Generic Name: hydrocodone-ibuprofen, Oral tablet

Ibudone,Reprexain,Vicoprofen,Xylon 10

All Brands

  • Ibudone
  • Reprexain
  • Vicoprofen
  • Xylon 10
SECTION 1 of 4

Highlights for hydrocodone-ibuprofen

Oral tablet
1

Hydrocodone bitartrate/ibuprofen is an oral medication that’s generally used short term for moderate to severe pain.

2

This medication is a combination of two drugs that both work to decrease pain.

3

Hydrocodone bitartrate has a high potential for abuse and can be habit forming. Don’t take more than prescribed by your doctor.

4

Side effects include sleepiness and dizziness. The drug can also slow you down both mentally and physically. Don’t perform any hazardous tasks while taking this medication until you know how it affects you.

5

Ibuprofen may increase your risk for potentially fatal heart or stomach problems. Tell your doctor if you have heart problems or a history of stomach issues, including ulcers and stomach bleeding.

IMPORTANT INFORMATION

FDA Warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

Potentially fatal heart risks. Ibuprofen, one ingredient of this medication, may increase your chances of having a blood clot, heart attack, or stroke. Your risk may be higher if you take this medication for a long time or if you already have heart problems.

Don’t take this medication for pain before or after a major heart surgery known as coronary artery bypass graft (CABG). It may increase your risk of heart attack or stroke.

While taking this medication, you may develop new high blood pressure. If you already have high blood pressure, this medication can make it worse.  Blood pressure that’s not controlled may increase your chance of getting a blood clot, heart attack, or stroke.

While taking this medication, you may see swelling in your legs, feet, hands, and arms. This is a sign of heart failure.

Potentially fatal stomach problems. Ibuprofen may increase your risk of serious stomach problems, such as bleeding, ulcers, or small holes in the lining of your stomach or intestines. These conditions can be fatal. They can occur without any signs or symptoms. If you’re 65 years or older, you may have a greater chance for severe stomach issues.

Abuse and misuse warning

This medication comes with a high risk for misuse, abuse, or recreational use (diversion). Hydrocodone bitartrate, one of its ingredients, can increase your risk for addiction, abuse, and misuse. These can lead to overdose and death.

Alcohol warning

Taking hydrocodone bitartrate and alcohol together will increase both of their effects. This puts you at risk for more side effects. Combining alcohol with this drug also increases your chance of serious stomach problems. It’s strongly recommended that you avoid drinking alcohol while taking this medication.

May cause breathing problems

Hydrocodone bitartrate may slow or stop your breathing. In high doses, it can affect the parts of the brain that control your breathing. If you have trouble breathing, call your doctor or get emergency medical help right away.

If you have asthma, ibuprofen may cause narrowing of your airways, which could be fatal. If you have asthma and have had difficulties breathing while on aspirin or other NSAIDs, don’t take this medication.

Drug Features

Hydrocodone bitartrate/ibuprofen is a prescription drug and a controlled substance. It’s available in oral tablet form. 

It’s also available in a generic version. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand. Talk to your healthcare provider to see if the generic will work for you. 

This is a combination of two drugs in a single form. It’s important to know about all the drugs in the combination because they each may have unique traits.

Why It's Used

Hydrocodone bitartrate/ibuprofen is used for short-term pain relief. It’s generally used for fewer than 10 days.

How It Works

Hydrocodone bitartrate/ibuprofen is a combination of two pain medications.

More Details

How It Works

Hydrocodone bitartrate/ibuprofen is a combination of two pain medications. Hydrocodone bitartrate is an opioid (or narcotic) drug. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID).

It isn’t exactly known how hydrocodone bitartrate works. It’s believed to decrease pain by blocking pain signals in your brain. This will then change the way you feel and respond to pain.

Similarly, it isn’t exactly known how ibuprofen works. It’s believed that it decreases pain by reducing inflammation in your body.

SECTION 2 of 4

hydrocodone-ibuprofen Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with hydrocodone bitartrate/ibuprofen include:

  • headache

  • sleepiness or drowsiness

  • dizziness

  • constipation

  • upset stomach

  • nausea

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

  • skin problems. Signs and symptoms may include:

    • rash
    • hives
    • skin that’s itching, red, swollen, blistered, or peeling
  • allergic reaction. Signs and symptoms may include:

    • tightness in your chest
    • trouble breathing
    • swelling of your face, lips, tongue, mouth, or throat
  • heart problems:

    • heart attack. Signs and symptoms may include:
      • chest pain
      • shortness of breath
    • stroke. Signs and symptoms may include:
      • slurred speech
      • weakness on one side of your body
    • heart failure. Signs and symptoms may include:
      • unexplained weight gain
      • swelling in your legs, feet, hands, and arms
  • stomach problems, including ulcers and bleeding in your stomach and intestines. These conditions can be deadly. Signs and symptoms may include:

    • very bad upset stomach
    • pain in your upper stomach
    • bloody vomit
    • sticky black stools
  • liver problems. Signs and symptoms may include:

    • tiredness
    • yellowing of your skin or whites of your eyes
    • nausea
    • itching
    • pain in your upper right stomach
    • fatigue
  • vision problems. Signs and symptoms may include:

    • blurry eyes
    • other eye problems
Pharmacist's Advice
Healthline Pharmacist Editorial Team

This medication can cause sleepiness and dizziness. It can also slow you down mentally and physically. Don’t drive, operate machinery, or perform any hazardous tasks while taking this medication until you know how it affects you.

Mild side effects may go away within a few days or a couple of weeks. Talk to your doctor or pharmacist if they’re more severe or don’t go away.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

hydrocodone-ibuprofen May Interact with Other Medications

Oral tablet

Hydrocodone bitartrate/ibuprofen can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Alcohol Interaction

Using alcohol while taking this drug can be very dangerous. Combining the two can cause severe sedation. You may experience slowed reflexes, poor judgment, and sleepiness.

It’s strongly recommended to avoid drinking alcohol when using hydrocodone bitartrate/ibuprofen.

Medications That Might Interact with This Drug

Blood pressure drugs

These include:

  • ACE inhibitors
  • diuretics

Hydrocodone bitartrate/ibuprofen may cause these medications not to work as well.

Antidepressants

These include:

  • monoamine oxidase inhibitors (MAOI):
    • selegiline
    • phenelzine
    • moclobemide
  • tricyclic antidepressants:
    • amitriptyline
    • nortriptyline

Combining hydrocodone bitartrate/ibuprofen with these drugs may increase the effect of either the antidepressant or hydrocodone. This could cause sleepiness, dizziness, or light-headedness.

There have been cases when using an MAOI and opioid (hydrocodone) together caused anxiety, confusion, stopped breathing, or even coma. Don’t combine this medication with MAOIs or within 14 days of stopping a MAOI.

Nonsteroidal anti-inflammatory drugs (NSAIDs)

Examples are:

  • aspirin
  • diclofenac
  • naproxen
  • etodolac
  • flurbiprofen
  • ketoprofen
  • meloxicam

Combining these drugs may cause NSAID levels in your body to increase. This may put you at a greater risk of side effects, such as ulcers or bleeding in stomach and intestines.

Bipolar disorder drug
  • lithium

Combining these drugs may cause lithium levels in your body to increase to toxic levels. This may cause nausea, vomiting, diarrhea, tremors, or confusion.

Disease-modifying antirheumatic drug (DMARD)
  • methotrexate

Combining these drugs may cause methotrexate levels in your body to increase to toxic levels. This could cause vomiting, diarrhea, fever, chills, or serious infections. 

Anticoagulant, blood thinner
  • warfarin

Taking these drugs together may increase your risk for side effects, such as bleeding in your stomach and intestines.

Drugs that cause drowsiness

You’re at an increased risk of sleepiness, dizziness, confusion, or slowed or stopped breathing if you take this medication with:

  • other opioids
  • antihistamines (for allergies)
  • antipsychotics (for bipolar disorder, schizophrenia, or depression)
  • benzodiazepines (for anxiety, sleep) 

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with heart problems

This medication can make existing heart conditions worse. Examples are high blood pressure and heart failure. If you have a heart condition, you may also be at a greater risk of heart attack, stroke, or heart failure.

People with stomach problems

This medication increases your risk of stomach bleeding, ulcers, and small holes in your stomach or intestines if you have a history of these problems. These conditions can be fatal.

People with head injury

This drug can increase the pressure in the area surrounding your brain if you currently have a head injury. It can also make it difficult for doctors to diagnose or find the cause of the problem.

People with kidney problems

If you have kidney problems, using this drug long term may damage your kidneys even more.

People with asthma

If you have asthma, this medication may cause narrowing of your airways, which can be fatal. If you have asthma and have had difficulties breathing while taking aspirin or other NSAIDs, don’t take this medication at all.

People with history of drug abuse

Avoid taking hydrocodone bitartrate/ibuprofen if you have a history of drug abuse. This medication is highly addictive.

Pregnant women

Hydrocodone bitartrate/ibuprofen is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Some infants born to mothers who were taking opioids like hydrocodone bitartrate regularly during pregnancy have shown an increased risk of drug dependence. These babies showed withdrawal symptoms, such as excessive crying and irritability, tremors, extremely fast breathing, vomiting, and fever.

Also, some infants born to mothers taking NSAIDs like ibuprofen during pregnancy have had problems. In these pregnancies, the blood vessel that supplies nutrients and oxygen from the mother to the fetus closed too early.

Tell your doctor if you’re pregnant or plan to become pregnant. This medication should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Women who are nursing

Hydrocodone passes through breast milk. It isn’t known if this could harm a breastfeeding baby.

You and your doctor may decide whether you’ll take this medication or breastfeed.

For Seniors

If you’re aged 65 years or older, your liver and kidneys may not work as well. This may cause you to experience more side effects from this medication. Your doctor may prescribe this medication with extra caution and at lower doses.

For Children

It isn’t known if this medication is safe and effective in children younger than 16 years old.

When to call the doctor

Tell your doctor if your pain doesn’t get better or if it gets worse.

Let your doctor know before starting any new medications. These include new prescription or over-the-counter drugs, vitamins, herbs, or supplements.

Allergies

Hydrocodone bitartrate/ibuprofen can cause a severe allergic reaction. Symptoms may include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives

Don’t take this drug again if you’ve ever had an allergic reaction to it, other similar opioids, or other NSAIDs. Taking it a second time could be fatal.

SECTION 4 of 4

How to Take hydrocodone-ibuprofen (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Short-term pain

Generic

Form: Oral Tablet
Strengths: 2.5 mg hydrocodone/200 mg ibuprofen, 5 mg hydrocodone/200 mg ibuprofen, 7.5 mg hydrocodone/200 mg ibuprofen, 10 mg hydrocodone/200 mg ibuprofen

Brand: Reprexain

Form: Oral Tablet
Strengths: 2.5 mg hydrocodone/200 mg ibuprofen, 5 mg hydrocodone/200 mg ibuprofen, 10 mg hydrocodone/200 mg ibuprofen

Brand: Vicoprofen

Form: Oral Tablet
Strengths: 7.5 mg hydrocodone/200 mg ibuprofen

Brand: Xylon

Form: Oral Tablet
Strengths: 10 mg hydrocodone/200 mg ibuprofen
Adult Dosage (ages 18 years and older)
  • The dose is one tablet taken every 4–6 hours as needed.
  • Don’t take more than 5 tablets in a 24-hour period.
Child Dosage (ages 16-17 years)
  • The dose is one tablet taken every 4–6 hours as needed.
  • Don’t take more than 5 tablets in a 24-hour period.
Child Dosage (ages 0-15 years)

A safe and effective dosage hasn’t been determined for this age group.

Special Considerations

Seniors: If you’re 65 years or older, your doctor may prescribe this medication with extra caution and at lower doses. Your doctor may monitor your liver and kidneys while you take it to make sure it’s safe for you.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Hydrocodone bitartrate/ibuprofen comes with serious risks if you don't take it as prescribed.

If You Don't Take It At All

Your pain may not improve or it may even get worse.

If You Take Too Much

You can overdose on this medication if you take too much. Symptoms may include:

  • slowed or stopped breathing
  • slowed heart rate
  • very low blood pressure
  • possible coma
  • ulcers or bleeding in your stomach or intestines
  • kidney damage
  • liver damage
  • anemia and low blood counts

If you think you’ve taken too much, get emergency medical attention right away.

What to Do If You Miss a Dose

This medication is taken as needed for pain, so you may not be taking it on a schedule. If you’re taking it regularly, take the missed dose as soon as you can. Skip the missed dose if it’s almost time for your next scheduled dose.

Don’t use extra medication to make up the missed dose. This could result in toxic side effects.

How to Tell If the Drug Is Working

You can tell if hydrocodone bitartrate/ibuprofen is working if your pain decreases after you take it.

This is a short-term treatment.

Important Considerations for Taking Hydrocodone bitartrate/ibuprofen

Taking with food isn’t necessary

But if the medication upsets your stomach, it’s okay to take it with food.

Store in temperatures from 59–86°F (15–30°C)

Don’t freeze this medication.

Keep it in the original container, and keep the bottle tightly closed. Keep it away from light and high temperatures.

Note: Keep your medications away from areas where they could get wet, such as bathrooms. Store them away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry it with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt this medication.
  • You may need to show your pharmacy’s preprinted label to identify the medication. Keep the original prescription-labeled box with you when traveling.
  • Since this is a controlled substance, you won’t have refills from your doctor. Be sure to check that you have enough medication before you leave on your trip.

Clinical Monitoring

While you’re on this medication, your doctor may monitor:

  • signs and symptoms of bleeding or ulcers in your stomach and intestines.
  • blood tests to check if your liver and kidneys are working properly and to make sure that the medication isn’t damaging them.
  • blood pressure. This medication can cause high blood pressure. If you already have high blood pressure, it could make it worse.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for hydrocodone bitartrate/ibuprofen.

What does the pill look like?

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Are There Any Alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.


Show Sources

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on May 28, 2015

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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