Generic Name: glimepiride-pioglitazone, Oral tablet

Generic Name:

glimepiride-pioglitazone, Oral tablet

Duetact

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SECTION 1 of 4

Highlights for glimepiride-pioglitazone

Oral tablet
1

Glimepiride/pioglitazone is a combination of two drugs in a single form that’s used to treat type 2 diabetes. It helps to control blood sugar levels, along with diet and exercise.   

2

The standard starting dose of glimepiride/pioglitazone is 2 mg/30 mg or 4 mg/30 mg taken by mouth once per day. Your doctor may adjust your dose based on your blood sugar levels.

3

Take this drug with breakfast or your first main meal of the day. It’s important to take it at the same time each day to avoid big changes in your blood sugar levels.

4

Before you start this medication, tell your doctor if you have any of these conditions: a sulfa allergy, heart failure, kidney, liver, or eye problems, bladder cancer, or glucose 6-phosphate dehydrogenase (G6PD) deficiency. You should also tell your doctor if you’re pregnant, breastfeeding, or don’t get regular menstrual periods. You may not be allowed to take this drug or your doctor may give you special instructions.

5

Common side effects include cold-like symptoms, such as upper respiratory tract infection, headache, sinus infection, diarrhea, nausea, muscle pain, and sore throat.

IMPORTANT INFORMATION

FDA Warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

  • Heart failure warning. Pioglitazone can cause your body to retain extra fluid. This can make some heart problems worse or lead to heart failure.
    • People who have symptoms of heart failure or moderate to severe heart failure shouldn’t take this medication.
    • Tell your doctor right away if you have any signs of heart failure, such as:
      • swelling or fluid retention, especially in your ankles or legs
      • shortness of breath or trouble breathing, especially when you lie down
      • fast weight gain
      • unusual tiredness
    • If you develop heart failure, your doctor may lower your dose or stop this medication.

Bladder cancer

You may have a higher risk of bladder cancer when you take glimepiride/pioglitazone. Don’t take this drug if you have bladder cancer. If you have a history of bladder cancer, your doctor will decide if the benefits of glimepiride/pioglitazone outweigh the risks of your bladder cancer coming back. Tell your doctor right away if you have any symptoms of bladder cancer, such as:

  • blood or red-colored urine
  • urinating more often
  • pain in your bladder when you urinate

Increased chance of pregnancy

Pioglitazone may cause ovulation (release of an egg from an ovary in women), which can lead to pregnancy. Ovulation may even occur in premenopausal women who don’t have regular periods. Ask your doctor about using effective forms of birth control while you’re taking this medication.

Type 1 diabetes

Don’t use glimepiride/pioglitazone if you have type 1 diabetes or diabetic ketoacidosis. These conditions should be treated with insulin instead.

Drug Features

Glimepiride/pioglitazone is a prescription drug. It is available as an oral tablet.

Glimepiride/pioglitazone is available in its generic form. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand. Talk to your healthcare provider to see if the generic will work for you.

This is a combination drug. It contains two drugs: glimepiride and pioglitazone. It’s important to know about all the drugs in the combination because each drug may affect you in a different way.

This drug may be used as part of a combination therapy. You may need to take it with insulin or other diabetes medications to help control your high blood sugar.

Why It's Used

Glimepiride/pioglitazone is used to lower blood sugar levels in adults with type 2 diabetes. It’s used along with diet and exercise.

How It Works

Glimepiride/pioglitazone is a combination of two antidiabetic medications that work in different ways.

More Details

How It Works

Glimepiride/pioglitazone is a combination of two antidiabetic medications that work in different ways:

  • Glimepiride belongs to a class of drugs called sulfonylureas.
    • Glimepiride works by helping your body release more insulin from your pancreas. Insulin is a chemical that your body makes to help move sugar (glucose) from your bloodstream into your body’s cells. Once the sugar enters your cells, they’re able to use the sugar as fuel for your body. If your body doesn’t make enough insulin or can't use the insulin that it makes properly, the sugar will stay in your bloodstream. This causes high blood sugar levels (hyperglycemia).
  • Pioglitazone belongs to a class of drugs called thiazolidinediones.
    • It improves how you respond to the insulin that your body makes. It also decreases the amount of glucose made by your liver. Pioglitazone doesn’t cause the body to make more insulin, so when it’s used alone it won’t cause low blood sugar (hypoglycemia).
SECTION 2 of 4

glimepiride-pioglitazone Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with glimepiride/pioglitazone include:

  • cold-like symptoms, such as upper respiratory tract infection

  • headache

  • sinus infection

  • diarrhea

  • nausea

  • muscle pain

  • sore throat

  • ovulation. This can increase your chance of getting pregnant.

  • low blood sugar (hypoglycemia). Symptoms may include:

    • hunger
    • dizziness
    • shakiness
    • lightheadedness
    • sweating
    • irritability
    • headache
    • fast heart rate
    • confusion

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • severe low blood sugar (less than 35–40 mg/dL). This can happen if you skip meals, use another medication that lowers blood sugar, or if you have certain medication problems. Symptoms may include:

    • mood changes, such as irritability, impatience, anger, stubbornness, or sadness
    • confusion, including delirium
    • lightheadedness or dizziness
    • sleepiness
    • blurred or impaired vision
    • tingling or numbness in your lips or tongue
    • headaches
    • weakness or fatigue
    • lack of coordination
    • nightmares or crying out in your sleep
    • seizures
    • unconsciousness
  • heart failure. Symptoms may include:

    • swelling or fluid retention, especially in your ankles or legs
    • shortness of breath or trouble breathing, especially when you lie down
    • fast weight gain
    • unusual tiredness
  • liver problems. Symptoms may include:  

    • nausea
    • vomiting
    • stomach pain
    • unusual or unexplained tiredness
    • loss of appetite
    • dark-colored urine
    • yellowing of your skin or the whites of your eyes
  • bladder cancer. Symptoms may include:

    • blood in your urine
    • urinating more often
    • pain in your bladder when you urinate
  • broken bones (fractures). These may be more likely to happen in your hand, upper arm, or foot. Women have a higher risk.

  • diabetic eye disease with swelling in the back of the eye (macular edema). Symptoms may include:

    • changes in your vision
  • hypersensitivity (allergic) reactions. This drug can cause several types of allergic reactions, including:

    • anaphylaxis. This is a severe and possibly life-threatening allergic reaction. Symptoms may include trouble breathing, swelling of your throat or tongue, hives, or difficulty swallowing.
    • angioedema. This involves swelling of your skin, the layers under your skin, and your mucous membranes (inside your mouth).
    • Stevens-Johnsons syndrome. This is a rare and serious disorder of your skin and mucous membranes (mouth and nose). It starts with flu-like symptoms and is followed by a painful red rash and blisters.
  • low blood cell or platelet counts. Symptoms may include:

    • infections
    • bruising and bleeding that doesn’t stop as quickly as normal
  • low sodium levels (hyponatremia) and syndrome of inappropriate antidiuretic hormone secretion (SIADH). In SIADH, your body is unable to get rid of excess water by urinating. This leads to lower sodium levels in your blood (hyponatremia), which is dangerous. Symptoms may include:

    • nausea and vomiting
    • headache
    • confusion
    • loss of energy and fatigue
    • restlessness and irritability
    • muscle weakness, spasms or cramps
    • seizures
    • coma
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Glimepiride/pioglitazone doesn’t cause drowsiness.

Glimepiride/pioglitazone can decrease your blood sugar levels.

If you have a low blood sugar reaction, you need to treat it.

  • For mild hypoglycemia (55–70 mg/dL), treatment is 15–20 grams of glucose (a type of sugar). You need to eat or drink one of the following:
    • 3–4 glucose tablets
    • a tube of glucose gel
    • ½ cup of juice or regular, non-diet soda
    • 1 cup of nonfat or 1% cow’s milk
    • 1 tablespoon of sugar, honey, or corn syrup
    • 8–10 pieces of hard candy, such as lifesavers
  • Test your blood sugar 15 minutes after you treat the low blood sugar reaction. If your blood sugar is still low, then repeat the above treatment.
  • Once your blood sugar is back in the normal range, eat a small snack if your next planned meal or snack is more than 1 hour later. 

If you don’t treat low blood sugar, you can have a seizure, pass out, and possibly develop brain damage. Low blood sugar can even be fatal. If you pass out because of a low sugar reaction or cannot swallow, someone will have to give you an injection of glucagon to treat the reaction. You may need to go to the emergency room.

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

glimepiride-pioglitazone May Interact with Other Medications

Oral tablet

Glimepiride/pioglitazone can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Alcohol Interaction

Drinking alcohol while taking glimepiride may affect your blood sugar levels unpredictably. They can either increase or decrease. Limit alcohol while taking this medication.

Medications That Might Interact with This Drug

Quinolone antibiotics
  • ciprofloxacin (Cipro)
  • gatifloxacin (Zymar)
  • levofloxacin (Levaquin)

These drugs can cause low blood sugar (hypoglycemia) when taken with glimepiride/pioglitazone.

Heart and blood pressure drugs
  • angiotensin-converting enzyme inhibitors (ACE inhibitors), such as:
    • benazepril (Lotensin)
    • captopril (Capoten)
    • enalapril (Vasotec)
    • enalaprilat
    • fosinopril (Monopril)
    • lisinopril (Prinivil)
    • moexipril (Univasc)
    • perindopril (Aceon)
    • quinapril (Accupril)
    • ramipril (Altace)
    • trandolapril (Mavik)

These drugs can cause low blood sugar (hypoglycemia) when taken with glimepiride/pioglitazone.

  • beta blockers, such as:
    • acebutolol (Sectral)
    • atenolol (Tenormin)
    • bisoprolol (Zebeta)
    • carteolol (Cartrol)
    • esmolol (Brevibloc)
    • metoprolol (Lopressor, Toprol XL)
    • nadolol (Corgard)
    • nebivolol (Bystolic)
    • propranolol (Inderal LA) 

These drugs may increase or decrease the blood sugar-lowering effect of glimepiride/pioglitazone. They may also mask the symptoms of low blood sugar (hypoglycemia).

Antifungals
  • fluconazole (Diflucan)
  • ketoconazole (Nizoral)
  • oral miconazole

These drugs can cause low blood sugar (hypoglycemia) when taken with glimepiride/pioglitazone.

Chloramphenicol

This drug can cause low blood sugar (hypoglycemia) when taken with glimepiride/pioglitazone.

Clofibrate

This drug can cause low blood sugar (hypoglycemia) when taken with glimepiride/pioglitazone.

Gemfibrozil

This drug can cause low blood sugar (hypoglycemia) when taken with glimepiride/pioglitazone.

Depression drugs
  • monoamine oxidase inhibitors (MAOIs), such as:
    • isocarboxazid (Marplan)
    • phenelzine (Nardil)
    • tranylcypromine (Pamate)

These drugs can cause low blood sugar (hypoglycemia) when taken with glimepiride/pioglitazone.

Salicylates
  • aspirin
  • magnesium salicylate (Doan’s)
  • salsalate (Disalcid)

These drugs can cause low blood sugar (hypoglycemia) when taken with glimepiride/pioglitazone.

Sulfonamides
  • sulfacetamide
  • sulfadiazine
  • sulfamethoxazole/trimethoprim (Bactrim®)
  • sulfasalazine (Azulfidine®)
  • sulfisoxazole

These drugs can cause low blood sugar (hypoglycemia) when taken with glimepiride/pioglitazone.

Colesevelam (Welchol)

Colesevelam may stick with glimepiride in your gastrointestinal system. This can decrease the amount of glimepiride absorbed by your body. This means that it won’t work as well to lower your blood sugar. Take glimepiride/pioglitazone at least 4 hours before taking colesevelam.

Diazoxide (Proglycem)

This drug can cause high blood sugar (hyperglycemia) when taken with glimepiride/pioglitazone.

Rifamycins
  • rifabutin (Myobutin)
  • rifampin (Rifadin)
  • rifapentine (Priftin)
  • rifaximin (Xifaxan)

These drugs can cause high blood sugar (hyperglycemia) when taken with glimepiride/pioglitazone.

Thiazide diuretics
  • chlorothiazide (Diuril)
  • chlorthalidone
  • hydrochlorothiazide (Hydrodiuril)
  • indapamide (Lozol)
  • metolazone (Zaroxolyn)

These drugs can cause high blood sugar (hyperglycemia) when taken with glimepiride/pioglitazone.

Clonidine

This drug may increase or decrease the blood sugar-lowering effect of glimepiride/pioglitazone. It may also mask the symptoms of low blood sugar (hypoglycemia).

Reserpine

This drug may increase or decrease the blood sugar-lowering effect of glimepiride/pioglitazone. It may also mask the symptoms of low blood sugar (hypoglycemia).

Guanethedine

This drug may mask the symptoms of low blood sugar (hypoglycemia) when taken with glimepiride/pioglitazone.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with bladder cancer

Don’t take this drug if you have bladder cancer. This drug may make your bladder cancer worse. If you have a history of bladder cancer, your doctor will decide if the benefits of glimepiride/pioglitazone outweigh the risks of your bladder cancer coming back.

People with diabetic eye disease (macular edema)

Don’t take glimepiride/pioglitazone if you have macular edema. This drug may make your eye problems worse.

People with G6PD deficiency

Glimepiride can cause hemolytic anemia (fast breakdown of red blood cells) in people with the genetic problem Glucose 6-Phosphate Dehydrogenase (G6PD) deficiency. Your doctor may switch you to another diabetes drug if you have this condition.

People with heart failure

Pioglitazone can cause your body to retain extra fluid. Extra body fluid can make some heart problems worse or lead to heart failure. Don’t take glimepiride/pioglitazone if you have severe heart failure.

People with kidney disease

Glimepiride is removed from your body by your kidneys. If your kidneys aren’t working as well, glimepiride may build up in your body and cause low blood sugar (hypoglycemia). Your doctor may start you at a lower dose and slowly increase your dose if needed.

People with liver disease

If you have liver disease, you may be more sensitive to glimepiride. Plus, pioglitazone has been shown to cause liver failure in some people. Use glimepiride/pioglitazone with caution if you have liver disease. Your doctor may start you at a lower dose and slowly increase your dose if needed.

People with type 1 diabetes

Don’t use glimepiride/pioglitazone if you have type 1 diabetes or diabetic ketoacidosis. These conditions should be treated with insulin instead.

Pregnant women

Glimepiride/pioglitazone is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Tell your doctor if you’re pregnant or plan to become pregnant. Glimepiride/pioglitazone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Women who are nursing

It isn’t known if glimepiride/pioglitazone passes through breast milk. If it does, it may cause serious effects in a breastfeeding child.

You and your doctor will need to decide if you’ll breastfeed or take this medication.

For Seniors

As you age, your organs, such as your kidneys and liver, may not work as well as they did when you were younger. You may be more sensitive to the effects of this medication. It may also be more difficult for you to spot the symptoms of low blood sugar (hypoglycemia). Your doctor may watch you closely and give you a lower dose of this drug to avoid side effects, such as low blood sugar.

For Children

It isn’t known if glimepiride/pioglitazone is safe and effective in children younger than 18 years old. This drug isn’t recommended for use in children.

Special Kid Safety:

  • Keep glimepiride/pioglitazone and all medicines out of the reach of children.
  • Lancets (a needle used to prick your finger to get drops of blood) are used to test your blood sugar while you’re taking glimepiride. Don’t throw out individual lancets into trashcans or recycling bins, and never flush them down the toilet. Ask your pharmacist for a safe container for disposing used lancets. Your community may have a program for throwing away lancets. If disposing the container in the trash, label it “do not recycle”. 

When to call the doctor

  • Call your doctor if you get sick or injured, have an infection, or plan to have surgery. Glimepiride/pioglitazone may not control your blood sugar levels during these times. Your doctor may need to stop the drug for a short time and give you insulin to control your blood sugar.
  • If your dose isn’t working well enough to control your blood sugar, your diabetes won’t be under control. Call your doctor if you have symptoms of high blood sugar (hyperglycemia):
    • urinating more often than usual
    • feeling very thirsty
    • feeling very hungry even though you are eating
    • extreme fatigue
    • blurred vision
    • cuts or bruises that are slow to heal
    • tingling, pain, or numbness in your hands or feet

Allergies

This medication contains glimepiride, which is chemically similar to a class of medications called sulfonamides (sulfa drugs). If you’re allergic to sulfa medications, you may be allergic to glimepiride. If you have a sulfa allergy, tell your doctor before taking this medication.

Glimepiride/pioglitazone can cause a severe allergic reaction. Symptoms may include:

  • trouble breathing
  • swelling of your face, lips, throat, or tongue
  • hives

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal.

SECTION 4 of 4

How to Take glimepiride-pioglitazone (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Type 2 diabetes
Form: Oral tablet
Strengths: glimepiride 2 mg/pioglitazone 30 mg and glimepiride 4 mg/pioglitazone 30 mg
Adult Dosage (ages 18-64 years)
  • Standard starting dose: glimepiride/ pioglitazone 2 mg/30 mg or 4 mg/30 mg taken by mouth once per day with breakfast or your first meal of the day. Your doctor will adjust your dose as needed.
  • If your blood sugar isn’t controlled with glimepiride alone: Your starting dose is glimepiride/pioglitazone 2 mg/30 mg or 4 mg/30 mg taken once per day. Your doctor will adjust your dose as needed.
  • If your blood sugar isn’t controlled with pioglitazone alone: Your starting dose is glimepiride/pioglitazone 2 mg/30 mg taken once per day. Your doctor will adjust your dose as needed.
  • If you’re taking sulfonylurea single therapy or combination pioglitazone plus a different sulfonylurea: Start glimepiride/pioglitazone 2 mg/30 mg once per day. Your doctor will adjust your dose gradually as needed.
  • If you’re on glimepiride/pioglitazone combination therapy but given as separate tablets: Start at a dose as close to your current dose as possible.
Child Dosage (ages 0-17 years)

A safe and effective dose for children hasn’t been established.

Senior Dosage (ages 65 years and older)

As you age, your organs, such as your kidneys and liver, may not work as well as they did when you were younger. You may be more sensitive to the effects of this medication. It may also be more difficult for you to spot the symptoms of low blood sugar (hypoglycemia). Your doctor may watch you closely and give you a lower dose of this drug to avoid side effects, such as low blood sugar.

Special Considerations
  • Kidney disease: Glimepiride is removed from your body by your kidneys. If your kidneys aren’t working as well, glimepiride may build up in your body and cause low blood sugar (hypoglycemia). Your doctor may start you at a lower dose and slowly increase your dose if needed.
  • Liver disease: If you have liver disease, you may be more sensitive to glimepiride. Plus, pioglitazone has been shown to cause liver failure in some people. Use glimepiride/pioglitazone with caution if you have liver disease. Your doctor may start you at a lower dose and slowly increase your dose if needed.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Glimepiride/pioglitazone comes with serious risks if you don't take it as prescribed.

If You Don't Take It at All

You may still experience high blood sugar levels. Over time, higher blood sugar levels can harm your eyes, kidneys, nerves, or heart. Severe issues include heart attack, stroke, blindness, kidney failure and dialysis, and possible amputations of your limbs.

If You Take Too Much

If you take too much glimepiride/pioglitazone, you may experience symptoms of severe low blood sugar (hypoglycemia). Symptoms may include:

  • mood changes, such as irritability, impatience, anger, stubbornness, or sadness
  • confusion, including delirium
  • lightheadedness or dizziness
  • sleepiness
  • blurred or impaired vision
  • tingling or numbness in your lips or tongue
  • headaches
  • weakness or fatigue
  • lack of coordination
  • nightmares or crying out in your sleep
  • seizures
  • unconsciousness

If you think that you’ve taken too much of this medication or have any of signs of severe low blood sugar, call your doctor or go to the emergency room right away.

What to Do If You Miss a Dose

If you miss a dose of glimepiride/pioglitazone, take your next dose as prescribed unless your doctor tells you differently.

Don’t try to catch up by taking two doses at once. This could result in toxic side effects.

How to Tell If the Drug Is Working

If glimepiride/pioglitazone is working, your blood sugar readings will be lower. Unless otherwise directed by your physician, target ranges for blood sugar are as follows:

  • Blood sugar before a meal (pre-prandial plasma glucose): between 70–130 mg/dL.
  • Blood sugar 1–2 hours after starting a meal (postprandial plasma glucose): less than 180 mg/dL.

Your symptoms of high blood sugar should also decrease. For instance, you may not feel as hungry or thirsty, and you may urinate less often.

Glimepiride/pioglitazone is a long-term drug treatment.

Important Considerations for Taking Glimepiride/pioglitazone

Store glimepiride/pioglitazone at room temperature from 68–77ºF (20–25°C)

Keep it away from high temperatures.

Keep it in its original container to protect it from light.

Keep the bottle closed tightly and keep tablets dry.

Do not store this medication in moist or damp areas, such as bathrooms.

Travel

When traveling with your medication:

  • Always carry your medication with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt this medication.
  • You may need to show your pharmacy’s label to clearly identify the medication. Keep the original prescription label with you.
  • Don’t leave this medicine in the car, especially when the temperature is hot or freezing.
  • Check for special rules about traveling with medicine and lancets. Lancets need to be used to check your blood sugar levels.

Self-Management

You’ll need to learn how to do the following:

  • use a blood glucose monitor to test your blood sugar regularly at home
  • recognize the signs and symptoms of high and low blood sugar
  • be able to treat low and high blood sugar reactions 

While taking glimepiride/pioglitazone, you’ll need to regularly test your blood sugar levels. You may need to purchase the following:

  • sterile alcohol wipes
  • lancing device and lancets (to prick your finger to test your blood sugar)
  • needle container for safe disposal of lancets
  • blood sugar test strips
  • blood glucose monitor

Clinical Monitoring

Before starting and while taking glimepiride/pioglitazone, your doctor may check your:

  • blood sugar levels
  • glycosylated hemoglobin (A1C) levels. This test measures your blood sugar control over the last 2–3 months.
  • liver function. If your liver tests are abnormal, or if you have symptoms of liver damage, your doctor may decide to stop this medication.

Your Diet

Managing type 2 diabetes well should include eating a healthy diet.

When you eat foods that contain a lot of calories and fat, your body responds by raising your blood sugar levels (hyperglycemia). Over time, this can damage many of your organs, such as your eyes, kidneys, heart, and brain. Making healthy food choices and tracking your eating habits can help you manage your blood sugar levels.

You should talk to your doctor about how to change your eating habits. In general, a healthy diet is made up of fruits, vegetables, whole grains, fiber-rich foods, fish, and good fats, such as avocados, almonds, and olives. 

Sun Sensitivity

Glimepiride/pioglitazone may cause increased sensitivity to the sun (photosensitivity). Use sunscreen, wear protective clothing, and limit how often you’re in the sun while taking this medication.

Hidden Costs

In addition to this medicine, you may need to purchase the following:

  • sterile alcohol wipes
  • lancing device and lancets (to prick your finger to test your blood sugar)
  • needle container for safe disposal of lancets
  • blood sugar test strips
  • blood glucose monitor

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for glimepiride/pioglitazone.

Are There Any Alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

What does the pill look like?

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on July 14, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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