Generic Name: glyburide, Oral tablet

Generic Name:

glyburide, Oral tablet

Diabeta,Glycron,Glynase PresTab,Micronase

All Brands

  • Diabeta
  • Glycron
  • Glynase PresTab
  • Micronase
SECTION 1 of 5

Highlights for glyburide

Oral tablet
1

Glyburide is an oral drug that’s used to treat type 2 diabetes.

2

While taking this medication, you’ll need to test your blood sugar level. You’ll also need to learn how to spot and treat low and high blood sugar reactions.

3

Make sure to carry a quick source of sugar, such as hard candy or glucose tablets, with you in case you have symptoms of low blood sugar.

4

Your dose depends on your age, blood sugar levels, and the form of the drug that you’re taking.

5

Common side effects include diarrhea, dizziness, headache, heartburn, nausea, and gas.

IMPORTANT INFORMATION

Low blood sugar (hypoglycemia)

Glyburide can cause low blood sugar. Symptoms may include:

  • shakiness
  • nervousness or anxiety
  • sweating, chills, and clamminess
  • irritability or impatience
  • confusion
  • rapid or fast heart rate
  • lightheadedness or dizziness
  • intense hunger
  • nausea
  • sleepiness
  • blurred or impaired vision
  • tingling or numbness in your lips or tongue
  • headaches
  • weakness or fatigue
  • anger, stubbornness, or sadness
  • lack of coordination
  • nightmares or crying out during sleep
  • seizures
  • unconsciousness

If you don’t treat low blood sugar, you can have a seizure, pass out, and possibly develop brain damage. Low blood sugar can even be fatal. If you pass out because of a low sugar reaction or cannot swallow, someone will have to give you an injection of glucagon to treat the reaction. You may need to go to the emergency room.

Different forms of this drug

Micronized glyburide and regular glyburide are not the same and shouldn’t be used interchangeably. If you’re switching from one form to the other, your doctor will slowly increase your dose.

Injury/infection/surgery

If you have an infection, get injured, or are having major surgery, your doctor may take you off of glyburide temporarily. Increased stress on your body can affect how well your body controls your sugar levels. This means that glyburide may not work as well. You may be put on insulin temporarily to control your blood sugar during this time.

Drug Features

Glyburide is a prescription drug. It’s available as an oral tablet.

Glyburide is available in its generic form. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand. Talk to your healthcare provider to see if the generic will work for you.

This drug may be used as part of a combination therapy. That means you need to take it with other drugs.

Why It's Used

Glyburide is used with diet and exercise to treat type 2 diabetes in adults.

How It Works

Glyburide belongs to a class of medications called sulfonylureas.

More Details

How It Works

Glyburide belongs to a class of medications called sulfonylureas. A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

Glyburide helps release insulin from your pancreas. Insulin moves sugar from your bloodstream to your cells, where it belongs. This decreases your blood sugar levels.

SECTION 2 of 5

glyburide Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with glyburide include:

  • diarrhea

  • dizziness

  • headache

  • heartburn

  • nausea

  • gas

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • allergic reaction. Symptoms may include:

    • skin rash
    • itching
    • hives
    • swelling of your face, lips, or tongue
    • trouble breathing
  • low blood sugar (hypoglycemia). Symptoms may include:

    • confusion
    • increased hunger
    • dizziness
    • feeling anxious
    • sweating
    • shakiness
    • feeling cold
    • irritability
    • headache
    • blurred vision
    • fast heart rate
    • loss of consciousness
    • feeling unusually weak or tired
  • liver problems. Symptoms may include:

    • dark-colored urine
    • yellowing of your skin or the whites of your eyes
  • flu-like symptoms. Symptoms may include:

    • fever
    • chills
    • sore throat
  • unusual bleeding or bruising

Pharmacist's Advice
Healthline Pharmacist Editorial Team

Glyburide doesn’t cause drowsiness.

If you have a low blood sugar reaction, you need to treat it.

  • For mild hypoglycemia (55–70 mg/dL), treatment is 15–20 grams of glucose (a type of sugar). You need to eat or drink one of the following:
    • 3–4 glucose tablets
    • a tube of glucose gel
    • ½ cup of juice or regular, non-diet soda
    • 1 cup of nonfat or 1% cow’s milk
    • 1 tablespoon of sugar, honey, or corn syrup
    • 8–10 pieces of hard candy, such as lifesavers
  • Test your blood sugar 15 minutes after you treat the low sugar reaction. If your blood sugar is still low, then repeat the above treatment.

Once your blood sugar is back in the normal range, eat a small snack if your next planned meal or snack is more than 1 hour later.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

glyburide May Interact with Other Medications

Oral tablet

Glyburide can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Alcohol Interactions

Drinking alcohol can affect how well your body can control your blood sugar. You should limit how much alcohol you drink while you’re on this drug.

Medications That Might Interact with This Drug

Bosentan (Tracleer)

You shouldn’t take bosentan and glyburide at the same time. Taking these medications together may damage your liver.

Cisapride

If you’re taking these drugs together, your dose of glyburide may need to be changed to make sure that it’s controlling your blood sugar.

Antibiotics for infections and ulcers due to H. pylori
  • clarithromycin

Taking clarithromycin with glyburide can increase the amount of glyburide in your body. This may cause symptoms of low blood sugar.

Drugs for reflux, nausea, and vomiting
  • metoclopramide

If you’re taking metoclopramide with glyburide, your dose of glyburide may need to be changed. This is done to make sure that it’s still controlling your blood sugar.

Drugs for cancer, rheumatoid arthritis, and psoriasis
  • methotrexate

You shouldn’t take methotrexate and glyburide at the same time. Taking these medications together can cause methotrexate levels to increase in your body and become toxic.

Drugs for tuberculosis
  • rifampin

Rifampin can lower the amount of glyburide in your body. This means that glyburide may not work as well to control your blood sugar.

Antacids
  • cimetidine
  • ranitidine 

Taking antacids with glyburide may cause increased effects of glyburide in your body. This can cause symptoms of low blood sugar.

Diuretics
  • bumetanide
  • furosemide
  • hydrochlorothiazide
  • triamterene

Taking diuretics can cause high or low blood sugar in people with diabetes. You should monitor your blood sugar regularly if you’re taking the medications together. Your doctor may change your dose of glyburide or other diabetes medications.

Nonsteroidal anti-inflammatory drugs (NSAIDs)

Examples are:

  • ibuprofen
  • naproxen

Taking NSAIDs with glyburide can cause symptoms of low blood sugar. 

Drugs for fungal or yeast infections
  • fluconazole
  • ketoconazole

Taking antifungal drugs with glyburide can increase the levels of glyburide in your body. This can cause symptoms of low blood sugar.

Aspirin

This drug may increase the effect of glyburide and cause low blood sugar.

Drugs for gout
  • probenecid

This drug may increase the effect of glyburide and cause low blood sugar.

Drugs for eye infections
  • chloramphenicol

This drug may increase the effect of glyburide and cause low blood sugar.

Monoamine oxidase inhibitors (MAOIs)
  • phenelzine
  • selegeline

These drugs may increase the effect of glyburide and cause low blood sugar.

Drugs for blood pressure (beta blockers)
  • nadolol
  • propranolol
  • sotolol

These drugs may increase the effect of glyburide and cause low blood sugar.

Corticosteroids
  • prednisone

These drugs can decrease the effect of glyburide and cause high blood sugar.

Antipsychotic drugs
  • clozapine
  • Zyprexa
  • Abilify
  • Geodon

These drugs can decrease the effect of glyburide and cause high blood sugar.

Thyroid drugs
  • levothyroxine
  • liotrix
  • liothyronine

These drugs can decrease the effect of glyburide and cause high blood sugar.

Hormone therapy or oral birth control pills
  • estrogen
  • progesterone

These drugs can decrease the effect of glyburide and cause high blood sugar.

Drugs for seizures
  • phenytoin

This drug can decrease the effect of glyburide and cause high blood sugar.

Drugs for blood pressure (calcium channel blockers)
  • amlodipine
  • verapamil
  • nifedipine

These drugs can decrease the effect of glyburide and cause high blood sugar.

Vitamins
  • niacin

This drug can decrease the effect of glyburide and cause high blood sugar.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with diabetic ketoacidosis

Don’t use glyburide if you have diabetic ketoacidosis (with or without coma). Diabetic ketoacidosis is a serious complication of diabetes. It occurs when your body produces high levels of the blood acids called ketones. This condition should be treated with insulin.

People with type 1 diabetes

Don’t use glyburide for the treatment of type 1 diabetes. Glyburide works by increasing the amount of insulin your pancreas produces. In type 1 diabetes, your body no longer produces insulin, so glyburide won’t help.

People with heart problems

Glyburide can increase your risk of a heart attack or stroke. This can sometimes be fatal. Tell your doctor if you have a heart condition before you take this drug.

People with thyroid problems

Tell your doctor if you have a thyroid disorder because this affects how your body controls your blood sugar levels. Your doctor may need to change the dose of your medications to help control your diabetes and thyroid.

People with kidney disease

If you have kidney problems, you may not be able to clear this drug from your body as well as you should. Glyburide may build up in your body, which can cause lower blood sugar levels.

People with liver disease

Your doctor may lower your dose of glyburide if you have liver damage or liver disease.

Pregnant women

Depending on which manufacturer of glyburide you use, it’s classified as a pregnancy category B or C drug.

Glynase Prestabs (Micronized glyburide)

Pregnancy category B means two things:

  1. Studies of the drug in pregnant animals haven’t shown risk to the fetus.
  2. There aren’t enough studies done in pregnant women to show the drug poses a risk to the fetus.

Diabeta (Glyburide)

Pregnancy category C means two things:  

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Tell your doctor if you’re pregnant or plan to become pregnant. Glyburide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Women who are nursing

Glyburide isn’t shown to pass through breast milk. 

However, you should tell your doctor if you’re breastfeeding. Your child will be monitored for signs of low blood sugar. 

You and your doctor may need to decide if you’ll take glyburide or breastfeed.

For Seniors

People 65 years and older may have a stronger reaction to glyburide. It may also be more difficult to recognize the symptoms of low blood sugar. Your doctor may give you a lower dose.

For Children

The safety and effectiveness of glyburide haven’t been established in people younger than 18 years old.

When to call the doctor

Call your doctor if you have signs of low blood sugar or high blood sugar. If these symptoms are severe, go to the emergency room.

Symptoms of low blood sugar include:

  • sweating
  • chills
  • feeling nervous or anxious
  • headaches
  • dizziness
  • shakiness
  • blurred vision
  • fast heart rate
  • seizures
  • loss of consciousness
  • loss of coordination

Symptoms of high blood sugar include:

  • frequent urination
  • feeling very thirsty or hungry
  • fatigue
  • blurred vision
  • bruises that heal slowly
  • tingling, pain, or numbness in your hands or feet

Allergies

Glyburide can cause a severe allergic reaction. Symptoms may include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal.

SECTION 4 of 5

How to Take glyburide (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Type 2 diabetes

Brand: Diabeta

Form: Oral tablet
Strengths: 1.25 mg, 2.5 mg, and 5 mg

Brand: Glynase Prestabs

Form: Oral tablet
Strengths: 1.5 mg, 3 mg, and 6 mg

Generic: Glyburide

Form: Oral tablet
Strengths: 1.25 mg and 2.5 mg

Generic: Glyburide (Micronized)

Form: Oral tablet
Strengths: 1.5 mg, 3 mg, and 6 mg
Adult Dosage (ages 18-64 years)

Glyburide tablets

  • Starting dose: 2.5–5 mg taken by mouth once per day
  • Dose adjustments: Your doctor may increase your dose or switch you to taking two doses per day. They’ll decide this based on your blood sugar levels.

Glyburide (Micronized) tablets

  • Starting dose: 1.5–3 mg taken by mouth once per day
  • Dose adjustments: Your doctor may increase your dose each week by up to 1.5 mg per day based on your blood sugar levels.
Child Dosage (ages 0-17 years)

A safe and effective dose for children hasn’t been established.

Senior Dosage (ages 65 years and older)

Glyburide tablets

  • Starting dose: 1.25 mg taken by mouth once per day
  • Dose adjustments will be done slowly, if needed.

Glyburide (Micronized) tablets

  • Starting dose: 0.75 mg taken by mouth once per day
  • Dose adjustments will be done slowly, if needed.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Glyburide comes with serious risks if you don’t take it as prescribed.

If You Miss Doses or Don’t Take It at All

If you don’t take glyburide as prescribed by your doctor, your blood sugar levels won’t be controlled. This can lead to complications from diabetes, such as nerve damage, heart disease, heart attack, stroke, and eye damage.

If You Take Too Much

If you think you’ve taken too much glyburide, go to the emergency room right away or call your local poison control center.

Taking too much glyburide can lower your blood sugar (hypoglycemia). Symptoms may include:

  • shakiness
  • nervousness or anxiety
  • sweating, chills, and clamminess
  • irritability or impatience
  • confusion, including delirium
  • fast heart rate
  • lightheadedness or dizziness
  • hunger and nausea
  • sleepiness
  • blurred or impaired vision
  • tingling or numbness in your lips or tongue
  • headaches
  • weakness or fatigue
  • anger, stubbornness, or sadness
  • lack of coordination
  • nightmares or crying out in your sleep
  • seizures
  • unconsciousness

What to Do If You Miss a Dose

If you miss a dose of glyburide, take it as soon as you remember. If it’s almost time for your next dose, take only one dose at that time. Don’t take extra doses to make up for the missed dose.

How to Tell If the Drug Is Working

You may be able to tell if glyburide is working if your blood sugar levels are lower.

Glyburide is used for long-term treatment.

Store glyburide at room temperature from 59–77°F (15–25°C)

Don’t freeze glyburide.

Keep it away from light and high temperatures.

Keep your drugs away from areas where they could get wet, such as bathrooms. Store your drugs away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry your medication with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt this medication.
  • You may need to show your pharmacy’s preprinted label to clearly identify the medication. Keep the original prescription label with you.

Self-Management

You may need to test your blood sugar levels at home using a blood glucose monitor.

You’ll need to learn how to do the following:

  • use a blood glucose monitor to test your blood sugar regularly at home
  • recognize the signs and symptoms of high and low blood sugar
  • treat low and high blood sugar reactions 

In addition to the medication, you may also need:

  • a safe needle disposal container
  • alcohol swabs
  • lancets to prick your finger to test your blood sugar
  • blood sugar test strips
  • blood glucose monitor to test you blood sugar at home

Clinical Monitoring

Before you start and while you take glyburide, your doctor may check your:

  • blood sugar levels
  • glycosylated hemoglobin (A1C) levels. This test measures your blood sugar control over the last 2–3 months.
  • liver function
  • kidney function
  • heart function
  • thyroid function

Your Diet

Glyburide is used to treat diabetes along with diet changes and exercise. Talk to your doctor about how to change your eating habits.

Sun Sensitivity

Glyburide can make your skin more sensitive to the sun. This increases your risk of sunburn. Use sunscreen and wear protective clothing if you’re in the sun. Don’t use sun lamps or tanning beds or booths.

Hidden Costs

In addition to the medication, you may also need to purchase:

  • a safe needle disposal container
  • alcohol swabs
  • lancets to prick your finger to test your blood sugar
  • blood sugar test strips
  • blood glucose monitor to test your blood sugar at home

Are There Any Alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

What does the pill look like?

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SECTION 5 of 5

How Much Does glyburide Cost?

Oral tablet
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Lowest price for glyburide

Walmart $8.00
Kroger Pharmacy $8.00
Target $8.00
These represent the lowest cash prices for glyburide and may be lower than your insurance.

Find the lowest prices of glyburide near you

These represent the lowest cash prices for glyburide and may be lower than your insurance.

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on July 14, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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