavers
  • Test your blood sugar 15 minutes after you treat the low sugar reaction. If your blood sugar is still low, then repeat the above treatment.
  • Once your blood sugar is back in the normal range, eat a small snack if your next planned meal or snack is more than 1 hour later. 

If you don’t treat low blood sugar, you can have a seizure, pass out, and possibly develop brain damage. Low blood sugar can even be fatal. If you pass out because of a low sugar reaction or cannot swallow, someone will have to give you an injection of glucagon to treat the low sugar reaction. You may need to go to the emergency room.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

metformin-pioglitazone May Interact with Other Medications

Oral tablet

Metformin/pioglitazone can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist. 

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Alcohol interaction

The use of drinks that contain alcohol can increase your risk of lactic acidosis from metformin/pioglitazone. Alcohol may also raise or lower your blood sugar levels. If you drink alcohol, talk to your doctor.

Medications that might interact with this drug

Seizure drugs

Taking these drugs with metformin/pioglitazone may raise your risk of lactic acidosis. 

These drugs include:

  • topiramate
  • zonisamide
  • zcetazolamide

Intravenous (IV) dyes

Having an x-ray procedure while taking this drug may raise your risk of lactic acidosis. 

These drugs include:

  • radiopaque contrast agents that are used for laboratory studies, such as x-rays

High triglycerides drugs

Taking these medicines with metformin/pioglitazone may cause low blood sugar. 

These drugs include:

  • gemfibrozil

Water pills (diuretics)

Taking these drugs with metformin/pioglitazone may cause low blood sugar. 

These drugs include:

  • amiloride 
  • furosemide
  • triamterene

Taking these drugs with metformin/pioglitazone may cause high blood sugar.

These drugs include:

  • chlorothiazide
  • chlorthalidone
  • hydrochlorothiazide
  • indapamide
  • metolazone

Heart drugs

Taking these drugs with metformin/pioglitazone may cause low blood sugar.

These drugs include:

  • digoxin

Pain drugs

Taking these drugs with metformin/pioglitazone may cause low blood sugar.

These drugs include:

  • morphine

Heart rhythm problem drugs

Taking these drugs with metformin/pioglitazone may cause low blood sugar.

These drugs include:

  • quinidine
  • dofetilide
  • procainamide

Antibiotics

Taking these drugs with metformin/pioglitazone may cause low blood sugar. 

These drugs include:

  • vancomycin

Taking other antibiotics with metformin/pioglitazone may cause high blood sugar. 

These drugs include:

  • rifabutin
  • rifampin
  • rifapentine
  • rifaximin

Heartburn drugs

Taking these drugs with metformin/pioglitazone may cause low blood sugar.

These drugs include:

  • histamine H2 blockers, such as:
    • cimetidine
    • ranitidine

Diabetes drugs

Taking these drugs with metformin/pioglitazone may cause low blood sugar.

These drugs include:

  • other oral diabetes drugs
  • insulin

Oral steroids

Taking these drugs with metformin/pioglitazone may cause high blood sugar.

These drugs include:

  • dexamethasone
  • hydrocortisone
  • methylprednisolone
  • prednisone
  • prednisolone

Anti-psychotic and anti-nausea drugs

Taking these drugs with metformin/pioglitazone may cause high blood sugar.

These drugs include:

  • chlorpromazine
  • fluphenazine
  • perphenazine
  • prochlorperazine
  • thioridazine

Thyroid drugs

Taking this drug with metformin/pioglitazone may cause high blood sugar. 

These drugs include:

  • levothyroxine

Estrogens

Taking these drugs with metformin/pioglitazone may cause high blood sugar.

These drugs include:

  • conjugated estrogens
  • estradiol

Oral birth control pills

Taking these drugs with metformin/pioglitazone may cause high blood sugar.

Seizure drugs

Taking these drugs with metformin/pioglitazone may cause high blood sugar.

These drugs include:

  • fosphenytoin
  • phenytoin

Heart and blood pressure drugs

Taking these drugs with metformin/pioglitazone may cause high blood sugar.

These drugs include:

  • calcium channel blockers, such as:
    • amlodipine
    • diltiazem
    • felodipine
    • isradipine
    • nicardipine
    • nifedipine
    • nisoldipine
    • verapamil

Other heart and high blood pressure drugs may either increase or decrease the effect of metformin/pioglitazone. This means that you may have more side effects or the drug won’t work to treat your diabetes.

These drugs include:

  • clonidine
  • reserpine
  • beta blockers, such as:
    • acebutolol (Sectral)
    • atenolol (Tenormin)
    • bisoprolol (Zebeta)
    • carteolol (Cartrol)
    • esmolol (Brevibloc)
    • metoprolol (Lopressor, Toprol XL)
    • nadolol (Corgard)
    • nebivolol (Bystolic)
    • propranolol (Ineral LA)

Tuberculosis drugs

Taking these drugs with metformin/pioglitazone may cause high blood sugar. 

These drugs include:

  • isoniazid

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with diabetic eye disease

If you have swelling in the back of the eye (macular edema), you shouldn’t take this drug. It may make your condition worse.

People with heart failure and swelling (edema)

This drug can cause your body to retain extra fluid. This leads to swelling and weight gain, and may worsen your heart problems or lead to heart failure. Don’t take metformin/pioglitazone if you have severe heart failure. Your doctor will monitor you for signs of heart failure while you take this drug.

People with kidney disease

Metformin is removed from your body by your kidneys. If your kidneys aren’t working as well, metformin may build up in your body and cause lactic acidosis. Your doctor may start you at a lower dose and slowly increase your dose if needed. You shouldn’t take this drug if you have a serum creatinine level of 1.5 mg/dL or higher (males) or 1.4 mg/dL or higher (females).

People with liver disease

Liver disease may put you at a higher risk of lactic acidosis, and pioglitazone may cause liver failure in some people. You shouldn’t use this drug if you have liver disease.

People with bone fractures

Pioglitazone can lead to fractures or broken bones, especially in women. Your doctor may recommend other treatments to help your bone health.

People with anemia

Pioglitazone may cause anemia. Metformin may decrease your vitamin B12 levels and cause anemia as well. Your doctor may do blood tests to check if this drug is safe for you to take.

People with type 1 diabetes

You shouldn’t use metformin/pioglitazone if you have type 1 diabetes or diabetic ketoacidosis. These conditions should be treated with insulin instead.

Pregnant women

Metformin/pioglitazone is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus. 

Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk to the fetus.

Women who are breast-feeding

It isn’t known if metformin/pioglitazone passes into breast milk. If it does, it may cause side effects in a child who is breast-fed. 

Talk to your doctor if you breast-feed your baby. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors

As you age, your kidneys don’t work as well as they once did. Metformin is removed from your body by your kidneys. If your kidneys don’t work as well as they should, this drug can build up in your body and cause more side effects. This drug should only be used if you have normal kidney function. Whether or not it is okay for you to take this drug is based on your kidney function. Your kidney function will be monitored by your doctor.

For children

It isn’t known if metformin/pioglitazone is safe and effective in people younger than 18 years. This drug shouldn’t be used in children. 

Special kid safety:

  • Keep metformin/pioglitazone and all medicines out of the reach of children.
  • Lancets (a needle used to draw blood from your finger) are used to test your blood sugar. Don’t throw out lancets into trash cans or recycling bins, and never flush them down the toilet. Ask your pharmacist for a safe container for disposing used lancets. Your community may have a program for disposing lancets. If throwing out the container in the trash, label it “do not recycle.”

When to call the doctor

  • Call your doctor if you get sick or injured, have an infection, or plan to have surgery. Metformin/pioglitazone may not control your blood sugar levels during these times. Your doctor may stop this drug for a short time and give you insulin instead.
  • If your dose of metformin/pioglitazone isn’t working well, your diabetes won’t be under control. You will have signs of high blood sugar (hyperglycemia). Call your doctor if you have any of the following symptoms:  
    • urinating more often than usual
    • extreme thirst
    • extreme hunger
    • extreme fatigue
    • blurry vision
    • cuts or bruises that are slow to heal
    • tingling, pain, or numbness in your hands or feet

Allergies

Metformin/pioglitazone can cause a severe allergic reaction. Symptoms include: 

  • trouble breathing
  • swelling of your throat or tongue
  • hives 

Call 9-1-1 or go to the nearest emergency room if you develop these symptoms. 

Don’t take this drug again if you’ve ever had an allergic reaction to it before. Taking it again could be fatal (cause death).

SECTION 4 of 4

How to Take metformin-pioglitazone (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on: 

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Type 2 diabetes

Brand: Actoplus Met

Form: Oral tablet
Strengths:
  • 500 mg metformin/15 mg pioglitazone
  • 850 mg metformin/15 mg pioglitazone
Form: Oral extended-release tablet
Strengths:
  • 1,000 mg metformin/15 mg pioglitazone
  • 1,000 mg metformin/30 mg pioglitazone

Generic: metformin/pioglitazone

Form: Oral tablet
Strengths:
  • 500 mg metformin/15 mg pioglitazone
  • 850 mg metformin/15 mg pioglitazone
Adult dosage (ages 18–64 years)
  • People with diabetes not controlled on diet and exercise alone: 
    • The starting dose is 500 mg metformin/15 mg pioglitazone taken by mouth twice per day with meals or 850 mg metformin/15 mg pioglitazone taken by mouth once per day with meals.
  • People with diabetes not controlled on metformin alone: 
    • The starting dose is 15 mg of pioglitazone per day plus your current dose of metformin given in divided doses with food.
  • People with diabetes not controlled on pioglitazone alone: 
    • The starting dose is 1,000 mg of metformin per day plus your current dose of pioglitazone given in divided doses with food.
  • People switching from combination therapy of metformin and pioglitazone as separate tablets:
    • Use your current dose of metformin and pioglitazone.
  • Maximum dose:
    • Oral tablet: 2,550 mg metformin/45 mg pioglitazone per day. It’s taken as 850 mg metformin/15 mg pioglitazone three times per day.
    • Oral extended-release tablet: 2,000 mg metformin/45 mg pioglitazone per day. It’s taken as one 1,000 mg metformin/15 mg pioglitazone extended-release tablet plus one 1,000 mg metformin/30 mg pioglitazone extended-release tablet once per day.
Child dosage (ages 0–17 years)

This medicine hasn’t been studied in children and shouldn’t be used in people younger than 18 years.

Senior dosage (ages 65 years and older)

As you age, your kidneys and liver may not work as well as they did when you were younger. This means that you may be more sensitive to the effects of this medication. Your doctor may reduce your starting dose and adjust your dose more gradually.

Metformin/pioglitazone shouldn’t be used in people 80 years and older unless you have normal kidney function.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Metformin/pioglitazone comes with serious risks if you don't take it as prescribed.

If you don’t take it at all

You may still experience high blood sugar levels. Over time, high blood sugar levels can harm your eyes, kidneys, nerves, or heart. This can lead to heart attack, stroke, blindness, kidney failure and dialysis, and limb amputations.

If you take too much

If you take too much metformin/pioglitazone, you may experience low blood sugar. Symptoms include:

  • mood changes, such as irritability, impatience, anger, stubbornness, or sadness
  • confusion
  • lightheadedness
  • dizziness
  • sleepiness
  • blurred vision
  • tingling or numbness in your lips or tongue
  • headaches
  • weakness
  • tiredness
  • lack of coordination
  • nightmares or crying out during your sleep
  • seizures
  • loss of consciousness

If you think that you’ve taken too much of this medication or have symptoms of low blood sugar, treat your low blood sugar.

  • For mild hypoglycemia (55–70 mg/dL), treatment is 15–20 grams of glucose (a type of sugar). You need to eat or drink one of the following:
    • 3–4 glucose tablets
    • a tube of glucose gel
    • ½ cup of juice or regular, non-diet soda
    • 1 cup of nonfat or 1% cow’s milk
    • 1 tablespoon of sugar, honey, or corn syrup
    • 8–10 pieces of hard candy, such as lifesavers
  • Test your blood sugar 15 minutes after you treat the low sugar reaction. If your blood sugar is still low, then repeat the above treatment.
  • Once your blood sugar is back in the normal range, eat a small snack if your next planned meal or snack is more than 1 hour later. 

If your symptoms continue to worsen, call your doctor or go to the emergency room right away.

What to do If you miss a dose

If you miss a dose of metformin/pioglitazone, take it as soon as you remember. If it’s just a few hours before the time for your next dose, then only take one dose at that time.

Don’t take two doses to try to make up for a missed dose. This could cause toxic side effects.

How to tell if the drug is working

If metformin/pioglitazone is working, your symptoms of high blood sugar should decrease. You may not urinate as often or be as thirsty or hungry. Your blood sugar readings will be lower.

Metformin/pioglitazone is used for long-term treatment.

Metformin/pioglitazone should be taken with meals

This will reduce your risk of diarrhea, nausea, and upset stomach.

Store metformin/pioglitazone at room temperature

  • Keep it between 59°F and 86°F (15°C and 30°C).
  • Keep the bottle closed tightly and keep tablets dry.
  • Don’t freeze this drug.
  • Keep it away from high temperature.
  • Keep your drugs away from areas where they could get wet, such as bathrooms. Store this drug away from moisture and damp locations.

A prescription for this medication is not refillable

You or your pharmacy will have to contact your doctor for a new prescription if you need this medication refilled.

Travel

When traveling with your medication:

  • Always carry your medication with you in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t hurt your medication.
  • You may need to show your pharmacy’s label to clearly identify the medication. Keep the original prescription label with you when traveling.
  • Don’t leave this medicine in the car, especially when the temperature is hot or freezing.
  • Lancets need to be used to test your blood sugar levels. Check for special rules about traveling with lancets.

Self-management

You will need to test your blood sugar levels at home using a blood glucose monitor.  Your doctor may adjust your dose of metformin/pioglitazone based on your blood sugar levels.

You’ll need to learn how to do the following:

  • use a blood glucose monitor to test your blood sugar regularly at home
  • recognize the signs and symptoms of high and low blood sugar
  • be able to treat low and high blood sugar reactions 

While taking metformin/pioglitazone, you’ll need to regularly test your blood sugar levels. You’ll need to purchase the following:

  • sterile alcohol wipes
  • lancing device and lancets (a pricking needle used to prick your finger to draw a drop of blood for testing blood sugar)
  • blood sugar test strips
  • blood glucose monitoring machine
  • needle container for safe disposal of lancets

Clinical monitoring

Before starting and while you’re taking metformin/pioglitazone, your doctor may check your:

  • blood sugar levels
  • glycosylated hemoglobin (A1C) levels. This test measures your blood sugar control over the last 2–3 months.
  • liver function. If your liver tests are abnormal, or if you have symptoms of liver damage, your doctor may decide to stop this medication.
  • kidney function. If your kidney tests are abnormal, your doctor may stop this medication.
  • blood cell counts. Pioglitazone may cause anemia. Metformin may decrease your vitamin B12 levels and cause anemia as well.
  • eye exams. Pioglitazone may cause macular edema. 

Your diet

Managing type 2 diabetes well includes a healthy diet. 

You should talk to your doctor about how to change your eating habits. In general, a healthy diet is made up of fruits, vegetables, whole grains, fiber-rich foods, fish, and good fats, such as avocados, almonds, and olives.

Hidden costs

In addition to the medicine, you will need to purchase the following:

  • sterile alcohol wipes
  • lancing device and lancets (a pricking needle used to prick your finger to draw a drop of blood for testing blood sugar)
  • blood sugar test strips
  • blood glucose monitoring machine
  • needle container for safe disposal of lancets

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for metformin/pioglitazone.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

What does the pill look like?

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on October 26, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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