Dutasteride/tamsulosin | Side Effects, Dosage & More
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Generic Name:

dutasteride-tamsulosin, Oral capsule

All Brands

  • Jalyn
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Highlights for dutasteride-tamsulosin

Oral capsule
1

This medication is a combination of two different drugs: dutasteride and tamsulosin. Both are used to treat the symptoms of benign prostatic hyperplasia (BPH) in men with an enlarged prostate.

2

Dutasteride/tamsulosin is for use by men only.

3

The most common side effects of dutasteride/tamsulosin include ejaculation problems, trouble getting or keeping an erection, decrease in sex drive, dizziness, enlarged or painful breasts, and runny nose. 

4

Dutasteride, one of the ingredients in this medication, has been shown to reduce sperm count, semen volume, and sperm movement. However, it isn’t known if dutasteride actually affects fertility.

5

Dutasteride/tamsulosin may cause a sudden drop in your blood pressure upon standing from a sitting or lying position, especially when you first start treatment.  Symptoms of low blood pressure may include: fainting, dizziness, or feeling lightheaded.

IMPORTANT INFORMATION

Low blood pressure

Dutasteride/tamsulosin may cause a sudden drop in your blood pressure when you stand up, especially when you first start treatment. A sudden drop in blood pressure may cause you to faint, feel dizzy, or feel lightheaded. Avoid driving, operating machinery, or other dangerous activities when starting treatment with dutasteride/tamsulosin until you know how it affects you.

Prostate cancer

Dutasteride/tamsulosin may increase your risk of prostate cancer. Your doctor may check if you have prostate cancer by doing a blood test to check for prostate-specific antigen (PSA) before and during treatment. Dutasteride/tamsulosin lowers PSA concentrations in your blood. If there is an increase your PSA, your doctor may do more tests to check if you have prostate cancer.

Pregnancy

If a woman is pregnant with a male baby and accidently gets enough dutasteride in her body by swallowing or touching dutasteride, the baby may be born with deformed sex organs. If your female partner becomes pregnant or is planning to become pregnant, and her skin comes in contact with leaking dutasteride capsules, she should wash the area of contact with soap and water immediately.

Blood donations

Dutasteride can stay in your blood for up to 6 months after you stop taking it. Don’t donate blood during that time. Blood containing dutasteride can cause fetal damage in pregnant women.

What is dutasteride/tamsulosin?

Dasteride/tamsulosin is a prescription drug. It’s available as an oral capsule.

This is a combination of two of more drugs in a single form. It’s important to know about all the drugs in the combination because they each may have unique traits.

This drug may be used as part of a combination therapy. That means you need to take it with other drugs.

Why it's used

Dutasteride/tamsulosin is used to treat the symptoms of benign prostatic hyperplasia (BPH) in men with an enlarged prostate. When the prostate is enlarged, it can pinch or squeeze your urethra and affect your ability to urinate.

How it works

Dutasteride shrinks the enlarged prostate and tamsulosin relaxes muscles in the prostate and neck of the bladder. These two medications, when used together, can improve symptoms of BPH better than either medication when used alone.

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dutasteride-tamsulosin Side Effects

Oral capsule

Most Common Side Effects

The most common side effects that occur with dutasteride/tamsulosin include:

  • ejaculation problems (may continue after you stop taking this drug)

  • trouble getting or keeping an erection (may continue after you stop taking this drug)

  • decrease in sex drive (may continue after you stop taking this drug)

  • dizziness

  • enlarged or painful breasts. If you notice breast lumps or nipple discharge, talk to your doctor.

  • runny nose

If these effects are mild, they may disappear within a few days or a couple of weeks. If they’re more severe or don’t disappear, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

Dutasteride/tamsulosin may cause serious side effects, including:

  • sudden drop in blood pressure. Symptoms may include:

    • fainting
    • dizziness
    • lightheadedness
  • rare and serious allergic reactions. Symptoms may include:

    • swelling of your face, tongue, or throat
    • difficulty breathing
    • serious skin reactions, such as skin peeling
  • prostate cancer. This drug belongs to a class of drugs that could increase your risk of a faster growing and/or irregular form of prostate cancer.

  • painful erection (priapism). This is a painful erection that lasts for a very long time or doesn’t go away. If this isn’t treated immediately, there could be permanent damage to your penis, including not being able to have an erection.

Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Dutasteride/tamsulosin doesn’t cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
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dutasteride-tamsulosin May Interact with Other Medications

Oral capsule

Dutasteride and tamsulosin can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications That Might Interact with This Drug

Human immunodeficiency virus (HIV) drugs
  • protease inhibitors
    • atazanavir
    • darunavir
    • fosemprenavir
    • indinavir
    • lopoinavir
    • nelfinavir
    • ritonavir
    • saquinavir
    • tipranavir

When you take these drugs with dutasteride, they cause more dutasteride to stay in your blood. This puts you at increased risk of side effects.

Fungal infection drugs
  • itraconazole
  • ketoconazole
  • posaconazole
  • voriconazole

When you take these drugs with dutasteride, they cause more dutasteride to stay in your blood. This puts you at increased risk of side effects.

Blood pressure drugs
  • verapamil
  • diltiazem

When you take these drugs with dutasteride, they cause more dutasteride to stay in your blood. This puts you at increased risk of side effects.

Acid reflux drug
  • cimetidine

When you take this drug with dutasteride, it causes more dutasteride to stay in your blood. This puts you at increased risk of side effects.

Antibiotics
  • ciprofloxacin
  • erythromycin

When you take these drugs with dutasteride/tamsulosin, it causes more dutasteride and tamsulosin to stay in your blood. This puts you at increased risk of side effects.

Anxiety disorders drug
  • paroxetine 

When you take this drug with dutasteride/tamsulosin, it causes more tamsulosin to stay in your blood. This puts you at increased risk of side effects.

Erectile dysfunction drugs
  • sildenafil
  • tadalafil
  • vardenafil

These drugs can lower your blood pressure. Using these drugs with dutasteride/tamsulosin may lower your blood pressure to unsafe levels.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Dutasteride/tamsulosin Warnings
liver disease
People with liver diseae

If you have liver disease, your body may not be able to process dutasteride correctly. This may cause more dutasteride to stay in your blood, putting you at an increased risk of side effects. Let your doctor know if you have liver disease before taking this medication.

low blood pressure
People with low blood pressure

This medication can cause a sudden drop in your blood pressure, especially when you first start taking it. Symptoms include fainting, dizziness, or feeling lightheaded. Avoid driving or operating machinery until you know how dutasteride/tamsulosin affects you.

prostate cancer
People with prostate cancer

Dutasteride/tamsulosin may increase your risk for prostate cancer. Your doctor may check if you have prostate cancer by doing a blood test to check for prostate-specific antigen (PSA) before and during treatment. Dutasteride/tamsulosin lowers PSA levels in your blood. If there is an increase in your PSA level, your doctor may do more tests to check if you have prostate cancer.

pregnant women
Pregnant women

Dutasteride/tamsulosin is pregnancy category X drug. Category X drugs should never be used during pregnancy.

breastfeeding
Women who are breast-feeding

Dutasteride/tamsulosin should never be used in breastfeeding women. It isn’t known if dutasteride passes through breast milk.

for children
For Children

Dutasteride/tamsulosin shouldn’t be used in children. The safety and effectiveness of dutasteride/tamsulosin in children haven’t been established.

contact with drug
Contact with drugs

If a woman is pregnant with a male baby and accidently gets enough dutasteride in her body by swallowing or touching dutasteride, the baby may be born with deformed sex organs. If your female partner becomes pregnant or is planning to become pregnant, and her skin comes in contact with leaking dutasteride capsules, she should wash the area of contact with soap and water immediately.

allergies
Allergies

Dutasteride and tamsulosin can cause a severe allergic reaction, causing symptoms such as:

  • swelling of your face, tongue, or throat
  • difficulty breathing
  • serious skin reactions such as skin peeling

Get medical help right away if you have these serious allergic reactions.

Don’t take this drug again if you’ve ever had an allergic reaction to this drug, dutasteride, other 5 alpha-reductase inhibitors, or tamsulosin. Taking it again could be fatal.

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How to Take dutasteride-tamsulosin (Dosage)

Oral capsule

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Benign prostatic hyperplasia
Form: Oral capsule
Strengths: 0.5 mg dutasteride 0.5 mg/0.4 mg tamsulosin hydrochloride
Adult Dosage (ages 18 years and older)

Take 1 capsule of 0.5 mg dutasteride/0.4 mg tamsulosin once per day, about 30 minutes after the same meal every day. For example, you may take this medication 30 minutes after dinner every day.

Child Dosage (ages 0-17 years)

Dosage for people younger than 18 years old hasn’t been established.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Dutasteride/tamsulosin comes with serious risks if you don't take it as prescribed.

If You Don’t Take It or Stop Taking It

If you don’t take or stop taking dutasteride/tamsulosin, you may have increased symptoms of BPH such as difficulty starting to urinate, straining while trying to urinate, a weak urine flow, frequent urges to urinate, or more frequent need to wake up during the night to urinate. If you stop or forget to take this medication for several days, talk with your doctor before starting again.

If You Take Too Much

What happens when you take too much dutasteride (one of the drugs in this capsule) isn’t known. Since there is no antidote for dutasteride, your doctor will treat whatever symptoms you experience.

Taking too much tamsulosin (one of the drugs in this capsule) may lead to low blood pressure. Symptoms may include dizziness, lightheadedness, and fainting. You could also experience problems with your heart or shock. If you think you may have taken too much of this medication, call your doctor or get emergency medical help right away.

What to Do If You Miss a Dose

If you miss a dose, you can take it later that same day, 30 minutes after a meal. Don’t take two dutasteride/tamsulosin capsules in the same day.

How to Tell If the Drug Is Working

Your symptoms should decrease. You may have less difficulty starting to urinate, less straining while trying to urinate, less frequent urges to urinate, and less dribbling (leaking) after you urinate.

Dutasteride/tamsulosin is a long-term drug treatment.

Important Considerations for Taking Dutasteride/tamsulosin

Don't crush, chew, or open the capsules

The contents of the capsule may irritate your lips, mouth, or throat.

Store this medication at room temperature

Keep it at 59–86°F (15–30ºC).

Keep it away from high temperature.

Don’t use this medication if the capsule is deformed, discolored, or leaking.

Safely throw away medicine that’s no longer needed.

Keep your drugs away from areas where they could get wet, such as bathrooms. Store these drugs away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry your medication with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines; they can’t hurt your medication.
  • You may need to produce your pharmacy’s preprinted label clearly identifying the medication. Keep the original pharmacy prescription-labeled box when traveling with your medication.
  • Don’t put this medicine in your glove compartment or leave it in the car, especially when the temperature is hot or freezing.

Clinical Monitoring

Prostate cancer: Dutasteride/tamsulosin may increase your risk for prostate cancer. Your doctor will check if you have prostate cancer by doing a blood test for prostate-specific antigen (PSA) before and during your treatment with dutasteride/tamsulosin to see if there are any changes. This medication lowers PSA concentrations in your blood. If there is an increase in your PSA, your doctor may decide to do more tests to check if you have prostate cancer.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for dutasteride/tamsulosin.

Are There Any Alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

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How Much Does dutasteride-tamsulosin Cost?

Oral capsule

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Lowest price for dutasteride-tamsulosin

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These prices represent the lowest priced national pharmacies for dutasteride-tamsulosin on GoodRx. They may be lower than your insurance.

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on July 20, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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