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Generic Name:

eribulin, Injectable solution

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  • Halaven
SECTION 1 of 5

Highlights for eribulin

Injectable solution
1

Eribulin is an injected drug used to treat advanced breast cancer that’s metastatic (has spread to other parts of your body). It’s only used if you’ve received at least two other types of cancer treatments. It’s also used to treat metastatic liposarcoma (a soft tissue cancer that occurs in fat cells). It’s given when the cancer hasn’t responded to other cancer treatments and can’t be removed with surgery.

2

Eribulin is given through a needle in your vein (injection). Your doctor will decide what dose is right for you. You’ll go to an infusion center or hospital to receive eribulin. You won’t take this drug at home.

3

Common side effects include weakness, tiredness, hair loss, nausea, constipation, and decrease in your red blood cells (anemia).

4

Eribulin can cause a low white blood cell count. This can make you more likely to get serious infections. These can be fatal. Tell your doctor right away if you have symptoms of an infection, including fever, chills, cough, and burning or pain when you urinate.

5

This drug can cause nerve pain. Symptoms include burning, tingling, or numbness in your hands and feet. You should tell your doctor right away if you have these symptoms.

IMPORTANT INFORMATION

Low white blood cells risk

Eribulin can lower your white blood cell count (neutropenia). This can increase your risk of serious infections. These can lead to hospitalization or may even be fatal. You doctor will do a blood test to check your blood cells before each dose of eribulin. If you develop neutropenia, your doctor may delay or decrease your next dose of eribulin.

Nerve pain

Eribulin can cause nerve pain (peripheral neuropathy). Tell your doctor right away if you have burning, tingling, or numbness in your hands and feet. These are signs of neuropathy. If you develop neuropathy, your doctor may delay or decrease your next dose of eribulin.

Heart problems

Eribulin can cause serious changes in your heart rate called QT prolongation. This condition can be fatal. Tell your doctor if you have long QT syndrome or heart problems. You may need heart monitoring or blood tests while you’re being treated with eribulin.

What is eribulin?

Eribulin is a prescription drug. It’s available as an intravenous (IV) solution, which is only given by a healthcare provider.

Why it's used

Eribulin is an injected drug used to treat advanced breast cancer that’s metastatic (has spread to other parts of your body). It’s only used if you’ve received at least two other types of cancer treatments. It’s also used to treat metastatic liposarcoma (a soft tissue cancer that occurs in fat cells) that hasn’t responded to other cancer treatments and can’t be removed with surgery.

How it works

Eribulin belongs to a class of drugs called microtubule inhibitors. A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

Eribulin works by blocking structures within cancer cells called microtubules. This stops the cancer cells from dividing and growing.

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SECTION 2 of 5

eribulin Side Effects

Injectable solution

Most Common Side Effects

The most common side effects that occur with eribulin include:

  • weakness or tiredness

  • hair loss

  • nausea

  • constipation

  • decrease in your red blood cells (anemia)

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • Low white blood cell count and infection. Symptoms include:

    • fever (body temperature above 100.5°F)
    • chills
    • cough
    • burning or pain when you urinate
  • Nerve pain (peripheral neuropathy). Symptoms include:

    • numbness, tingling, or burning in your hands and feet
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Eribulin doesn’t cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

eribulin May Interact with Other Medications

Injectable solution

Eribulin can interact with other medications, herbs, or vitamins you might be taking. Your healthcare provider will look out for interactions with your current medications. Always be sure to tell your doctor about all medications, herbs or vitamins you’re taking.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Eribulin warnings
liver disease
People with liver disease

This drug is processed by your liver. If you have liver problems, it may take longer to clear this drug from your body. This can cause more of the drug to build up, which may lead to more side effects. Your doctor may start you on a lower dose of eribulin if you have liver disease or damage.

kidney disease
People with kidney disease

This drug is processed by your kidneys. If you have kidney problems, it may take longer to clear this drug from your body. This can cause more of the drug to build up, which may lead to more side effects. Your doctor may start you on a lower dose of eribulin if you have kidney disease or damage.

pregnant women
Pregnant women

Eribulin is a category D pregnancy drug. That means two things:

  1. Research in humans has shown adverse effects to the fetus when the mother takes the drug.
  2. This drug should only be used during pregnancy in serious cases where it's needed to treat a dangerous condition in the mother.

Tell your doctor if you’re pregnant or plan to become pregnant. Eribulin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

breastfeeding
Women who are breast-feeding

It’s unknown if eribulin passes into breast milk. If it does, it may cause serious effects in a breastfeeding child.

You and your doctor may need to decide if you’ll take eribulin or breastfeed.

for children
For children

The effectiveness and safety of eribulin haven’t been established in people younger than 18 years.

allergies
Allergies

Eribulin can cause a severe allergic reaction. Symptoms may include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal.

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How to Take eribulin (Dosage)

Injectable solution

Your doctor will determine a dose that’s right for you based on your individual needs. Your general health may affect your dose. Tell your doctor about all health conditions you have before your doctor or nurse administers the drug to you.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Eribulin comes with serious risks if you don’t take it as prescribed.

If you don’t take it at all

If you don’t take eribulin, your condition won’t get better. Your cancer may grow or spread to other parts of your body.

What to do if you miss a dose or appointment

If you think that you’ll miss a dose of eribulin, call your doctor right away to reschedule.

If you take too much

If you receive too much eribulin, you can develop low white blood cell count (neutropenia) or an allergic reaction. If you think that you’ve received too much, tell your doctor or nurse right away.

How to tell the drug Is working

You may not be able to tell if eribulin is working. Your doctor will do blood tests, scans, and X-rays to see how you are responding to treatment.

Eribulin may be a short-term or long-term drug treatment.

The length of treatment will depend on your response to the drug.

You’ll receive this drug on a schedule

You’ll receive eribulin on days 1 and 8 of a 21-day cycle.

How long does it take?

Receiving eribulin takes 2–5 minutes. However, you may need to allow for additional time for your appointment. Your doctor may do blood tests before your injection, and may watch you for side effects after it.

Can I drive home after?

You should be able to drive home after your injection.

Travel

Talk to your doctor before travelling. You need to make sure you can receive your injection. It’s important that you stick to your scheduled cycle of chemotherapy.

Clinical monitoring

Your doctor will do tests during your treatment. Your doctor will test your:

  • heart function
  • liver function
  • kidneys function
  • blood cell count
  • electrolytes levels

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for eribulin.

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How Much Does eribulin Cost?

Injectable solution

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Lowest price for eribulin

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Target (CVS) $12,701.70
These prices represent the lowest priced national pharmacies for eribulin on GoodRx. They may be lower than your insurance.

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These prices represent the lowest priced national pharmacies for eribulin on GoodRx. They may be lower than your insurance.

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on February 17, 2016

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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