Isradipine | Side Effects, Dosage, Uses & More
Advertisement

Generic Name:

isradipine, Oral capsule

All Brands

  • DynaCirc (Discontinued)
A discontinued drug is a drug that has been taken off the market due to safety issues, shortage of raw materials, or low market demand.
SECTION 1 of 5

Highlights for isradipine

Oral capsule
1

Isradipine is an oral drug that’s used to lower blood pressure. Medicines that reduce blood pressure help to lower your chance of having a stroke or heart attack.

2

This drug may be taken as part of a combination therapy with other medications to treat high blood pressure.

3

The standard starting dose is 2.5 mg taken by mouth twice per day. If needed, your doctor may increase your dose after 2–4 weeks to a maximum dose of 20 mg per day.

4

Isradipine may cause low blood pressure. This may cause you to feel faint or dizzy. If this happens, call your doctor right away and lie down.

5

Common side effects include headache, dizziness or lightheadedness, swelling or fluid retention, fast heart rate, and feelings of warmth and reddening of your face (flushing).

IMPORTANT INFORMATION

Allergy

You shouldn’t take isradipine if you’ve ever had an allergic reaction to it.

Low blood pressure (hypotension)

This drug may cause low blood pressure. This may cause you to feel faint or dizzy. If this happens, call your doctor right away and lie down.

What is isradipine?

Isradipine is a prescription drug. It’s available as an oral capsule.

Isradipine is available as a generic drug. Generic drugs usually cost less. In some cases they may not be available in all strengths or forms as the brand. Talk to your healthcare provider to see if the generic will work for you.

Isradipine may be taken as part of a combination therapy with other medications to manage high blood pressure.

Why it's used

Isradipine is used to treat high blood pressure. Medicines that lower blood pressure reduce your chance of having a stroke or heart attack.

How it works

Isradipine belongs to a class of drugs called calcium channel blockers.

More Details

How it works

Isradipine belongs to a class of drugs called calcium channel blockers. A class of drugs is a group of medications that work in a similar way. They’re often used to treat similar conditions.

Isradipine works by preventing calcium from moving into your heart and arteries. Less calcium makes the arteries open wider. This makes it easier to pump blood through them. This lowers your blood pressure.

Advertisement
SECTION 2 of 5

isradipine Side Effects

Oral capsule

Most Common Side Effects

The most common side effects that occur with isradipine include:

  • headache

  • dizziness or lightheadedness

  • swelling or fluid retention

  • fast heart rate

  • feelings of warmth and reddening of your face (flushing)

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

Call your doctor right away if you have any of these serious side effects. Call 9-1-1 if your symptoms feel life threatening or if you think you’re having a medical emergency.

  • low blood pressure (hypotension): Symptoms include:

    • faintness or dizziness, especially when you stand up from a sitting or lying position
    • tiredness
    • lightheadedness
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Isradipine doesn’t cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

isradipine May Interact with Other Medications

Oral capsule

Isradipine can interact with other medications, herbs, or vitamins you might be taking. An interaction is when a substance changes the way a drug works. This can be harmful or cause the drugs that you take to not work as well. To help prevent interactions, your doctor should manage all of your medications carefully. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Alcohol interaction

The use of drinks that contain alcohol can lower your blood pressure even more when taken with isradipine. This may cause you to have more side effects, such as dizziness and fainting. If you drink alcohol, talk to your doctor.

Medications that might interact with this drug

Cimetidine

This medicine can increase the levels of isradipine in your body. This means that you may have more side effects.

Fentanyl

When this drug is used as anesthesia, it could make your blood pressure drop too low when taken with isradipine.

Rifampicin

This drug can decrease the levels of isradipine in your body. This means that it might not work as well to lower your blood pressure.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Isradipine warnings
congestive heart failure
People with congestive heart failure

If you have heart failure, this drug can make your condition worse. Your risk may be higher if you’re also taking a beta blocker. Your doctor will monitor you for signs of worsening heart failure. These include swelling or fluid retention, trouble breathing, dizziness, or fainting.

kidney disease
People with kidney disease

This drug is cleared from your body by your kidneys. If your kidneys don’t work well, more of this drug may stay in your body. This may cause more side effects. Your doctor may adjust your dose.

liver disease
People with liver disease

This drug is cleared from your body by your liver. If you have liver disease, your liver doesn’t work as well. More of this drug may build up in your body. This could cause more side effects. Your doctor may adjust your dose.

pregnant women
Pregnant women

Isradipine is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Tell your doctor if you’re pregnant or plan to become pregnant. Isradipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

breastfeeding
Women who are breast-feeding

It isn’t known if isradipine passes into breast milk. If it does, it may cause side effects in a breastfeeding child.

You and your doctor may need to decide if you’ll take this drug or breastfeed.

for seniors
For seniors

Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule.

for children
For children

This medicine hasn’t been studied in children and shouldn’t be used in children under the age of 18 years.

allergies
Allergies

Isradipine can cause a severe allergic reaction. Symptoms include:

  • swelling of your face, lips, tongue, or throat
  • trouble breathing or swallowing
  • skin rash
  • hives

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

SECTION 4 of 5

How to Take isradipine (Dosage)

Oral capsule

All possible dosages and forms may not be included here. Your doctor will tell you what dosage is right for you. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

High blood pressure
Form: Oral capsule
Strengths: 2.5 mg and 5 mg
Adult dosage (ages 18–64 years)
  • starting dose: 2.5 mg taken by mouth twice per day
  • dose increases: If needed, your doctor may increase your dose after 2–4 weeks slowly to a maximum dose of 20 mg per day.
Child dosage (ages 0–17 years)

This medicine hasn’t been studied in children and shouldn’t be used in children under the age of 18 years.

Senior dosage (ages 65 years and older)

There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal. If you’re a senior, you may need a lower dose or a different schedule.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Isradipine comes with serious risks if you don't take it as prescribed.

If you skip or miss doses

If you skip or miss doses, your blood pressure may get worse. This could lead to a stroke or heart attack.

If you take too much

If you take too much isradipine, you may have the following symptoms:

  • low blood pressure
  • reddening and warming of your face (flushing)
  • heart rhythm problems
  • feeling very weak

If you think you’ve taken too much of the drug, act right away. Call your doctor or local Poison Control Center, or go to the nearest emergency room.

What to do if you miss a dose

If you forget to take your dose, take it as soon as you remember. If it’s just a few hours until the time for your next dose, then wait and only take one dose at that time.

Never try to catch up by taking two doses at once. This could cause toxic side effects.

How to tell if the drug is working

You’ll know isradipine is working when you check your blood pressure at home. If your blood pressure is at or below the goal your doctor set for you, the drug is working. 

Isradipine is a long-term drug treatment.

Important considerations for taking isradipine
take with or without food
Isradipine may be taken with or without food
storage
Store at room temperature from 68–77°F (20–25°C)
See Details
refillable
Prescription is refillable
travel
Travel
See Details
self-management
Self-management
See Details
clinical monitoring
Clinical monitoring
See Details
not usually stocked
Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead.
hidden costs
Hidden costs
See Details
prior authorization
Insurance
See Details

Store at room temperature from 68–77°F (20–25°C)

Don’t freeze this drug.

Keep it away from light and high temperature.

Keep your drugs away from areas where they could get wet, such as bathrooms. Store this drug away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry your medication with you, such as in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Self-management

Your doctor may ask you to check your blood pressure at home. You should keep a log with the date, time of day, and your blood pressure readings. Bring this diary with you to your doctor appointments.

You’ll need to purchase a blood pressure monitor to check your blood pressure at home. These are available at most pharmacies.

Clinical monitoring

During treatment with isradipine, your doctor will check the following to make sure the drug is working and is safe for you to take:

  • blood pressure
  • liver function, if you have liver disease
  • kidney function, if you have kidney disease

Hidden costs

You may need to purchase a home blood pressure monitor to keep track of your blood pressure.

Insurance

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other options that may work for you.

What does the pill look like?

Showing - out of 6
SECTION 5 of 5

How Much Does isradipine Cost?

Oral capsule

We've partnered with GoodRx so you can compare prices, find discounts and save up to 80% on your next prescription. Check out the low coupon prices below — no insurance required.

Compare prices and save up to 80% on your next refill!

Lowest price for isradipine

Walmart $30.95
Walgreens $51.33
Duane Reade $51.33
These prices represent the lowest priced national pharmacies for isradipine on GoodRx. They may be lower than your insurance.

Enter your zip code to find the best deal near you.

These prices represent the lowest priced national pharmacies for isradipine on GoodRx. They may be lower than your insurance.

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on August 26, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
Advertisement
Advertisement
Advertisement