Generic Name: fosamprenavir, Oral tablet

Lexiva

All Brands

  • Lexiva
SECTION 1 of 4

Highlights for fosamprenavir

Oral tablet
1

Lexiva is an oral medication used to treat human immunodeficiency virus (HIV) infection in adults and children.

2

A dose of Lexiva is usually taken once or twice per day. Your doctor will decide your dose and schedule based on your infection status and other health factors.

3

Common side effects include diarrhea, vomiting, and headache.

4

Lexiva can interact with many drugs. To avoid problems, make sure you tell your doctor or pharmacist about all drugs and supplements that you take.

5

You could be allergic to this drug if you have a sulfa allergy. Talk to your doctor and pharmacist before taking Lexiva.

IMPORTANT INFORMATION
  • blood droplet

    May cause increased blood sugar levels See Details

  • heart

    May cause increased triglycerides and cholesterol levels See Details

  • body fat buildup

    May cause a buildup of body fat in new places, such as the back of your neck.

  • blood droplet

    Warning for hemophilia See Details

  • dangerous rash

    May cause dangerous rash See Details

May cause increased blood sugar levels

This medication may lead to the development of diabetes or worsen blood sugar control in people who already have diabetes. If you have diabetes, tell your doctor if your blood sugar levels are higher than normal. Symptoms of increased blood sugar include:

  • tiredness
  • thirst
  • headache
  • frequent urination

May cause increased triglycerides and cholesterol levels

Your cholesterol treatment may need to be changed while you take this drug.

Warning for hemophilia

You may be more likely to develop bruising or bleeding while taking this drug if you have hemophilia. You may need additional treatment for hemophilia.

May cause dangerous rash

It’s possible for this medication to cause a life-threatening skin reaction called Steven Johnson syndrome. Call your doctor right away if you experience:

  • severe rash
  • rash with:
    • fever
    • blistering
    • mouth sores
    • eye redness and swelling
    • muscle or joint aches

Drug Features

Lexiva is a prescription drug. It is available in these forms: oral tablet, oral suspension.

Lexiva is used as part of a combination therapy. That means you will need to take it in combination with other drugs.

Why It's Used

Lexiva is used in combination with other drugs to help control human immune deficiency virus (HIV) infection. It doesn’t cure infection, but it may help to prevent HIV from multiplying.

Lexiva is approved to treat HIV infection in adults and children aged 4 weeks and older.  

How It Works

Lexiva belongs to a class of drugs called protease inhibitors. A class of drugs refers to medications that work similarly and are often used to treat similar conditions.

In order to insert its genetic material into your cells and make copies of itself, HIV needs to use a protein called protease. Protease inhibitors block this enzyme, which limits the virus’s ability to spread in your body.

SECTION 2 of 4

fosamprenavir Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with Lexiva include:

  • diarrhea

  • rash

  • nausea

  • vomiting

  • headache

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • immune reconstitution syndrome. In this condition, your recovering immune system causes infections that you’ve had in the past to return. Examples of past infections include fungal infections, pneumonia, or tuberculosis. Your doctor may need to treat the infections if this happens. Watch for returning symptoms of your past infections.

  • severe skin reaction. A rare, life-threatening skin reaction called Stevens-Johnson syndrome can occur. Call your doctor right away If you have a severe skin reaction with any of these symptoms:

    • fever
    • blistering
    • mouth sores
    • redness or swelling of your eyes
    • muscle or joint aches
  • liver toxicity. You’re at greater risk if you have hepatitis B or hepatitis C virus infections. See your doctor right away if you experience these symptoms of liver toxicity:

    • stomach pain
    • nausea
    • tiredness
    • yellow skin or whites of your eyes
    • stomach swelling
  • kidney stone. Symptoms include:

    • sudden pain in the front or side of your abdomen
    • difficulty urinating
    • nausea
    • fever
    • blood in your urine
  • hemolytic anemia. This is a reaction in which your body attacks your red blood cells. One patient developed hemolytic anemia while taking this drug. Symptoms can include:

    • darkened urine
    • fatigue
    • pale skin
    • racing heart
    • shortness of breath
    • yellowing skin
  • increased blood sugar levels. This medication may lead to the development of diabetes or worsen blood sugar control in people with existing diabetes. Symptoms include:

    • tiredness
    • thirst
    • headache
    • frequent urination
  • increased triglycerides and cholesterol levels.

  • a buildup of body fat in new places, such as the back of your neck.

Pharmacist's Advice
Healthline Pharmacist Editorial Team

Lexiva does not cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

fosamprenavir May Interact with Other Medications

Oral tablet

Lexiva can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications That Might Interact with This Drug

Acid-reducing drugs
  • cimetidine (Tagamet)
  • esomeprazole (Nexium)
  • famotidine (Pepcid)
  • lansoprazole (Prevacid)
  • nizatidine (Axid)
  • omeprazole (Prilosec)
  • pantoprazole (Protonix)
  • ranitidine (Zantac)
  • rabeprazole (AcipHex)

Antibiotic
  • rifabutin (Mycobutin)
  • rifampin (Rifadin)

Antidepressants
  • amitriptyline (Elavil)
  • imipramine (Tofranil)
  • paroxetine (Paxil)
  • trazodone (Desyrel)

Antifungal drugs
  • ketoconazole 
  • itraconazole (Sporanox)

Antiretroviral (HIV) drugs
  • atazanavir (Reyataz)
  • efavirenz (Sustiva)
  • indinavir (Crixivan)
  • lopinavir/ritonavir (Kaletra)
  • maraviroc (Selzentry)
  • nevirapine (Viramune)
  • nelfinavir (Viracept)
  • raltegravir (Isentress)
  • saquinavir (Invirase)

Asthma and allergy drugs (inhaled)
  • fluticasone (Flonase)
  • salmeterol (Serevent)

Blood thinner (anticoagulant)
  • warfarin (Coumadin)

Cholesterol-lowering drug
  • atorvastatin (Lipitor)
  • lovastatin (Altoprev, Mevacor)
  • rosuvastatin (Crestor)
  • simvastatin (Zocor)

Epilepsy drugs
  • carbamazepine (Tegretol)
  • phenobarbital     
  • phenytoin (Dilantin)

Erectile dysfunction drugs
  • sildenafil (Viagra)
  • tadalafil (Cialis)
  • vardenafil (Levitra)

Gout drug
  • colchicine (Colcrys)

Heart drugs, calcium channel blockers, and drugs for heart arrhythmia, such as:
  • amiodarone (Cordarone)
  • amlodipine (Norvasc)
  • diltiazem (Cardizem)
  • felodipine (Plendil)
  • flecainide (Tambocor)
  • isradipine
  • lidocaine (when given intravenously)
  • nicardipine (Cardene)
  • nifedipine (Procardia, Adalat)
  • nimodipine (Nymalize)
  • propafenone (Rythmol)
  • quinidine
  • verapamil (Calan, Verelan, Isoptin)

Hepatitis C drugs
  • boceprevir (Victrelis)
  • telaprevir (Incivek)

Migraine drugs with ergotamine
  • dihydroergotamine (D.H.E. 45, Migranal),
  • ergotamine (Cafergot, Ergomar)
  • methylergonovine

Oral contraceptive/hormone
  • Ethinyl estradiol/norethindrone

Taking Lexiva can decrease the effectiveness of oral contraceptives.

Pain drug
  • methadone

Post-transplant drugs (immunosuppressants)
  • cyclosporine (Gengraf, Neoral)
  • tacrolimus (Prograf)
  • sirolimus (rapamycin)

Pulmonary arterial hypertension (PAH) drug
  • bosentan (Tracleer)

Sleeping medications
  • alprazolam (Xanax)
  • clorazepate
  • diazepam (Valium)
  • flurazepam (Dalmane)

Steroid
  • dexamethasone (Decadron)

Tourette’s syndrome drug
  • pimozide (Orap)

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with diabetes

This drug can increase your blood sugar levels. Monitor your blood sugar levels carefully while taking it, especially the first few weeks.

People with hemophilia

You could be more likely to develop bruising or bleeding while taking this medication if you have hemophilia. You may need additional treatment.

People with liver disease

If you have liver disease, especially hepatitis B or hepatitis C virus infection, this medication could cause your liver disease to get worse. Your doctor may monitor you more closely.

Pregnant women

Lexiva is a category C pregnancy drug. That means two things

  1. Research in animals has shown adverse effects to the fetuses of mothers who take the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus. Lexiva should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus.

If you’re pregnant or plan to become pregnant, talk to your doctor before taking Lexiva.

Women who are nursing

According to the U.S. Department of Health and Human Services, you should not breastfeed your infant if you have human immunodeficiency virus (HIV). There is a risk of passing HIV to the baby. 

Additionally, it is not known if Lexiva passes into breast milk. If it does, it may cause side effects in a child who is breastfed.

For Children

Children aged 4 weeks to 18 years are sometimes given Lexiva. Children may use the oral suspension form, which comes premixed and ready to use. Shake it well before measuring the dose. Your child’s doctor will decide which dose is right for your child. Give your child this medication with food.

Children may be curious how the oral suspension tastes. Make sure to keep it out of their reach.

When to call the doctor

Call your doctor if you experience:

  • fever
  • weakness
  • chills
  • night sweats
  • sore throat
  • joint pain

These symptoms may be a sign the drug isn’t working, and you may need a different treatment.

Allergies

A drug hypersensitivity reaction is possible when you take this drug. The reaction often starts with a rash in the first several weeks of treatment. 

In rare cases, this rash can be life-threatening. Call your doctor right away if you have a severe skin rash or a skin rash along with any of these symptoms:

  • fever
  • blistering
  • sores in your mouth
  • redness or swelling of your eyes
  • muscle or joint aches
SECTION 4 of 4

How to Take fosamprenavir (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Human immunodeficiency virus (HIV) infection

Brand: Lexiva

Form: Oral Tablet, Oral Suspension
Strengths: 700 mg tablet and 50 mg per mL suspension
Adult Dosage (ages 18-64 years)

700 mg to 1,400 mg taken once or twice per day. Your dose depends on whether you take Lexiva with the drug ritonavir. The dose for adults who are experienced with protease inhibitors is usually 700 mg, taken twice each day, plus 100 mg of ritonavir, taken twice per day. Your doctor will decide the correct dose and schedule for you. If you take the oral suspension, take it on an empty stomach.

Child Dosage (ages 4 weeks to 17 years)

Children are sometimes given Lexiva. Your child’s doctor will decide which dose is right for your child. Infants and young children can take the oral solution, and older children can take the tablet. Give your child the tablet or oral solution with food.

Child Dosage (ages 0-3 weeks)

Dosage for infants younger than 4 weeks has not been established.

Senior Dosage (ages 65 years and older)

There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of the drug to be higher than normal. If you’re a senior, you may need a lower dose or you may need a different schedule.

Special considerations

Liver Disease: Lexiva is processed in your liver. If you have liver disease, your liver could take longer to process the drug. This may cause drug levels to be too high, which may lead to increased side effects. Your doctor may change your dose of Lexiva. Tell your doctor about your liver disease before taking this drug.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Keeping human immunodeficiency virus (HIV) infection under control requires long-term treatment and long-term effort.

If You Don’t Take it At All

If you don’t take it at all, your HIV infection will eventually reduce your immunity to a point that your body won’t be able to defend itself against many types of infections, even infections that are commonly cured in people who don’t have HIV infection.

If You Stop or Miss Doses

If you stop taking this medication, miss doses, or don’t take it on schedule, the amount of medication in your body fluctuates. This can allow the HIV in your body to become resistant to the drug, which means the drug stops working.

If You Don’t Take it on Schedule

Taking your drug at the same time every day keeps a constant amount of the drug in your body. This helps make the drug as effective as possible at keeping the virus under control.

What to Do if You Miss a Dose

If you miss a dose, take it as soon as possible. Then take your next dose at the regular time and continue your normal dosing schedule.  Do not ever double up on doses. This can cause your side effects to be worse.

How Can I Tell if the Drug Is Working?

To see how well your treatment is working, your doctor will check your:

  • symptoms
  • virus count. The virus count measures the number of copies of HIV in your body. A decreased virus count is a sign that your treatment is working.
  • CD4 cell count. A CD4 cell count measures the amount of CD4 cells in your body. CD4 cells are white blood cells that fight infection. An increased CD4 count is a sign that your HIV treatment is working.

Lexiva is a long-term drug treatment.

Tablets can be taken with or without food

Adults taking the oral suspension should take the drug without food. Children should take the oral suspension with food.

If you take this drug once per day, take it at the same time each day

If you take it twice per day, space your doses evenly and take them at the same two times each day. Keeping a consistent schedule for the time you take these drugs helps to keep a consistent amount of the drug in your body. This helps make the drug as effective as possible.

Do not cut or crush the oral tablet

If you have problems swallowing tablets, ask your doctor or pharmacist about taking the oral suspension (liquid).

Store the tablets at room temperature 77°F (25°C)

You can store them briefly in temperatures as low as 59°F (15°C) and as high as 86°F (30°C). Keep the container tightly closed.

You can store the oral suspension in a refrigerator or at room temperature: 41–86°F (5–30°C). Do not freeze the oral suspension.

Self-Management

This medication may increase your blood sugar levels. If you have diabetes, you may need to check your blood sugar more often, especially when you first start taking it.

Clinical Monitoring

To see how well your treatment is working, your doctor will check your:

  • virus count also known as a viral load. The virus count measures the number of copies of human immunodeficiency virus (HIV) in your body. A decreased virus count is a sign that your treatment is working.
  • CD4 cell count. A CD4 cell count measures the amount of CD4 cells in your body. CD4 cells are white blood cells that fight infection. An increased CD4 count is a sign that your treatment is working.

If you have diabetes, you may have additional blood tests to see if the drug is increasing your blood sugar levels.

If you have liver disease, you may need more frequent blood tests to monitor your liver function.

Not every pharmacy stocks this drug, so call ahead

If you only need a few tablets, you should call and ask if your pharmacy dispenses only a small number of tablets. Some pharmacies can't dispense only part of a bottle.

This drug is often available from specialty pharmacies through your insurance plan. These pharmacies operate like mail order pharmacies and ship the drug to you.

In larger cities, there will often be human immunodeficiency virus (HIV) pharmacies where you can have your prescriptions filled. Ask your doctor if there's an HIV pharmacy in your area.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for Lexiva. Your doctor may need to do paperwork for you, which could take a week or two.

Are There Any Alternatives?

There are other drugs and combinations that can treat human immunodeficiency virus (HIV) infection. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.


Show Sources

Content developed in collaboration with Susan J. Bliss, RPh, MBA

Medically reviewed by Philip Gregory, PharmD, MS, FACN on April 23, 2015

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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