Generic Name: ketoprofen, Oral capsule

Orudis

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  • Orudis
SECTION 1 of 4

Highlights for ketoprofen

Oral capsule
1

Ketoprofen is an oral medication used to treat rheumatoid arthritis, osteoarthritis, pain, and menstrual pain.

2

Common side effects include upset stomach, headache, dizziness, and drowsiness.

3

Your dose will depend on the condition you’re treating. Your doctor may prescribe an immediate-release or extended-release form of the drug.

4
IMPORTANT INFORMATION

FDA Warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects. 

Heart risks. This medication can increase your risk of serious and sometimes fatal heart events, such as heart attack and stroke. 

Heart surgery warning. Don’t take this medication if you’ve recently had a coronary artery bypass graft surgery.

Stomach risks. This medication belongs to a class of drugs that can cause serious and sometimes fatal stomach problems. These include bleeding, damage to stomach lining, and a hole in your stomach.

Aspirin/NSAID allergy warning

Don’t take this medication if you’ve had allergic reactions to aspirin or a nonsteroidal anti-inflammatory drug (NSAID). This includes trouble breathing, breaking out in hives, or another type of serious allergic reaction.

High blood pressure warning

This medication can cause high blood pressure or make existing high blood pressure worse.

Drug Features

Ketoprofen is a prescription medication. It’s available as an oral capsule and oral extended-release capsule. It’s also available in a generic version. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand. Talk to your healthcare provider to see if the generic will work for you.

Why It's Used

Ketoprofen is used to reduce inflammation and relieve pain.

It’s approved to treat:

  • rheumatoid arthritis
  • osteoarthritis
  • pain
  • menstrual pain

How It Works

Ketoprofen belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs help reduce pain, inflammation, and fever.

It isn’t known how this medication works to decrease pain. It may help reduce swelling by lowering levels of prostaglandin, a hormone-like substance that usually causes inflammation.

SECTION 2 of 4

ketoprofen Side Effects

Oral capsule

Most Common Side Effects

The most common side effects that occur with ketoprofen include:

  • upset stomach

  • nausea

  • diarrhea

  • headache

  • dizziness

  • drowsiness

Mild side effects may go away within a few days or a couple of weeks. Talk to your doctor or pharmacist if they’re more severe or don’t go away.

Serious Side Effects

If you experience any of these side effects, call your doctor right away.  If your symptoms are potentially life threatening or if you think you’re experiencing a medical emergency dial 9-1-1.

  • heart attack or stroke. Symptoms may include:

    • chest pain
    • shortness of breath
    • weakness on one side of your body
    • slurred speech
  • kidney damage (if you use it for a long time). Symptoms may include:

    • decreased urination
    • swelling in your arms, legs, hands, or feet
  • heart failure. Symptoms may include:

    • unusual weight gain
    • swelling in your arms, legs, hands, or feet
  • stomach problems, such as ulcers or bleeding. Symptoms may include:

    • stomach pain or upset stomach
    • black tarry stools
    • vomiting up blood
  • liver problems. Symptoms may include:

    • yellowing of your skin or the whites of your eyes
    • flu-like symptoms, such as body aches, fever, nausea, and vomiting
    • tiredness
    • pain in the upper part of your stomach
    • itching
  • skin reactions. Symptoms may include:

    • reddening, blistering, or peeling skin
  • allergic reactions. Symptoms may include:

    • shortness of breath
    • swelling of your face, lips, or throat
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Ketoprofen doesn’t cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

ketoprofen May Interact with Other Medications

Oral capsule

Ketoprofen can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully.  If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist. 

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications That Might Interact with This Drug

Blood pressure drugs
  • angiotensin-converting enzyme (ACE) inhibitors

Combining ketoprofen with these drugs may cause increased blood pressure.

Bipolar disorder drug
  • lithium 

Combining these drugs may increase the level of lithium in your body. This may cause confusion, irregular heartbeat, and increased thirst. Your doctor may have to monitor your kidney function to be sure you don’t have too much lithium in your system.

Gout, uric acid drug
  • probenecid

Combining these drugs may increase the level of ketoprofen in your body. This could cause more side effects from ketoprofen.

Anticoagulant, blood thinner
  • warfarin

Combining these drugs increases your risk of stomach bleeding.

Nonsteroidal anti-inflammatory drugs

These include: 

  • aspirin
  • ibuprofen
  • naproxen

Combining ketoprofen with other nonsteroidal anti-inflammatory drugs may increase your risk of side effects, especially stomach pain, bleeding, or holes in your stomach.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with liver problems

Ketoprofen can increase certain liver enzymes and in some cases may damage your liver.

People with asthma

Don’t use ketoprofen if you have aspirin-sensitive asthma. It could cause a fatal allergic reaction.

Pregnant women

Ketoprofen is a category C pregnancy drug. That means two things: 

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Speak with your doctor if you’re pregnant or plan to become pregnant. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Women who are nursing

It isn’t known if ketoprofen passes into breast milk and causes harm to your baby. 

You and your doctor may decide whether you’ll take ketoprofen or breastfeed.

For Seniors

Older adults may have reduced kidney function. Since ketoprofen is removed from the body by the kidneys, this may cause increased side effects. If you’re older than 75 years, your doctor may give you a lower dose of ketoprofen and monitor your kidney function.

For Children

The effectiveness and safety of this drug haven’t been established in people younger than 18 years old.

Allergies

Ketoprofen can cause a severe allergic reaction. Symptoms may include:

  • trouble breathing
  • swelling of your face or throat
  • hives

Don’t take this medication again if you’ve ever had an allergic reaction to it.  Taking it again could be fatal.

SECTION 4 of 4

How to Take ketoprofen (Dosage)

Oral capsule

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on: 

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Rheumatoid arthritis
Form: Oral Capsule
Strengths: 50 mg and 75 mg
Form: Oral extended-release Capsule
Strengths: 200 mg
Adult Dosage (ages 18 years and older)

Immediate-release capsule:

  • Either 75 mg taken 3 times per day in evenly spaced doses or 50 mg taken 4 times per day in evenly spaced doses
  • The maximum daily amount is 300 mg.

Extended-release capsule:

  • 200 mg taken once per day.
  • The maximum daily amount is 200 mg.
Child Dosage (ages 0-17 years)

Dosage for people younger than 18 years hasn’t been established.

Special considerations

Liver Disease: If you have liver disease or impaired liver function, the recommend maximum daily dose is 100 mg. This may help to reduce the risk of side effects.

Osteoarthritis
Form: Oral Capsule
Strengths: 50 mg and 75 mg
Form: Oral extended-release Capsule
Strengths: 200 mg
Adult Dosage (ages 18 years and older)

Immediate-release capsule:

  • Either 75 mg taken 3 times per day in evenly spaced doses or 50 mg taken 4 times per day in evenly spaced doses
  • The maximum daily amount is 300 mg.

Extended-release capsule:

  • 200 mg taken once per day.
  • The maximum daily amount is 200 mg.
Child Dosage (ages 0-17 years)

Dosage for people younger than 18 years hasn’t been established.

Special considerations

Liver Disease: If you have liver disease or impaired liver function, the recommend maximum daily dose is 100 mg. This may help to reduce the risk of side effects.

Pain
Form: Oral Capsule
Strengths: 50 mg and 75 mg
Form: Oral extended-release Capsule
Strengths: 200 mg
Adult Dosage (ages 18 years and older)

Immediate-release capsule:

  • 25–50 mg taken every 6–8 hours as needed.
  • The maximum daily amount is 300 mg.
Child Dosage (ages 0-17 years)

Dosage for people younger than 18 years hasn’t been established.

Special considerations

Liver Disease: If you have liver disease or impaired liver function, the recommend maximum daily dose is 100 mg. This may help to reduce the risk of side effects.

Menstrual pain
Form: Oral Capsule
Strengths: 50 mg and 75 mg
Form: Oral extended-release Capsule
Strengths: 200 mg
Adult Dosage (ages 18 years and older)

Immediate-release capsule:

  • 25–50 mg taken every 6–8 hours as needed.
  • The maximum daily amount is 300 mg.
Child Dosage (ages 0-17 years)

Dosage for people younger than 18 years hasn’t been established.

Special considerations

Liver Disease: If you have liver disease or impaired liver function, the recommend maximum daily dose is 100 mg. This may help to reduce the risk of side effects.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Ketoprofen comes with risks if you don’t take it as prescribed by your doctor.

If Don’t Take It or Stop Taking It

If you don’t take this drug at all or stop taking it too soon, your pain may get worse and become more difficult to treat.

If You Take Too Much

Taking too much ketoprofen can cause drowsiness, stomach pain, and vomiting. An overdose could lead to seizures and kidney problems. Get emergency medical help if you take or think you’ve taken too much.

What to Do If You Miss a Dose

If you miss a dose, take it as soon as possible. If it’s close to time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Don’t take more than one dose at a time. If you’re unsure about what to do, ask your doctor or pharmacist.

How Can I Tell if the Drug is Working?

You may be able to tell this drug is working if you experience reduced pain.

This is a short-term medication.

Important Considerations for Taking Ketoprofen

You can take this medication with or without food

You can take it with food, milk, or antacids to avoid upset stomach.

Store ketoprofen at room temperature: 68–77°F (20–25°C)

Keep this medication away from light and high temperatures. Store it out of the reach of children.

Note: Keep your medications away from areas where they could get wet, such as bathrooms. Store them away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry it with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt this medication.
  • You may need to show your pharmacy’s preprinted label to identify the medication. Keep the original prescription-labeled box with you when traveling.

Clinical Monitoring

Your doctor may check:

  • kidney function. Your doctor may check your kidney function with blood tests if you have a kidney disorder or if you’ve had abnormal kidney tests.
  • blood pressure. Ketoprofen can increase your blood pressure, so your doctor may monitor it regularly.
  • stomach bleeding. Ulcers or stomach bleeding can occur when taking ketoprofen for a long period of time. Your doctor may monitor for signs and symptoms of ulcers or stomach bleeding.

What does the pill look like?

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Are There Any Alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.


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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on May 11, 2015

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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