Highlights for goserelin
Goserelin is an injectable medication used to treat breast cancer, prostate cancer, endometriosis, and endometrial thinning.
This drug is in the form of an implant that is injected under your skin only by a healthcare provider in a clinic or hospital. The implant dissolves and releases the drug slowly during the time between injections.
Common side effects include diarrhea, rectal bleeding, bladder inflammation, hot flashes, nausea, and more.
If you have breast or prostate cancer, starting this medication might cause a temporary rise in your estrogen or testosterone level. Your cancer symptoms may also get worse during the first few weeks of treatment.
Goserelin may increase your blood sugar levels and raise the risk of developing diabetes in men. If you already have diabetes, it may make blood sugar control more difficult. It may also increase the risk of heart attack and stroke in men.
What is goserelin acetate?
This drug is a prescription drug. This drug is available as an implant that is injected only by a health care provider in a hospital or clinic. It comes in a prefilled syringe. It is injected just under your skin (subcutaneously). It gradually dissolves and releases the drug during the time between injections.
This drug may be used as part of a combination therapy. That means you need to take it with other drugs.
This drug can be used in combination with another drug, flutamide, for the management a particular type of prostate cancer (Stage T2b-T4).
Why it's used
This drug is used to reduce or relieve symptoms of advanced breast cancer.
How it works
This drug belongs to a class of drugs called GnRH analogs.
goserelin Side Effects
Most Common Side Effects
The most common side effects that occur with goserelin include:
bone pain or breast pain/tenderness
sexual problems, such as:
- decreased sex drive
- difficulty getting or maintaining erections
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
Serious Side Effects
If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.
Bone thinning or weakness. Goserelin lowers estrogen in your body, which may cause your bones to become weak or thin. Symptoms include:
Liver problems. Goserelin may increase your liver enzymes.
Heart problems. Goserelin may increase your cholesterol levels.
Injection site reaction. Symptoms include:
- loss of consciousness
This drug doesn’t cause drowsiness.
goserelin May Interact with Other Medications
This drug can interact with other medications, herbs, or vitamins you might be taking. Your healthcare provider will look out for interactions with your current medications. Always be sure to tell your doctor about all medications, herbs, or vitamins you’re taking.
How to Take goserelin (Dosage)
Your doctor will determine a dose that’s right for you based on your individual needs. Your general health may affect your dose. Tell your doctor about all health conditions you have before your doctor or nurse administers the drug to you.
This drug comes with serious risks if you don’t take it as prescribed.
If you don't take it at all
If you stop receiving your injection, your symptoms of cancer or endometriosis may get worse.
If you skip or miss doses/appointments
Your injections need to be taken on schedule. Try to stick to the dosing schedule that your doctor has recommended.
If you miss an appointment, call your doctor right away to reschedule it.
If you take too much
Taking too much will increase your chance of side effects.
How to tell the drug is working
Your doctor will do tests and monitor you to check if goserelin is working for you.
This drug is a long-term drug treatment.
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- About Zoladex, Approved uses. (2014, November). Retrieved from http://www.aboutzoladex.com/#approved_uses
- About Zoladex, Prostate cancer, What if I miss an injection? (2015, June). Retrieved from http://www.aboutzoladex.com/prostate-cancer#isi
- Zoladex – goserelin acetate implant. (2015, February). Retrieved from http://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=ZOLADEX
Content developed in collaboration with University of Illinois-Chicago, Drug Information Group
Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on August 17, 2015