Generic Name: esomeprazole-naproxen, Oral tablet

Vimovo

All Brands

  • Vimovo
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Highlights for esomeprazole-naproxen

Oral tablet
1

Naproxen/esomeprazole magnesium is an oral medication used to treat the symptoms of ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis in people who also have a high risk of stomach ulcers.

2

This medication can cause serious heart-related side effects in some people, especially if you have heart disease or risk factors for heart disease.

3

Common side effects include indigestion, diarrhea, nausea, upset stomach, stomach pain, peptic ulcers, and stomach bleeding.

4

You should take this medication at least 30 minutes before meals.

IMPORTANT INFORMATION

FDA Warning

Naproxen/esomeprazole magnesium has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

Heart risks. Use this medication with caution if you have heart disease or risk factors for heart disease, such as high blood pressure. Naproxen/esomeprazole magnesium can increase your risk of blood clots, heart attack, and stroke, which may lead to death.

Don’t take this medication if you’re having surgery to improve blood flow to your heart, known as coronary artery bypass graft surgery. Your risk of heart attack or stroke may increase if you take naproxen to treat pain before or after your surgery.

Stomach problems. Naproxen can increase your risk of stomach bleeding and stomach ulcers. It can also create small holes in the lining of your stomach or intestines, which can lead to death. These events may occur at any time and may not have symptoms. Older adults are at higher risk for these problems.

Severe allergic reaction

This medication can cause severe allergic reactions. Symptoms may include:

  • hives
  • trouble breathing
  • swelling of the throat or tongue
  • rash
  • chest pain

Don’t take this medication if you’ve experienced asthma or allergic reactions after taking aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs).

Serious skin conditions

Naproxen can cause serious skin problems. These include Steven-Johnson syndrome and toxic epidermal necrolysis. These reactions can lead to death. Stop taking this medication and tell your doctor right away if you experience:

  • rash
  • blisters
  • fever
  • other skin reactions

Bruising or bleeding easily

This medication may cause you to bruise or bleed more easily. This includes bleeding from your gums.

Drug Features

Naproxen/esomeprazole magnesium is a prescription drug. It’s available as an oral delayed-release tablet.

Naproxen/esomeprazole magnesium is a combination of two or more drugs in a single form. It’s important to know about all the drugs in the combination because they each may have unique traits.

Why It's Used

Naproxen/esomeprazole magnesium treats different types of arthritis. It also helps to prevent stomach ulcers in people who are at risk for getting ulcers with nonsteroidal anti-inflammatory drugs (NSAIDs).

More Details

How It Works

This medication is a combination of two drugs. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Esomeprazole is a proton-pump inhibitor (PPI) that helps to protect against ulcers.

More Details

Why It's Used

Naproxen/esomeprazole magnesium treats different types of arthritis. It also helps to prevent stomach ulcers in people who are at risk for getting ulcers with nonsteroidal anti-inflammatory drugs (NSAIDs).

It’s approved to treat the symptoms of:

  • rheumatoid arthritis
  • osteoarthritis
  • ankylosing spondylitis

How It Works

This medication is a combination of two drugs. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Esomeprazole is a proton-pump inhibitor (PPI) that helps to protect against ulcers.

Naproxen treats symptoms of different types of pain and arthritis. It can cause stomach ulcers, so this medication also contains esomeprazole, which helps to prevent ulcers.

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esomeprazole-naproxen Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with this medication include:

  • indigestion pain in your upper stomach

  • heartburn

  • stomach pain

  • diarrhea

  • nausea

  • damage and inflammation to the protective layer of your stomach

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

  • allergic reactions. Symptoms may include:

    • skin rash
    • itching or hives
    • swelling of your face, lips, or tongue
  • high blood pressure

  • heart problems, such as heart failure. Symptoms may include:

    • swelling of your body, hands, or feet
    • sudden weight gain
    • trouble breathing
  • stomach bleeding. Symptoms may include:

    • black, sticky stools
    • vomiting or coughing up blood or dark particles (may look like coffee grounds)
  • skin reactions, including:

    • reddening, blistering, or peeling skin
    • blistering or bleeding lips, eyelids, mouth, nose, or genitals
  • severe inflammation of your stomach lining. Symptoms may include:

    • stomach pain
    • nausea
    • vomiting
    • weight loss
  • low magnesium levels. Symptoms may include:

    • seizures
    • dizziness
    • rapid heart beat
    • jitteriness
    • jerking movements or shaking (tremors)
    • muscle weakness
    • spasms of the hands, feet, or throat
    • cramps or muscle aches
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Naproxen/esomeprazole magnesium does not cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
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esomeprazole-naproxen May Interact with Other Medications

Oral tablet

Naproxen/esomeprazole magnesium can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Alcohol Interaction

Drinking alcohol while taking this drug increases your risk of stomach bleeding and ulcer.

Medications That Might Interact with This Drug

Human immunodeficiency virus (HIV) drugs
  • atazanavir (Reyataz). If combined with naproxen/esomeprazole magnesium, your body may not absorb this drug, and it might not work as well.  
  • nelfinavir (Viracept). Naproxen/esomeprazole magnesium may decrease the amount of nelfinavir in your body, and nelfinavir won’t work as well.
  • saquinavir/ritonavir. Levels of these drugs can increase in your body when you take them with naproxen/esomeprazole. This can cause toxic effects.

Herb
  • St. John’s wort

The herb may cause naproxen/esomeprazole magnesium not to work as well.

Anticoagulant
  • warfarin

This drug may increase your risk for bleeding.

Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • aspirin
  • diclofenac
  • ibuprofen
  • etodolac
  • ketoprofen
  • meloxicam
  • flurbiprofen

This drug may increase your risk for stomach bleeding or ulcers.

Antifungal drug
  • ketoconazole. Your body may not absorb this drug, and it might not work as well.

Post-transplant drug
  • cyclosporine. This drug may cause damage to your kidneys.
  • mycophenolate mofetil. Your body may not absorb this drug, and it might not work as well.

Blood pressure medications

These include:

  • angiotensin-converting enzyme (ACE) inhibitors
  • angiotensin II receptor antagonists
  • beta blockers
  • diuretics

Naproxen/esomeprazole magnesium may reduce the blood pressure-lowering effects of these drugs.

Bipolar drug
  • lithium

Naproxen/esomeprazole magnesium can cause a toxic increase in lithium. This can cause side effects, such as tremors, excessive thirst, and confusion.

Disease-modifying antirheumatic drug (DMARD)
  • methotrexate

Naproxen/esomeprazole magnesium can cause amounts of methotrexate in your blood to increase to toxic levels and cause side effects.

Cancer drug
  • erlotinib. Your body may not absorb this drug, and it might not work as well.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with heart disease

If you have heart disease or are at risk of heart disease, don’t take this medication. It may increase your risk of blood clots, heart attack, or stroke.

People with stomach problems

If you have a history of stomach bleeding or ulcers, you’re at greater risk of having another ulcer or bleeding event. Seniors are at increased risk.

People with liver problems

If you have liver problems, this medication may cause more damage to your liver. Your doctor may decide to decrease your dose.

People with kidney disease

If you have kidney disease, this medication may cause more damage to your kidneys if you take it for a long time.

People with asthma

This medication may cause asthma symptoms or make breathing problems worse. This is more likely to happen if you have ever had asthma-like symptoms after using aspirin or nonsteroidal anti-inflammatory drugs.

Pregnant women

This medication falls into one of two pregnancy categories, depending on how far along you are in your pregnancy.

In the third trimester, this medication is a category D drug. That means two things:

  1. Studies show a risk of adverse effects to the fetus when the mother takes the drug.
  2. This drug should only be used during pregnancy in serious cases when it is needed to treat a life-threatening condition in the mother.

In the first and third trimester, this medication is a category C pregnancy drug. This means:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Speak with your doctor if you’re pregnant or plan to become pregnant.

Women who are nursing

Naproxen/esomeprazole magnesium can pass through breast milk and may harm your baby. You and your doctor should decide whether you should take this medication or breastfeed.

Allergies

Naproxen/esomeprazole can cause a severe allergic reaction. Symptoms may include trouble breathing, swelling of your throat or tongue, or hives.

Don’t take this drug again if you’ve ever had an allergic reaction to:

  • naproxen
  • esomeprazole magnesium
  • benzimidazoles
  • aspirin
  • other nonsteroidal anti-inflammatory drugs (NSAIDs)

Taking it a second time after an allergic reaction to any of these medications could be fatal.

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How to Take esomeprazole-naproxen (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Ankylosing spondylitis

Brand: Vimovo

Form: Oral delayed-release Tablet
Strengths: 375 mg naproxen/20 mg esomeprazole, 500 mg naproxen/20 mg esomeprazole
Adult Dosage (ages 18 years and older)

1 tablet taken twice per day 30 minutes before a meal.

Child Dosage (ages 0-17 years)

Dosage for people younger than 18 years hasn’t been established.

Osteoarthritis

Brand: Vimovo

Form: Oral delayed-release Tablet
Strengths: 375 mg naproxen/20 mg esomeprazole, 500 mg naproxen/20 mg esomeprazole
Adult Dosage (ages 18 years and older)

1 tablet taken twice per day 30 minutes before a meal.

Child Dosage (ages 0-17 years)

Dosage for people younger than 18 years hasn’t been established.

Rheumatoid arthritis

Brand: Vimovo

Form: Oral delayed-release Tablet
Strengths: 375 mg naproxen/20 mg esomeprazole, 500 mg naproxen/20 mg esomeprazole
Adult Dosage (ages 18 years and older)

1 tablet taken twice per day 30 minutes before a meal.

Child Dosage (ages 0-17 years)

Dosage for people younger than 18 years hasn’t been established.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

This medication comes with risks if you don’t take it as prescribed by your doctor.

If You Don’t Take It at All

If you don’t take this drug, the symptoms of your condition may not go away.

If You Stop or Miss Doses

If you stop taking this medication, miss doses, or don’t take it on schedule, you may experience more pain caused by your condition.

If You Take Too Much

Taking too much increases your risk of side effects.

What to Do If You Miss a Dose

If you miss a dose, take it as soon as you remember. However, if it’s just a few hours until your next dose, wait and take a single dose at the usual time.

Never try to catch up by taking two doses at once. This could result in toxic side effects.

How to Tell If the Drug Is Working

You may be able to tell this drug is working if you experience a decrease in pain.

Naproxen/esomeprazole magnesium is a short-term treatment.

Important Considerations for Taking Naproxen/esomeprazole magnesium

Take 30 minutes before eating

Take this medication 30 minutes before a meal with a full glass of water. Make sure to swallow the tablet whole.

Store in temperatures from 59–86°F (15–30°C)

Note: Keep your medications away from areas where they could get wet, such as bathrooms. Store them away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry it with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt this medication.
  • You may need to show your pharmacy’s preprinted label to identify the medication. Keep the original prescription-labeled bottle with you when traveling.

Clinical Monitoring

Your doctor may do tests to check your:

  • liver function
  • kidney function
  • blood or signs of stomach bleeding
  • magnesium levels to make sure this medication isn’t lowering magnesium in your body

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for naproxen/esomeprazole magnesium.

Are There Any Alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

What does the pill look like?

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on May 6, 2015

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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