Generic Name: ibuprofen-oxycodone, Oral tablet

Generic Name:

ibuprofen-oxycodone, Oral tablet

Combunox

All Brands

  • Combunox
SECTION 1 of 4

Highlights for ibuprofen-oxycodone

Oral tablet
1

Oxycodone/ibuprofen is an oral drug used to treat moderate to severe pain for a short amount of time. You shouldn’t take it for more than 7 days.

2

This medication comes with the risk of addiction, abuse, and misuse, which can lead to overdose and death.

3

This is a controlled substance because it can be a target for people who abuse drugs. Never give this medication to anyone else. Selling or giving it away is against the law.

4

Avoid alcohol while taking this medication. Alcohol can increase sedation caused by this medication. It can also increase the chance of serious stomach side effects, such as ulcers and bleeding.

5

Don’t use this medication if you currently have stomach ulcer. It increases your risk of ulcers or small holes in the lining of your stomach or intestines, which can be fatal.

IMPORTANT INFORMATION

FDA Warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

Heart risks that can result in death. Don’t take this medication if you have heart disease or risk factors for heart disease, such as high blood pressure or heart failure. It may increase your risk of having a blood clot, heart attack, or stroke.

Don’t use this medication if you’re having coronary artery bypass graft surgery. Using this drug to treat pain before or after your surgery increases your risk of heart attack or stroke.

Stomach problems that can result in death. Don’t use this medication if you have current stomach bleeding. It increases your risk of stomach bleeding, ulcers, or creating small holes in the lining of your stomach or intestines. These events can be fatal. They may occur at any time and without any warning symptoms. You’re at greater risk if you’re aged 65 years or older.

Addiction and abuse warning

This drug can lead to addiction, abuse, and misuse, which can result in overdose and death.

Alcohol warning

Mixing this drug with alcohol may increase the effects of both the medication and the alcohol and increase your risk of side effects. It’s strongly recommended to avoid using oxycodone/ibuprofen with alcohol.

Drug Features

Oxycodone/ibuprofen is a prescription drug and a controlled substance. It’s available as an oral tablet.  It’s also available in a generic version. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand. Talk to your healthcare provider to see if the generic will work for you.

Why It's Used

Oxycodone/ibuprofen is used for the short-term management of moderate to severe pain. Don’t use it for more than 7 days.

How It Works

This medication is a combination of two drugs: oxycodone (an opioid) and ibuprofen (a nonsteroidal anti-inflammatory drug (NSAID).

More Details

How It Works

This medication is a combination of two drugs: oxycodone (an opioid) and ibuprofen (a nonsteroidal anti-inflammatory drug (NSAID). Both medications work differently to help treat your pain.

  • Oxycodone works in your brain to change how your body feels and responds to pain.
  • Ibuprofen works to reduce inflammation and change how your body feels and responds to pain.
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ibuprofen-oxycodone Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with oxycodone/ibuprofen include:

  • headache

  • constipation

  • sleepiness or drowsiness

  • dizziness

  • nausea or vomiting

Mild side effects may disappear within a few days or a couple of weeks. Talk to your doctor or pharmacist If they’re more severe or don’t go away.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

  • heart problems. Symptoms may include:

    • chest tightness
    • increased heart rate
  • stomach problems. Symptoms may include:

    • constipation
    • nausea or vomiting
    • bloody stools
  • allergic reaction. Symptoms may include:

    • swelling of your face, lips, tongue, or throat
    • wheezing
  • flu-like symptoms, including:

    • fever
    • chills
    • headache
    • muscle and joint pains
    • tiredness
  • severe dizziness

Pharmacist's Advice
Healthline Pharmacist Editorial Team

This medication may make you feel sleepy, dizzy, or lightheaded. Don’t drive a car or operate heavy machinery while taking it.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

ibuprofen-oxycodone May Interact with Other Medications

Oral tablet

Oxycodone/ibuprofen may interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Alcohol Interaction

Combining alcohol with this medication may increase the effects of both the medication and the alcohol. It can also increase your risk of side effects. It’s strongly recommended to avoid using oxycodone/ibuprofen with alcohol.

Medications That Might Interact with This Drug

“Drying” medications

These drugs are used to treat a variety of conditions, including asthma, gastrointestinal disorders, chronic obstructive pulmonary disease, insomnia, and more. Using oxycodone/ibuprofen with these medications can lead to constipation, nausea and vomiting. 

These drugs include: 

  • trihexyphenidyl (Artane)
  • benztropine mesylate (Cogentin)
  • biperiden
  • procyclidine
  • antihistamines (orphenadrine)
  • Atropine
  • flavoxate (Urispas)
  • oxybutynin (Ditropan, Oxytrol)
  • scopolamine
  • hyoscyamine (Levsinex)
  • tolterodine (Detrol)
  • belladonna alkaloids
  • fesoterodine (Toviaz)
  • solifenacin (VESIcare)
  • darifenacin (Enablex)

Sedating drugs

Using oxycodone/ibuprofen with other sedating drugs can increase your risk of breathing issues, low blood pressure, significant sedation, and coma (rare).

Examples are:

  • other opioid painkillers, such as:
    • hydrocodone
    • codeine
    • morphine
  • benzodiazepines, such as:
    • lorazepam
    • alprazolam
  • some antihistamines, including diphenhydramine
  • muscle relaxants, such as:
    • carisoprodol
    • cyclobenzaprine

Blood pressure drugs
  • angiotensin-converting enzyme (ACE) inhibitors

Oxycodone/ibuprofen may lower the blood pressure-lowering effects of these drugs.

Nonsteroidal anti-inflammatory drugs

Examples are:

  • aspirin
  • naproxen
  • etodolac
  • diclofenac
  • meloxicam
  • indomethacin
  • piroxicam

Combining these drugs increases your risk of side effects, including stomach bleeding and ulcers.

Diuretics

Oxycodone/ibuprofen may lower the effect of diuretics. These include:

  • hydrochlorothiazide
  • furosemide

Bipolar disorder drug
  • lithium 

Oxycodone/ibuprofen increases the levels of lithium in your body, which can increase lithium’s side effects.

Disease-modifying anti-rheumatic drug (DMARD)
  • methotrexate 

Combining these medications increases your risk of side effects from methotrexate.

Anticoagulant, blood thinner
  • warfarin 

Combining these medications increases your risk of bleeding.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with heart problems

This medication can worsen heart problems or increase your risk of heart problems. These include heart attack, blood clots, and stroke. 

People with high blood pressure

This medication may cause high blood pressure or make existing high blood pressure worse. 

People with heart failure

This medication may make fluid buildup caused by heart failure worse. 

People with stomach problems

This medication increases your risk of ulcer or stomach bleeding if you have a history of these problems.

People with breathing problems

Oxycodone/ibuprofen may affect your breathing. Use this medication with extreme caution if you’ve been diagnosed with a breathing problem, such as asthma or chronic obstructive pulmonary disease (COPD). 

People with advanced kidney disease

There is a risk of kidney damage from taking this drug. This medication isn’t recommended if you already have advanced kidney disease.

Pregnant women

Oxycodone/ibuprofen is a category C pregnancy drug. That means two things: 

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Tell your doctor if you’re pregnant or plan to become pregnant.  This drug should be avoided in your third trimester of pregnancy. It can delay your pregnancy, prevent labor, and cause breathing problems with the newborn.

Women who are nursing

Oxycodone passes through breast milk and may cause side effects in a breastfeeding child. Breastfeeding isn’t recommended while taking this medication.

For Seniors

If you’re older than 65 years, you may be more sensitive to this drug or have a greater risk of drug-related side effects. 

For Children

The safety and effectiveness of this medication haven’t been studied in people under the age of 14 years.

Allergies

Oxycodone/ibuprofen can cause a severe allergic reaction. Symptoms may include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal.

SECTION 4 of 4

How to Take ibuprofen-oxycodone (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Moderate to severe pain
Form: Oral Tablet
Strength: 5 mg oxycodone/ 400 mg ibuprofen
Adult Dosage (ages 18 years and older)
  • The usual dose is one tablet taken every 6 hours as needed. The dose will be adjusted based on how well the medication works.
  • The maximum 24-hour dose is 4 tablets.
  • Don’t take this drug for more than 7 days.
Child Dosage (ages 14-17 years)
  • The usual dose is one tablet taken every 6 hours as needed. The dose will be adjusted based on how well the medication works.
  • The maximum 24-hour dose is 4 tablets.
  • Don’t take this drug longer than 7 days.
Child Dosage (ages 0-13 years)

Dosage for people younger than 14 years hasn’t been established.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

What to Do If You Miss a Dose

If you miss a dose, take the missed dose as soon as you can. However, if it’s almost time for your next scheduled dose, skip the missed dose and take the next one on schedule.

Don’t take a double dose to make up for the missed one. You risk more serious side effects or toxicity.

How Can I Tell if the Drug is Working?

You may be able to tell this medication is working if you feel less pain.

This Is a Short-Term Treatment

You shouldn’t take it for more than 7 days because of the risk of addiction or dependence.

Important Considerations for Taking Oxycodone/ibuprofen

Store oxycodone/ibuprofen in a safe place at 77°F (25°C)

You can briefly store this drug in temperatures from 59–86°F (15–30°C).

Keep it away from light and high temperatures.

Note: Keep your medications away from areas where they could get wet, such as bathrooms. Store them away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry it with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt this medication.
  • You may need to show your pharmacy’s preprinted label to identify the medication. Keep the original prescription-labeled box with you when traveling.
  • This is a controlled substance, so you won’t be able to refill the prescription. Check with your doctor and be sure you have enough medication before you leave for your trip. If you’re going to be gone for an extended period, you may need to have your doctor write a prescription to take with you.

Insurance

Many insurance companies may require a prior authorization before they approve the prescription and pay for oxycodone/ibuprofen.

Are There Any Alternatives?

There are many drugs and combinations that can treat pain. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

What does the pill look like?

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on May 11, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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