Generic Name: digoxin, Oral tablet

Generic Name:

digoxin, Oral tablet

Digitek,Lanoxin

All Brands

  • Digitek
  • Lanoxin
SECTION 1 of 5

Highlights for digoxin

Oral tablet
1

Digoxin is available as an oral tablet and oral solution.

2

Digoxin is used to treat atrial fibrillation, mild to moderate heart failure in adults, and heart failure in children.

3

Your dose will be based on your weight, age, kidney function, other conditions you have, and other drugs you take. You may start with a larger loading dose and then reduce your dose to a maintenance dose.

4

Common side effects include breast enlargement and diarrhea.

5

Your doctor will monitor your levels of digoxin during treatment. This is done to make sure your levels aren’t too high and cause side effects.

IMPORTANT INFORMATION

Signs your dose is too high

Call your doctor if you experience:

  • nausea
  • vomiting
  • persistent diarrhea
  • confusion
  • weakness
  • loss of appetite
  • abnormal heart rhythm
  • problems with vision

These could be a sign that your digoxin dose is too high.

Risk of overdose in children

If your child is taking digoxin, make sure you’re aware of the symptoms of overdose in children. These include weight loss, failure to thrive, stomach pain, and behavioral changes.

Drug Features

Digoxin is a prescription drug. It’s available in these forms: oral tablet and oral solution.

Digoxin is available in its generic form. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand.  Talk to your healthcare provider to see if the generic will work for you. 

Why It's Used

Digoxin is used to treat heart rhythm problems and heart failure. It increases the strength of your heart muscle, normalizes heart rhythm, and helps remove excess water from your body.

How It Works

Digoxin belongs to a class of drugs called antiarrhythmics. It works by affecting the sodium pump in your body.

More Details

How It Works

Digoxin belongs to a class of drugs called antiarrhythmics. It works by affecting the sodium pump in your body. Digoxin blocks the sodium pump, which causes sodium to move out of the cells and potassium to move into cells. This affects your heart rhythm, increases your heart strength, and removes excess water from your body.

SECTION 2 of 5

digoxin Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with digoxin include:

  • breast enlargement

  • diarrhea

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

  • allergic reactions. Symptoms may include:

    • skin rash
    • hives
    • itching
    • swelling of your face, lips, or tongue
  • changes in vision, such as blurred vision and yellow vision

  • mental changes, such as:

    • inability to think clearly
    • anxiety
    • depression
    • hallucinations
  • neurological problems. Symptoms may include:

    • confusion
    • changes in behavior
    • feeling lightheaded or faint
    • headache
  • gastrointestinal problems. Symptom may include:

    • nausea or vomiting
    • persistent diarrhea
    • severe stomach pain
  • fast, irregular heart rate

  • unexplained bleeding or bruising

  • unusual weakness or tiredness

Pharmacist's Advice
Healthline Pharmacist Editorial Team

Digoxin does not cause drowsiness.

Mild side effects may go away within a few days or a couple of weeks. Talk to your doctor or pharmacist if they’re more severe or don’t go away.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

digoxin May Interact with Other Medications

Oral tablet

Digoxin may interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce the chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications That Might Interact with This Drug

Heart rhythm drugs
  • amiodarone
  • quinidine
  • dofetilide
  • dronedarone
  • propafenone

These drugs may increase the levels of digoxin in your body. This can lead to toxicity and more side effects, such as heart problems. Your doctor may adjust your dose of digoxin if you have to take these medicines together.

HIV medications
  • atazanavir/cobicistat (Evotaz)
  • darunavir/cobicistat (Prezcobix)
  • ritonavir (Norvir)
  • saquinavir (Invirase)
  • lopinavir/ritonavir (Kaletra)

These medicines increase the level of digoxin in your body. This could result in more side effects or toxicity. Your doctor may lower your dose of digoxin before starting these medications.

Blood pressure drugs
  • captopril 
  • carvedilol
  • diltiazem
  • verapamil
  • nifedipine
  • spironolactone
  • telmisartan

These drugs increase the levels of digoxin in your body. Your digoxin levels will be monitored and your dose may be reduced before you start taking these blood pressure medicines.

Antibiotics
  • clarithromycin
  • erythromycin
  • gentamicin
  • trimethoprim
  • tetracyclines

These medications increase digoxin levels in your body. Your digoxin levels will be monitored and your dose may need to be reduced.

Lung cancer drug
  • crizotinib

Crizotinib increases digoxin levels in your body and can cause lower than normal heart rate. You will need to be monitored for digoxin toxicity if you take these medications together.

Immune suppressing drug
  • cyclosporine

Cyclosporine increases digoxin levels in your body. Your digoxin levels will be monitored and your dose may need to be reduced.

Cholesterol drug
  • atorvastatin

Atorvastatin increases digoxin levels in your body. Your digoxin levels will be monitored and your dose may need to be reduced.

Antifungal drug
  • itraconazole

Itraconazole increases digoxin levels in your body. Your digoxin levels will be monitored and your dose may need to be reduced.

Nonsteroidal anti-inflammatory drugs (NSAIDs)

Examples are:

  • indomethacin
  • ibuprofen
  • naproxen

NSAIDs increase digoxin levels in your body. Your digoxin levels will be monitored and your dose may need to be reduced.

Antidepressant
  • nefazodone

Nefazodone increases digoxin levels in your body. Your digoxin levels will be monitored and your dose may need to be reduced.

Leukemia drug
  • nilotinib

Nilotinib increases digoxin levels in your body. Your digoxin levels will be monitored and your dose may need to be reduced.

Propantheline

Propantheline increases digoxin levels in your body. Your digoxin levels will be monitored and your dose may need to be reduced.

Antimalarial
  • quinine

Quinine increases digoxin levels in your body. Your digoxin levels will be monitored and your dose may need to be reduced.

Chest pain drug
  • ranolazine

Ranolazine increases digoxin levels in your body. Your digoxin levels will be monitored and your dose may need to be reduced. Your digoxin levels will need to be monitored and your dose of digoxin may need to be reduced before starting ranolazine.

Succinylcholine

Taking succinylcholine with digoxin it can lead to irregular heart rhythm.

Stimulant drugs

Examples are:

  • epinephrine
  • norepinephrine
  • phenylephrine

If you take these medications with digoxin, it can lead to irregular heart rhythm.

Low sodium level drug
  • tolvaptan

Tolvaptan increases digoxin levels in your body. Your digoxin levels will be monitored and your dose may need to be reduced.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with heart problems

People with ventricular fibrillation: Digoxin can’t be used if you have ventricular fibrillation. It may make your ventricular fibrillation worse.

People with Wolff-Parkinson-White syndrome: If you have Wolff-Parkinson-White syndrome, you’re at a higher risk for an abnormal heart rhythm. Digoxin may increase your risk even further.

People with sinus node disease and AV block: Digoxin can cause severe low heart rate and complete heart block if you have sinus node disease. You should get a pacemaker before starting digoxin if you have sinus node disease or heart block.

People with preserved left ventricular systolic function: If you have this type of heart failure you should not use digoxin. It may increase your risk of side effects, such as chest pain and shortness of breath.

People with a risk of ventricular arrhythmias during electrical cardioversion: If you’re going to receive electrical cardioversion, your dose of digoxin may be reduced or you may be taken off of the medication 1–2 days before your procedure. This is done to prevent heart rhythm problems.

People with a history of a heart attack: Digoxin isn’t recommended for people with a history of a heart attack. Using this drug can restrict blood flow to the heart.

People with myocarditis: You shouldn’t use digoxin if you have myocarditis. It can narrow your blood vessels and cause inflammation.

People with kidney disease

Digoxin is cleared from your body by your kidneys. If your kidneys don’t work as well, the drug may build up and cause toxicity. Your dose should be lower than normal if you have kidney problems.

People with thyroid disorders

If you have hypothyroidism you might be more sensitive to digoxin. Because of this, your dose of digoxin may need to be reduced.

People with electrolyte imbalances

If you have low levels of potassium, digoxin may be more active in your body, increasing the risk for toxicity. If you have low levels of magnesium, your heart may be more sensitive to changes in heart rhythm due to digoxin. If you have high levels of calcium, digoxin will cause more calcium to enter your body’s cells, which can make you more sensitive to changes in heart rhythm. You may be more likely to get digoxin toxicity, even at normal digoxin levels, if you have any of these electrolyte imbalances.

Pregnant women

Digoxin is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Tell your doctor if you’re pregnant or plan to become pregnant. Digoxin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Women who are nursing

Studies have shown that digoxin passes through breast milk. It’s unknown if this causes any effects in a breastfeeding child.

You and your doctor may need to decide if you’ll take digoxin or breastfeed.

For Seniors

Seniors may need smaller doses of digoxin and may be monitored more closely. Adults over 65 years old are more likely to have kidney problems, which may lead to greater drug side effects.

For Children

The safety and effectiveness of digoxin in people under 18 years hasn’t been established. But the drug may be used to treat heart failure in children.

Allergies

This drug may cause a severe allergic reaction. Symptoms may include:

  • skin rash
  • hives
  • itching
  • swelling of your face, lips, or tongue

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal.

SECTION 4 of 5

How to Take digoxin (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Mild to moderate heart failure in adults
Form: Oral tablet
Strengths: 62.5 mcg, 125 mcg, 187.5 mcg, and 250 mcg
Adult Dosage (ages 18 years and older)
  • Loading Dose: The total dose is 10–15 mcg per kilogram (kg) of bodyweight divided and taken 3 times per day.
  • You should take half of the loading dose first, and then take half of the remaining dose 6–8 hours later. Take the rest of the dose 6–8 hours after that.
  • Maintenance Dose: The maintenance dose is individualized. It’s based on weight, age, kidney function, current medical conditions, and other medications.
  • The maintenance dose is taken once per day.
Special Considerations

Kidney disease: Digoxin is cleared from your body by your kidneys. If you have kidney disease, your dose of digoxin will be lower.

Thyroid disorders: If you have hypothyroidism, you might be more sensitive to digoxin. Because of this, your dose of digoxin may need to be reduced.

Warnings

Toxic levels of digoxin are only slightly higher than therapeutic levels. Dosing can be started with a larger loading dose and followed by a reduced maintenance dose, or it can just be started with a maintenance dose.

Atrial fibrillation in adults
Form: Oral tablet
Strengths: 62.5 mcg, 125 mcg, 187.5 mcg, and 250 mcg
Adult Dosage (ages 18 years and older)
  • Loading Dose: The total dose is 10–15 mcg per kilogram (kg) of bodyweight divided and taken 3 times per day.
  • You should take half of the loading dose first, and then take half of the remaining dose 6–8 hours later. Take the rest of the dose 6–8 hours after that.
  • Maintenance Dose: The maintenance dose is individualized. It’s based on weight, age, kidney function, current medical conditions, and other medications.
  • The maintenance dose is taken once per day.
Special Considerations

Kidney disease: Digoxin is cleared from your body by your kidneys. If you have kidney disease, your dose of digoxin will be lower.

Thyroid disorders: If you have hypothyroidism, you might be more sensitive to digoxin. Because of this, your dose of digoxin may need to be reduced.

Warnings

Toxic levels of digoxin are only slightly higher than therapeutic levels. Dosing can be started with a larger loading dose and followed by a reduced maintenance dose, or it can just be started with a maintenance dose.

Heart failure in children
Form: Oral tablet
Strengths: 62.5 mcg, 125 mcg, 187.5 mcg, and 250 mcg
Child Dosage (ages 11-17 years)
  • Loading Dose: The total dose is 10–15 mcg per kilogram (kg) of bodyweight divided and taken 3 times per day.
  • You should take half of the loading dose first, and then take half of the remaining dose 6–8 hours later. Take the rest of the dose 6–8 hours after that.
  • Maintenance Dose: The maintenance dose is individualized. It’s based on weight, age, kidney function, current medical conditions, and other medications.
  • The maintenance dose is taken once per day.
Child Dosage (ages 5-10 years)
  • Loading Dose: The total dose is 20–45 mcg/kg divided and taken 3 times per day.
  • You should take half of the loading dose first, and then take half of the remaining dose 6–8 hours later. Take the rest of the dose 6–8 hours after that.
  • Maintenance Dose: The maintenance dose is individualized. It’s based on weight, age, kidney function, current medical conditions, and other medications.
  • The maintenance dose is taken two times per day.
Child Dosage (ages 0-4 years)

A safe and effective dose hasn’t been established for this age group.

Special Considerations

Kidney disease: Digoxin is cleared from your body by your kidneys. If you have kidney disease, your dose of digoxin will be lower.

Thyroid disorders: If you have hypothyroidism, you might be more sensitive to digoxin. Because of this, your dose of digoxin may need to be reduced.

Warnings

Toxic levels of digoxin are only slightly higher than therapeutic levels. Dosing can be started with a larger loading dose and followed by a reduced maintenance dose, or it can just be started with a maintenance dose.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Digoxin comes with serious risks if you don’t take it as prescribed.

If You Don’t Take It at All

If you don’t take it at all, your condition may get worse, which can lead to hospitalization or even death.

If You Skip or Miss Doses

If you miss doses or don’t take it on schedule, the amount of medication in your body fluctuates. This can cause symptoms of your condition to get worse.

If You Take Too Much

If you think you’ve taken too much, go to the emergency room or contact the poison control center. Signs of overdose with digoxin in adults and children include:

  • nausea
  • vomiting
  • loss of appetite
  • fatigue
  • irregular heart rate
  • dizziness
  • vision problems

Other signs of overdose in children and infants include:

  • failure to thrive
  • behavioral changes, such as hallucinations and psychotic episodes
  • weight loss
  • stomach pain

If You Miss a Dose

If you miss a dose, take it as soon as your remember. If it’s close to the time of your next dose, take only one dose at that time.

Don’t double a dose to try to make up for missed doses before speaking to your doctor or pharmacist.

How to Tell the Drug Is Working

You may be able to tell this drug is working if your heart rate returns to normal or your symptoms get better.

Digoxin is a long-term drug.

Important Considerations for Taking Digoxin
dont have to take with food You don’t have to take digoxin with food
can crush tablet You can crush or cut a digoxin tablet
storage Store at room temperature: 68–77°F (20–25°C) See Details
refillable Prescription is refillable
luggage Travel See Details
clinical monitoring Clinical Monitoring See Details
generic usually stocked The generic is usually stocked. The brand might not be stocked, so call ahead
prior authorization needed Insurance See Details

Store at room temperature: 68–77°F (20–25°C)

Keep the container tightly closed.

Store digoxin in its original container to protect it from light.

Keep this medication away from areas where it could get wet, such as bathrooms. Store it away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry it with you in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt this medication.
  • You may need to show your pharmacy’s preprinted label to clearly identify the medication. Keep the original prescription label with you when traveling.

Clinical Monitoring

While you are taking digoxin, your doctor will check the following:

  • electrolyte levels
  • kidney function
  • levels of digoxin to make sure that they are still safe for you
  • blood pressure and heart rate. You should also check your blood pressure and heart rate each day.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for digoxin.

Are There Any Alternatives?

There are several medications in this class that can be used to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

What does the pill look like?

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SECTION 5 of 5

How Much Does digoxin Cost?

Oral tablet
We've partnered with GoodRX so you can compare prices and save money on your next prescription. Check out the lowest cash prices below and enter your zip code to find the best deal near you.

Compare prices and save money on your next refill!

Lowest price for digoxin

Rite-Aid $9.99
CVS Pharmacy $10.39
Walgreens $14.58
These represent the lowest cash prices for digoxin and may be lower than your insurance.

Find the lowest prices of digoxin near you

These represent the lowest cash prices for digoxin and may be lower than your insurance.

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on June 10, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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