Generic Name: dolutegravir, Oral tablet

TIVICAY

All Brands

  • TIVICAY
SECTION 1 of 5

Highlights for dolutegravir

Oral tablet
1

Tivicay is an oral medication used to treat human immunodeficiency virus (HIV) infection.

2

This drug is generally well tolerated and has fewer side effects than many other HIV drugs. Common side effects include insomnia, fatigue, and others.

3 4

Tivicay has many drug interactions. It interacts with calcium, iron, antacids, and some supplements. You may still be able to take these drugs if you separate them from Tivicay by several hours. Talk to your pharmacist about how to do this.

5

Tivicay must be combined with other antiretroviral medications to treat your HIV.

IMPORTANT INFORMATION

Liver disease warning

If you have severe liver disease, Tivicay isn’t a good drug choice. There is some risk of worsening liver disease while taking this drug.

Kidney disease warning

If you have severe kidney disease, the drug may not work well for you. Talk to your doctor before taking Tivicay.  

Immune reconstitution syndrome

In this condition, your improved immune system causes infections you had in the past to return. These could include fungal infections, pneumonia, or tuberculosis. Your doctor may need to treat the old infection if this happens.

Drug Features

Tivicay is a prescription drug. It’s available as an oral tablet.

This drug is used as part of a combination therapy. That means you need to take it with other drugs.

Why It's Used

Tivicay is used in combination with other drugs to treat HIV infection. It’s approved for adults and children who are 12 years of age or older and weigh at least 88 pounds.

How It Works

Tivicay belongs to a class of drugs called integrase inhibitors.

More Details

How It Works

Tivicay belongs to a class of drugs called integrase inhibitors. Integrase inhibitors block the action of integrase, an enzyme that HIV uses to make copies of itself. When the HIV virus is unable to reproduce, the overall amount of the virus in the body can decrease.

SECTION 2 of 5

dolutegravir Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with Tivicay include:

  • rash. If the rash appears suddenly and you also have fever, swelling of your face, blisters, or trouble breathing, call 9-1-1 or get to an emergency room.

  • insomnia

  • fatigue

  • headache

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • allergic reactions, such as a rash.

  • rash along with:

    • fever
    • general feeling of illness
    • extreme fatigue
    • muscle or joint aches
    • mouth blisters or sores
    • skin blisters or peeling
    • swollen or red eyes
    • swollen mouth, face, lips, or tongue
    • difficulty breathing
  • liver problems. Symptoms may include:

    • yellowing of your skin or whites of your eyes
    • dark or tea-colored urine
    • pale-colored stools
    • nausea or vomiting
    • appetite loss
    • pain, aching, or tenderness on the right side under the ribs
  • changes in body fat. This may include an increase in fat in the upper back, neck, breast, or trunk. A decrease in fat in the legs, arms, and face may also occur.

  • immune reconstitution syndrome. system. In this condition, your recovering immune system responds to infections you had in the past. Watch for returning symptoms of past infections.

Pharmacist's Advice
Healthline Pharmacist Editorial Team

Tivicay may cause drowsiness.

Talk to your doctor if you have any side effects that bother you or that don’t go away on their own.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
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dolutegravir May Interact with Other Medications

Oral tablet

Tivicay can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy.

Medications That Might Interact with This Drug

Antacids, supplements, and laxatives

These include:

  • Alka-Seltzer
  • aluminum/magnesium or calcium/magnesium antacids (Maalox, Mylanta, Rolaids, and others)
  • calcium tablets
  • iron tablets (ferrous sulfate, ferrous gluconate, and others)
  • magnesium citrate and other magnesium products
  • sucralfate

You can use antacids, iron, laxatives, and supplements while you take Tivicay. However, you’ll need to take them either 2 hours before or 6 hours after you take Tivicay.

Antibiotic
  • rifampin

Diabetes drug
  • metformin

Buffered aspirin

Brands include Bufferin, Bayer aspirin, and others

Human immunodeficiency virus (HIV) drugs

These include:

  • efavirenz (Sustiva)
  • etravirine (Intelence)
  • fosamprenavir (Lexiva)
  • nevirapine (Viramune)
  • tipranavir/ritonavir (Aptivus)

Epilepsy drugs
  • oxcarbazepine (Trileptal)
  • phenobarbital
  • carbamazepine (Tegretol)

Herbal drug
  • St. John’s wort (Hypericum perforatum)

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with liver disease

If you have liver disease, your doctor will decide if this drug is appropriate for you. If your disease is mild or moderate, you may still be able to take the drug. If your disease is severe, Tivicay may not be a good choice for you.

People with kidney disease

If you have kidney disease, you may still be able to take Tivicay. Certain kinds of HIV are more difficult to treat if you have kidney disease and your kidneys filter out drugs more slowly. Tell your doctor if you have kidney disease before taking this drug.

Pregnant women

Tivicay is a pregnancy Category B drug. This means two things:

  1. Studies of the drug in pregnant animals haven’t shown risk to the fetus.
  2. There aren’t enough studies done in humans to show if the drug poses a risk to the fetus.

Tivicay crosses the placenta in animal studies. It should be used in pregnancy only if it’s clearly needed.

Women who are nursing

The Centers for Disease Control and Prevention (CDC) recommends women with HIV shouldn’t breastfeed in order to avoid passing the virus to the baby.

In addition, studies in animals have shown that the drug passes through breast milk, It isn’t known if the drug is passed in human milk. If the drug reaches a baby through breast milk, it can cause harmful reactions in the baby.

For Children

Children at least 12 years old and at least 88 pounds (40 kg) can be treated with Tivicay. The drug hasn’t been studied in younger children or those who weigh less than 40 kg. Your child’s doctor will determine the correct dose.

When to call the doctor

Call your doctor if you experience:

  • fever
  • weakness
  • chills
  • night sweats
  • sore throat
  • joint pain

These symptoms may be a sign the drug isn’t working, and you may need a different treatment.

Allergies

Tivicay may cause allergic reaction. Call 9-1-1 or go to an emergency room if you develop a severe rash or rash accompanied by:

  • fever
  • general malaise
  • fatigue
  • muscle or joint aches
  • blisters or peeling of the skin
  • red eyes
  • swelling in your face
  • trouble breathing
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How to Take dolutegravir (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Human immunodeficiency virus (HIV) infection

Brand: Tivicay

Form: Oral Tablet
Strength: 50 mg
Adult Dosage (ages 18-64 years)

The dose is 50 mg taken twice per day.

Child Dosage (ages 12–17 years and weighing at least 88 pounds)

The recommended dose is 50 mg taken once per day.

Child Dosage (ages 0-11 years)

This medication hasn’t been studied in children under the age of 12 years. It shouldn’t be used in children under 12.

Senior Dosage (ages 65 years and older)

There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of the drug to be higher than normal. If you’re a senior, you may need a lower dose or you may need a different schedule.

Special considerations

Liver Disease: If you have liver disease, your doctor will decide if this drug is appropriate for you. If your disease is mild or moderate, you may still be able to take the drug. The dose may be the same as the dose given to other patients. 

If your liver disease is severe, Tivicay may not be a good choice for you.

Kidney Disease: If you have kidney disease, you may still be able to take Tivicay.  Certain kinds of HIV are more difficult to treat if you have kidney disease and your kidneys filter out drugs more slowly. Tell your doctor if you have kidney disease before taking this drug.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Keeping HIV under control requires long-term treatment and long-term effort. There can be very serious health consequences if you don’t take this drug exactly how your doctor tells you.

If You Stop Taking It or Miss a Dose

If you stop taking this medication or miss doses, your HIV can become worse. You may have many more serious infections and HIV-related problems.

If You Don’t Take it on Schedule

Taking this drug at the same time every day increases your ability to keep the virus under control. If you don’t, you risk worsened infection.

What To Do if I Miss a Dose

If you miss a dose, take it as soon as you can. If it’s within a few hours of your next dose, don’t take the missed dose. Take the next dose at the usual time.

Take just one dose at a time. Never try to catch up by taking two tablets at once. This could result in toxic side effects.

How Can I Tell if the Drug Is Working?

To see how well your treatment is working, your doctor will check your:

  • virus count. A virus count measures the number of copies of HIV in your body.
  • CD4 count. A CD4 count measures the amount of CD4 cells in your body. CD4 cells are white blood cells that fight infection. An increased CD4 count is a sign that your HIV treatment is working.

Tivicay is a long-term drug treatment.

Important Considerations for Taking Tivicay

Store at room temperature: 68–77°F (20–25°C)

The drug can be kept briefly in temperatures as low as 59°F (15°C) and as high as 86°F (30°C).

Keep the bottle tightly closed and away from heat and light.

Note: Be careful of moist environments, including bathrooms. To keep drugs away from moisture, store them somewhere other than your bathroom and any other damp location.

Clinical Monitoring

Before you begin taking Tivicay, your doctor may test for:

  • liver function
  • kidney function
  • hepatitis B

While you take the drug, your doctor may test your:

  • cholesterol
  • virus count. A virus count measures the number of copies of HIV in your body.
  • CD4 count. A CD4 count measures the amount of CD4 cells in your body. CD4 cells are white blood cells that fight infection. An increased CD4 count is a sign that your HIV treatment is working.

Not every pharmacy stocks this drug, so call ahead

If you only need a few tablets, you should call and ask if your pharmacy dispenses only a small number of tablets. Some pharmacies can't dispense only part of a bottle.

This drug is often available from specialty pharmacies through your insurance plan. These pharmacies operate like mail order pharmacies and ship the drug to you.

In larger cities, there will often be HIV pharmacies where you can have your prescriptions filled. Ask your doctor if there's an HIV pharmacy in your area.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for Tivicay.

Are There Any Alternatives?

There are many drugs and drug combinations that can treat HIV. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

What does the pill look like?

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How Much Does dolutegravir Cost?

Oral tablet
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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Susan J. Bliss, RPh, MBA and Alan Carter, PharmD on February 3, 2015

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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