Highlights for lomustine
lomustine Side Effects
Side effects that you should report to your doctor or health care professional as soon as possible:
- allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
- low blood counts - this medicine may decrease the number of white blood cells, red blood cells and platelets. You may be at increased risk for infections and bleeding.
- signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine
- signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine
- signs of decreased red blood cells - unusually weak or tired, fainting spells, lightheadedness
- breathing problems
- changes in vision
- dry cough
- mouth sores
- swelling of the ankles, feet, hands
- trouble passing urine or change in the amount of urine
- unusual bleeding or bruising
- yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
- hair loss
- loss of appetite
- nausea, vomiting
lomustine May Interact with Other Medications
- medicines to increase blood counts like filgrastim, pegfilgrastim, sargramostim
Talk to your doctor or health care professional before taking any of these medicines:
How to Use lomustine
Wear impervious gloves when handling this medicine. Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. To provide the correct dose for you, there may be capsules of different sizes and colors to take as a single dose. Make sure you understand how to take your dose. This medicine is usually taken as a single dose once every 6 weeks. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
They need to know if you have any of these conditions:
- infection (especially a virus infection such as chickenpox, cold sores, or herpes)
- low blood counts like low platelets, red blood cells, or white blood cells
- lung disease
- an unusual or allergic reaction to lomustine, CCNU, other chemotherapy, other medicines, foods, dyes, or preservatives
- pregnant or trying to get pregnant
It is important not to miss your dose. Call your doctor or health care professional for directions if you are unable to take your dose or if you miss your dose.
Visit your doctor for checks on your progress. This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.
This medicine is taken only every 6 weeks. You may need to wait longer between doses if you have low blood counts. Your doctor will order blood work to check your blood count and to monitor your condition.
In some cases, you may be given additional medicines to help with side effects. Follow all directions for their use.
Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.
This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.
Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.
Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.
Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Protect from heat, 40 degrees C (104 degrees F). Throw away any unused medicine after the expiration date.
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Last Updated: June 22, 2009