Generic Name: maraviroc, Oral tablet

Selzentry

All Brands

  • Selzentry
SECTION 1 of 4

Highlights for maraviroc

Oral tablet
1

Selzentry is used to treat adults with human immunodeficiency virus (HIV) infection who have a unique strain of HIV. This strain is sometimes called CCR5-tropic virus, macrophage strain, tropic strain, and R5 virus.

2

The adult dose of Selzentry ranges from 150–600 mg, taken twice per day, approximately every 12 hours. The dose depends on other drugs you take and how well your kidneys work.

3

Some people have toxic liver reactions to this drug. Before liver damage occurs, you could experience symptoms of an allergic reaction, such as a skin rash and fever. If you have these symptoms or signs of liver damage such as stomach pain, fatigue, or yellowing skin or eyes, call your doctor right away.

4

Selzentry can be taken with or without food.

IMPORTANT INFORMATION

FDA Warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). Though the medication can still be sold and used, a black box warning alerts doctors and patients to potentially dangerous effects.

Warning: May cause liver damage. Selzentry can cause liver damage. You may have signs of an allergic reaction before liver damage occurs. Contact your doctor right away if you have the following symptoms:

  • stomach pain
  • yellowing of your skin or the whites of your eyes
  • fatigue
  • nausea
  • symptoms of an allergic reaction, such as an itchy rash and fever

May cause dizziness

This drug might make you dizzy. If this happens, don’t drive or operate machinery. If it continues, call your doctor.

May cause serious skin reactions

Though rare, Selzentry has caused serious skin reactions, including Stevens-Johnson syndrome. These reactions can include raised welts, facial swelling, fever, and difficulty breathing. See a doctor right away or call 9-1-1 if you have signs of a serious or sudden reaction to your skin after taking this drug.

Drug Features

Selzentry is a prescription drug. It is available in these forms: oral tablet.

Selzentry is used as part of a combination therapy. That means you’ll need to take it with other drugs for your treatment.

Why It's Used

Selzentry is approved for people with human immunodeficiency virus (HIV) infection who have a specific HIV strain.

More Details

How It Works

Selzentry works against a specific strain of human immunodeficiency virus (HIV). It works by blocking this virus from entering certain cells and making copies of itself.

Why It's Used

Selzentry is approved for people with human immunodeficiency virus (HIV) infection who have a specific HIV strain. This strain is sometimes called CCR5-tropic virus, macrophage strain, tropic strain, and R5 virus. Your doctor will test your blood to determine if this is the kind of virus you have before you take this drug.

Selzentry is always used in combination with other HIV medications.

SECTION 2 of 4

maraviroc Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with Selzentry include:

  • upper respiratory tract infections. Symptoms include cough, congestion, fever, and a runny nose

  • cough

  • fever

  • rash

  • dizziness

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • toxic damage reactions. Before liver damage occurs, you may notice symptoms of an allergic reaction, including an itchy rash, and fever. Contact a doctor right away if you have the following symptoms:

    • stomach pain
    • yellowing of your skin or the whites of your eyes
    • fatigue, or nausea
    • symptoms of an allergic reaction, including itchy rash and fever
  • skin reactions, including Stevens-Johnson syndrome, a pattern of allergic reaction that can include raised welts, fever, and difficulty breathing. These skin reactions are rare. See a doctor right away or call 9-1-1 if you have a sudden or serious reaction to your skin after taking this drug.

  • dizziness. Don’t drive or operate machinery if this happens. Call your doctor if it continues.

  • immune reconstitution. This drug may cause immune reconstitution syndrome. In this condition, your recovering immune system causes past infections to return. Examples of past infections that may return include fungal infections, pneumonia, or tuberculosis. Your doctor may need to re-treat the old infection if this happens. Watch for returning symptoms of past infections.

Pharmacist's Advice
Healthline Pharmacist Editorial Team

Selzentry does not cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

maraviroc May Interact with Other Medications

Oral tablet

Selzentry can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications That Might Interact with This Drug

Antibiotics
  • clarithromycin (Biaxin)
  • rifampin (Rifadin)
  • telithromycin (Ketek)

Antidepressant
  • nefazodone

Antifungal drugs
  • ketoconazole
  • itraconazole (Sporonox)

Epilepsy drugs
  • carbamazepine
  • phenobarbital
  • phenytoin

Other human immunodeficiency virus (HIV) medications
  • atazanavir (Reyataz)
  • darunavir (Prezista)
  • delavirdine (Rescriptor)
  • efavirenz (Sustiva)
  • etravirine (Intelence)
  • fosamprenavir (Lexiva)
  • indinavir (Crixivan)
  • lopinavir/ritonavir (Kaletra)
  • nelfinavir (Viracept)
  • ritonavir (Norvir)
  • saquinavir (Invirase)

Herbal supplement
  • St. John's wort (Hypericum perforatum)

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with heart disease

Some people taking Selzentry have experienced dangerous heart-related side effects, including heart attack. If you have heart disease, you might have a greater chance of having these side effects.

People with kidney disease

If you have kidney disease and decreased kidney function, you may have a higher chance of experiencing dizziness, especially when changing positions or standing up. If your kidney dysfunction is severe, you might not be able to take this drug. Your doctor will check your kidney function and determine if you can take this drug and what dose is appropriate.

Pregnant women

Selzentry is a pregnancy category B drug. That means two things:

  1. Studies of the drug in pregnant animals have not shown risk to the fetus.
  2. There aren’t enough studies done in pregnant women to show if the drug poses a risk to the fetus.

Selzentry should be used in pregnancy only if it’s clearly needed.

Women who are nursing

According to the U.S. Department of Health and Human Services, you shouldn’t breastfeed your infant if you have human immunodeficiency virus (HIV). There is a risk of passing HIV to your baby. Additionally, it is not known if Selzentry passes through human breast milk.

For Children

This drug hasn’t been tested in children younger than 16 years. It isn’t recommended to treat children with human immunodeficiency virus (HIV).

When to call the doctor

Call your doctor if you experience:

  • fever
  • weakness
  • chills
  • night sweats
  • sore throat
  • joint pain

These symptoms may be a sign the drug isn’t working, and you may need a different treatment.

Allergies

Though rare, Selzentry has caused serious skin reactions, including Stevens-Johnson syndrome. Stevens-Johnson syndrome is a pattern of allergic reactions that can include raised welts, fever, and difficulty breathing.

See a doctor right away or call 9-1-1 if you have signs of a serious or sudden skin reaction after taking this drug.

SECTION 4 of 4

How to Take maraviroc (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Human immunodeficiency virus (HIV) infection

Brand: Selzentry

Form: Oral Tablet
Strengths: 150 mg and 300 mg
Adult Dosage (ages 18-64 years)

The dose ranges from 150 mg to 600 mg, taken twice per day, divided evenly throughout the day.

Child Dosage (ages 0-17 years)
  • Dosage has not been established for people younger than 16 years.
  • Your dose may depend on other drugs you’re taking.
  • Selzentry is always given with other human immunodeficiency (HIV) medications.
Senior Dosage (ages 65 years and older)

There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of the drug to be higher than normal. If you’re a senior, you may need a lower dose or you may need a different schedule.

Special considerations

Liver Disease: Selzentry is processed through the liver. If you have liver disease, your doctor may need to lower your dose because your liver may process the drug more slowly. If you are given a regular dose the drug may build up in your body and increase your risk of side effects or make them worse. Depending on how severe your liver disease is, you may not be able to take this drug.

Kidney Disease: Kidney disease may cause your kidneys to take longer to filter out drugs. If you have kidney disease, your doctor may lower your dose or change your dose schedule so that the drug does not build up in your body. This could increase your risk of side effects or make them worse.

Tell your doctor that you have kidney disease before taking Selzentry.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Keeping human immunodeficiency virus (HIV) infection under control requires lifelong treatment. Selzentry is a very specific treatment for variation of HIV. It can add to the effectiveness of other HIV drugs you are taking. There can be serious health consequences if you don’t take this drug exactly how your doctor tells you.

If You Don’t Take it at All

If you don’t take it at all, your HIV infection will eventually reduce your immunity to a point that your body won’t be able to defend itself against many types of infections, even infections that are commonly cured in people who don’t have HIV infection.

If You Stop or Miss Doses

If you stop taking this medication or don’t take it as scheduled, the amount of medication in your body can fluctuate and make the medication less effective. This can allow the HIV in your body to become resistant to the drug, which means the drug might not work any more.

If You Don’t Take it on Schedule

Taking your drug at the same time every day keeps a constant amount of the drug in your body. This helps make the drug as effective as possible at keeping the virus under control.

What to Do if You Miss a Dose

If you miss a dose, take it as soon as possible and then take the next dose at the regular time. If it is less than 6 hours before your next scheduled dose, just skip the missed dose and take the next dose at the regular time.  Don’t take two doses at once in order to keep up.

How Can I Tell if the Drug Is Working?

To see how well the drug is working, your doctor will check your:

  • virus count. A virus count measures the number of copies of human immunodeficiency virus (HIV) in your body. A decrease in your virus count is a sign that your treatment is working.
  • CD4 cell count. A CD4 cell count measures the number of CD4 cells in your body. CD4 cells are white blood cells that fight infection. An increased CD4 count is a sign that your treatment is working.

Selzentry is a long-term drug.

Important Considerations for Taking Selzentry
clock Take Selzentry in evenly spaced doses (approximately every 12 hours) for the best effect
do not crush The tablets are film-coated and can’t be cut or crushed
storage Store Selzentry tablets at room temperature: 77°F (25°C) See Details
refillable prescription Prescription is refillable
clinical monitoring Clinical Monitoring See Details
not usually stocked Not every pharmacy stocks this drug, so call ahead See Details
prior authorization needed Insurance See Details

Store Selzentry tablets at room temperature: 77°F (25°C)

You can keep them briefly in temperatures as low as 59°F (5°C) and as high as 86°F (30°C).

They will keep fresh for a maximum of 24 months.

Note: Do not store Selzentry in moist environments, including bathrooms and other damp locations.

Clinical Monitoring

To see how well your treatment is working, your doctor will check your:

  • virus count. The virus count measures the number of copies of human immunodeficiency virus (HIV) in your body. A decrease in the number of copies is a sign that your treatment is working.
  • CD4 cell count. A CD4 cell count measures the amount of CD4 cells in your body. CD4 cells are white blood cells that fight infection. An increased CD4 count is a sign that your treatment is working.

Your doctor may check for side effects, including skin problems, liver damage, allergic reactions, or light-headedness. 

Your doctor may check your liver and kidney function periodically during treatment.

Not every pharmacy stocks this drug, so call ahead

If you only need a few tablets, you should call and ask if your pharmacy dispenses only a small number of tablets. Some pharmacies can't dispense only part of a bottle.

This drug is often available from specialty pharmacies through your insurance plan. These pharmacies operate like mail order pharmacies and ship the drug to you.

In larger cities, there will often be human immunodeficiency virus (HIV) pharmacies where you can have your prescriptions filled. Ask your doctor if there's an HIV pharmacy in your area.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for Selzentry. Your doctor may need to do paperwork for you, which could take a week or two.

Are There Any Alternatives?

There are several drugs and combinations that can treat human immunodeficiency virus (HIV). Some may be more suitable for you than others. Talk to your doctor about possible alternatives.


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Content developed in collaboration with Susan J. Bliss, RPh, MBA

Medically reviewed by Philip Gregory, PharmD, MS, FACN on April 27, 2015

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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