Generic Name: isocarboxazid, Oral tablet

Marplan

All Brands

  • Marplan
SECTION 1 of 5

Highlights for isocarboxazid

Oral tablet
1
ISOCARBOXAZID (eye soe kar BOX azid) is an monoamine oxidase inhibitor (MAOI). It is used to treat depression.
2 3 4
Talk to your healthcare provider if you have any of these conditions.
5
Know what to watch for and get tips for reducing your risks while taking this drug.
SECTION 2 of 5

isocarboxazid Side Effects

Oral tablet

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • chest pain
  • enlarged pupils
  • fast talking and excited feelings or actions that are out of control
  • feeling faint or lightheaded, falls
  • fever, clammy skin, increased sweating, sore throat
  • headache
  • high blood pressure
  • muscle or neck stiffness or spasm
  • seizures
  • slow, fast, or irregular heartbeat
  • suicidal thoughts or other mood changes
  • trouble passing urine or change in the amount of urine
  • yellowing of the skin or eyes

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • change in sex drive or performance
  • constipation or diarrhea
  • difficulty sleeping
  • increased appetite or weight increase
  • increased sensitivity to sunlight
  • muscle aches or pains, trembling
  • nausea or vomiting
  • swelling of the feet or legs
  • tired or weak
SECTION 3 of 5

isocarboxazid May Interact with Other Medications

Oral tablet

Do not take this medicine with any of the following medications:

  • altretamine
  • atomoxetine
  • barbiturates, like phenobarbital
  • brimonidine
  • buspirone
  • caffeine
  • carbamazepine
  • certain medicines for blood pressure like guanabenz, guanadrel, guanethidine, or reserpine
  • cocaine
  • cyclobenzaprine
  • dextromethorphan
  • diet pills or stimulants, like amphetamines or ephedra
  • diphenoxylate
  • diuretics
  • doxapram
  • ephedrine
  • general or local anesthetics
  • ginseng
  • green tea
  • guarana
  • isoniazid
  • linezolid
  • MAOIs like Carbex, Eldepryl, Nardil, and Parnate
  • medicines for migraine headaches
  • medicines for movement abnormalities as in Parkinson's disease like entacapone, levodopa, selegiline, tolcapone
  • meperidine
  • methylene blue
  • other medicines for mental depression, anxiety, or mood or mental problems
  • prescription pain medicines
  • procarbazine
  • SAM-e
  • St. John's wort
  • succinylcholine
  • tramadol
  • tryptophan
  • tyramine (found in cheese, red wine, beer, chocolate and other foods)
  • yohimbine

This medicine may also interact with the following medications:

  • disulfiram
  • medicines for allergies, colds, flu symptoms, sinus congestion, and breathing difficulties
  • medicines for diabetes
  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
SECTION 4 of 5

How to Use isocarboxazid

Oral tablet

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly except upon the advice of your doctor. Stopping this medicine too quickly may cause serious side effects or your condition may worsen.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • frequently drink alcohol-containing beverages
  • glaucoma
  • headaches or migraine
  • heart disease
  • high blood pressure
  • history of irregular heartbeat
  • history of stroke
  • kidney disease
  • liver disease
  • mental illness
  • pheochromocytoma
  • recent head trauma
  • seizures
  • suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member
  • an unusual or allergic reaction to isocarboxazid, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What should I watch for while using this medicine?

Tell your doctor if your symptoms do not get better or if they get worse. Visit your doctor or health care professional for regular checks on your progress. Because it may take several weeks to see the full effects of this medicine, it is important to continue your treatment as prescribed by your doctor.

This medicine can interact with certain foods that contain tyramine. The combination may cause severe headaches, a rise in blood pressure, or irregular heart beat. Foods that contain significant amounts of tyramine include aged cheeses, meats and fish (especially aged, smoked, pickled, or processed such as bologna, pepperoni, salami, summer sausage), beer and ale, alcohol-free beer, wine (especially red), sherry, hard liquor, liqueurs, avocados, bananas, figs, raisins, soy sauce, miso soup, yeast/protein extracts, bean curd, fava or broad bean pods, or any over-ripe fruit. Ask your doctor or health care professional, pharmacist, or nutritionist for a complete listing of tyramine-containing foods. Also, avoid drinks containing caffeine, such as tea, coffee, chocolate, or cola. After stopping this medicine, ask your health care professional how long you should continue avoiding these foods and drinks.

Patients and their families should watch out for new or worsening thoughts of suicide or depression. Also watch out for sudden changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your health care professional.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the problem does not go away or is severe.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

Do not treat yourself for coughs, colds, or allergies without asking your doctor or health care professional for advice. Do not take any medications for weight loss without your doctor's approval. Some ingredients in these products may increase possible side effects.

This medicine may affect blood sugar levels. If you have diabetes, check with your doctor or health care professional before you change your diet or the dose of your diabetic medicine.

Tell your health care professional that you are taking this medicine if you are scheduled to have any surgery, procedure or medical testing. You should usually stop taking this drug at least 10 days before elective surgery.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.

What does the pill look like?

Showing - out of 1
SECTION 5 of 5

How Much Does isocarboxazid Cost?

Oral tablet
We've partnered with GoodRX so you can compare prices and save money on your next prescription. Check out the lowest cash prices below and enter your zip code to find the best deal near you.

Compare prices and save money on your next refill!

Lowest price for isocarboxazid

Membership warehouse $485.63
Publix $487.43
Kroger Pharmacy $487.52
These represent the lowest cash prices for isocarboxazid and may be lower than your insurance.

Find the lowest prices of isocarboxazid near you

These represent the lowest cash prices for isocarboxazid and may be lower than your insurance.

Send us your feedback

Thank you.

Your message has been sent.

We're sorry, an error occurred.

We are unable to collect your feedback at this time. However, your feedback is important to us. Please try again later.

Last Updated: July 22, 2014

The Healthline Site, its content, such as text, graphics, images, search results, and other material contained on the Healthline Site ("Content"), its services, and any information or material posted on the Healthline Site by third parties are provided for informational purposes only. None of the foregoing is a substitute for professional medical advice, examination, diagnosis, or treatment. Always seek the advice of a physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on the Healthline Site. If you think you may have a medical emergency, call your doctor or 911 immediately. Please read the Terms of Service for more information regarding use of the Healthline Site.
Content licensed by
Gold Standard Logo

Healthline - Gold Standard License

Terms of Use

Licensee provides access to Alchemy provided by Gold Standard, Inc. ("Gold Standard"). Although Gold Standard makes reasonable efforts to ensure the accuracy and reliability of Alchemy, End User acknowledges and agrees that Licensee, its affiliates, and their respective officers, directors, employees and information providers and Gold Standard, its affiliates, its licensors, and their respective officers, directors, employees and information providers will not be held liable for any damages suffered or incurred by End User or any third person arising out of: a) any faults, interruptions or delays in Alchemy or its delivery, b) any use of or reliance on Alchemy by any person, or c) any inaccuracies, errors or omissions in Alchemy, irrespective of however such faults, interruptions, delays, inaccuracies, errors or omissions arise. Gold Standard shall not be liable to End User for any loss, cost or damages resulting from any delays in delivery and/or non-delivery of Alchemy or its content. End User acknowledges and agrees that its sole and exclusive remedy in the event of such delay is to not accept these terms and conditions. Gold Standard does not represent or warrant that Alchemy will meet the objectives or needs of End User or any third party. Gold Standard makes no warranty of merchantability of Alchemy or of the fitness of Alchemy for any purpose.

About Gold Standard

The Gold Standard editorial staff develops clinically-based drug information content through an independent, peer-reviewed process. Content updates to the database include new FDA-approved drugs, new non-prescription and herbal therapies, newly published information regarding FDA label changes and relevant clinical studies affecting off-label utilization. Editors do not have any significant financial relationships with the industry that would introduce bias in the editing or review of database content.

Read This Next

How to Stop Leg Muscle Cramps
How to Stop Leg Muscle Cramps
How to Defrost Chicken the Safe Way
How to Defrost Chicken the Safe Way
14 Things You Didn’t Know About Alzheimer’s
14 Things You Didn’t Know About Alzheimer’s
Advertisement
Advertisement
Advertisement