Highlights for glyburide-metformin
glyburide-metformin Side Effects
Side effects that you should report to your doctor or health care professional as soon as possible:
- allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
- breathing problems
- dark urine
- feeling faint or lightheaded, falls
- fever, chills, sore throat
- muscle aches or pains
- nausea, vomiting
- signs and symptoms of low blood sugar such as feeling anxious, confusion, dizziness, increased hunger, unusually weak or tired, sweating, shakiness, cold, irritable, headache, blurred vision, fast heartbeat, loss of consciousness
- slow or irregular heartbeat
- unusual bleeding or bruising
- unusual stomach upset or pain
- yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
- metallic taste in mouth
- stomach gas
glyburide-metformin May Interact with Other Medications
Do not take this medicine with any of the following medications:
- certain contrast medicines given before X-rays, CT scans, MRI, or other procedures
This medicine may also interact with the following medications:
- aspirin and aspirin-like drugs
- female hormones, like estrogens or progestins and birth control pills
- medicines for blood pressure, heart disease, irregular heart beat
- medicines for fungal infections like fluconazole, ketoconazole, itraconazole, posaconazole, and voriconazole
- medicines called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl
- NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
- phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
- steroid medicines like prednisone or cortisone
- stimulant medicines for attention disorders, weight loss, or to stay awake
- thyroid medicine
How to Use glyburide-metformin
Take this medicine by mouth with meals. Swallow with a drink of water. Follow the directions on the prescription label. Take your medicine at the same time each day. Do not take more often than directed.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Patients over 65 years old may need a smaller dose than younger adults.
They need to know if you have any of these conditions:
- become easily dehydrated
- diabetic ketoacidosis
- glucose-6-phosphate dehydrogenase deficiency
- heart disease
- if you frequently drink alcohol containing drinks
- kidney disease
- liver disease
- polycystic ovaries
- serious infection or injury
- thyroid disease
- undergoing surgery or certain x-ray procedures with injectable contrast agents
- an unusual or allergic reaction to glyburide, metformin, sulfa drugs, other medicines, foods, dyes, or preservatives
- pregnant or trying to get pregnant
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Visit your doctor or health care professional for regular checks on your progress.
A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.
Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.
Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.
Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.
Do not skip meals. Ask your doctor or health care professional if you should avoid alcohol. Many nonprescription cough and cold products contain sugar or alcohol. These can affect blood sugar.
This medicine may cause ovulation in premenopausal women who do not have regular monthly periods. This may increase your chances of becoming pregnant. You should not take this medicine if you become pregnant or think you may be pregnant. Talk with your doctor or health care professional about your birth control options while taking this medicine. Contact your doctor or health care professional right away if think you are pregnant.
If you are going to need surgery, a MRI, CT scan, or other procedure, tell your doctor that you are taking this medicine. You may need to stop taking this medicine before the procedure.
This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.
Keep out of the reach of children.
Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F). Keep container tightly closed and protect from light. Throw away any unused medicine after the expiration date.
Last Updated: April 1, 2014