Generic Name: guaifenesin-phenylephrine, Oral syrup

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Highlights for guaifenesin-phenylephrine

Oral syrup
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GUAIFENESIN; PHENYLEPHRINE (gwye FEN e sin; fen il EF rin) is a expectorant, decongestant combination. It is used to provide relief from cough and congestion. This medicine will not treat an infection.
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This drug also comes in other forms, including Oral capsuleOral SuspensionOral SolutionOral tabletOral Drops Solution
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Talk to your healthcare provider if you have any of these conditions.
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Know what to watch for and get tips for reducing your risks while taking this drug.
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guaifenesin-phenylephrine Side Effects

Oral syrup

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • confusion
  • fast, irregular heartbeat
  • hallucinations
  • high blood pressure
  • seizure
  • tremor
  • trouble passing urine

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • anxiety, excitement, irritability, or nervousness
  • diarrhea
  • dizziness
  • headache
  • loss of appetite
  • stomach upset, nausea
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guaifenesin-phenylephrine May Interact with Other Medications

Oral syrup

Do not take this medicine with any of the following medications:

  • bromocriptine
  • ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • procarbazine
  • stimulant medicines for attention disorders, weight loss, or to stay awake

This medicine may also interact with the following medications:

  • indomethacin
  • mecamylamine
  • medicines for chest pain, heart disease, high blood pressure, or heart rhythm problems
  • medicines for depression, anxiety, or psychotic disturbances
  • methyldopa
  • other medicines for allergies or colds
  • reserpine
  • some medicines used during surgery
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
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How to Use guaifenesin-phenylephrine

Oral syrup

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Use a specially marked spoon or container to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take your medicine at regular intervals. Do not take it more medicine than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 2 years old for selected conditions, precautions do apply.

Patients over 65 years old may have a stronger reaction to this medicine and need smaller doses.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of the following conditions:

  • blood vessel disease
  • diabetes
  • fever
  • glaucoma
  • heart disease or heart rhythm problems
  • high blood pressure
  • other chronic disease
  • prostate trouble
  • taken an MAOI like Carbex, Eldepryl, Marplan, Nardil, or Parnate within the last 14 days
  • thyroid disease
  • an unusual or allergic reaction to guaifenesin, phenylephrine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What should I watch for while using this medicine?

Tell your doctor or health care professional if your symptoms do not start to get better within 5 days or if they get worse. If you have trouble falling asleep at night, take the last dose of the day at least a few hours before bedtime.

Drink 6 to 8 glasses water daily while you are taking this medicine to help loosen mucus.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature, between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Throw away any unused medicine after the expiration date.

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Last Updated: April 29, 2009

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