Indapamide | Side Effects, Dosage, Uses & More
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Generic Name:

indapamide, Oral tablet

All Brands

  • Lozol (Discontinued)
A discontinued drug is a drug that has been taken off the market due to safety issues, shortage of raw materials, or low market demand.
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Highlights for indapamide

Oral tablet
1

Indapamide is an oral drug that’s used to treat high blood pressure. It can be used to treat salt and fluid retention (edema) in people with congestive heart failure.

2

The standard starting dose for high blood pressure is 1.25 mg taken by mouth once per day in the morning. The starting dose for fluid retention is 2.5 mg taken once per day in the morning. Based on your response, your doctor may increase your dose up to 5 mg per day.

3

Common side effects include headache, dizziness, fatigue, muscle cramps, and more.

4

Indapamide can cause low blood potassium, sodium, or other electrolyte levels. Your doctor should check your electrolyte levels while you’re taking this drug.

5

You may have to change your diet while you’re taking this drug. Talk to your doctor about the amount of sodium and potassium in your diet.

IMPORTANT INFORMATION

People who don't make urine

If you don’t produce urine (anuria), you shouldn’t take this drug.

Sulfa drugs

Don’t use indapamide if you’re allergic to sulfonamide-derived (sulfa) drugs.

Low blood potassium/salt

Indapamide can cause low blood potassium or low sodium. Call your doctor if you have these symptoms:

  • intense thirst
  • tiredness
  • drowsiness
  • restlessness
  • muscle pains or cramps
  • nausea
  • vomiting
  • fast heart rate or pulse

What is indapamide?

Indapamide is a prescription drug. It’s available as an oral tablet.

Indapamide is only available as a generic drug. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand. Talk to your healthcare provider to see if the generic will work for you.

Indapamide may be taken in combination with other drugs to treat high blood pressure or swelling.

Why it's used

Indapamide is used to lower blood pressure in people with high blood pressure. It can also be used to treat salt and fluid retention (edema) in people with congestive heart failure.

How it works

Indapamide belongs to a class of drugs called diuretics. A class of drugs refers to medications that work similarly.

More Details

How it works

Indapamide belongs to a class of drugs called diuretics. A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

Indapamide makes your body get rid of extra water and salt through your urine. This results in less swelling and lower blood pressure.

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indapamide Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with indapamide include:

  • headache

  • dizziness

  • fatigue, weakness, or loss of energy

  • muscle cramps or spasms

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • fast, unexplained weight loss

  • severe skin rash with itching

  • trouble breathing or swallowing

Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Indapamide may cause drowsiness.

You may urinate more often when you first start taking this drug. But this should go away after a few weeks.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
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indapamide May Interact with Other Medications

Oral tablet

Indapamide can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Alcohol interaction

Using alcohol while taking this drug can cause a sedative effect. You may have slowed reflexes, poor judgment, and sleepiness. This can be dangerous.

Medications that might interact with this drug

Drugs used to treat high blood pressure

When indapamide is taken with other drugs that lower your blood pressure, the blood pressure-lowering effects can be increased. This means that it might lower your blood pressure too much.

These drugs include:

  • hydrochlorothiazide
  • furosemide
  • propranolol
  • metoprolol
  • lisinopril
  • ramipril
  • losartan
  • valsartan

Lithium

Taking these drugs together can cause lithium to build up in your body. This raises your risk for lithium toxicity.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Indapamide warnings
gout
People with gout

This drug can cause gouty episodes. Let your doctor know if you have gout.

kidney disease
People with kidney disease

Indapamide can cause kidney problems. This drug should be used with caution if you have kidney disease.

liver disease
People with liver disease

Indapamide can cause fluid and electrolyte imbalances. These imbalances can make your liver disease worse. People with liver disease should use this drug with caution.

lupus
People with lupus

This drug may make your lupus worse. Let your doctor know if you have lupus.

pregnant women
Pregnant women

Indapamide is a category B pregnancy drug. That means two things:

  1. Studies of the drug in pregnant animals haven’t shown risk to the fetus.
  2. There aren’t enough studies done in pregnant women to show the drug poses a risk to the fetus.

Tell your doctor if you’re pregnant or plan to become pregnant. Indapamide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

breastfeeding
Women who are breast-feeding

It isn’t known if indapamide passes into breast milk. If it does, it may cause serious effects in a breastfeeding child.  

You and your doctor may need to decide if you’ll take this drug or breastfeed.

for seniors
For seniors

Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule.

for children
For children

This medicine hasn’t been studied in children and shouldn’t be used in children under the age of 18 years.

allergies
Allergies

Indapamide can cause a severe allergic reaction. Symptoms include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

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How to Take indapamide (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

High blood pressure (hypertension)
Form: Oral tablet
Strengths: 1.25 mg and 2.5 mg
Adult dosage (ages 18–64 years)
  • starting dose: 1.25 mg taken by mouth once per day taken in the morning.
  • dose increases: After 4 weeks, your doctor may increase your dose to 2.5 mg taken once per day. After another 4 weeks, your doctor may increase your dose to 5 mg taken once per day. If your blood pressure is still high, your doctor may give you another drug to take along with indapamide.
Child dosage (ages 0–17 years)

This medicine hasn’t been studied in children and shouldn’t be used in children under the age of 18 years.

Senior dosage (ages 65 years and older)

There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule.

Warnings

Doses greater than 5 mg per day haven’t been shown to treat high blood pressure or heart failure better. Doses this high may cause more side effects.

Fluid retention (edema) in people with congestive heart failure
Form: Oral tablet
Strengths: 1.25 mg and 2.5 mg
Adult dosage (ages 18–64 years)
  • starting dose: 2.5 mg taken by mouth once per day taken in the morning.
  • dose increases: After one week, your doctor may increase your dose to 5 mg taken once per day.
Child dosage (ages 0–17 years)

This medicine hasn’t been studied in children and shouldn’t be used in children under the age of 18 years.

Senior dosage (ages 65 years and older)

There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule.

Warnings

Doses greater than 5 mg per day haven’t been shown to treat high blood pressure or heart failure better. Doses this high may cause more side effects.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Indapamide comes with serious risks if you don't take it as prescribed.

If you stop taking it suddenly

Don’t stop taking indapamide without talking to your doctor. Stopping this drug suddenly may cause your blood pressure to spike. This may increase your chance for a heart attack or stroke. If you have heart failure, you may also experience fluid buildup if you stop taking indapamide suddenly.

If you don't take it on schedule

Your blood pressure may not improve or may get worse.You may have a higher chance of a heart attack or stroke. If you have heart failure, you may have fluid buildup.

If you don't take it at all

For treatment of high blood pressure:

Indapamide reduces high blood pressure. If you don’t take it, your blood pressure will stay high. This raises your chance of having a stroke or heart attack.

For treatment of fluid retention:

Indapamide gets rid of excess fluid and salt in your body. If you have heart failure, this is important to keep your heart from working too hard. This can also help with your breathing. If you don’t take your indapamide as prescribed, your heart will work harder and you may have trouble breathing because of fluid buildup.

If you take too much

You may have the following symptoms:

  • nausea
  • vomiting
  • weakness
  • stomach problems
  • changes in the amount of electrolytes in your blood. This can be dangerous.

If you think that you’ve taken too much indapamide, call your doctor right away.

What to do if you miss a dose

If you forget to take your dose, take it as soon as you remember. If it’s just a few hours until the time for your next dose, then wait and only take one dose at that time.

Never try to catch up by taking two doses at once. This could cause toxic side effects.

How to tell if the drug is working

For treatment of high blood pressure:

You won’t be able to feel indapamide working. If you check your blood pressure, your readings will be lower.

For treatment of fluid retention:

You may have less swelling or fluid retention.

Indapamide is a long-term drug treatment for lowering blood pressure.

It will control your high blood pressure but it won’t cure it. When taken long-term, it may prevent you from having a heart attack or stroke.

Indapamide may be short-term or long-term drug treatment for fluid retention.

It will control your swelling or fluid retention, but it won’t cure it. When taken long-term, it may keep your heart failure from getting worse.

Important considerations for taking indapamide
take with or without food
Indapamide can be taken with or without food
timing
Take indapamide at the same time each morning
can crush or cut
You can cut or crush the tablet
storage
Store at room temperature from 68–77°F (20–25°C)
See Details
refillable
Prescription is refillable
travel
Travel
See Details
self-management
Self-management
See Details
clinical monitoring
Clinical monitoring
See Details
diet considerations
Your diet
See Details
sun sensitivity
Sun sensitivity
See Details
not usually stocked
Not every pharmacy stocks this drug, so call ahead
hidden costs
Hidden costs
See Details
prior authorization
Insurance
See Details

Store at room temperature from 68–77°F (20–25°C)

Don’t freeze this drug.

Keep it away from light and high temperature.

Keep your drugs away from areas where they could get wet, such as bathrooms. Store this drug away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry your medication with you, such as in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Self-management

Your doctor may ask you to check your blood pressure at home. You should keep a log with the date, time of day, and your blood pressure readings. Bring this diary with you to your doctor appointments.

You may need to buy a blood pressure monitor to check your blood pressure at home. These are available at most pharmacies.

Clinical monitoring

While being treated with indapamide, your doctor will monitor your:

  • blood pressure
  • electrolyte levels
  • kidney function
  • liver function

Your diet

Your doctor may have you follow a set diet, such as a low-salt and/or a high-potassium diet. Foods high in potassium include prunes, bananas, and orange juice.

Sun sensitivity

Indapamide may make your skin sensitive to sunlight. You should wear protective clothing and sunscreen when you’re in the sun.

Hidden costs

You may need to purchase a home blood pressure monitor to keep track of your blood pressure.

Insurance

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

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How Much Does indapamide Cost?

Oral tablet

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Lowest price for indapamide

Walmart $4.00
Kroger Pharmacy $7.77
Publix $9.63
These prices represent the lowest priced national pharmacies for indapamide on GoodRx. They may be lower than your insurance.

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These prices represent the lowest priced national pharmacies for indapamide on GoodRx. They may be lower than your insurance.

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on August 28, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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