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Generic Name:

donepezil-memantine, Oral capsule

All Brands

  • Namzaric
SECTION 1 of 4

Highlights for donepezil-memantine

Oral capsule
1

Memantine/donepezil is an oral drug that’s used to treat moderate to severe dementia in people with Alzheimer’s disease. It contains two medications in a single form that work in different ways to treat Alzheimer’s disease.

2

The standard maintenance dose is 28 mg memantine/10 mg donepezil taken by mouth once per day in the evening.

3

Common side effects include diarrhea, nausea, vomiting, headache, loss of appetite, dizziness, and bruising. In most cases, these side effects are mild and temporary, lasting up to 3 weeks.

4

When this drug is taken with certain anesthesia medicines, it may cause muscle problems. Tell your doctor if you have surgeries or dental or medical procedures planned.

IMPORTANT INFORMATION

Slow heart rate/fainting

This drug may cause a slow heart rate and fainting. Your risk may be higher if you have heart problems. Call your doctor right away if this happens.

Stomach bleeding/ulcers

This drug can increase your stomach acid. This raises your risk of stomach bleeding or ulcers. Tell your doctor if you have a history of ulcers or take drugs like aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). You may have a higher risk for ulcers.

What is memantine/donepezil?

This drug is a prescription drug. It’s available as an oral capsule.

This drug isn’t available as a generic drug.

This drug is a combination of two drugs in a single form. It’s important to know about all the drugs in the combination because they each may have unique traits.

Why it's used

This drug is used to treat moderate to severe dementia in people with Alzheimer’s disease. This medication is for people who are stable on certain doses of memantine and donepezil.

More Details

How it works

A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

More Details

Why it's used

This drug is used to treat moderate to severe dementia in people with Alzheimer’s disease. This medication is for people who are stable on certain doses of memantine and donepezil.

  • When you have dementia due to Alzheimer’s disease, your mental function may be getting worse. You may have memory loss, confusion, and other thinking or behavior problems. These issues may affect your ability to do daily tasks.
  • While taking this drug, your symptoms may briefly improve. This medication isn’t a cure. All people with Alzheimer’s disease get worse over time, even if they take medications to help treat it.

How it works

A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions. This drug is a combination of two drugs in a single form: memantine and donepezil.

  • Memantine belongs to a class of drugs called N-methyl-D-aspartate (NMDA) receptor antagonists.
  • Donepezil belongs to a class of drugs called acetylcholinesterase inhibitors. 

This drug works in different ways to affect the action of certain chemicals (neurotransmitters) in your brain. This may help decrease the symptoms of Alzheimer’s disease.

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SECTION 2 of 4

donepezil-memantine Side Effects

Oral capsule

Most Common Side Effects

The most common side effects that occur with memantine/donepezil include:

  • nausea

  • vomiting

  • diarrhea

  • headache

  • dizziness

  • not wanting to eat (anorexia)

  • bruising

  • trouble sleeping

  • muscle cramps

  • tiredness

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

  • slow heart rate and fainting. Your risk may be higher if you have heart problems.

  • stomach ulcers and bleeding. Your risk may be higher if you have a history of ulcers or take drugs like aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). Symptoms include:

    • heartburn
    • stomach pain that won’t go away
    • nausea or vomiting
    • blood in your vomit, or dark vomit that looks like coffee grounds
    • bowel movements or stools that look like black tar
  • trouble passing urine

  • seizures

  • worsening of lung problems in people with asthma or other lung diseases

Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug doesn’t cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

donepezil-memantine May Interact with Other Medications

Oral capsule

Memantine/donepezil can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications that might interact with this drug

Alzheimer’s disease medications

These drugs work similarly to donepezil. Taking them together may increase your risk for side effects.

These drugs include:

  • galantamine
  • rivastigmine

Anesthesia medications

These medications work similarly to memantine/donepezil. This may increase your risk for side effects.

These drugs include:

  • ketamine
  • succinylcholine

Antacids

Some drugs can lower the acidity of your urine. This can reduce the amount of memantine that’s removed from your body by your kidneys. This can increase your risk for side effects.

These drugs include:

  • sodium bicarbonate

Antifungal medications

These drugs can increase the levels of donepezil in your body. This can increase your risk for side effects.

These drugs include:

  • ketoconazole

Antihistamines

Donepezil can interfere with how these medications work.

These drugs include:

  • dimenhydrinate
  • diphenhydramine
  • hydroxyzine

Cough medications

These medications work similarly to memantine/donepezil. This may increase your risk for side effects.

These drugs include:

  • dextromethorphan

Depression medications

Donepezil can interfere with how these medications work.

These drugs include:

  • amitriptyline
  • desipramine
  • doxepin
  • nortriptyline

Glaucoma medications

Some drugs can lower the acidity of your urine. This can reduce the amount of memantine that’s removed from your body by your kidneys. This can increase your risk for side effects.

These drugs include:

  • acetazolamide
  • methazolamide

Heart medications

These drugs can increase the levels of donepezil in your body. This can increase your risk for side effects.

These drugs include:

  • quinidine

Overactive bladder (OAB) medications

Donepezil can interfere with how these medications work.

These drugs include:

  • darifenacin
  • oxybutynin
  • tolterodine
  • trospium

Parkinson's disease medications

These medications work similarly to memantine/donepezil. This may increase your risk for side effects.

These drugs include:

  • amantadine

Seizure medications

These drugs can decrease the levels of donepezil in your body. This can affect how well donepezil works to treat your Alzheimer’s disease.

These drugs include:

  • phenytoin
  • carbamazepine
  • phenobarbital

Steroids

These drugs can decrease the levels of donepezil in your body. This can affect how well donepezil works to treat your Alzheimer’s disease.

These drugs include:

  • dexamethasone

Stomach medications

Donepezil can interfere with how these medications work.

These drugs include:

  • dicyclomine
  • hyoscyamine
  • loperamide

Tuberculosis medications

These drugs can decrease the levels of donepezil in your body. This can affect how well donepezil works to treat your Alzheimer’s disease.

These drugs include:

  • rifampin

Urinary retention medications

These drugs work similarly to donepezil. Taking them together may increase your risk for side effects.

These drugs include:

  • bethanechol

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
heart problems
People with heart problems

Let your doctor know if you have heart problems, especially issues with irregular, slow, or fast heart rate. You have a higher risk of having a slow heart rate and fainting while taking this drug.

stomach ulcers
People with stomach ulcers or bleeding

Talk to your doctor if you have a history of stomach problems, ulcers, or bleeding. This drug may increase the amount of acid in your stomach. This may put you at risk of having another stomach ulcer or bleed.

breathing problems
People with breathing or lung problems

Talk to your doctor if you have asthma or other lung diseases, such as chronic obstructive pulmonary disease (COPD). Taking this drug may make your condition worse.

seizures or epilepsy
People with seizures or epilepsy

This drug may cause seizures. Tell your doctor if you have a history of seizures or epilepsy. Alzheimer’s disease may also cause seizures.

bladder problems
People with bladder problems

This drug may block your bladder, making it harder to pass urine. Talk to your doctor if you’ve had any bladder problems in the past.

severe kidney problems
People with severe kidney problems

Your doctor may give you a lower dose of this drug if you have severe kidney problems. This may help reduce your chance of side effects.

severe liver problems
People with severe liver problems

If your liver isn’t working well, more of this drug may stay in your body longer. This puts you at greater risk for side effects. If you have severe liver disease, your doctor will decide if this medication is safe for you to take.

pregnant women
Pregnant women

This drug is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Talk to your doctor if you are pregnant or plan to become pregnant. It isn’t known if this medication can harm an unborn baby. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

breastfeeding
Women who are breast-feeding

t isn’t known if this medication passes into breast milk. If it does, it may cause side effects in a child who is breast-fed.

Talk to your doctor if you breast-feed your baby. You may need to decide whether to stop breast-feeding or stop taking this medication.

for seniors
For seniors

As you age, your organs (such as your liver and kidneys) may not work as well as they did compared to when you were younger. More of the drug may stay in your body longer, putting you at risk for side effects.

for children
For children

The safety and effectiveness of this drug in children under 18 years of age haven’t been established.

call doctor
When to call the doctor

Call your doctor if you plan to have surgery or other medical procedures. When this drug is taken with certain anesthesia medicines, it may cause muscle problems. Tell your doctor if you have surgeries or dental or medical procedures planned.

allergies
Allergies

This drug can cause a severe allergic reaction. Symptoms include:

  • trouble breathing or swallowing
  • swelling of your face, lips, throat, or tongue
  • hives

Don’t take this drug again if you’ve ever had an allergic reaction to it, its individual components (memantine or donepezil), or piperidines. Taking it again could be fatal (cause death).

SECTION 4 of 4

How to Take donepezil-memantine (Dosage)

Oral capsule

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Dementia caused by Alzheimer’s disease

Brand: Namzaric

Form: Oral capsule
Strengths:
  • 7 mg memantine hydrochloride extended-release/10 mg donepezil hydrochloride
  • 14 mg memantine hydrochloride extended-release/10 mg donepezil hydrochloride
  • 21 mg memantine hydrochloride extended-release/10 mg donepezil hydrochloride
  • 28 mg memantine hydrochloride extended-release/10 mg donepezil hydrochloride
Adult dosage (ages 18–64 years)

For people who are stable on memantine (either on 10 mg taken twice daily or 28 mg extended-release taken once daily) and donepezil 10 mg daily: take 28 mg memantine/10 mg donepezil by mouth once per day in the evening.

Child dosage (ages 0–17 years)

This medicine hasn’t been studied in children and shouldn’t be used in children under the age of 18 years.

Special considerations

Severe kidney problems: For people with severe kidney problems who are stable on memantine (5 mg taken twice daily or 14 mg extended-release taken once daily) and donepezil 10 mg daily: take 14 mg memantine/10 mg donepezil once per day in the evening.

Severe liver problems: If your liver isn’t working well, more of this drug may stay in your body longer. This puts you at greater risk for side effects. Your doctor will decide if this medication is safe for you.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with serious risks if you don’t take it as prescribed.

If you don't take it at all or stop taking it

If you don't take this drug regularly, it won’t work as expected and your symptoms may not improve. Don’t stop taking this drug or change your dose without talking to your doctor.

If you take too much

If you take too much of this drug, you may have the following symptoms:

  • slow heart rate
  • loss of energy
  • restlessness
  • agitation
  • sleepiness
  • dizziness
  • unsteadiness when you walk
  • weakness
  • vomiting
  • severe nausea
  • drooling
  • sweating
  • low blood pressure, which may cause lightheadedness and dizziness
  • trouble breathing
  • seizures
  • confusion
  • psychosis or hallucinations
  • coma

If you think that you’ve taken too much of this drug, call your doctor or poison control center, or go to the emergency room right away.

What to do if you miss a dose

If you miss a dose, skip the dose and take this drug at your next scheduled dose.

Don’t take two doses at the same time. This may cause toxic effects.

How to tell if the drug is working

You can tell if the drug is working if your mental function improves. Your ability to perform your simple, everyday tasks may briefly get better. However, this medication isn’t a cure. All people with Alzheimer’s disease get worse over time, even if they take drugs to help treat it.

This drug is used for long-term treatment.

Don’t divide, chew, or crush the capsule

If you can’t swallow the capsule whole, you can open the capsule and sprinkle its contents onto applesauce. Then swallow the applesauce without chewing. If you do this, swallow it right away. Don’t save the mixture for future use and don’t divide doses.

Store this medication at room temperature

Keep it at 77°F (25°C).

Keep this drug away from light and high temperature.

Store the medicine in its original container.

Keep your drugs away from areas where they could get wet, such as bathrooms. Store this drug away from moisture and damp locations.

Keep all medicines out of the reach of children.

A prescription for this medication is refillable

You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

  • Always carry your medication with you, such as in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

Before starting and during treatment with this drug, your doctor may check the following to decide if this drug is safe for you:

  • kidney function
  • liver function

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for this drug.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.


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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on September 21, 2016

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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