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Generic Name:

dyphylline, Oral tablet

All Brands

  • Dilor (Discontinued)
  • Lufyllin
A discontinued drug is a drug that has been taken off the market due to safety issues, shortage of raw materials, or low market demand.
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Highlights for dyphylline

Oral tablet
1

Dyphylline is an oral drug that’s used to treat the symptoms of asthma or other lung conditions that block your airways, such as emphysema or chronic bronchitis. 

2

The usual adult dose is up to 15 mg/kg of body weight taken by mouth once every six hours. 

3

This drug is only available as a brand name drug called Lufyllin. 

4

Common side effects include nausea, vomiting, diarrhea, headache, feeling nervous, anxious, or excited, and irritability. 

5

This drug can cause serious side effects if the dose is too high. These include seizures, irregular heart rate, and severe vomiting. Your doctor will watch your drug levels closely to make sure your dose isn’t too high.

IMPORTANT INFORMATION

Not for severe asthma attacks

You shouldn’t use this drug for a severe condition in which asthma attacks follow each other (status asthmaticus). That condition is a medical emergency.

Nausea and vomiting

Nausea and vomiting may be signs that your dose of dyphylline is too high. Your doctor may check the amount of dyphylline in your blood.

Seizures

This medication may cause seizures. Symptoms include:

  • confusion
  • trouble talking
  • tremors or twitching
  • loss of muscle tone or tense muscles 

Call your doctor right away if you have any of these symptoms while taking dyphylline. 

What is dyphylline?

Dyphylline is a prescription drug. It’s available as an oral tablet.

Dyphylline isn’t available as a generic drug.

Dyphylline may be used as part of a combination therapy. This means you may need to take it with other medications.

Why it's used

Dyphylline is used to treat symptoms of asthma or other lung conditions that block your airways, such as emphysema or chronic bronchitis.

How it works

Dyphylline belongs to a class of drugs called methylxanthines. A class of drugs is a group of medications that work in a similar way.

More Details

How it works

Dyphylline belongs to a class of drugs called methylxanthines. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Dyphylline works by opening up the air passages of the lungs (bronchial tubes). It also increases the flow of air through them. This helps your breathe better.

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dyphylline Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that can occur with dyphylline include:

  • diarrhea

  • nausea

  • vomiting

  • headache

  • feeling nervous or anxious

  • feeling excited

  • irritability

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

Call your doctor right away if you have serious side effects. Call 9-1-1 if your symptoms feel life threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • seizures. Symptoms include:

    • confusion
    • trouble talking
    • tremors or twitching
    • loss of muscle tone or tense muscles
  • irregular heart rate. Symptoms include:

    • shortness of breath
    • dizziness
    • fluttering heart or pain in your chest
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Dyphylline doesn’t cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
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dyphylline May Interact with Other Medications

Oral tablet

Dyphylline can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Medications that might interact with this drug

Asthma or other lung disease medicines

These drugs may increase the side effects of dyphylline.

These drugs include:

  • theophylline
  • aminophylline
  • pentoxyphylline

Ephedrine

This drug may increase the side effects of dyphylline.

Probenecid

This drug may increase your risk of side effects from dyphylline.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Dyphylline warnings
kidney disease
People with kidney disease

If you have kidney disease, you may not be able to clear dyphylline from your body as well as you should. This may increase the amount of the drug in your body and cause more side effects. Your dose of dyphylline will be lower if you have kidney disease.

heart disease
People with heart disease

If you have severe heart disease or high blood pressure, dyphylline may make it worse.

high thyroid
People with a high thyroid

If you have high thyroid levels, this drug may make your symptoms of high thyroid worse.

seizures
People with seizures

If you have seizures, dyphylline may make them worse.

stomach ulcers
People with stomach ulcers

If you have ulcers, dyphylline may make them worse.

pregnant women
Pregnant women

Dyphylline is a category C pregnancy drug. That means two things: 

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Talk to your doctor if you’re pregnant or plan to become pregnant. This drug should be used only if the potential benefit justifies the potential risk to the fetus.

breastfeeding
Women who are breast-feeding

Dyphylline passes into breast milk and may cause side effects in a child who is breastfed.

Talk to your doctor if you breastfeed your baby. You may need to decide whether to stop breastfeeding or stop taking this medication.

for seniors
For seniors

Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule.

for children
For children

This medication hasn’t been studied in children. It shouldn’t be used in people younger than 18 years.

call doctor
When to call the doctor

Call your doctor if you have trouble breathing or if symptoms of your condition get worse.

allergies
Allergies

Dyphylline may cause a severe allergic reaction. Symptoms include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives 

Call 9-1-1 or go to the emergency room if you have these symptoms.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

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How to Take dyphylline (Dosage)

Oral tablet

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Asthma and other lung diseases

Brand: Lufyllin

Form: Oral tablet
Strengths: 200 mg, 400 mg
Adult dosage (ages 18–64 years)

The standard adult dosage is up to 15 mg/kg of body weight taken by mouth once every six hours. Your doctor will decide your dose based on how severe your lung disease is and how well you respond to treatment.

Child dosage (ages 0–17 years)

This medication hasn’t been studied in children. It shouldn’t be used in people younger than 18 years.

Senior dosage (ages 65 years and older)
  • The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of this drug may stay in your body for a longer time. This increases your risk of side effects.
  • Your doctor may start you on a lowered dose or a different medication schedule. This can help keep levels of this drug from building up too much in your body.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Dyphylline comes with risks if you don’t take it as prescribed.

If You Stop Taking the Drug or Don’t Take It At All

Your symptoms, including trouble breathing, may get worse. This can be fatal.

If You Miss Doses or Don’t Take the Drug on Schedule

Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If You Take Too Much

You could have dangerous levels of the drug in your body. You may have the following symptoms:

  • nausea
  • severe vomiting
  • diarrhea
  • feeling restless or irritated
  • seizures
  • heart rhythm problems

If you think that you’ve taken too much of this drug, call your doctor or local poison control center, or go to the emergency room right away.

What to Do If You Miss a Dose

Take the next dose at its usually scheduled time. Don’t take another dose to make up for the missed dose.

How to Tell If the Drug Is Working

If this drug is working, you may be able to breathe better.

Dyphylline is a long-term drug treatment.

Important considerations for taking dyphylline

Dyphylline should be taken on an empty stomach

Take it 1 hour before or after a meal to help it absorb faster. If it upsets your stomach, you can take it with food.

Store at room temperature from 68–77°F (20–25°C)

Keep it away from high temperatures.

Don’t store this medication in moist or damp areas, such as bathrooms.

Travel

When traveling with your medication:

  • Always carry it with you, such as in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt this medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Self-management

You may need to monitor your lung function. Your doctor may show you how to monitor your lung function at home. You may be asked to record your symptoms or to monitor how well your lungs are working with a peak flow meter.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

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How Much Does dyphylline Cost?

Oral tablet

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Lowest price for dyphylline

Kroger Pharmacy $136.21
Walmart $137.38
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These prices represent the lowest priced national pharmacies for dyphylline on GoodRx. They may be lower than your insurance.

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These prices represent the lowest priced national pharmacies for dyphylline on GoodRx. They may be lower than your insurance.

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on August 27, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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