Advertisement

Generic Name:

Rosiglitazone maleate/glimepiride, Oral tablet

All Brands

  • Avandaryl
SECTION 1 of 4

Highlights for Rosiglitazone maleate/glimepiride

Oral tablet
1

Rosiglitazone maleate/glimepiride is a combination of two drugs in a single form that’s used to treat type 2 diabetes.

2

Rosiglitazone maleate/glimepiride should be used with diet and exercise to help control your blood sugar level.

3

The standard starting dose for rosiglitazone maleate/glimepiride is 4 mg/1 mg taken by mouth once per day with breakfast or your first meal of the day.

4

This drug may increase your risk of heart failure. Rosiglitazone can cause your body to retain extra fluid. Fluid can make some heart problems worse or lead to heart failure.

5

Common side effects include cold-like symptoms and headache. Glimepiride can also cause very low blood sugar (hypoglycemia).

IMPORTANT INFORMATION

FDA Warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

  • Heart failure warning: This drug may increase your risk of heart failure.
  • Your risk may be higher if you take this medication with insulin. Most people who take insulin shouldn’t take this drug combination.
    • Rosiglitazone can cause your body to retain extra fluid. Extra body fluid can make some heart problems worse or lead to heart failure.
    • People who have symptoms of heart failure or moderate to severe heart failure shouldn’t take this medication.
    • Tell your doctor right away if you have any signs of heart failure, such as:
      • swelling or fluid retention, especially in your ankles or legs
      • shortness of breath or trouble breathing, especially when you lie down
      • fast weight gain
      • unusual tiredness
    • If you develop heart failure, your doctor may lower your dose or stop this medication.

Vision problems

Rosiglitazone may rarely cause swelling in the back of your eyes. This can lead to blurred vision or changes in your vision. Tell your doctor right away if you have any vision changes while you’re taking this drug.

Increased chance of pregnancy

Rosiglitazone may cause ovulation (release of an egg from an ovary in women), which can lead to pregnancy. Ovulation may even occur in premenopausal women who don’t have regular periods. Ask your doctor about using effective forms of birth control while you’re taking this medication.

What is rosiglitazone maleate/glimepiride?

Rosiglitazone maleate/glimepiride is a prescription drug. It’s available as an oral tablet.

Rosiglitazone maleate/glimepiride is only available as a generic drug.

This is a combination of two or more drugs in a single form. It’s important to know about all the drugs in the combination because they each may have unique traits.

This drug may be used as part of a combination therapy. That means you need to take it with other drugs.

Why it's used

Rosiglitazone maleate/glimepiride is used to decrease blood sugar levels in adults with type 2 diabetes. It’s used along with diet and exercise.

How it works

Rosiglitazone maleate/glimepiride is a combination of two antidiabetic medications that work in different ways.

More Details

How It Works

Rosiglitazone maleate/glimepiride is a combination of two antidiabetic medications that work in different ways:

  • Glimepiride belongs to a class of drugs called sulfonylureas.
    • It works by helping your body release more insulin from your pancreas. Insulin is a chemical that your body makes to help move sugar (glucose) from your bloodstream into your body’s cells. Once the sugar enters your cells, they’re able to use the sugar as fuel for your body. If your body doesn’t make enough insulin or can't use the insulin that it makes properly, the sugar will stay in your bloodstream. This causes high blood sugar levels (hyperglycemia).
  • Rosiglitazone maleate belongs to a class of drugs called thiazolidinediones. 
    • It works by helping you respond better to the insulin that your body makes.
Advertisement
SECTION 2 of 4

Rosiglitazone maleate/glimepiride Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with rosiglitazone maleate/glimepiride include:

  • symptoms of the common cold, such as:

    • sore throat
    • stuffy nose
  • headache

  • high blood pressure

  • low blood sugar (hypoglycemia)

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • severe low blood sugar (less than 35–40 mg/dL). Symptoms may include:

    • mood changes, such as irritability, impatience, anger, stubbornness, or sadness
    • confusion, including delirium
    • lightheadedness or dizziness
    • sleepiness
    • blurred or impaired vision
    • tingling or numbness in your lips or tongue
    • headaches
    • weakness or fatigue
    • lack of coordination
    • nightmares or crying out in your sleep
    • seizures
    • unconsciousness

    If you don’t treat low blood sugar, you can have a seizure, pass out, and possibly develop brain damage. Low blood sugar can even be fatal. If you pass out because of a low sugar reaction or cannot swallow, someone will have to give an injection of glucagon to treat the low sugar reaction. You may need to go to the emergency room.

  • heart failure. Symptoms may include:

    • swelling or fluid retention, especially in your ankles or legs
    • shortness of breath or trouble breathing, especially when you lie down
    • fast weight gain
    • unusual tiredness
  • heart attack. Symptoms may include:

    • chest pain in the center of your chest that lasts for more than a few minutes, or that goes away or comes back
    • pressure, squeezing, fullness, or pain in your chest
    • pain or discomfort in your arms, back, neck, jaw, or stomach
    • breaking out in a cold sweat
    • nausea or vomiting
    • lightheadedness
  • liver problems. Symptoms may include:

    • nausea or vomiting
    • stomach pain
    • unusual tiredness
    • loss of appetite
    • dark-colored urine or discolored stools
    • yellowing of your skin or the whites of your eyes
  • eye or vision problems (macular edema). Rosiglitazone may rarely cause swelling in the back of your eyes. Symptoms may include:

    • blurry vision
    • changes in your vision
  • allergic reaction. Symptoms may include:

    • skin rash or itching
    • hives (raised red areas on your skin)
    • trouble breathing or swallowing
    • swelling of your face, lips, tongue, or throat
    • blisters on your skin or in your mouth, nose, or eyes
    • peeling of your skin
    • fainting or feeling dizzy
    • very fast heart rate
  • bone fractures. Rosiglitazone can increase your risk of getting bone fractures, especially in women. Bone breaks may be more likely to happen in the hand, upper arm, or foot.

  •  low red blood cells (anemia). Symptoms may include:

    • general tiredness
    • weakness
    • fast heart rate
    • shortness of breath
    • dizziness or lightheadedness
    • confusion
    • pale-looking skin
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Rosiglitazone maleate/glimepiride doesn’t cause drowsiness.

This drug will decrease your blood sugar levels. Rosiglitazone maleate/glimepiride can cause your blood sugar level to drop too low (hypoglycemia). If you have a low blood sugar reaction, you need to treat it.

  • For mild hypoglycemia (55–70 mg/dL), treatment is 15–20 grams of glucose (a type of sugar). You need to eat or drink one of the following:
    • 3–4 glucose tablets
    • a tube of glucose gel
    • ½ cup of juice or regular, non-diet soda
    • 1 cup of nonfat or 1% cow’s milk
    • 1 tablespoon of sugar, honey, or corn syrup
    • 8–10 pieces of hard candy, such as lifesavers
  • Test your blood sugar 15 minutes after you treat the low sugar reaction. If your blood sugar is still low, then repeat the above treatment.

Once your blood sugar level is back in the normal range, eat a small snack if your next planned meal or snack is more than 1 hour later.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

Rosiglitazone maleate/glimepiride May Interact with Other Medications

Oral tablet

Rosiglitazone maleate/glimepiride can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Alcohol Interaction

Drinking alcohol while taking glimepiride may affect your blood sugar levels. They can either increase or decrease. Avoid drinking alcohol while taking this medication.

Medications That Might Interact with This Drug

Other diabetes medications

Examples are:

  • canagliflozin
  • pioglitazone
  • glyburide
  • pramlintide
  • insulin

These drugs can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Heart and blood pressure drugs (angiotensin-converting enzyme (ACE) inhibitors)

Examples are:

  • benazepril (Lotensin)
  • captopril (Capoten)
  • enalapril (Vasotec)
  • fosinopril (Monopril)
  • lisinopril (Prinivil, Zestril)
  • quinapril (Accupril)
  • ramipril (Altace)

These drugs can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Drugs for treating reflux
  • H2 receptor antagonists
    • nizatidine
    • cimetidine
    • famotidine

These drugs can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Fibrates

Examples are:

  • gemfibrozil
  • fenofibrate

These drugs can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Propoxyphene

This drug can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Pentoxifylline

This drug can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Somatostatin analogs

Such as:

  • somatropin

These drugs can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Anabolic steroids and androgens

Examples are:

  • testosterone
  • danazol
  • oxandrolone

These drugs can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Cyclophosphamide

This drug can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Phenyramidol

This drug can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Guanethidine

This drug can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Sulfinpyrazone

This drug can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Antibiotics

Examples are:

  • tetracycline
  • clarithromycin
  • quinolones

These drugs can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Disopyramide

This drug can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Nonsteroidal anti-inflammatory drugs (NSAIDs)

Examples are:

  • ibuprofen
  • naproxen

These drugs can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Salicylates

Examples are:

  • aspirin
  • magnesium salicylate (Doan’s)
  • salsalate (Disalcid)

These drugs can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Sulfonamides

Examples are:

  • sulfacetamide
  • sulfadiazine
  • sulfamethoxazole/trimethoprim (Bactrim)
  • sulfasalazine (Azulfidine)
  • sulfisoxazole

These drugs can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Chloramphenicol

This drug can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Blood thinners

These drugs can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Probenecid

This drug can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Drugs for depression
  • Monoamine oxidase inhibitors (MAOIs): such as:
    • isocarboxazid (Marplan)
    • phenelzine (Nardil)
    • tranylcypromine (Parnate)
    • fluoxetine

These drugs can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Drugs to treat fungal infections

Examples are:

  • miconazole
  • fluconazole

These drugs can cause low blood sugar (hypoglycemia) when taken with rosiglitazone maleate/glimepiride.

Glucagon

This drug can cause high blood sugar (hyperglycemia) when taken with rosiglitazone maleate/glimepiride.

Human immunodeficiency virus (HIV) medications
  • protease inhibitors

These drugs can cause high blood sugar (hyperglycemia) when taken with rosiglitazone maleate/glimepiride.

Atypical antipsychotic medications

Examples are:

  • olanzapine
  • clozapine

These drugs can cause high blood sugar (hyperglycemia) when taken with rosiglitazone maleate/glimepiride.

Barbiturates

These drugs can cause high blood sugar (hyperglycemia) when taken with rosiglitazone maleate/glimepiride.

Diazoxide

This drug can cause high blood sugar (hyperglycemia) when taken with rosiglitazone maleate/glimepiride.

Laxatives

These drugs can cause high blood sugar (hyperglycemia) when taken with rosiglitazone maleate/glimepiride.

Tuberculosis drugs

Examples are:

  • rifabutin (Myobutin)
  • rifampin (Rifadin)
  • rifapentine (Priftin)
  • isoniazid

These drugs can cause high blood sugar (hyperglycemia) when taken with rosiglitazone maleate/glimepiride.

Thiazides and other diuretics

Examples are:

  • chlorothiazide (Diuril)
  • chlorthalidone
  • hydrochlorothiazide (Hydrodiuril)
  • indapamide (Lozol)
  • metolazone (Zaroxolyn)

These drugs can cause high blood sugar (hyperglycemia) when taken with rosiglitazone maleate/glimepiride.

Corticosteroids

These drugs can cause high blood sugar (hyperglycemia) when taken with rosiglitazone maleate/glimepiride.

Phenothiazines

These drugs can cause high blood sugar (hyperglycemia) when taken with rosiglitazone maleate/glimepiride.

Thyroid hormones

These drugs can cause high blood sugar (hyperglycemia) when taken with rosiglitazone maleate/glimepiride.

Estrogens and oral birth control pils

These drugs can cause high blood sugar (hyperglycemia) when taken with rosiglitazone maleate/glimepiride.

Phenytoin

This drug can cause high blood sugar (hyperglycemia) when taken with rosiglitazone maleate/glimepiride.

Niacin

This drug can cause high blood sugar (hyperglycemia) when taken with rosiglitazone maleate/glimepiride.

Sympathomimetics

Examples are:

  • epinephrine
  • albuterol
  • terbutaline

These drugs can cause high blood sugar (hyperglycemia) when taken with rosiglitazone maleate/glimepiride.

Colsevelam

When used with rosiglitazone maleate/glimepiride, this drug can decrease the amount of glimepiride absorbed in the intestines. This means that it may not work as well to control your blood sugar level. Rosiglitazone maleate/glimepiride should be taken at least 4 hours before taking colesevelam.

Heart and blood pressure drugs (beta blockers)

Examples are:

  • acebutolol (Sectral)
  • atenolol (Tenormin)
  • bisoprolol (Zebeta)
  • carteolol (Cartrol)
  • esmolol (Brevibloc)
  • metoprolol (Lopressor, Toprol XL)
  • nadolol (Corgard)
  • nebivolol (Bystolic)
  • propranolol (Inderal LA) 

These drugs may increase or decrease the blood sugar-lowering effect of rosiglitazone maleate/glimepiride. They may also mask the symptoms of low blood sugar (hypoglycemia).

Clonidine

This drug may increase or decrease the blood sugar-lowering effect of rosiglitazone maleate/glimepiride. It may also mask the symptoms of low blood sugar (hypoglycemia).

Reserpine

This drug may increase or decrease the blood sugar-lowering effect of rosiglitazone maleate/glimepiride. It may also mask the symptoms of low blood sugar (hypoglycemia).

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Rosiglitazone maleate/glimepiride Warnings
heart failure
People with heart failure

Rosiglitazone can cause your body to retain extra fluid. Extra body fluid can make some heart problems worse or lead to heart failure. Don’t use rosiglitazone maleate/glimepiride if you have symptoms of heart failure. Don’t use this drug if you have moderate to severe heart failure (defined as NYHA Class III or IV).

enzyme deficiency
People with an enzyme deficiency

Glimepiride can cause hemolytic anemia (fast breakdown of red blood cells) in people with the genetic problem Glucose 6-Phosphate Dehydrogenase (G6PD) deficiency. Your doctor may switch you to another diabetes drug if you have this condition.

kidney disease
People with kidney disease

Glimepiride is removed from your body by your kidneys. If your kidneys aren’t working as well, glimepiride may build up in your body and cause low blood sugar (hypoglycemia). Your doctor may start you at a lower dose and slowly increase your dose if needed.

liver problems
People with liver problems

If you have liver disease, you may be more sensitive to glimepiride. Your doctor may start you at a lower dose and slowly increase your dose if needed. If you develop liver damage while taking this drug, your doctor may stop this medication.

bone fractures
People prone to bone fractures

Rosiglitazone can lead to broken bones, especially in women. Your doctor may recommend treatments to help your bone health.

eye problems
People with eye or vision problems

Let your doctor know if you have the diabetic eye disease macular edema. Using rosiglitazone maleate/glimepiride may lead to an eye disease with swelling in the back of your eyes. If you have any changes in vision, talk to your doctor immediately. You should have a regular eye exam with an eye doctor if you have diabetes and are taking this medication. Symptoms of macular edema include blurred vision, decreased ability to see certain colors, and decreased ability to focus your eyes.

type 1 diabetes
People with type 1 diabetes or ketoacidosis

You shouldn’t use rosiglitazone maleate/glimepiride if you have type 1 diabetes or have diabetic ketoacidosis. These conditions should be treated with insulin instead.

pregnant women
Pregnant women

Rosiglitazone maleate/glimepiride is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Tell your doctor if you’re pregnant or plan to become pregnant. Rosiglitazone maleate/glimepiride should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

breastfeeding
Women who are breast-feeding

It isn’t known if rosiglitazone maleate/glimepiride passes through breast milk. If it does, it may cause serious effects in a breastfeeding child.

You and your doctor may need to decide if you’ll take rosiglitazone maleate/glimepiride or breastfeed.

for seniors
For seniors

Your organs, such as your kidneys, liver, and heart, may not work as well as they did when you were younger. Your doctor may watch you closely and give you a lower dose of these medications to avoid serious side effects, such as low blood sugar (hypoglycemia).

for children
For children

The safety and effectiveness of rosiglitazone maleate/glimepiride haven’t been established in people younger than 18 years old.

Special Kid Safety:

  • Keep glimepiride and all medications out of the reach of children.
  • Lancets (a needle used to prick your finger to get drops of blood for blood sugar testing) are used to test your blood sugar while you’re taking glimepiride. Don’t throw out individual lancets into trashcans or recycling bins, and never flush them down the toilet. Ask your pharmacist for a safe container for disposing used lancets. Your community may have a program for throwing away lancets. If disposing the container in the trash, label it “do not recycle”. 
call doctor
When to call the doctor
  • Call your doctor if you get sick or injured, have an infection, or plan to have surgery. Rosiglitazone maleate/glimepiride may not control your blood sugar levels during these times. Your doctor may need to stop this drug for a short time and give you insulin to control your blood sugar level.
  • If your dose of rosiglitazone maleate/glimepiride isn’t working well enough to control your blood sugar, your diabetes won’t be under control. Call your doctor if you have symptoms of high blood sugar (hyperglycemia):
    • urinating more often than usual
    • feeling very thirsty
    • feeling very hungry even though you’re eating
    • extreme fatigue
    • blurred vision
    • cuts or bruises that are slow to heal
    • tingling, pain, or numbness in your hands or feet
allergies
Allergies

The glimepiride component of this drug is similar to a class of drugs called sulfonamides (sulfa drugs). If you’re allergic to sulfa medications, you may be allergic to glimepiride. If you have a sulfa allergy, tell your doctor before taking this drug.

Rosiglitazone maleate/glimepiride can cause a severe allergic reaction. Symptoms may include:

  • skin rash or itching
  • hives (raised red areas on your skin)
  • trouble breathing or swallowing
  • swelling of your face, lips, tongue, or throat
  • blisters on your skin or in your mouth, nose, or eyes
  • peeling of your skin
  • fainting or feeling dizzy
  • very fast heart rate 

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal.

SECTION 4 of 4

How to Take Rosiglitazone maleate/glimepiride (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Type 2 diabetes

Generic

Form: Oral tablet
Strengths:
  • 4 mg rosiglitazone/ 1 mg glimepiride
  • 4 mg rosiglitazone/ 2 mg glimepiride
  • 8 mg rosiglitazone/ 2 mg glimepiride
  • 4 mg rosiglitazone/ 4 mg glimepiride
  • 8 mg rosiglitazone/ 4 mg glimepiride
Adult Dosage (ages 18-64 years)
  • The standard starting dose is 4 mg rosiglitazone maleate/1 mg glimepiride, taken by mouth, once per day, with breakfast or your first meal of the day.
  • Adults who have already been treated with either a sulfonylurea or rosiglitazone may start on a higher dosage. Their dose may be 4 mg rosiglitazone maleate/2 mg glimepiride, taken once per day.
  • Your doctor may use a higher or lower dose of rosiglitazone maleate/glimepiride depending on your blood sugar levels and your response to the drugs.
  • The maximum recommended dose per day is 8 mg rosiglitazone maleate/ 4 mg glimepiride.
Child Dosage (ages 0-17 years)

A safe and effective dose for children hasn’t been established.

Senior Dosage (ages 65 years and older)

You may be more sensitive to this medication. As you age, your organs, such as your kidneys, liver, and heart, may not work as well as they once did. You may be more likely to get side effects, such as low blood sugar (hypoglycemia). Your doctor may start you on a lower dose of this drug and watch you closely.

Special Considerations
  • Kidney disease: Glimepiride is removed from your body by your kidneys. If your kidneys aren’t working as well, glimepiride may build up in your body and cause low blood sugar (hypoglycemia). Your doctor may start you at a lower dose and slowly increase your dose if needed.
  • Liver disease: If you have liver disease, you may be more sensitive to the blood sugar-lowering (hypoglycemic) action of this drug. Your doctor may start you at a lower dose and slowly increase your dose if needed.

Warnings

It may take a few days for rosiglitazone maleate/glimepiride to start lowering your blood sugar. It may take 2–3 months to see its full effect on your blood sugar levels.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Rosiglitazone maleate/glimepiride comes with serious risks if you don't take it as prescribed.

If You Don't Take It At All

You may still experience high blood sugar levels. Over time, higher blood sugar levels can harm your eyes, kidneys, nerves, or heart. Severe issues include heart attack, stroke, blindness, kidney failure and dialysis, and possible amputations of your limbs.

If You Take Too Much

You may experience signs of severe low blood sugar. Symptoms include:

  • mood changes, such as irritability, impatience, anger, stubbornness, or sadness
  • confusion, including delirium
  • lightheadedness or dizziness
  • sleepiness
  • blurred or impaired vision
  • tingling or numbness in your lips or tongue
  • headaches
  • weakness or fatigue
  • lack of coordination
  • nightmares or crying out in your sleep
  • seizures
  • unconsciousness

If you think that you’ve taken too much of this medication or experience any of the symptoms above, call your doctor or go to the emergency room right away.

What to Do If You Miss a Dose

If you miss a dose of rosiglitazone maleate/glimepiride, take it as soon as you remember. If it’s almost time to take your next dose, then take only one dose at that time.

Don’t take double doses to make up for a missed dose. This could result in toxic side effects, such as severe low blood sugar (hypoglycemia).

How to Tell If the Drug Is Working

If rosiglitazone maleate/glimepiride is working, your blood sugar readings will be lower. This drug may help you reach your target blood sugar goals. The target ranges for people with type 2 diabetes are as follows:

  • Blood sugar before a meal (pre-prandial plasma glucose): between 70–130 mg/dL.
  • Blood sugar 1–2 hours after starting a meal (postprandial plasma glucose): less than 180 mg/dL.

Rosiglitazone maleate/glimepiride is a long-term drug treatment.

Important Considerations for Taking Rosiglitazone maleate/glimepiride
take with first meal
Take this medication with breakfast or your first meal of the day
do not crush or cut
Don’t cut or crush the tablet
storage
Store this medication at room temperature
See Details
refillable
Prescription is refillable
travel
Travel
See Details
self-management
Self-management
See Details
clinical monitoring
Clinical monitoring
See Details
diet considerations
Your diet
See Details
sun sensitivity
Sun sensitivity
See Details
not usually stocked
Not every pharmacy stocks this drug, so call ahead
hidden costs
Hidden costs
See Details
prior authorization
Insurance
See Details

Store this medication at room temperature

Keep it from 59–86ºF (15–30ºC).

Keep this medication in the container it comes in. Keep the container closed tightly.

Safely throw away any medication that’s expired or no longer needed. Ask your pharmacist how to dispose of your drugs safely.

Keep it away from light and high temperatures.

Don’t freeze glimepiride.

Keep your drugs away from areas where they could get wet, such as bathrooms. Store these drugs away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry your medication with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt this medication.
  • You may need to show your pharmacy’s label to clearly identify the medication. Keep the original prescription label with you when traveling.
  • Don’t leave this medication in the car, especially when the temperature is hot or freezing
  • Lancets need to be used to check your blood sugar levels. Check for special rules about traveling with medicine and lancets.

Self-management

You may need to test your blood sugar levels at home using a blood glucose monitor.

You’ll need to learn how to do the following:

  • use a blood glucose monitor to test your blood sugar regularly at home
  • recognize the signs and symptoms of high and low blood sugar
  • be able to treat low and high blood sugar reactions

While taking rosiglitazone maleate/glimepiride, you may need to purchase the following to test your blood sugar levels:

  • sterile alcohol wipes
  • lancing device and lancets (a pricking needle used to prick your finger to draw a drop of blood for testing blood sugar)
  • blood sugar test strips
  • blood glucose monitor
  • needle container for safe disposal of lancets

Clinical monitoring

Before starting and while taking rosiglitazone maleate/glimepiride, your doctor may check your:

  • blood sugar levels
  • glycosylated hemoglobin (A1C) levels. This test measures your blood sugar control over the last 2–3 months.
  • liver function. If your liver tests are abnormal, or if you have symptoms of liver damage, your doctor may decide to stop this medication.

Your diet

Managing type 2 diabetes well should include eating a healthy diet. Having good nutrition, losing weight, and exercising regularly are important for controlling your blood sugar levels.

Sun sensitivity

Glimepiride, a component of this medication, may cause increased sensitivity to the sun (photosensitivity). Use sunscreen, wear protective clothing, and limit how often you’re in the sun while taking this medication.

Hidden costs

In addition to the medicine, you may also need to purchase the following:

  • sterile alcohol wipes
  • lancing device and lancets (a pricking needle used to prick your finger to draw a drop of blood for testing blood sugar)
  • blood sugar test strips
  • blood glucose monitor
  • needle container for safe disposal of lancets

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for rosiglitazone maleate/glimepiride.

Are There Any Alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.


Show Sources

 

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on May 20, 2016

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
Advertisement
Advertisement
Advertisement