Highlights for mercaptopurine
mercaptopurine Side Effects
Side effects that you should report to your doctor or health care professional as soon as possible:
- allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
- low blood counts - this medicine may decrease the number of white blood cells, red blood cells and platelets. You may be at increased risk for infections and bleeding.
- signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine
- signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine
- signs of decreased red blood cells - unusually weak or tired, fainting spells, lightheadedness
- breathing problems
- mouth soreness or patches
- nausea, vomiting
- right upper belly pain
- swelling of the ankles, feet, hands, or stomach
- trouble passing urine or change in the amount of urine
- yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
- darkening of the skin
- hair loss
- loss of appetite
mercaptopurine May Interact with Other Medications
Do not take this medicine with any of the following medications:
This medicine may also interact with the following medications:
- medicines to increase blood counts like filgrastim, pegfilgrastim, sargramostim
- other chemotherapy drugs like doxorubicin
- mesalazine, 5-ASA
How to Use mercaptopurine
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for selected conditions, precautions do apply.
They need to know if you have any of these conditions:
- infection (especially virus infection such as chickenpox or herpes)
- kidney disease
- liver disease
- low blood counts like low platelets, red blood cells, or white blood cells
- thiopurine methyltransferase (TPMT) deficiency
- an unusual or allergic reaction to mercaptopurine, azathioprine, other chemotherapy, other medicines, foods, dyes, or preservatives
- pregnant or trying to get pregnant
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose and skip your missed dose. Do not take double or extra doses.
This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.
To protect your kidneys, drink water or other fluids as directed while you are taking this medicine.
In some cases, you may be given additional medicines to help with side effects. Follow all directions for their use.
Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.
This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.
Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.
Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.
Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.
Men should inform their doctors if they wish to father a child. This medicine may lower sperm counts.
Keep out of the reach of children.
Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F). Protect from moisture. Keep container tightly closed. Throw away any unused medicine after the expiration date.
Last Updated: January 28, 2009