Generic Name: insulin-lispro-insulin-lispro-protamine, Parenteral Suspension

Humalog KwikPen Mix 50/50,Humalog KwikPen Mix 75/25,Humalog Mix 50/50,Humalog Mix 75/25

All Brands

  • Humalog KwikPen Mix 50/50
  • Humalog KwikPen Mix 75/25
  • Humalog Mix 50/50
  • Humalog Mix 75/25
SECTION 1 of 4

Highlights for insulin-lispro-insulin-lispro-protamine

Parenteral Suspension
1
INSULIN LISPRO; INSULIN LISPRO PROTAMINE (IN su lin LYE sproe; IN su lin LYE sproe PRO ta meen) is a human-made form of insulin. This drug lowers the amount of sugar in your blood. This medicine is a mixture of a rapid-acting insulin and a longer-acting insulin. It starts working quickly after injection and continues to work for as long as 12 to 24 hours.
2 3 4
Talk to your healthcare provider if you have any of these conditions.
5
Know what to watch for and get tips for reducing your risks while taking this drug.
SECTION 2 of 4

insulin-lispro-insulin-lispro-protamine Side Effects

Parenteral Suspension

Side effects that you should report to your health care professional or doctor as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • signs and symptoms of high blood sugar such as dizziness, dry mouth, dry skin, fruity breath, nausea, stomach pain, increased hunger or thirst, increased urination
  • signs and symptoms of low blood sugar such as feeling anxious, confusion, dizziness, increased hunger, unusually weak or tired, sweating, shakiness, cold, irritable, headache, blurred vision, fast heartbeat, loss of consciousness

Side effects that usually do not require medical attention (report to your health care professional or doctor if they continue or are bothersome):

  • increase or decrease in fatty tissue under the skin due to overuse of a particular injection site
  • itching, burning, swelling, or rash at site where injected
SECTION 3 of 4

insulin-lispro-insulin-lispro-protamine May Interact with Other Medications

Parenteral Suspension
  • other medicines for diabetes

Many medications may cause an increase or decrease in blood sugar, these include:

  • alcohol containing beverages
  • aspirin and aspirin-like drugs
  • chloramphenicol
  • chromium
  • diuretics
  • female hormones, like estrogens or progestins and birth control pills
  • heart medicines
  • isoniazid
  • male hormones or anabolic steroids
  • medicines for weight loss
  • medicines for allergies, asthma, cold, or cough
  • medicines for mental problems
  • medicines called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl
  • niacin
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • pentamidine
  • phenytoin
  • probenecid
  • quinolone antibiotics like ciprofloxacin, levofloxacin, ofloxacin
  • some herbal dietary supplements
  • steroid medicines like prednisone or cortisone
  • thyroid medicine

Some medications can hide the warning symptoms of low blood sugar. You may need to monitor your blood sugar more closely if you are taking one of these medications. These include:

  • beta-blockers such as atenolol, metoprolol, propranolol
  • clonidine
  • guanethidine
  • reserpine
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
SECTION 4 of 4

How to Use insulin-lispro-insulin-lispro-protamine

Parenteral Suspension

This medicine is for injection under the skin. Use exactly as directed. It is important to follow the directions given to you by your health care professional or doctor. You should inject this medicine within 15 minutes before or after your meal. You will be taught how to use this medicine and how to adjust doses for activities and illness. Do not use more insulin than prescribed. Do not use more or less often than prescribed.

Always check the appearance of your insulin before using it. This medicine should be white and cloudy. Do not use it if is not uniformly cloudy after mixing. To mix this medicine, roll the vial gently 10 times in your hands. If using the Humalog Mix disposable pen, roll the pen gently 10 times in your hands. Then, turn the pen upside down so that the glass ball moves from one end of the pen to the other. Do this at least 10 times. Make sure to perform the mixing procedures before each injection. In addition, the pen should be primed before each injection. Your doctor or diabetes educator will teach you how to use the pen.

Do not mix this medicine with any other insulin or diluent.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • episodes of hypoglycemia
  • kidney disease
  • liver disease
  • an unusual or allergic reaction to insulin, metacresol, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
What if I miss a dose?

It is important not to miss a dose. Your health care professional or doctor should discuss a plan for missed doses with you. If you do miss a dose, follow their plan. Do not take double doses.

What should I watch for while using this medicine?

Visit your health care professional or doctor for regular checks on your progress.

A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.

Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.

Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.

Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.

Do not skip meals. Ask your doctor or health care professional if you should avoid alcohol. Many nonprescription cough and cold products contain sugar or alcohol. These can affect blood sugar.

Make sure that you have the right kind of syringe for the type of insulin you use. Try not to change the brand and type of insulin or syringe unless your health care professional or doctor tells you to. Switching insulin brand or type can cause dangerously high or low blood sugar. Always keep an extra supply of insulin, syringes, and needles on hand. Use a syringe one time only. Throw away syringe and needle in a closed container to prevent accidental needle sticks.

Insulin pens and cartridges should never be shared. Even if the needle is changed, sharing may result in passing of viruses like hepatitis or HIV.

Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.

Where should I keep my medicine?

Keep out of the reach of children.

Store unopened insulin vials in a refrigerator between 2 and 8 degrees C (36 and 46 degrees F). Do not freeze or use if the insulin has been frozen. Opened vials (vials currently in use) may be stored in the refrigerator or at room temperature, at approximately 30 degrees C (86 degrees F) or cooler. Keeping your insulin at room temperature decreases the amount of pain during injection. Once opened, your insulin can be used for 28 days. After 28 days, the vial of insulin should be thrown away.

Store unopened Humalog Mix pens in a refrigerator between 2 and 8 degrees C (36 and 46 degrees F). Do not freeze or use if the insulin has been frozen. Once opened, the pens should be kept at room temperature, approximately 30 degrees C (86 degrees F) or cooler. Do not store in the refrigerator. Once opened, the insulin can be used for 10 days. After 10 days, the pen should be thrown away.

Protect from light and excessive heat. Throw away any unused medicine after the expiration date or after the specified time for room temperature storage has passed.

Send us your feedback

Thank you.

Your message has been sent.

We're sorry, an error occurred.

We are unable to collect your feedback at this time. However, your feedback is important to us. Please try again later.

Last Updated: February 26, 2015

The Healthline Site, its content, such as text, graphics, images, search results, and other material contained on the Healthline Site ("Content"), its services, and any information or material posted on the Healthline Site by third parties are provided for informational purposes only. None of the foregoing is a substitute for professional medical advice, examination, diagnosis, or treatment. Always seek the advice of a physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on the Healthline Site. If you think you may have a medical emergency, call your doctor or 911 immediately. Please read the Terms of Service for more information regarding use of the Healthline Site.
Content licensed by
Gold Standard Logo

Healthline - Gold Standard License

Terms of Use

Licensee provides access to Alchemy provided by Gold Standard, Inc. ("Gold Standard"). Although Gold Standard makes reasonable efforts to ensure the accuracy and reliability of Alchemy, End User acknowledges and agrees that Licensee, its affiliates, and their respective officers, directors, employees and information providers and Gold Standard, its affiliates, its licensors, and their respective officers, directors, employees and information providers will not be held liable for any damages suffered or incurred by End User or any third person arising out of: a) any faults, interruptions or delays in Alchemy or its delivery, b) any use of or reliance on Alchemy by any person, or c) any inaccuracies, errors or omissions in Alchemy, irrespective of however such faults, interruptions, delays, inaccuracies, errors or omissions arise. Gold Standard shall not be liable to End User for any loss, cost or damages resulting from any delays in delivery and/or non-delivery of Alchemy or its content. End User acknowledges and agrees that its sole and exclusive remedy in the event of such delay is to not accept these terms and conditions. Gold Standard does not represent or warrant that Alchemy will meet the objectives or needs of End User or any third party. Gold Standard makes no warranty of merchantability of Alchemy or of the fitness of Alchemy for any purpose.

About Gold Standard

The Gold Standard editorial staff develops clinically-based drug information content through an independent, peer-reviewed process. Content updates to the database include new FDA-approved drugs, new non-prescription and herbal therapies, newly published information regarding FDA label changes and relevant clinical studies affecting off-label utilization. Editors do not have any significant financial relationships with the industry that would introduce bias in the editing or review of database content.

Read This Next

7 Health Claims About Astaxanthin
7 Health Claims About Astaxanthin
7 Creepy But (Mostly) Harmless Food and Drug Reactions
7 Creepy But (Mostly) Harmless Food and Drug Reactions
6 Kinds of Natural Mosquito Repellent
6 Kinds of Natural Mosquito Repellent
Advertisement
Advertisement
Advertisement