Generic Name: lisdexamfetamine, Oral capsule

Vyvanse

All Brands

  • Vyvanse
SECTION 1 of 4

Highlights for lisdexamfetamine

Oral capsule
1

Lisdexamfetamine dimesylate is a drug that’s used to treat attention deficit hyperactivity disorder (ADHD) and binge eating disorder (BED).

2

The standard starting dose is 30 mg per day. The dose will be slowly increased until you reach the dose that you respond to best. The maximum dose is 70 mg per day.

3

Common side effects include anxiety, headache, loss of appetite, nausea, vomiting, trouble sleeping, and weight loss.

4

This drug may raise your risk for sudden death, stroke, and heart attack. Your risk may be higher if you already have heart problems. Tell your doctor if you have any heart problems or defects or a family history of these issues.

5

Lisdexamfetamine dimesylate is a controlled substance because it can be abused and lead to addiction. Selling or giving it away may harm others and is against the law.

IMPORTANT INFORMATION

FDA Warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

Abuse and addiction. This medication has a high potential for abuse and addiction. Your doctor will talk to you about the risk before prescribing you the medication. They will monitor you for signs of abuse and addiction while you’re on this drug.

May cause heart problems

Lisdexamfetamine dimesylate may cause stroke, heart attack, or sudden death in adults with or without heart issues. It may cause sudden death in children and teens with preexisting heart problems or defects. Tell your doctor if you have any heart problems or heart defects or a family history of these problems.

This drug can also raise your blood pressure and heart rate. Tell your doctor if you have any problems with blood pressure or heart rate. Your doctor will monitor you for these conditions.

Risk of mental health issues

If you have mental health conditions, this drug may make your symptoms worse. It can also cause psychotic or manic symptoms in children and teenagers without a history of these problems. They may have symptoms such as seeing, hearing, or believing things that aren’t real, or feeling suspicious.

Tell your doctor if you have mental health problems or a family history of suicide, bipolar disease, or depression. Call your doctor right away if you have any new or worsening mental health symptoms.

Risk of circulation problems

This drug may cause circulation problems in your fingers and toes. Tell your doctor right away if you have numbness, pain, skin color change, sensitivity to temperature, or any unexplained wounds on your fingers or toes.

Drug Features

Lisdexamfetamine dimesylate is a controlled substance drug. It’s available as an oral capsule.

It is available in its generic form. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand. Talk to your healthcare provider to see if the generic will work for you.

Why It's Used

Lisdexamfetamine dimesylate is used to treat ADHD and moderate to severe binge eating disorder (BED) in adults.

This medication is not for weight loss. It isn’t known if it’s safe and effective for the treatment of obesity.

How It Works

Lisdexamfetamine dimesylate belongs to a class of drugs called amphetamines. It increases levels of certain brain chemicals to improve concentration and focus and to reduce hyperactivity and impulsiveness.

SECTION 2 of 4

lisdexamfetamine Side Effects

Oral capsule

Most Common Side Effects

  • The most common side effects that occur with lisdexamfetamine dimesylate in attention deficit hyperactivity disorder (ADHD) include:
    • anxiety
    • decreased appetite
    • diarrhea
    • dizziness
    • dry mouth
    • irritability
    • loss of appetite
    • nausea
    • trouble sleeping
    • upper stomach pain
    • vomiting
    • weight loss
  • The most common side effects that occur with lisdexamfetamine dimesylate in binge eating disorder (BED) include:
    • dry mouth
    • trouble sleeping
    • decreased appetite
    • increased heart rate
    • constipation
    • feeling jittery
    • anxiety

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • allergic reactions. Symptoms may include:
    • skin rash
    • itching or hives
    • swelling of your face, lips, or tongue
  • mental health problems. Symptoms may include:
    • suicidal thoughts or other mood changes
    • hallucinations or loss of contact with reality
  • heart problems. Symptoms may include:
    • chest pain or chest tightness
    • fast, irregular heart rate
    • high blood pressure
    • shortness of breath
  • vision problems, including:
    • changes in vision
    • blurred vision
  • neurological problems, including:
    • confusion or trouble speaking or understanding
    • seizures
    • severe headaches
    • trouble walking, dizziness, or loss of balance or coordination
    • uncontrollable head, mouth, neck, arm, or leg movements
  • fingers or toes that feel numb, cool, or painful
  • prolonged or painful erection
Pharmacist's Advice
Healthline Pharmacist Editorial Team

This medication does not cause drowsiness.

Mild side effects may disappear within a few days or a couple of weeks. Talk to your doctor or pharmacist if they’re more severe or don’t go away.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

lisdexamfetamine May Interact with Other Medications

Oral capsule

Lisdexamfetamine dimesylate can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications That Might Interact with This Drug

Monoamine Oxidase Inhibitors (MAOIs)

Examples are:

  • isocarboxazid (Marplan)
  • phenelzine (Nardil)
  • tranylcypromine (Parnate)

Using MAOIs with lisdexamfetamine dimesylate can cause extremely high blood pressure, which may lead to serious problems. You shouldn’t take this drug with MAOIs or within 14 days after stopping MAOI treatment.

Medications that acidify your urine

Examples are:

  • ascorbic acid

These drugs can decrease the amount of time that lisdexamfetamine dimesylate stays in your body. This makes it less effective. Your doctor may need to adjust your dose of lisdexamfetamine dimesylate if you’re taking this type of medication.

Medications that alkalinize your urine

Such as:

  • sodium bicarbonate

This drug can increase the amount of time that lisdexamfetamine dimesylate stays in your body. This increases the effect of lisdexamfetamine dimesylate. Your doctor may need to adjust your dose.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with heart problems

Lisdexamfetamine dimesylate may cause stroke, heart attack, or sudden death in adults with heart issues. It may cause sudden death in children and teens with preexisting heart problems or defects. Tell your doctor if you have any heart problems or heart defects or a family history of these issues.

People with blood pressure and heart rate problems

This drug can raise your blood pressure and heart rate. Tell your doctor if you have any blood pressure or heart rate problems. Your doctor will monitor you for these conditions.

People with mental health conditions

If you have mental health conditions, this drug may make your symptoms worse. It can also cause psychotic or manic symptoms in children and teenagers without a history of these problems. Tell your doctor if you have mental health problems or a family history of suicide, bipolar disease, or depression. Call your doctor right away if you have any new or worsening mental health symptoms.

People with a history of drug abuse and addiction

This drug can be abused and lead to addiction. Tell your doctor if you’ve ever abused or been addicted to alcohol or drugs.

Pregnant women

Lisdexamfetamine dimesylate is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Taking this drug during pregnancy may increase the risk of having a premature or low birth weight baby.

Tell your doctor if you’re pregnant or plan to become pregnant. Lisdexamfetamine dimesylate should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Women who are nursing

Lisdexamfetamine dimesylate may pass through breast milk and cause serious effects in a breastfeeding child.

You and your doctor may need to decide if you’ll take lisdexamfetamine dimesylate or breastfeed.

For Seniors

Seniors may process this drug more slowly. Your doctor may start you on a lower dose to prevent too much of this drug from building up in your body. This effect could be toxic.

For Children

For treating ADHD, the safety and effectiveness of this drug haven’t been established in children younger than 6 years old.

For treating binge eating disorder, the safety and effectiveness of this drug haven’t been established in people younger than 18 years old.

Your child’s growth will be monitored during treatment with this drug. Children who don’t grow or gain weight as expected may need to stop treatment.

Allergies

This drug contains amphetamines. If you have an allergy or sensitivity to stimulant medicines, tell your doctor before taking this drug.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal.

SECTION 4 of 4

How to Take lisdexamfetamine (Dosage)

Oral capsule

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Attention deficit hyperactivity disorder (ADHD)

Brand: Vyvanse

Form: Oral Capsule
Strengths: 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, 70 mg
Adult Dosage (ages 18–64 years)
  • Starting dose: 30 mg taken once per day in the morning
  • Usual dose: 30—70 mg taken once per day
  • Maximum dose: 70 mg per day
  • Your doctor may adjust your dose by 10-20 mg each week until you’re at a dose that relieves your symptoms.
Child Dosage (ages 6–17 years)
  • Starting dose: 30 mg taken once per day in the morning
  • Usual dose: 30—70 mg taken once per day
  • Maximum dose: 70 mg per day
  • Your doctor may adjust your dose by 10-20 mg each week until you’re at a dose that relieves your symptoms.
Child Dosage (ages 0–5 years)

This drug should not be used in children younger than 6 years of age.

Senior Dosage (65 years and older)

Your body may process this drug more slowly. Your doctor may start you on a lower dose to prevent too much of this drug from building up in your body. Too much of the drug can be toxic.

Special Considerations

Kidney Disease: If you have kidney disease, your doctor may adjust your dose according to your kidney function:

  • Moderate kidney disease: The maximum dose is 50 mg per day.
  • Severe kidney disease: The maximum dose is 30 mg per day.
  • End-stage kidney disease requiring dialysis: The maximum dose is 30 mg per day. This medication is not removed from your body by dialysis.

Moderate to severe binge eating disorder

Brand: Vyvanse

Form: Oral Capsule
Strengths: 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, 70 mg
Adult Dosage (ages 18–64 years)
  • Starting dose: 30 mg taken once per day in the morning
  • Usual dose: 50—70 mg taken once per day
  • Maximum dose: 70 mg per day
  • Your doctor may adjust your dose by 20 mg each week to a target dose of 50—70 mg taken once per day.
Child Dosage (ages 0–17 years)

This medicine shouldn’t be used in people younger than 18 years old.

Senior Dosage (65 years and older)

Your body may process this drug more slowly. Your doctor may start you on a lower dose to prevent too much of this drug from building up in your body. Too much of the drug can be toxic.

Special Considerations

Kidney Disease: If you have kidney disease, your doctor may adjust your dose according to your kidney function:

  • Moderate kidney disease: The maximum dose is 50 mg per day.
  • Severe kidney disease: The maximum dose is 30 mg per day.
  • End-stage kidney disease requiring dialysis: The maximum dose is 30 mg per day. This medication is not removed from your body by dialysis.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Lisdexamfetamine dimesylate comes with serious risks if you don't take it as prescribed.

If You Stop Taking It Suddenly

You may experience withdrawal symptoms if you stop taking this drug suddenly. This is especially likely if you’ve been taking a high dose for a long time. Your doctor will slowly lower your dose when you’re ready to stop treatment to prevent withdrawal.

If You Take Too Much

If you take too much lisdexamfetamine dimesylate call the poison control center or go to the emergency room right away.

What to Do If You Miss a Dose

If you miss a dose, take it as soon as you can. However, if it’s just a few hours until your next scheduled dose, wait and take the single dose.

Never try to catch up by taking two doses at once. This could result in toxic side effects.

How to Tell If the Drug Is Working

For ADHD, you may be able to tell the drug is working if you’re able to pay attention better and have decreased impulsiveness and hyperactivity.

For binge eating, you may be able to tell it’s working if you have fewer binge eating days.

This is a long-term drug.

Your dose and length of treatment will depend on your condition and response to therapy. In general, you’ll take the lowest effective dose to avoid side effects.

Important Considerations for Taking Lisdexamfetamine dimesylate
with food You can take this drug with or without food
timing Take once a day in the morning
no crush Don’t cut or crush the oral capsule See Details
store Store in temperatures from 68—77°F (20—25°C) See Details
Refillable Prescription is refillable
Travel Travel See Details
Clinical Monitoring Clinical Monitoring See Details
Not stocks Not every pharmacy stocks this drug, so call ahead
Prior Authorization Needed Insurance See Details

Don’t cut or crush the oral capsule

Swallow the capsules whole. You can open it and pour the contents into yogurt, water, or orange juice. Be sure to empty all of the powder from the capsule so that you get the full dose. Eat or drink all of the yogurt, water, or orange juice right away after the drug has been mixed in. Don’t save it after once it’s been mixed with the drug.

Store in temperatures from 68—77°F (20—25°C)

Keep the medication away from light.

Store the drug in a safe place, such as in a locked cabinet.

Don’t throw away unused lisdexamfetamine dimesylate in your household trash. Ask your doctor or pharmacist about a medicine take-back program in your community.

Keep your medications away from areas where they could get wet, such as bathrooms. Store them drugs away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry it with you in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt this medication.
  • You may need to show your pharmacy’s label to identify the medication. Keep the original pharmacy label with you when traveling.

Clinical Monitoring

Your doctor may check the following regularly to look for possible side effects:

  • blood pressure
  • heart rate
  • weight
  • height in children
  • mental health status

To look for signs of abuse, your doctor may check the following regularly:

  • heart rate
  • breathing rate
  • blood pressure
  • weight
  • physical appearance
  • mental health status

Your doctor may check your kidney function to make sure the drug is safe for you.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for lisdexamfetamine dimesylate.

Are There Any Alternatives?

There are other drugs available to treat your condition. If you’re treating binge eating, there are other therapies that can treat your condition, such as cognitive behavioral therapy and weight loss therapy. Some treatments may be more suitable for you than others. Talk to your doctor about possible alternatives.

What does the pill look like?

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on June 3, 2015

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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