Lurasidone | Side Effects, Dosage, Uses & More
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Generic Name:

lurasidone, Oral tablet

All Brands

  • Latuda
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Highlights for lurasidone

Oral tablet
1

Lurasidone is used to treat schizophrenia or bipolar depression in adults.

2

This drug comes in the form of a tablet you take by mouth. You must take it with a meal of at least 350 calories.

3

Lurasidone is only available as a brand-name drug called Latuda. It isn’t available as a generic drug.

4

The more common side effects of this drug include sleepiness or drowsiness, restlessness and feeling like you need to move around, trouble moving, slow movements, muscle stiffness, tremors, and nausea.

5

In some cases, lurasidone can cause serious side effects. These can include increased risk of death in seniors with dementia, suicidal thoughts (thoughts of harming yourself) or changes in behavior, and triggering of mania in people with bipolar disorder.

IMPORTANT INFORMATION

FDA warning

This drug has a black box warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients about drug effects that may be dangerous.

Suicidal thoughts warning. Drugs used to treat depression, including lurasidone, may increase the risk of suicidal thinking (thoughts of harming yourself) in children, adolescents, and young adults.

Dementia-related psychosis warning. People with psychosis that’s caused by dementia shouldn’t take this drug. Seniors with this type of psychosis who are treated with drugs like lurasidone have a higher chance of death.

Uncontrollable movements

Lurasidone may cause you to have movements you can’t control in your face, tongue, or other body parts. This is called tardive dyskinesia. Your doctor may have you stop taking this drug if this happens.

Weight gain and high blood sugar or cholesterol

Lurasidone can cause metabolic changes that might increase your risk of having a stroke or heart attack. You and your doctor should watch your blood sugar, symptoms of diabetes (weakness or increased urination, thirst, or hunger), weight, and cholesterol levels.

Neuroleptic malignant syndrome

Lurasidone may cause neuroleptic malignant syndrome. This is a rare but serious condition that can be fatal (cause death). Symptoms include fever, stiff muscles, delirium, confusion, fast heart rate, high blood pressure, sweating, and heart rhythm problems. 

What is lurasidone?

Lurasidone is a prescription drug. It’s available as an oral film-coated tablet.

Lurasidone isn’t available as a generic drug. It’s only available as the brand-name drug Latuda.

Lurasidone may be used by itself or as part of a combination therapy when used to treat depression. This means you may need to take it with other medications. These may include lithium or valproate.

Why it's used

Lurasidone is used to treat schizophrenia and episodes of depression in people with certain types of bipolar disorder. This drug should only given to adults.

More Details

How it works

Lurasidone belongs to a class of drugs called atypical antipsychotics. A class of drugs is a group of medications that work in a similar way.

More Details

Why it's used

Lurasidone is used to treat schizophrenia and episodes of depression in people with certain types of bipolar disorder. This drug should only given to adults.

Schizophrenia is a chronic disorder of the brain. Symptoms include seeing, hearing, smelling, or feeling things that aren’t there. These are called hallucinations. People with schizophrenia also may have false, illogical beliefs or disorganized ways of thinking. Some people with this condition don’t move their face when they talk or cannot finish or complete tasks.

Bipolar I disorder is a mental illness. It’s also called manic-depressive disorder. People with this disorder experience manic episodes, where they are full of energy and have an elevated mood, and depressive episodes.

How it works

Lurasidone belongs to a class of drugs called atypical antipsychotics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Lurasidone works by blocking the dopamine and serotonin receptors in your brain. It isn’t known exactly how this drug improves the symptoms of schizophrenia and bipolar depression.

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lurasidone Side Effects

Oral tablet

More common side effects

The more common side effects of lurasidone can include:

  • sleepiness or drowsiness

  • akathisia (restlessness and feeling like you need to move around)

  • trouble moving, slow movements, muscle stiffness, or tremors (uncontrollable rhythmic movement in one part of your body)

  • nausea

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 9-1-1 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Neuroleptic malignant syndrome (NMS). Symptoms can include:

    • high fever (over 100.4°F)
    • heavy sweating
    • stiff muscles
    • confusion
    • changes in your breathing, heart rhythm, and blood pressure
  • Tardive dyskinesia. Symptoms can include:

    • movements you cannot control in your face, tongue, or other body parts
  • Hyperglycemia (high blood sugar). Symptoms can include:

    • feeling very thirsty
    • needing to urinate more often than usual
    • feeling very hungry
    • weakness or tiredness
    • nausea
    • confusion
    • fruity smelling breath
  • Orthostatic hypotension (low blood pressure upon standing). Symptoms can include:

    • lightheadedness or fainting caused by a sudden change in heart rate and blood pressure when standing up too quickly from a sitting or lying position
  • Seizures

  • Trouble swallowing

  • Overheating and dehydration. This drug makes your body unable to maintain a normal body temperature. You’re at risk for overheating if you exercise intensely, spend a lot of time in hot weather, or become dehydrated.

Pharmacist's Advice
Healthline Pharmacist Editorial Team

Antipsychotic drugs, including lurasidone, may cause neuroleptic malignant syndrome (NMS). This is a rare but serious condition that must be treated in a hospital and may be fatal (cause death).

This drug can increase your blood sugar (hyperglycemia). Extremely high blood sugar can lead to coma (being unconscious for a long time) or death.

Lurasidone may cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
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lurasidone May Interact with Other Medications

Oral tablet

Lurasidone can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Food interactions

You shouldn’t eat grapefruit or drink grapefruit juice if you’re taking this drug. Grapefruit can make it harder for your body to process lurasidone. As a result, you may have higher amount of this drug in your body. This can be dangerous.

Alcohol interaction

The use of drinks that contain alcohol raises your risk of side effects from lurasidone. These can include drowsiness, restlessness, trouble moving, slow movements, muscle stiffness, and nausea. If you drink alcohol, talk to your doctor. You shouldn’t drink alcohol while taking this drug.

Medications that might interact with this drug

Drugs you should not use with lurasidone

Do not take these drugs with lurasidone. Doing so can cause dangerous effects in the body. Examples of these drugs include:

  • Ketoconazole, clarithromycin, ritonavir, voriconazole, and mibefradil. These drugs can increase the levels of lurasidone in your body. This raises your risk of side effects.
  • Rifampin, avasimibe, St. John’s wort, phenytoin, and carbamazepine. These drugs can decrease the levels of lurasidone in your body. This means it may not work as well to treat your condition.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Lurasidone warnings
diabetes
People with diabetes

This drug may increase your blood sugar levels. If you have diabetes, this can cause extremely high blood sugar, which can lead to coma (being unconscious for a long time) or death. You should monitor your blood sugar levels closely if you need to take lurasidone. 

low white blood cell counts
People with history of low white blood cell counts

This drug may reduce the number of white blood cells in your body. White blood cells help to fight infection. The risk is higher in people who have a history of low white blood cell counts. Your doctor should monitor your for fever or symptoms of an infection. If your white blood cell count drops too low, your doctor may have you stop this drug.

history of seizures
People with history of seizures

If you have a history of seizures, ask your doctor whether this drug is safe for you. This drug can make it easier for you to experience seizures.

Parkinson’s disease or dementia
People with Parkinson’s disease or dementia

People with these conditions are more sensitive to lurasidone. Taking this drug could lead to confusion, frequent falls, uncontrollable movements, and reduced alertness. 

heart or cerebrovascular disease
People with heart or cerebrovascular disease

Because of the risk of low blood pressure and fainting, your doctor may start you on a lower dose and increase your dose more slowly than usual.

kidney problems
People with kidney problems

If you have kidney problems, you may not be able to clear this drug from your body well. This may increase the levels of this drug in your body and cause more side effects.

liver problems
People with liver problems

If you have liver problems, your body may not be able to process this drug well. This may increase the levels of this drug in your body and cause more side effects.

Pregnant women
Pregnant women

Lurasidone is a category B pregnancy drug. That means two things:

  1. Research in animals hasn’t shown a risk to the fetus when the mother takes the drug.
  2. There aren’t enough studies done in humans to show if the drug poses a risk to the fetus. 

Talk to your doctor if you’re pregnant or planning to become pregnant. Animal studies don’t always predict the way humans would respond. Therefore, this drug should only be used in pregnancy if clearly needed.

breast-feeding
Women who are breast-feeding

It isn’t known if lurasidone passes into breast milk. If it does, it may cause serious side effects in a child who is breast-fed.

Talk to your doctor if you breast-feed your child. You may need to decide whether to stop breast-feeding or stop taking this medication.

seniors
For seniors

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

If you’re older than 65 years and have dementia, this drug increases your risk of death.

children
For children

This drug hasn’t been approved for use in children. It shouldn’t be used in people younger than 18 years.

call the doctor
When to call the doctor

Call your doctor if your schizophrenia or bipolar depression symptoms aren’t improving or are getting worse. Note that it may take up to 6 weeks for this drug to work. 

Allergies
Allergies

Lurasidone can cause a severe allergic reaction. Symptoms can include: 

  • trouble breathing
  • swelling of your throat or tongue 

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

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How to Take lurasidone (Dosage)

Oral tablet

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Schizophrenia

Brand: Latuda

Form: Oral film-coated tablet
Strengths: 20 mg, 40 mg, 60 mg, 80 mg, 120 mg
Adult dosage (ages 18 years and older)
  • Typical starting dose: 40 mg taken once per day.
  • Dose increases: Your doctor will slowly increase your dose as needed.
  • Maximum dose: 160 mg taken once per day.
Child dosage (ages 0–17 years)

Lurasidone hasn’t been shown to be safe and effective for use in people younger than 18 years.

Special considerations

Kidney disease: If you have moderate or severe kidney disease, your starting dose should be 20 mg per day. You shouldn’t take more than 80 mg per day.

Liver disease: If you have moderate or severe liver disease, your starting dose should be 20 mg per day. You shouldn’t take more than 80 mg per day if you have moderate liver disease. Don’t take more than 40 mg per day if you have severe liver disease.

Bipolar-related depression

Brand: Latuda

Form: Oral film-coated tablet
Strengths: 20 mg, 40 mg, 60 mg, 80 mg, 120 mg
Adult dosage (ages 18 years and older)
  • Typical starting dose: 20 mg taken once per day.
  • Dose increases: Your doctor will slowly increase your dose as needed.
  • Maximum dose: 120 mg taken once per day.
Child dosage (ages 0–17 years)

Lurasidone hasn’t been shown to be safe and effective for use in people younger than 18 years.

Special considerations

Kidney disease: If you have moderate or severe kidney disease, your starting dose should be 20 mg per day. You shouldn’t take more than 80 mg per day.

Liver disease: If you have moderate or severe liver disease, your starting dose should be 20 mg per day. You shouldn’t take more than 80 mg per day if you have moderate liver disease. Don’t take more than 40 mg per day if you have severe liver disease.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Lurasidone comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all

You may have symptoms if you stop taking this drug suddenly. These include movements you cannot control in your face, tongue, or other body parts. You should talk to your doctor before stopping this medication.

If you don’t take this drug, your symptoms of schizophrenia or bipolar disorder won’t get better and may get worse.

If you miss doses or don’t take the drug on schedule

Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much

You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

  • heart rhythm problems
  • very low blood pressure
  • severe uncontrollable movements
  • loss of alertness
  • seizures
  • abnormal or irregular movements of your head

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room right away.

What to do if you miss a dose

Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working

You should have fewer symptoms of schizophrenia or be in a better mood if you have bipolar depression.

Lurasidone is used for short-term treatment (6 weeks or less) of schizophrenia and bipolar depression.

Important considerations for taking lurasidone
take with food
Take lurasidone with food
See Details
timing
Take this drug at the time(s) recommended by your doctor
Don’t cut or crush
Don’t cut or crush the tablet
storage
Store this drug carefully
See Details
medication is refillable
A prescription for this medication is refillable
See Details
Travel
Travel
See Details
diet
Your diet
See Details
not usually stocked
Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead
prior authorization
Insurance
See Details

Take lurasidone with food

You need to take this drug with a meal of at least 350 calories to help your body absorb the drug.

Store this drug carefully

  • Store lurasidone at room temperature. Keep it between 68°F and 77°F (20°C and 25°C).
  • Keep lurasidone and all drugs out of the reach of children.
  • Don’t store this medication in moist or damp areas, such as bathrooms.

A prescription for this medication is refillable

You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

You and your doctor should monitor certain health issues. This can help make sure you stay safe while you take this drug. These issues include:

  • Blood sugar levels. Your doctor may do blood tests to check your blood sugar levels. They may have you stop taking this drug if your levels are too high.
  • Cholesterol levels. Your doctor may do blood tests to check your cholesterol levels. They may have you stop taking this drug if your levels are too high.
  • Kidney function. Your doctor may do blood tests to check how well your kidneys are working. If your kidneys aren’t working well, your doctor may lower your dose of this drug.
  • Liver function. Your doctor may do blood tests to check how well your liver is working. If your liver isn’t working well, your doctor may lower your dose of this drug.
  • White blood cell count. Your doctor may do blood tests to check your white blood cell levels. They may have you stop taking this drug if your levels are too low. You should also tell your doctor if you have a fever and any signs of infection.  
  • Blood pressure. You should tell your doctor if you feel dizzy when you stand up after sitting or lying down. This may be more likely to happen when you first start the treatment and when your dose is increased. Your doctor may lower your dose if this happens to you.
  • Mental health and behavioral problems. You and your doctor should watch for any unusual changes in your behavior and mood. This drug can cause new mental health and behavior problems, or worsen problems you already have.
  • Overheating and dehydration. It’s important that you avoid overheating or getting dehydrated when taking this drug. Lurasidone makes your body unable to maintain a normal body temperature. You’re at risk for overheating if you exercise intensely, spend a lot of time in hot weather, or become dehydrated.

Your diet

You should eat a nutritious diet. This drug can cause you to gain weight and cause high cholesterol and blood sugar levels. Ask your doctor about what and how much you should eat.

Insurance

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

What does the pill look like?

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How Much Does lurasidone Cost?

Oral tablet

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on December 1, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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