Epinastine | Side Effects, Dosage, Uses & More
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Generic Name:

epinastine, Ophthalmic solution

All Brands

  • Elestat
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Highlights for epinastine

Ophthalmic solution
1

Epinastine is used to prevent itching in your eyes that’s caused by allergic conjunctivitis. This is inflammation of your eyes caused by allergies.

2

This drug comes in the form of eye drops that you drop into your eye.

3

This drug is available as the brand-named drug Elestat. It’s also available as a generic drug.

4

More common side effects of taking this drug include a burning sensation in your eyes, tearing, itching, bumps on the whites of your eyes, redness in your eye, infections, headaches, runny nose, stuffy nose, cough, and sore throat.

5

Don’t touch the tip of the dropper on the bottle to any surface. This may contaminate the eye drops and may cause eye infections. Using contaminated eye drops may cause serious damage to your eyes and even vision loss.

What is epinastine?

This drug is a prescription drug. It comes in an ophthalmic solution, which is eye drops. It’s available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version. Talk to your doctor to see if the generic version will work for you.

This drug may be used as part of a combination therapy. This means you may need to take it with other medications.

Why it’s used

This drug is used to prevent itching in your eyes that’s caused by allergic conjunctivitis. Allergic conjunctivitis occurs when the conjunctiva (the clear layer of tissue covering the whites of the eyes and lining the eyelids) becomes swollen from an allergic reaction to pollen, dander, mold, or other substances.

How it works

This drug belongs to a class of drugs called H1 histamine antagonists. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

More Details

How it works

This drug belongs to a class of drugs called H1 histamine antagonists. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

This drug works by blocking the release of a substance called histamine in your body that causes itchiness. Histamine is released when you’re exposed to certain things that you may be allergic to, like pollen, dander, or mold. When you apply this drug in your eyes, it helps prevent the itchiness.

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epinastine Side Effects

Ophthalmic solution

More Common Side Effects

The more common side effects of epinastine can include:

  • burning in your eyes

  • tearing

  • itching

  • bumps on the conjunctiva (layer covering the white part of your eye)

  • eye redness

  • infections, such as upper respiratory infections

  • headaches

  • runny nose

  • stuffy nose

  • cough

  • sore throat

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug doesn’t cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
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epinastine May Interact with Other Medications

Ophthalmic solution

Interactions are not expected. Do not use any other eye products without telling your doctor or health care professional.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
Pregnant women
Pregnant women

This drug is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Talk to your doctor if you’re pregnant or planning to become pregnant. Since this drug doesn’t absorb well into the body, there is a low risk to the fetus.

Women who are breast-feeding
Women who are breast-feeding

This drug may pass into breast milk and may cause side effects in a child who is breast-fed.

Talk to your doctor if you breast-feed your child or plan to breast-feed your child. Since this drug doesn’t absorb well into the body, there is a low risk to the fetus.

For children
For children

Safety and effectiveness of the use of Elestat in children younger than 2 years haven’t been established.

When to call the doctor
When to call the doctor

Call your doctor if your eyes still itch after using this drug. Also call your doctor if you have eye pain, a change in vision, or pus or mucus coming from your eyes. This could mean the drug isn’t working for you or that you have an eye infection

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How to Take epinastine (Dosage)

Ophthalmic solution

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Allergic conjunctivitis

Brand: Elestat

Form: ophthalmic solution 0.05%

Generic: epinastine

Form: ophthalmic solution 0.05%
Adult Dosage (ages 18 years and older):
  • The recommended dosage is one drop in each eye, twice per day.
  • Continue using the eye drops as long as you’re exposed to the allergy causing substances, even when you don’t have itching or other symptoms of allergic conjunctivitis.
Child dosage (ages 2–17 years):

The recommended dosage is one drop in each eye, twice per day. Continue using the eye drops as long as you’re exposed to the allergy causing substances, even when you don’t have itching or other symptoms of allergic conjunctivitis.

Child Dosage (ages 0–1 years):

Safety and effectiveness of the use of epinastine in children younger than 2 years haven’t been established.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug or don’t take it at all

You may begin to have an increase in symptoms of allergic conjunctivitis, such as itching or burning eyes, puffy eyelids, red and watery eyes.

If you miss doses or don’t take the drug on schedule

Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times before you’re exposed to a substance causing your allergic conjunctivitis.

If you take too much

You’re more likely to experience side effects, such as burning or itching of your eye.

What to do if you miss a dose

Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once.

How to tell if the drug is working

Your eyes should itch less or stop itching. Since this drug works quickly, you should feel relief within 5 minutes. It has been shown to last for up to 8 hours.

This drug is used for long-term treatment.

Important considerations for taking this drug

Store this drug carefully

Store this drug at room temperature between 59°F and 77°F (15°C and 25°C). Keep it away from high temperatures.

  • Don’t touch the tip of the dropper on the bottle to any surface. This may contaminate the eye drops and may cause eye infections. Using contaminated eye drops may cause serious damage to your eyes and even vision loss.
  • Keep bottle tightly closed and out of the reach of children.

Prescription is refillable

You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

  • Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Self-management

Your healthcare provider will teach you how to properly apply your eye drops. If you wear contacts, take them out before you apply your eye drops. Soft contact lenses may absorb the preservative in the eye drops. You can put contact lenses back in 10 minutes after applying the eye drops.

Insurance

Some insurance companies may require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

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How Much Does epinastine Cost?

Ophthalmic solution

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Lowest price for epinastine

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These prices represent the lowest priced national pharmacies for epinastine on GoodRx. They may be lower than your insurance.

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on October 13, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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