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Generic Name:

edoxaban, Oral tablet

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  • Savaysa
SECTION 1 of 5

Highlights for edoxaban

Oral tablet
1

Edoxaban is an oral blood thinner drug. It’s used to reduce the risk of stroke and blood clots in people with an irregular heart rate called nonvalvular atrial fibrillation. Edoxaban is also used to treat blood clots in your legs (deep vein thrombosis) or lungs (pulmonary embolism) after you’ve been treated with an injectable blood thinner medicine for 5–10 days.

2

Your dose will depend on what condition is being treated, how well your kidneys work, your weight, and other medications that you take. Your doctor will decide a dose that’s right for you.

3

Your doctor will decide how long you should take edoxaban. Don’t change your dose or stop taking this medication unless your doctor tells you to. If you’re taking edoxaban for atrial fibrillation, stopping this drug may increase your risk of having a stroke.

4

Edoxaban may cause serious bleeding that can sometimes be fatal. This is because edoxaban is a blood thinner drug that decreases the chance of blood clots forming in your body.

5

This drug may cause you to bruise more easily, and it may take longer than usual for bleeding to stop.

IMPORTANT INFORMATION

FDA Warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

  • Decreased effectiveness in people with atrial fibrillation and good kidney function: Your doctor should check how well your kidneys are working before you start taking edoxaban. They ‘ll do a test called creatinine clearance (CrCl). People with good kidney function (CrCl greater than 95 mL/min) who have nonvalvular atrial fibrillation shouldn’t take this drug, because it may not work well to prevent a stroke. Your doctor should use another blood thinner.
  • Warning for stopping treatment early: Don’t stop taking edoxaban without talking to your doctor first. Stopping this drug before your treatment is done will increase your risk of blood clots, which raises your chance for stroke or heart attack. Your doctor may have you temporarily stop taking this drug before a surgery or a medical or dental procedure. Your doctor will tell you when to start taking edoxaban again. If you have to stop taking edoxaban, your doctor may prescribe another medicine to help prevent blood clots from forming.
  • Spinal or epidural blood clots (hematoma) risk: People who take edoxaban, and have another drug injected into their spinal and epidural area, or have a spinal puncture, have a risk of forming a dangerous blood clot. This blood clot can cause long-term or permanent loss of your ability to move (paralysis). Your risk is higher if:
    • a thin tube called an epidural catheter is placed into your back to give you a medicine.
    • you take non-steroidal anti-inflammatory drugs (NSAIDs) or another medicine to prevent blood from clotting.
    • you have a history of epidural or spinal punctures.
    • you have a history of problems with your spine or have had surgery on your spine.
    If you take edoxaban and receive spinal anesthesia or have a spinal puncture, your doctor should watch you closely for symptoms of spinal or epidural blood clots. Tell your doctor right away if you have these symptoms:
    • back pain
    • tingling or numbness in your legs and feet
    • muscle weakness, especially in your legs and feet
    • loss of control of the bowels or bladder (incontinence)

Serious bleeding risk

Edoxaban can cause serious bleeding that can sometimes be fatal. This is because edoxaban is a blood thinner medicine that reduces blood clotting. While taking this drug, you may bruise more easily and bleeding may take longer to stop. Call your doctor or go to the emergency room right away if you have any of these symptoms of serious bleeding:

  • unexpected bleeding or bleeding that lasts a long time, such as:
    • frequent nose bleeds
    • unusual bleeding from your gums
    • menstrual bleeding that’s heavier than normal
  • bleeding that is severe or that you can’t control
  • red, pink, or brown-colored urine
  • bright red or black-colored stools that look like tar
  • coughing up blood or blood clots
  • vomiting blood or vomit that looks like coffee grounds
  • headaches, dizziness, or weakness

You may have a higher risk of bleeding if you take edoxaban and take other medicines that increase your risk of bleeding, including:

  • aspirin or products that contain aspirin
  • long-term use of non-steroidal anti-inflammatory drugs (NSAIDs)
  • long-term use of other blood thinner medicines, such as:
    • warfarin sodium (Coumadin, Jantoven)
    • any medicine that contains heparin
    • other medicines to prevent or treat blood clots

Tell your doctor if you take any of these medicines.

Heart valve/mitral stenosis

If you have a mechanical heart valve or moderate to severe narrowing (stenosis) of your mitral valve, you shouldn’t use edoxaban. It isn’t known if edoxaban will work or be safe for you.

What is edoxaban?

Edoxaban is a prescription drug. It’s available as an oral tablet.

Why it's used

Edoxaban is used to reduce the risk of stroke and blood clots in people who have nonvalvular atrial fibrillation. This type of irregular heartbeat is not caused by a heart valve problem.

More Details

How it works

Edoxaban belongs to a class of drugs called anticoagulants, specifically factor Xa inhibitors (blockers). A class of drugs refers to medications that work similarly.

More Details

Why It's Used

Edoxaban is used to reduce the risk of stroke and blood clots in people who have nonvalvular atrial fibrillation. This type of irregular heartbeat is not caused by a heart valve problem.

Edoxaban is used to treat blood clots in the veins of your legs (deep vein thrombosis) or lungs (pulmonary embolism) after you’ve been treated with an injectable blood thinner medicine for 5–10 days.

How It Works

Edoxaban belongs to a class of drugs called anticoagulants, specifically factor Xa inhibitors (blockers). A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

Edoxaban helps prevent blood clots from forming by blocking the substance factor Xa. This is a blood clotting factor that’s needed for your blood to clot. When a drug like edoxaban blocks factor Xa, it decreases the amount of an enzyme called thrombin. Thrombin is a substance in your blood that’s needed to form clots. Thrombin also makes platelets in your blood stick together, causing clots to form. When thrombin is decreased, this prevents a clot (thrombus) from forming in your body.

In atrial fibrillation, part of the heart doesn’t beat the way it should. This may lead to blood clots forming in your heart. These clots can travel to your brain, causing a stroke, or to other parts of the body. Edoxaban is a blood thinner that decreases your chance of having a stroke by helping to prevent clots from forming.

Edoxaban is a blood thinner that decreases the chance of blood clots forming in your body.

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SECTION 2 of 5

edoxaban Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with edoxaban include:

  • bleeding that takes longer to stop

  • bruising more easily

  • skin rash

  • reduced liver function

  • low red blood cell count (anemia). Symptoms may include:

    • shortness of breath
    • feeling very tired
    • confusion
    • fast heart rate and palpitations
    • pale skin
    • trouble concentrating
    • headache
    • chest pain
    • cold hands and feet

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • serious bleeding: Symptoms include:

    • unexpected bleeding or bleeding that lasts a long time, such as:
      • frequent nose bleeds
      • unusual bleeding from your gums
      • menstrual bleeding that’s heavier than normal
    • bleeding that’s severe or that you can’t control
    • red, pink, or brown-colored urine
    • bright red or black-colored stools that look like tar
    • coughing up blood or blood clots
    • vomiting blood or vomit that looks like coffee grounds
    • headaches, dizziness, or weakness
  • spinal or epidural blood clots (hematoma). If you take this drug and also receive spinal anesthesia or have a spinal puncture, you’re at risk for spinal or epidural blood clots that may cause paralysis. Symptoms include:

    • back pain
    • tingling or numbness in your legs and feet
    • muscle weakness, especially in your legs and feet
    • loss of control of your bowels or bladder (incontinence)
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Edoxaban doesn’t cause drowsiness.

Mild side effects may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

edoxaban May Interact with Other Medications

Oral tablet

Edoxaban can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications That Might Interact with This Drug

Non-steroidal anti-inflammatory drugs (NSAIDs)

Examples are:

  • diclofenac (Cataflam)
  • etodolac
  • fenoprofen (Nalfon)
  • flurbiprofen
  • ibuprofen (Motrin)
  • indomethacin (Indocin)
  • ketoprofen
  • ketorolac (Sprix, Toradol)
  • meclofenamate
  • mefenamic acid (Ponstel)
  • meloxicam (Mobic)
  • nabumetone
  • naproxen (Naprosyn)
  • oxaprozin (Daypro)
  • piroxicam (Feldene)
  • sulindac (Clinoral)
  • tolmetin

Taking NSAIDs with this drug may increase your risk of bleeding. Use caution when taking these medicines with edoxaban.

Aspirin

Taking aspirin with this drug may increase your risk of bleeding. Use caution when taking aspirin with edoxaban.

Antiplatelet drugs
  • clopidogrel (Plavix)
  • ticagrelor (Brilinta)
  • prasugrel (Effient)
  • ticlopidine (Ticlid)

Taking antiplatelet medicines with this drug may increase your risk of bleeding. Use caution when taking these medicines with edoxaban.

Blood thinners
  • warfarin (Coumadin, Jantoven)
  • heparin

Don’t take edoxaban with other blood thinners long term. It increases your chance of bleeding. It may be OK to use these medicines together briefly when you’re switching from one to another. 

Medications that affect how your body processes edoxaban

Rifampin (Rifater, Rifamate, Rimactane, or Rifadin)

Don’t take edoxaban with rifampin. It reduces the levels of edoxaban in your blood. This makes it less effective.

Drugs that block the transporter P-glycoprotein
  • verapamil
  • quinidine
  • azithromycin
  • clarithromycin
  • erythromycin
  • oral itraconazole
  • oral ketoconazole

These drugs may increase the amount of edoxaban in your body. This puts you at greater risk for side effects, such as bleeding. Use caution when taking these drugs together. You may need to reduce your dose of edoxaban.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Edoxaban Warnings
bleeding problems
People with bleeding problems

If you currently have abnormal bleeding, you shouldn’t take edoxaban. Edoxaban is a blood thinner and may increase your risk for serious bleeding. Talk to your doctor if you have unusual bleeding, such as frequent nose bleeds, unusual bleeding from your gums, bleeding that’s severe or that you can’t control, coughing up blood or blood clots, or vomiting blood.

liver problems
People with liver problems

If you have liver problems, you may be prone to bleeding problems. Taking edoxaban may increase this risk even more. Edoxaban is not recommended in people with moderate to severe liver problems. Your doctor will do a blood test to see how well your liver is working and decide if this drug is safe for you to take.

kidney problems
People with kidney problems

You may not be able to take edoxaban or your doctor may give you a lower dose depending on how well your kidneys are working. If your kidneys aren’t working properly, your body won’t be able to clear out the drug as well. This causes more of the drug to stay in your body, which may increase your risk for bleeding.

mechanical heart valves
People with mechanical heart valves

If you have a mechanical heart valve, don’t use edoxaban. It isn’t known if edoxaban will work or be safe for you for take.

moderate to severe mitral stenosis
People with moderate to severe mitral stenosis

If you have moderate to severe narrowing (stenosis) of your mitral valve, don’t use edoxaban. It isn’t known if edoxaban will work or be safe for you for take.

pregnant women
Pregnant women

Edoxaban is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Tell your doctor if you’re pregnant or plan to become pregnant. Edoxaban should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

breastfeeding
Women who are nursing

It isn’t known if edoxaban passes through breast milk. If it does, it may cause serious effects in a breastfeeding child.

You and your doctor may need to decide if you’ll take edoxaban or breastfeed.

children
For Children

The safety and effectiveness of edoxaban haven’t been established in people younger than 18 years old.

Special Kid Safety:

  • Keep edoxaban and all medicines out of the reach of children.
  • Store edoxaban in containers with childproof lids. Keep them tightly closed.
  • Keep your medication in a safe place, such as a locked medicine cabinet, even if you don't think your child can reach it.
telephone
When to call the doctor
  • Call your doctor right away if you fall or hurt yourself, especially if you hit your head. Your doctor may need to check you for possible bleeding that might be happening inside of your body.
  • If you plan to have surgery, or a medical or a dental procedure, tell your doctor or dentist that you’re taking edoxaban. You may have to stop taking it for a short time. Ask your doctor who prescribes edoxaban how to stop taking the drug and when to start taking it again. Your doctor may prescribe another medicine to help prevent blood clots from forming.
allergies
Allergies

Edoxaban may cause a severe allergic reaction. Symptoms include:

  • trouble breathing
  • swelling of your face, lips, throat, or tongue
  • hives
  • skin rash
  • itching

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal.

SECTION 4 of 5

How to Take edoxaban (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Reduces the risk of stroke and blood clots in people who have atrial fibrillation not caused by a heart valve problem
Form: Oral tablet
Strengths: 15 mg, 30 mg, and 60 mg

Your dose will depend on:

  • the condition that’s being treated
  • how well your kidneys are working. This will measured by a laboratory test called creatinine clearance (CrCl).
  • your weight
  • other medications that you may be taking, specifically P-gp inhibitors
Adult Dosage (ages 18 years and older)
  • CrCl greater than 95 mL/min: You shouldn’t use edoxaban.
  • CrCl between 51–95 mL/min: The recommended dose is 60 mg taken once per day.
  • CrCl between 15–50 mL/min: The recommended dose is 30 mg taken once per day.
  • CrCl less than 15 mL/min: This drug isn’t recommended.
Child Dosage (ages 0-17 years)

This medicine has not been studied in children and shouldn’t be used in people under the age of 18 years.

Special Considerations

Kidney Problems: If your kidneys aren’t working properly, your body won’t be able to clear out the drug as well. This causes more of the drug to stay in your body. This may increase your risk for bleeding. Your doctor will do a blood test to check how well your kidneys are working before starting you on this drug. If your kidneys aren’t working well, you may be started on a lower dose of edoxaban.

Liver Problems: If you have liver problems, you may be prone to bleeding problems. Edoxaban may increase your risk even more. This drug isn’t recommended in people with moderate or severe liver problems. Your doctor will do a blood test to check how well your liver is working and decide if this drug is safe for you to take.

Treats blood clots in the veins of your legs (deep vein thrombosis) or lungs (pulmonary embolism) after you’ve been treated with an injectable blood thinner medicine for 5–10 days
Form: Oral tablet
Strengths: 15 mg, 30 mg, and 60 mg

Your dose will depend on:

  • the condition that’s being treated
  • how well your kidneys are working. This will measured by a laboratory test called creatinine clearance (CrCl).
  • your weight
  • other medications that you may be taking, specifically P-gp inhibitors
Adult Dosage (ages 18 years and older)
  • The recommended dose is 60 mg taken once per day.
  • The recommended dose is 30 mg taken once per day if you meet any of these criteria:
    • CrCl between 15–50 mL/min
    • You weigh 132 lbs. (60 kg) or less
    • You are also on P-gp inhibitor medications, such as:
      • verapamil
      • quinidine
      • azithromycin
      • clarithromycin
      • erythromycin
      • oral itraconazole
      • oral ketoconazole
    • CrCl less than 15 mL/min: This drug isn’t recommended.
Child Dosage (ages 0-17 years)

This medicine has not been studied in children and shouldn’t be used in people under the age of 18 years.

Special Considerations

Kidney Problems: If your kidneys aren’t working properly, your body won’t be able to clear out the drug as well. This causes more of the drug to stay in your body. This may increase your risk for bleeding. Your doctor will do a blood test to check how well your kidneys are working before starting you on this drug. If your kidneys aren’t working well, you may be started on a lower dose of edoxaban.

Liver Problems: If you have liver problems, you may be prone to bleeding problems. Edoxaban may increase your risk even more. This drug isn’t recommended in people with moderate or severe liver problems. Your doctor will do a blood test to check how well your liver is working and decide if this drug is safe for you to take.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Edoxaban comes with serious risks if you don't take it as prescribed.

Don’t take more than one dose of edoxaban at the same time to make up for the missed dose. This could result in toxic side effects, including bleeding.

If You Skip or Miss Doses

Your doctor will decide how long you should take edoxaban. Don’t stop taking it without talking to your doctor first. If you stop taking this drug, miss doses, or don’t take it on schedule, it may increase your risk of blood clots or stroke. Make sure to refill your prescription of this drug before you run out.

If You Take Too Much

If you take more than your prescribed dose of edoxaban, you have a greater risk of bleeding, which can be fatal. If you think that you’ve taken too much edoxaban, call your doctor or go to the emergency room right away.

What to Do If You Miss a Dose

If you forget to take your dose, take it as soon as you remember on the same day. Then take your next dose at your usual time the next day.

How to Tell If the Drug Is Working

  • If you’re being treated for a blood clot in your leg, your swelling, pain, warmth, and redness may improve.
  • If you’re being treated for a blood clot in your lungs, your shortness of breath and chest pain when breathing will get better.

Edoxaban can be both a long-term and a short term drug treatment.

Important Considerations for Taking Edoxaban
take with or without food
Edoxaban can be taken with or without food
do not crush
Don’t crush or cut the tablet
storage
Keep edoxaban at room temperature
See Details
refillable
Prescription is refillable
travel
Travel
See Details
clinical monitoring
Clinical Monitoring
See Details
not usually stocked
Not every pharmacy stocks this drug, so call ahead
prior authorization required
Insurance
See Details

Keep edoxaban at room temperature

Store it in temperatures from 68–77°F (20–25°C).

Don’t freeze this drug.

Keep it away from light and high temperatures.

Keep your drugs away from areas where they could get wet, such as bathrooms. Store this drug away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry your medication with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt this medication.
  • You may need to show your pharmacy’s label to clearly identify the medication. Keep the original prescription label with you when traveling.
  • Be sure that you have enough medication before you leave on your trip. It may be difficult to fill this prescription since not every pharmacy has it in stock.

Clinical Monitoring

In general, you won’t need blood tests to check how well this drug is working. Your doctor may check your:

  • symptoms of bleeding. If you have signs of bleeding, your doctor may do tests to see if you’re actively bleeding.
  • kidney function. If your kidneys aren’t working properly, your body won’t be able to clear out this drug as well. This causes more of the drug to stay in your body, which may increase your risk for bleeding. Your doctor will do a blood test to check how well your kidneys are working. This test will help your doctor decide if your dose of edoxaban needs to be decreased or if you should stop taking the drug.
  • liver function. If you have liver problems, you may be prone to bleeding problems. Edoxaban may increase your risk even more. This drug isn’t recommended in people with moderate or severe liver problems. Your doctor will do a blood test to see how well your liver is working and decide if edoxaban is safe for you to take. Your liver will also be checked during treatment.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for edoxaban.

Are There Any Alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

SECTION 5 of 5

How Much Does edoxaban Cost?

Oral tablet

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These prices represent the lowest priced national pharmacies for edoxaban on GoodRx. They may be lower than your insurance.

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on June 25, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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