Highlights for isosorbide-dinitrate
isosorbide-dinitrate Side Effects
Side effects that you should report to your doctor or health care professional as soon as possible:
- bluish discoloration of lips, fingernails, or palms of hands
- irregular heartbeat, palpitations
- low blood pressure
- nausea, vomiting
- persistent headache
- unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
- flushing of the face or neck
isosorbide-dinitrate May Interact with Other Medications
Do not take this medicine with any of the following medications:
- medicines used to treat erectile dysfunction (ED) like avanafil, sildenafil, tadalafil, and vardenafil
This medicine may also interact with the following medications:
- medicines for high blood pressure
- other medicines for angina or heart failure
How to Use isosorbide-dinitrate
Place this medicine under the tongue. Follow the directions on the prescription label. Do not cut, crush or chew this medicine. Take this medicine 15 minutes before an activity that may cause chest pain or as directed. Do not take your medicine more often than directed.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
They need to know if you have any of these conditions:
- low blood pressure
- previous heart attack or heart failure
- an unusual or allergic reaction to isosorbide dinitrate, nitrates, other medicines, foods, dyes, or preservatives
- pregnant or trying to get pregnant
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Check your heart rate and blood pressure regularly while you are taking this medicine. Ask your doctor or health care professional what your heart rate and blood pressure should be and when you should contact him or her. Tell your doctor if you feel your medicine is no longer working.
You may get dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Alcohol can make you more dizzy, and increase flushing and rapid heartbeats. Avoid alcoholic drinks.
Do not treat yourself for coughs, colds, or pain while you are taking this medicine without asking your doctor or health care professional for advice. Some ingredients may increase your blood pressure.
Keep out of the reach of children.
Store at room temperature, approximately 25 degrees C (77 degrees F). Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date.
Last Updated: October 17, 2014