Generic Name: insulin-lispro-insulin-lispro-protamine, Parenteral Suspension

Humalog KwikPen Mix 50/50,Humalog KwikPen Mix 75/25,Humalog Mix 50/50,Humalog Mix 75/25

All Brands

  • Humalog KwikPen Mix 50/50
  • Humalog KwikPen Mix 75/25
  • Humalog Mix 50/50
  • Humalog Mix 75/25
SECTION 1 of 4

Highlights for insulin-lispro-insulin-lispro-protamine

Parenteral Suspension
1

Humalog Mix is an injected medication used to treat high blood sugar in people with diabetes. The drug is a mixture of rapid-acting (lispro) and intermediate-acting (lispro protamine) insulins.

2

If you have type 2 diabetes, Humalog Mix may be used in combination with oral drugs to help control high blood sugar.

3

Dosing for Humalog Mix is individualized. Your doctor will decide the correct dose for you. Dosing will be based on your blood sugar levels, other health conditions you have, and how active you are

4

Eat regular meals when you take this drug. Food, including timing of meals, exercise, and other medicines can impact how well your insulin works.

5

Common side effects include low blood sugar (hypoglycemia) and injection site reactions.

IMPORTANT INFORMATION

Low blood sugar warning

Humalog Mix can cause low blood sugar (hypoglycemia). Low blood sugar can be dangerous. Symptoms of low blood sugar may include:

  • modest to intense hunger
  • dizziness
  • shakiness
  • lightheadedness
  • sweating
  • irritability
  • headache
  • fast heart rate
  • confusion

Heart failure risk

Taking diabetes pills called thiazolidinediones (TZDs) with Humalog Mix may cause heart failure in some people. This can happen even if you’ve never had heart problems before. If you already have heart failure, it may get worse while you take TZDs with Humalog Mix. Your healthcare provider may monitor you closely while you’re taking these drugs together. Tell your doctor if you have any new or worse symptoms of heart failure, including:

  • shortness of breath
  • swelling of your ankles or feet
  • sudden weight gain

Drug Features

Humalog Mix is a self-injectable prescription drug. It’s available in these forms: injectable suspension and injectable prefilled syringe.

This drug is a combination of two drugs in a single form. It’s a mixture of rapid-acting (lispro) and intermediate-acting (lispro protamine) insulins.

Humalog Mix may be used as part of a combination therapy. That means that you may need to take it with other drugs.

Why It's Used

Humalog Mix is a mixture of rapid-acting and intermediate-acting insulins. It’s used to decrease high blood sugar (hyperglycemia) in people with type 1 and type 2 diabetes.

How It Works

Humalog Mix belongs to a class of drugs called insulin.

More Details

How It Works

Humalog Mix belongs to a class of drugs called insulin. It works by helping to manage the amount of insulin in your body, which in turn helps to regulate your blood sugar levels.

Insulin is a hormone that your body makes to help move sugar from your bloodstream into your body’s cells. Your cells use the sugar as fuel for your body. If you have type 1 diabetes, your pancreas doesn’t make insulin. If you have type 2 diabetes, your body doesn’t make enough insulin, or it can't use the insulin that it makes properly. Without enough insulin, sugar stays in your bloodstream, causing high blood sugar.

SECTION 2 of 4

insulin-lispro-insulin-lispro-protamine Side Effects

Parenteral Suspension

Most Common Side Effects

The most common side effects that occur with Humalog Mix include:

  • low blood sugar (hypoglycemia). Symptoms may include:

    • moderate to intense hunger
    • dizziness
    • shakiness
    • lightheadedness
    • sweating
    • irritability
    • headache
    • fast heart rate
    • confusion

    If you have a low blood sugar reaction, you’ll need to treat it:

    • If your blood glucose level is below 70 mg/dL, treatment is 15–20 grams of glucose (a type of sugar). You’ll need to eat or drink one of the following:
      • 3–4 glucose tablets
      • a tube of glucose gel
      • ½ cup of juice or regular, non-diet soda
      • 1 cup of milk
      • 1 tablespoon of sugar, honey, or corn syrup
      • 8–10 pieces of hard candy, such as lifesavers
    • Test your blood sugar 15 minutes after you treat the low blood sugar reaction. If your blood sugar is still low, repeat the low blood sugar treatment steps again.
    • Once your blood sugar is back in the normal range, eat a small snack if your next planned meal or snack is more than 1 hour later.
  • injection site reactions. Symptoms may include:

    • redness
    • swelling
    • itching

    If you keep having injection site reactions, or if they’re serious, call your doctor. Don’t inject the drug into an area of your skin that’s red, swollen, or itchy.

  • skin thickening or pits at the injection site (lipodystrophy). Symptoms may include:

    • small lumps or dents in your skin

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

  • severe low blood sugar (hypoglycemia). Symptoms may include:

    • mood changes, including irritability or impatience, anger, stubbornness, or sadness
    • confusion, including delirium
    • lightheadedness or dizziness
    • sleepiness
    • blurred or impaired vision
    • tingling or numbness in your lips or tongue
    • headaches
    • weakness or fatigue
    • loss of coordination
    • nightmares or crying out during sleep
    • seizures
    • unconsciousness
  • severe allergic reaction. Symptoms may include:

    • rash and hives
    • itching
    • trouble breathing
    • tightness in your chest
    • fast heart rate (tachycardia)
    • swelling of your face, lips, tongue, or throat
    • sweating
  • heart failure. Taking certain diabetes pills called thiazolidinediones (TZDs) with Humalog Mix may cause new or worse heart failure in people with or without existing heart issues. Symptoms of heart failure may include:

    • shortness of breath
    • swelling of your ankles or feet
    • sudden weight gain
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Humalog mix does not cause drowsiness.

Mild side effects may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

insulin-lispro-insulin-lispro-protamine May Interact with Other Medications

Parenteral Suspension

Humalog Mix can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Alcohol Interactions

Drinking alcohol while taking this medication may make your diabetes more difficult to control. Talk to your doctor if you drink alcohol. You may need to limit when and how much you drink.

Combining Humalog Mix with These Drugs May Cause Reactions

Combinations that may cause fluid retention (edema) and heart failure
  • thiazolidinediones
    • pioglitazone (Actos)
    • rosiglitazone (Avandia)

Combinations that may cause low blood sugar (hypoglycemia)
  • androgens
    • fluoxymesterone
    • methyltestosterone
    • nandrolone
    • oxandrolone
    • oxymetholone
    • testosterone
  • diabetes drugs
    • alpha-glucosidase inhibitors
      • acarbose (Precose)
      • miglitol (Glyset)
    • biguanides:
      • metformin (Fortamet,Glucophage, Glumetza, Riomet)
    • incretin mimetics:
      • exenatide (Bydureon, Byetta)
      • dulaglutide (Trulicity)
      • liraglutide (Victoza)
    • meglitinides:
      • nateglinide (Starlix)
      • repaglinide (Prandin)
    • sodium-glucose co-transporter 2 (SGLT2) inhibitors:
      • dapagliflozin (Farxiga)
      • canagliflozin (Invokana)
    • sulfonylureas:
      • chlorpropamide
      • glimepiride (Amaryl)
      • glipizide (Glucotrol)
      • glyburide (Diabeta, Glynase)
      • tolbutamide
    • dipeptidyl peptidase-4 inhibitors
      • sitagliptin (Januvia
      • alogliptin (Nesina)
      • saxagliptin (Onglyza)
      • linagliptin (Tradjenta)
  • clofibrate (Atromid-S)
  • fenfluramine
  • monoamine oxidase inhibitors (MAOIs):
    • isocarboxazid (Marplan)
    • phenelzine (Nardil)
    • tranylcypromine (Parnate)
  • quinolone antibiotics
    • ciprofloxacin (Cipro)
    • gatifloxacin (Zymar)
    • levofloxacin (Levaquin)
  • salicylates
    • aspirin
    • bismuth subsalicylate (Pepto-Bismol)
    • magnesium salicylate (Doan’s)
    • salsalate (Disalcid)

Combinations that may cause high blood sugar (hyperglycemia)
  • thiazide diuretics
    • chlorothiazide (Diuril)
    • chlorthalidone
    • hydrochlorothiazide (Hydrodiuril)
    • indapamide (Lozol)
    • metolazone (Zaroxolyn)
  • steroids
    • dexamethasone
    • hydrocortisone
    • methylprednisolone
    • prednisolone
    • prednisone

Combinations may mask the symptoms of low blood sugar (hypoglycemia)
  • beta blockers (non-cardioselective)
    • carteolol (Cartrol)
    • nadolol (Corgard)
    • penbutolol (Levatol)
    • pindolol (Visken)
    • propranolol (Inderal)
    • timolol (Blocadren)

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with kidney disease

Insulin is removed from your body by your kidneys. If your kidneys aren’t working well, insulin may build up in your body and cause low blood sugar (hypoglycemia). Your doctor may start you at a lower dose of the drug and slowly increase your dose if needed.

People with liver disease

If you have liver problems, your body may be more sensitive to Humalog Mix. Your doctor may start you at a lower dose and slowly increase your dose if needed.

People with heart failure

Taking certain diabetes pills called thiazolidinediones (TZDs) with Humalog Mix may make your heart failure worse. Tell your doctor if you have any new or worse symptoms of heart failure, including:

  • shortness of breath
  • swelling of your ankles or feet
  • sudden weight gain

Pregnant women

Humalog Mix is a pregnancy category B drug. That means two things:

  1. Studies of the drug in pregnant animals haven’t shown risk to the fetus.
  2. There aren’t enough studies done in pregnant women to show the drug poses a risk to the fetus.

Tell your doctor if you’re pregnant or plan to become pregnant. Humalog Mix should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Women who are nursing

It isn’t known if Humalog Mix passes through breast milk. If it does, it’s not expected to cause side effects in a breastfeeding infant. The American Diabetes Association encourages breastfeeding in women with diabetes. If you’re breastfeeding, you may need to get your blood sugar checked.

For Seniors

Studies of Humalog Mix didn’t include enough people over the age of 65 years to tell if seniors react differently to Humalog Mix when compared to younger people.

However, as you age, your organs, such as your liver, kidneys, and heart, may not work as well as they once did. More insulin may stay in your body and increase your risk for side effects. It may also be more difficult to spot symptoms of low blood sugar. Your doctor may start you at a lower dose of Humalog Mix and adjust it if needed.

For Children

The effectiveness and safety of Humalog Mix haven’t been established in people under the age of 18 years.

When to call the doctor

Tell your doctor if you’re sick, under a lot of stress, or if you’ve changed your eating or exercise habits. Each of these things can affect how much Humalog Mix you need, and your doctor may need to adjust your dose.

If your dose of Humalog Mix isn’t working well enough to treat your blood sugar, your diabetes won’t be under control, and you may have signs of high blood sugar (hyperglycemia). Contact your doctor if you have any of these symptoms:

  • more frequent urination
  • feeling very thirsty
  • feeling very hungry even though you’re eating
  • extreme fatigue
  • blurred vision
  • cuts or bruises that are slow to heal
  • tingling, pain, or numbness in your hands or feet

Allergies

Humalog Mix can cause a severe allergic reaction. Symptoms may include:

  • rash and hives
  • itching
  • trouble breathing
  • tightness in your chest
  • fast heart rate (tachycardia)
  • swelling of your face, lips, tongue, or throat
  • sweating

Don’t take this drug again if you have ever had an allergic reaction to it. Taking it again could be fatal.

SECTION 4 of 4

How to Take insulin-lispro-insulin-lispro-protamine (Dosage)

Parenteral Suspension

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Diabetes: types 1 and 2
Form: Injectable suspension; Injectable prefilled syringe (KwikPen)
Strength: 10 mL vial: 100 units/mL; 3 mL prefilled syringe: 100 units/mL
Adult Dosage (ages 18–64 years)
  • Typically, you’ll take 2/3 of the daily amount before breakfast and 1/3 of the daily amount before dinner.
  • The doses are adjusted based on finger sticks to check blood glucose levels. Your doctor will decide the correct dose of Humalog Mix for you. Your dose will be based on:
    • severity of your diabetes
    • blood sugar levels
    • other health conditions you have
    • your response to previous drugs used to treat your diabetes
    • whether you’re ill
    • stress level
    • other medicines that you take
    • changes in your eating habits
    • changes in your activity level
Child Dosage (ages 0–17 years)

A safe and effective dose hasn’t been established for people younger than 18 years old.

Senior Dosage (ages 65 years and older)

As you age, your organs, such as your liver and kidneys, don’t work as well as they once did. More insulin may stay in your body and put you at an increased risk for side effects, such as low blood sugar (hypoglycemia). Your doctor may start you at a lower dose of Humalog Mix and adjust it if needed.

Special Considerations

Kidney disease: If your kidneys aren’t working well, insulin may build up in your body and cause low blood sugar (hypoglycemia). Your doctor may start you at a lower dose and slowly increase your dose if needed.

Liver disease: If you have liver problems, your body may be more sensitive to Humalog Mix. Your doctor may start you at a lower dose and slowly increase your dose if needed. You and your doctor should monitor your blood sugar closely.

Warnings

Measure each dose carefully. Use only the exact amount of Humalog Mix your doctor prescribes. Small errors in the amount of insulin measured and injected may have a large effect on your blood sugar levels.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Humalog Mix comes with serious risks if you don't take it as prescribed.

If You Don't Take It At All

If you don’t take Humalog Mix at all, you may continue to have high blood sugar and the symptoms associated with it. Over time, elevated blood sugar levels can harm your eyes, kidneys, nerves, or heart. This may lead to heart attack, stroke, blindness, kidney failure, and limb amputations.

If You Don't Take It On Schedule

If you don’t inject Humalog Mix on schedule, your blood sugar levels may not be well controlled. If your injections are given too close together, you may experience low blood sugar. If your injections are given too far apart, you may experience high blood sugar (hyperglycemia).

If You Take Too Much

If you take too much Humalog Mix, your blood sugar may become too low. Treat low blood sugar right away by drinking or eating something sugary, such as fruit juice, hard candies, or glucose tablets.

What to Do If You Miss a Dose

Inject Humalog Mix within 15 minutes of starting a meal. If you forget to take a dose before your meal, inject your dose shortly after your meal. If a long time has passed since you’ve eaten your meal, call your doctor for instructions.

Never try to catch up by doubling the amount of Humalog Mix you inject. Your blood sugar may become dangerously low (hypoglycemia).

How to Tell If the Drug Is Working

If Humalog Mix is working, your blood sugar readings will be lower. Your doctor will determine the best blood sugar range for you. Your symptoms of high blood sugar, such as feeling very hungry or thirsty and frequent urination, should decrease.

Humalog Mix is a long-term drug treatment.

Inject it within 15 minutes of starting a meal

If you don’t plan to eat within 15 minutes, delay the injection until the correct time (15 minutes before eating).

Pay careful attention to the timing of your meals

  • Take the drug within 15 minutes before a meal.
  • Don’t inject it if you’re not going to eat within 15 minutes.
  • If you inject it without eating, your blood sugar may become too low (hypoglycemia).

Storage depends on the type you’re using

  • Humalog Mix vial:
    • Store unopened vials at room temperature, below 86ºF (30ºC), for up to 28 days. After 28 days, throw out the vial.
    • Store unopened vials in the refrigerator from 36–46°F (2.2–7.8ºC) until the expiration date on the vial.
    • Store opened vials in the refrigerator or keep at room temperature for up to 28 days. After 28 days, throw out the vial.
  • Humalog Mix KwikPen:
    • Store unopened KwikPens at room temperature, below 86ºF (30ºC), for up to 10 days. After 10 days, throw out the KwikPen.
    • Unopened KwikPens can be stored in the refrigerator, 36–46°F (2.2–7.8ºC), until the expiration date on the KwikPen.
    • Keep in-use (opened) KwikPens at room temperature for up to 10 days. After 10 days, throw out the KwikPen. Don’t refrigerate in-use KwikPens.

Don’t freeze Humalog Mix. Keep it away from light and high temperatures.

Note: Keep your drugs away from areas where they could get wet, such as bathrooms. Store them away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry it with you in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt this medication.
  • You may need to show your pharmacy’s preprinted label to identify the drug. Keep the original prescription-labeled box with you when traveling.
  • This medication needs to be refrigerated. You may need to use an insulated bag with a cold pack to maintain the temperature when traveling.
  • Don’t keep your medication in your luggage or in a car where the temperature could get hot or cold.
  • Needles and syringes need to be used to take this drug. Check for special rules about traveling with medicine, needles, and syringes.

Self-Management

Your doctor or nurse will show you how to:

  • prepare and inject Humalog Mix using syringes and vials or KwikPens
  • use a blood glucose monitor to keep track of your blood sugar levels

You’ll also need to learn how to spot the signs of high and low blood sugar and how to manage these reactions when needed.

Self-monitoring

  • Test your blood sugar as often as your doctor recommends.
  • Ask your doctor what your blood sugar level should be.

Self-administration

  • Mix this drug well before each use. For the vials, carefully shake or rotate the vial until it’s completely mixed. For the prefilled pens (KwikPens), carefully follow the user manual for instructions on how to mix the pen. Humalog Mix should be cloudy or milky after mixing it well.
  • Look at your Humalog Mix before each injection. If it’s not evenly mixed or has solid particles or clumps in it, don’t use it
  • Measure each dose carefully. Use only the exact amount of Humalog Mix your doctor prescribes. Small errors in the amount of insulin measured and injected may have a large effect on your blood sugar levels.
  • Your doctor, pharmacist, nurse, or diabetes educator will show you how to withdraw insulin from the vial, attach needles, and give the Humalog Mix injection.
  • Inject Humalog Mix into the fatty part or your skin (subcutaneous fat). The best places for the injection include your stomach, buttocks, upper legs (thighs), or the outer part of your upper arm.
  • Rotate (change) the site of injection each time.
  • Don’t inject yourself where you have irritated or red skin.
  • Syringes and needles are used to inject Humalog Mix. Don’t throw out individual needles into trashcans or recycling bins, and never flush them down the toilet. Ask your pharmacist for a needle clipper and container to throw away used needles and syringes safely
  • Your community may have program for disposing needles and syringes. If you throw out the container in the trash, label it “do not recycle.”

Clinical Monitoring

Your doctor may monitor you with certain blood tests before and during treatment with Humalog Mix to make sure it’s safe for you to take. Tests include

  • blood sugar levels, including your hemoglobin A1c (HbA1c) to monitor your diabetes. This test shows the average level of your blood sugar over the last 3 months. It tells how well your diabetes is being controlled.
  • liver function
  • kidney function

Hidden Costs

Besides the medicine, you may need to buy:

  • sterile alcohol wipes
  • lancing device and lancets (a pricking device used to obtain drops of blood for testing your blood sugar)
  • syringes and needles
  • blood glucose test strips
  • blood glucose monitor
  • needle container for safe disposal of lancets, needles, and syringes

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for Humalog Mix.

Are There Any Alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.


Show Sources

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on June 11, 2015

Send us your feedback

Thank you.

Your message has been sent.

We're sorry, an error occurred.

We are unable to collect your feedback at this time. However, your feedback is important to us. Please try again later.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Read This Next

Why You Should Be Careful About Ginseng
Why You Should Be Careful About Ginseng
Diabetes: Can Fenugreek Lower My Blood Sugar?
Diabetes: Can Fenugreek Lower My Blood Sugar?
Doctor Discussion Guide: Type 2 Diabetes
Doctor Discussion Guide: Type 2 Diabetes
Advertisement
Advertisement
Advertisement