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Generic Name:

ergoloid-mesylates, Oral tablet

All Brands

  • Hydergine (Discontinued)
A discontinued drug is a drug that has been taken off the market due to safety issues, shortage of raw materials, or low market demand.
SECTION 1 of 5

Highlights for ergoloid-mesylates

Oral tablet
1

Ergoloid mesylates is an oral drug that’s used to treat the symptoms of a decrease in mental capacity (dementia) caused by the aging process or conditions such as Alzheimer's disease.

2

The usual dose is 1 mg taken by mouth three times per day. It may take up to 4 weeks before your symptoms improve.

3

Before you start ergoloid mesylates, tell your doctor if you have a history of psychosis. Also tell your doctor if you have liver disease, low blood pressure (hypotension), or a slow heart rate (bradycardia).

4

Common side effects include nausea, upset stomach, loss of appetite, runny or stuffy nose, lightheadedness, and reddening and feelings of warmth to your cheeks (flushing). 

5

Your doctor will check how you respond to this drug to make sure that it’s working for you.

IMPORTANT INFORMATION

Mental health conditions

You shouldn’t take ergoloid mesylates if you have a history of psychosis. This drug may make your condition worse.

Seniors

The American Geriatrics Society says that seniors shouldn’t use this drug due to lack of effectiveness.

What is ergoloid mesylates?

Ergoloid mesylates is a prescription drug. It’s available as an oral tablet.

Ergoloid mesylates is only available as a generic drug.

Why it's used

Ergoloid mesylates is used to treat the symptoms of a decrease in mental capacity (dementia) caused by the aging process or conditions such as Alzheimer's disease.

More Details

How it works

Ergoloid mesylates belongs to a class of drugs called ergot alkaloids. A class of drugs refers to medications that work similarly.

More Details

Why it's used

Ergoloid mesylates is used to treat the symptoms of a decrease in mental capacity (dementia) caused by the aging process or conditions such as Alzheimer's disease. Symptoms include:

  • memory loss
  • mood changes
  • not being able to care for yourself as well as you used to
  • less motivation
  • trouble interacting with other people

How it works

Ergoloid mesylates belongs to a class of drugs called ergot alkaloids. A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

It isn’t known how ergoloid mesylates exactly works to treat symptoms of dementia. Ergoloid mesylates may increase blood flow to your brain, or change the way that your brain uses chemicals.

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ergoloid-mesylates Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with ergoloid mesylates include:

  • nausea

  • upset stomach

  • loss of appetite

  • runny or stuffy nose

  • lightheadedness

  • reddening and feelings of warmth to your cheeks (flushing)

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

  • sudden drop in blood pressure when you stand up from a sitting or lying position (orthostatic hypotension). Getting up slowly from a sitting or lying position can help prevent this. Symptoms include:

    • feeling lightheaded or dizzy after standing up
    • fainting
    • blurry vision
    • nausea
    • weakness
    • confusion
  • slower than normal heart rate of fewer than 60 beats per minute (bradycardia). Symptoms include:

    • almost fainting or fainting
    • dizziness
    • weakness
    • getting tired more easily when exercising
    • trouble breathing or shortness of breath
    • chest pains
    • memory problems
    • confusion
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Ergoloid mesylates doesn’t cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

ergoloid-mesylates May Interact with Other Medications

Oral tablet

Ergoloid mesylates can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Food interactions

Grapefruit juice: Drinking grapefruit juice can increase the level of ergoloid mesylates in your body. This puts you at risk for more side effects.

Medications that might interact with this drug

Antibiotics

These drugs may increase the level of ergoloid mesylates in your body. This puts you at risk for more side effects.

These drugs include:

  • macrolide antibiotics, such as:
    • clarithromycin (Biaxin)
    • erythromycin (Ery-Tab)
    • telithromycin (Ketek)

Antifungals

These drugs may increase the level of ergoloid mesylates in your body. This puts you at risk for more side effects.

These drugs include:

  • azole antifungals, such as:
    • fluconazole (Diflucan)
    • itraconazole (Sporanox)
    • ketoconazole (Nizoral)
    • posaconazole (Noxafil)
    • voriconazole (Vfend)

Human immunodeficiency virus (HIV) drugs

These drugs may increase the level of ergoloid mesylates in your body. This puts you at risk for more side effects.

These drugs include:

  • protease inhibitors, such as:
    • atazanavir (Reyataz)
    • fosamprenavir (Lexiva)
    • indinavir (Crixivan)
    • lopinavir/ritonavir (Kaletra)
    • nelfinavir (Viracept)
    • ritonavir (Norvrir)
    • saquinavir (Invirase)
    • tipranavir (Aptivus)

Migraines medications

These drugs may increase your risk of blood vessel spasms when taken with ergoloid mesylates. You shouldn’t take these drugs within 24 hours of each other.

These drugs include:

  • almotriptan (Axert)
  • eletriptan (Relpax)
  • frovatriptan (Frova)
  • naratriptan (Amerge)
  • rizatriptan (Maxalt)
  • sumatriptan (Imitrex)
  • zolmitriptan (Zomig)

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Ergoloid mesylates warnings
mental health conditions
People with mental health conditions

You shouldn’t take ergoloid mesylates if you have a history of psychosis. This drug may make your condition worse.

liver disease
People with liver disease

Since this drug is processed by your liver, it may build up in your body if you have liver disease. Higher levels of ergoloid mesylates may increase your chance of having side effects.

low blood pressure
People with low blood pressure

Ergoloid mesylates may cause a sudden drop in blood pressure when you stand up from a sitting or lying position (orthostatic hypotension). If you already have this condition, this drug may make it worse.

slow heart rate
People with a slow heart rate

This medicine may cause your heart rate to slow down. This is known as bradycardia, a heart rate less than 60 beats per minute. If you already have this condition, ergoloid mesylates may decrease your heart rate even more.

pregnant women
Pregnant women

Ergoloid mesylates doesn’t have a pregnancy class. This drug shouldn’t be used during pregnancy because it can cause contractions. Based on data from similar drugs, it’s possible that ergoloid mesylates may harm your unborn baby if it’s taken during pregnancy.

Tell your doctor if you’re pregnant or plan to become pregnant. Ergoloid mesylates should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

breastfeeding
Women who are breast-feeding

It isn’t known if ergoloid mesylates passes into breast milk. Based on data from similar drugs, it’s possible that ergoloid mesylates may harm a child who is breast-fed.

You and your doctor may need to decide if you’ll take ergoloid mesylates or breast-feed.

for seniors
For seniors

The American Geriatrics Society says that seniors shouldn’t use ergoloid mesylates due to lack of effectiveness.

for children
For children

This medicine hasn’t been studied in children and shouldn’t be used in children under the age of 18 years.

call doctor
When to call the doctor

Call your doctor if you or a family member notices any worsening in your memory, mood, alertness, energy level, or your ability to care for yourself.

allergies
Allergies

Ergoloid mesylates can cause a severe allergic reaction. Symptoms include:

  • trouble breathing or swallowing
  • swelling of your face, lips, throat, or tongue
  • hives

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

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How to Take ergoloid-mesylates (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Dementia

Generic: ergoloid mesylates

Form: Oral tablet
Strengths: 1 mg
Adult dosage (ages 18 years and older)

Take one 1-mg tablet by mouth three times per day. This drug may not work right away. It can take 3–4 weeks or longer to notice improvement in your memory, mood, and ability to care for yourself. Your doctor may increase your dose slowly, up to a maximum of 12 mg per day.

Child dosage (ages 0–17 years)

This medicine hasn’t been studied in children and shouldn’t be used in people under the age of 18 years.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Ergoloid mesylates comes with serious risks if you don't take it as prescribed.

If you don't take it at all or skip doses

You may still have the symptoms of dementia if you don’t take ergoloid mesylates as prescribed by your doctor, such as:

  • memory loss
  • mood changes
  • not being able to care for yourself as well as you used to
  • less motivation
  • trouble interacting with other people

If you take too much

If you take too much of this drug, you may have more side effects. These include:

  • upset stomach
  • reddening and feelings of warmth to your cheeks (flushing)
  • low heart rate
  • low blood pressure

If you think you’ve taken too much of the drug, act right away. Call your doctor or local Poison Control Center, or go to the nearest emergency room.

What to do if you miss a dose

If you forget to take your dose, take it as soon as you remember. If it’s just a few hours until the time for your next dose, then wait and only take one dose at that time.

Never try to catch up by taking two doses at once. This could cause toxic side effects.

How to tell if the drug is working

If ergoloid mesylates is working, your memory, mood, and ability to care for yourself may improve. It may take several weeks or months for you to see an improvement.

Ergoloid mesylates is used for long-term treatment.

Important considerations for taking ergoloid mesylates
take with or without food
Take ergoloid mesylates with or without food. If this drug upsets your stomach, take it with food.
can crush or cut
You may crush or cut ergoloid mesylates tablets
storage
Store ergoloid mesylates at room temperature
See Details
refillable
Prescription is refillable
travel
Travel
See Details
clinical monitoring
Clinical monitoring
See Details
not usually stocked
Not every pharmacy stocks this drug, so call ahead

Store ergoloid mesylates at room temperature

Keep it from 68–77°F (20–25°C).

Keep this drug away from light and high temperature.

Don’t freeze ergoloid mesylates.

Keep your drugs away from areas where they could get wet, such as bathrooms. Store this drug away from moisture and damp locations.

Keep ergoloid mesylates and all drugs out of the reach of children.

Travel

When traveling with your medication:

  • Always carry your medication with you, such as in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

During treatment with this drug, your doctor may check your:

  • dementia symptoms. You, your caregiver, and your doctor should check if your symptoms of dementia are getting better.
  • blood pressure. This medication may cause sudden drops in blood pressure when you stand up from a sitting or lying position. Be careful when standing quickly.
  • heart rate, if you have existing heart problems. This medication may slow down your heart rate.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

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How Much Does ergoloid-mesylates Cost?

Oral tablet

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Lowest price for ergoloid-mesylates

Walgreens $98.02
Rite-Aid $104.75
Sams Club $123.41
These prices represent the lowest priced national pharmacies for ergoloid-mesylates on GoodRx. They may be lower than your insurance.

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These prices represent the lowest priced national pharmacies for ergoloid-mesylates on GoodRx. They may be lower than your insurance.

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on September 2, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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