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Generic Name:

empagliflozin-linagliptin, Oral tablet

All Brands

  • GLYXAMBI
SECTION 1 of 4

Highlights for empagliflozin-linagliptin

Oral tablet
1

Empagliflozin/linagliptin is a combination of two drugs in a single form. It is used with diet and exercise to lower and control blood sugar levels in adults with type 2 diabetes.

2

The drug comes in two strengths: empagliflozin 10 mg/linagliptin 5 mg and empagliflozin 25 mg/linagliptin 5 mg.

3

Your doctor will monitor your blood sugar levels and your levels of a substance called hemoglobin A1c. These blood tests tell how well your medicine is working to control your diabetes.

4

The most common side effects that occur with empagliflozin/linagliptin include urinary tract infections, stuffy or runny nose, sore throat, and upper respiratory tract infections.

IMPORTANT INFORMATION

Inflammation of the pancreas (pancreatitis)

This may be severe and lead to death. If you have already had pancreatitis or have had gallstones, high triglyceride levels, or a history of alcoholism, you’re at higher risk of pancreatitis if you take this drug. Symptoms of pancreatitis include a pain in your stomach area that’s severe and won’t go away. You may feel this pain going from your abdomen to your back. The pain may happen with or without vomiting. If you have these symptoms, contact your doctor right away.

Dehydration

This drug can cause some people to lose body water and salt (dehydration). Symptoms of dehydration include dizziness, fainting, lightheadedness, or weakness, especially when you stand up. If you notice these symptoms, contact your doctor.

Yeast infection

Women who take empagliflozin/linagliptin may get vaginal yeast infections. Symptoms of yeast infection in women include vaginal odor, white or yellowish vaginal discharge, and vaginal itching. Symptoms of yeast infection in men include redness, itching, swelling, and rash of the penis. They may also include pain in the skin around the penis and foul-smelling discharge from the penis. Talk to your doctor about what to do if you get symptoms of a yeast infection of the penis or vagina. Your doctor may tell you to use an over-the counter antifungal drug. Talk to your doctor right away if you taking an over-the-counter anti-fungal drug and your symptoms don’t go away.

Ketoacidosis

This drug may cause diabetic ketoacidosis. This is a serious complication of diabetes that can be fatal. It happens when your body makes high levels of the blood acids called ketones. This condition should be treated with insulin. If you develop ketoacidosis, your doctor may have you stop taking this drug temporarily or permanently. Call your doctor right away if you have signs of ketoacidosis. Symptoms can include nausea, vomiting, stomach pain, tiredness, or trouble breathing.

What is empagliflozin-linagliptin?

This drug is a prescription drug. It’s available as an oral tablet.

This is a combination of two or more drugs in a single form. It’s important to know about all the drugs in the combination because they each may have unique traits.

This drug may be used as part of a combination therapy. That means you need to take it with other drugs.

Why it's used

This drug is a drug that’s used with diet and exercise to lower and control blood sugar levels in adults with type 2 diabetes.

How it works

This drug is a combination of two diabetes drugs in a single pill that both help improve blood sugar levels in people with type 2 diabetes.

More Details

How it works

This drug is a combination of two diabetes drugs in a single pill that both help improve blood sugar levels in people with type 2 diabetes.

Empagliflozin prevents your body from pulling sugar into your blood so that your kidneys can get rid of it in your urine. This helps to lower your blood sugar level.

Linagliptin blocks a certain enzyme in your body so that your pancreas makes more insulin and prevents your liver from making more sugar. This helps to lower your blood sugar level.

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SECTION 2 of 4

empagliflozin-linagliptin Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with empagliflozin/linagliptin include:

  • urinary tract infections

  • stuffy or runny nose

  • sore throat

  • upper respiratory tract infections

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • inflammation of the pancreas (pancreatitis). Symptoms may include:

    • severe pain in your stomach area (abdomen) that won’t go away
    • pain going from your abdomen to your back (with or without vomiting)
  • dehydration. Symptoms may include:

    • dizziness
    • feeling faint
    • lightheadedness
    • weakness, especially when you stand up
  • yeast infection.
    Symptoms in women may include:

    • vaginal odor
    • white or yellowish vaginal discharge
    • vaginal itching

    Symptoms in men may include:

    • redness, itching, or swelling of the penis
    • rash of the penis
    • foul-smelling discharge from the penis
    • pain in the skin around the penis
  • low blood sugar (hypoglycemia). Symptoms may include:

    • drowsiness
    • headache
    • confusion
    • weakness
    • hunger
    • irritability
    • sweating
    • feeling jittery
    • fast heart beat
  • urinary tract infections. Symptoms may include:

    • burning feeling when passing urine
    • cloudy urine
    • pelvic pain
    • back pain
  • allergic reactions. Symptoms may include:

    • swelling of your face, throat, lips, and other areas on your skin
    • difficulty swallowing or breathing
    • raised, red areas on your skin (hives)
    • skin rash or flaking, itching, or peeling skin
  • kidney problems. Symptoms may include:

    • low blood pressure
    • dehydration
    • lightheadedness
    • fainting
  • high cholesterol

  • diabetic ketoacidosis. Symptoms can include:

    • excessive thirst
    • urinating more often than normal
    • nausea
    • vomiting
    • stomach pain
    • weakness
    • shortness of breath
    • fruity smelling breath
    • confusion
  • mouth ulcers (small lesions that form at the base of your gums) and stomatitis (a condition that causes painful swelling and sores inside of your mouth)

Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Mild side effects may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

This drug doesn’t cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

empagliflozin-linagliptin May Interact with Other Medications

Oral tablet

Empagliflozin/linagliptin can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications That Might Interact with This Drug

Fluid retention drugs

When empagliflozin is taken with diuretics, there’s an increased chance for dehydration.

Insulin or drugs that cause the release of insulin

Examples are:

  • chlorpropamide
  • glipizide
  • glimepiride
  • glyburide
  • tolbutamide
  • tolazamide
  • repaglinide
  • nateglinide

When you take empagliflozin with these drugs, your blood sugar level can get too low (hypoglycemia).

Anti-tuberculosis drug
  • rifampin

Taking this drug with linagliptin prevents linagliptin from working well.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
urinary system icon
People with kidney disease

This medication may cause kidney damage. If your kidney function decreases, your doctor may have you stop taking this drug. Don’t take this medication if you have severe kidney disease or if you’re on dialysis.

liver icon
People with liver disease

This medication is partly processed in your liver. If your liver is damaged, the levels of this medication in your body may change. This may affect how well this medication works for you and how safe it is for you to take.

warning icon
People with inflammation of the pancreas

There have been reports of pancreatitis in people taking this medication. Let your doctor know if you have or have had pancreatitis, gallstones, a history of alcoholism, or high triglyceride levels. If you have any signs and symptoms of pancreatitis, your doctor may decide to stop this drug.

warning icon
People with high cholesterol

This medication can increase your cholesterol levels. If you already have high cholesterol, your doctor will monitor your cholesterol closely and treat it if necessary.

Pregnant women
Pregnant women

This drug is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

If you’re pregnant, talk with your doctor about the best way to control your blood sugar while you’re pregnant. Tell your doctor right away if you become pregnant during treatment with empagliflozin/linagliptin.

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Women who are breast-feeding

It’s not known if this drug may pass through breast milk. You and your doctor need to decide if you’ll take this drug or breastfeed.

senior icon
For seniors

If you’re aged 65 years or older, you may have a higher risk for dehydration. Also, your kidney function may be decreased. This medication is removed from your body through your kidneys. Decreased kidney function may lead to higher levels of these drugs in your body. It may increase side effects or cause damage to your kidneys. Your doctor will monitor you more closely and may do a blood test to check how well the kidneys are working before starting you on this drug.

children icon
For children

The effectiveness and safety of this drug haven’t been established in people younger than 18 years old.

Special Kid Safety:

  • Always store this drug in containers with child-proof lids that are securely closed.
  • Keep your medication in a secure place, like a locked medicine cabinet, even if you don't think your child can reach it.
when to call doctor icon
When to call the doctor

Contact your doctor if your blood sugar level doesn’t decrease or begins to increase. This means that your medication is no longer working.

allergy icon
Allergies

This drug may cause a severe allergic reaction after your first dose or up to three months after starting it. Symptoms of allergic reactions may include:

  • swelling of your throat, face, lips, and other areas on your skin
  • trouble breathing or swallowing
  • raised, red areas on your skin (hives)
  • skin rash, flaking, itching, or peeling

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal.

SECTION 4 of 4

How to Take empagliflozin-linagliptin (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Type 2 diabetes
Form: Oral tablet
Strength: empagliflozin10 mg/linagliptin 5 mg and empagliflozin 25 mg/linagliptin 5mg
Adult Dosage (ages 18 years and older)
  • The initial dose is one tablet of empagliflozin 10 mg/linagliptin 5 mg each morning.
  • Your dosage may be increased to one tablet of empagliflozin 25 mg/linagliptin 5 mg each morning.
Child Dosage (ages 0–17 years)

Dosage for people younger than 18 years old hasn’t been established.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with serious risks if you don't take it as prescribed.

If you skip or miss doses

Your blood sugar level may increase. This means that your diabetes will be uncontrolled. This may lead to several long-term complications, such as nerve damage, heart disease, kidney damage, eye disease, and skin conditions.

If you take too much

Your blood sugar level may decrease too much (hypoglycemia). Serious symptoms of hypoglycemia include fainting, confusion, anxiety, racing heart, and even coma.

What to do if you miss a dose

If you forget to take your dose, take it as soon as you remember. If you don’t remember until it’s time for your next dose, skip the missed dose and continue with your next scheduled dose. Don’t try to catch up by taking 2 doses of empagliflozin/linagliptin at the same time. This could result in toxic side effects.

How to tell if the drug is working

If the drug is working, your blood sugar levels will go down.

This drug is a long-term drug treatment.

Important considerations for taking this drug
should take with food icon
This drug may be taken with or without food
timing icon
Take it in the morning
not crush icon
Don’t crush or cut the tablet
storage icon
Keep this medication at room temperature
See Details
Prescription refillable icon
Prescription is refillable
travel icon
Travel
See Details
Self-Management icon
Self-management
See Details
Clinical Monitoring icon
Clinical monitoring
See Details
Not Usually Stocked
Not every pharmacy stocks this drug, so call ahead
Prior authorization
Insurance
See Details

Keep this medication at room temperature

Store in temperatures from 59–86°F (15–30ºC).

Don’t freeze this drug.

Keep it away from high temperature.

Keep your drugs away from areas where they could get wet, such as bathrooms. Store these drugs away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry your medication with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines; they can’t hurt your medication.
  • You may need to produce your pharmacy’s preprinted label clearly identifying the medication. Keep the original pharmacy prescription labeled box when traveling with your medication.
  • Don’t put this medicine in your glove compartment or leave it in the car, especially when the temperature is hot or freezing.
  • Lancets need to be used to check your blood glucose. Check for special rules about traveling with medicine and lancets.

Self-management

Your doctor may have you test your blood sugar level on a regular basis with a home blood glucose monitor.

Clinical monitoring

Your doctor may do the following tests during treatment:

  • Blood test to measure your kidney function test. Your doctor may order a blood test to measure how well your kidneys are working before you start this medication and on a regular basis while you’re taking it.
  • Cholesterol level test. Your doctor may test your cholesterol levels while you are taking this drug. This drug may cause an increase in low-density lipoprotein (LDL) cholesterol levels, which may need to be treated.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for this drug.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.


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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on September 21, 2016

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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