Dexlansoprazole | Side Effects, Dosage, Uses & More
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Generic Name:

dexlansoprazole, Oral capsule

All Brands

  • Kapidex (Discontinued)
  • Dexilant
A discontinued drug is a drug that has been taken off the market due to safety issues, shortage of raw materials, or low market demand.
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Highlights for dexlansoprazole

Oral capsule
1

Dexlansoprazole is used to reduce the amount of acid in your stomach. It treats heartburn caused by gastroesophageal reflux disease (GERD). It also treats erosive esophagitis (inflammation and ulceration of the lining of your esophagus).  

2

This drug comes in the form of a delayed-release capsule and disinterating (dissolving) tablet you take by mouth. Delayed-release means the drug is released into your body more slowly.

3

Dexlansoprazole is only available as the brand-name drug Dexilant and Dexilant SoluTab. It isn’t available as a generic drug.

4

The more common side effects of this drug can include diarrhea, stomach pain, nausea, vomiting, and gas. They can also include upper respiratory infections, such as the common cold.

5

In some cases, dexlansoprazole can cause more serious side effects. These effects can include severe diarrhea, low magnesium levels, bone fractures (breaks), kidney damage, and vitamin B-12 deficiency. 

IMPORTANT INFORMATION

Severe diarrhea

This drug may increase your risk of severe diarrhea. Severe diarrhea can be caused by an infection in your intestines called Clostridium difficile. Call your doctor right away if you have signs of this condition. Symptoms include watery stools, stomach pain, and a fever that won’t go away. 

Bone fractures

People who have taken multiple doses per day for a year or longer may have an increased risk of bone breaks. These fractures may be more likely to happen in your hip, wrist, or spine. You should take this drug exactly as prescribed by your doctor, at the lowest dose possible, and for the shortest amount of time needed. Talk to your doctor about your risk of bone fractures.

Kidney damage

This drug may cause kidney damage. Call your doctor if you have flank pain (pain in your side and back) or changes in urination during treatment.

Vitamin B-12 deficiency

Taking this drug for longer than 3 years can cause vitamin B-12 deficiency. This can lead to anemia. If you take this medication long-term, your doctor may do blood tests to check your vitamin B-12 level. 

What is dexlansoprazole?

Dexlansoprazole is a prescription drug. It’s available as a delayed-release oral capsule and a delayed-release orally disintegrating (dissolving) tablet. Delayed-release drugs are released into your body more slowly.

Dexlansoprazole is only available as the brand-name drugs Dexilant and Dexilant SoluTab. It isn’t available as a generic drug.

Why it's used

Dexlansoprazole is used to reduce the amount of acid in your stomach. It treats heartburn caused by gastroesophageal reflux disease (GERD) and erosive esophagitis (inflammation of your esophagus).  

How it works

Dexlansoprazole belongs to a class of drugs called proton pump inhibitors (PPIs). A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

More Details

How it works

Dexlansoprazole belongs to a class of drugs called proton pump inhibitors (PPIs). A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

This drug works by reducing the amount of acid in your stomach. It also keeps the acid from entering your esophagus (the food pipe that connects your mouth to your stomach). This helps relieve your symptoms of heartburn (a burning feeling in your chest or throat, a sour taste in your mouth, or burping) or erosive esophagitis (trouble or pain when swallowing, a sore throat, or a hoarse voice).

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dexlansoprazole Side Effects

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More Common Side Effects

The more common side effects of this drug include:

  • Diarrhea

  • Stomach pain

  • Nausea

  • Vomiting

  • Gas

  • Upper respiratory infection, such as the common cold. Symptoms can include:

    • Sneezing
    • Runny nose
    • Cough
    • Sore throat
    • Sinus pressure or pain

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

Call your doctor right away if you have serious side effects. Call 9-1-1 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following: 

  • Vitamin B-12 deficiency. This drug reduces the amount of acid in your stomach. You need stomach acid to absorb vitamin B-12. If you’ve been taking this drug for more than 3 years, talk to your doctor. They may do blood tests to check your vitamin B-12 level. Symptoms of a deficiency can include:

    • fatigue 
    • headache
    • shortness of breath
    • pale skin
    • loss of appetite
    • bleeding gums 
  • Low magnesium levels in your body. This drug can cause low magnesium levels if you’ve been taking it for 3 months or longer. This condition can be serious. Your doctor may monitor your magnesium levels during your treatment with this drug. They may also tell you to take a magnesium supplement. Symptoms of low magnesium levels can include:

    • seizures
    • dizziness
    • abnormal or fast heart rate
    • jitters
    • tremors (jerking movements or shaking)
    • muscle weakness
    • spasms in your hands and feet
    • cramps or muscle aches
    • spasms of your voice box 
  • Serious allergic reactions. Symptoms can include:

    • rash
    • swelling of your face
    • throat tightness
    • trouble breathing
  • Bone fractures (breaks). These fractures may be more likely to happen in your hip, wrist, or spine.

Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Dexlansoprazole doesn’t cause drowsiness. You should take this drug exactly as prescribed by your doctor, at the lowest dose possible, and for the shortest time needed.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
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dexlansoprazole May Interact with Other Medications

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Dexlansoprazole can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Medications that might interact with this drug

Drugs you should not use with dexlansoprazole

Do not take these drugs with dexlansoprazole. Doing so can cause dangerous effects in the body. Examples of these drugs include:

  • Human immunodeficiency virus (HIV) drugs, such as atazanavir. Dexlansoprazole can lower the amount of atazanavir in your body. This means that atazanavir won’t work as well to treat HIV. You may even develop HIV resistance. This means that the HIV virus will no longer respond to treatment with that drug.

Interactions that increase your risk of side effects
  • Side effects from other drugs: Taking dexlansoprazole with certain medications raises your risk of side effects from those drugs. Examples of those drugs include:
    • Digoxin. You may experience confusion, a fast heart rate, nausea and vomiting, and blurred vision. Your doctor may check the levels of digoxin in your body and adjust your dose as needed. 
    • Warfarin. Taking these drugs together may cause bleeding. If you need to take both drugs, your doctor will monitor your blood tests closely and adjust your warfarin dose as needed.
    • Tacrolimus. You may experience kidney damage, headache, nausea and vomiting, and high blood pressure. Your doctor may check the levels of tacrolimus in your body and adjust your tacrolimus dose as needed.
    • Methotrexate. Dexlansoprazole can increase blood levels of methotrexate in your body. This puts you at an increased risk of side effects. Your doctor may have you stop taking dexlansoprazole for a short time if you’re on high doses of methotrexate.

Interactions that can make your drugs less effective
  • When other drugs are less effective: When certain drugs are used with dexlansoprazole, they may not work as well. This is because the amount of these drugs in your body may be decreased. Examples of these drugs include:
    • Ampicillin esters. Dexlansoprazole can keep your body from absorbing antibiotics like ampicillin well. Ampicillin may not work as well to treat your infection.
    • Ketoconazole. Dexlansoprazole can keep your body from absorbing ketoconazole well. Ketoconazole may not work as well to treat your infection.
    • Mycophenolate mofetil (MMF). Dexlansoprazole can keep your body from absorbing MMF well. That means MMF may not work as well. It isn’t known how this may affect your risk of organ rejection. If you take MMF, as your doctor whether dexlansoprazole is safe for you.
    • Iron salts. Dexlansoprazole can keep your body from fully absorbing iron.
    • Erlotinib. Dexlansoprazole can keep your body from absorbing erlotinib well. Erlotinib may not work as well to treat your cancer.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Dexlansoprazole warning
People with liver problems
People with liver problems

If you have liver problems or a history of liver disease, you may not be able to clear this drug from your body well. If you have moderate liver disease, your doctor may reduce your dose of this drug. It isn’t known if this drug is safe for people with severe liver disease. 

People with vitamin B-12 deficiency
People with vitamin B-12 deficiency

If you’ve been taking this drug for more than 3 years, it may affect how well your body can absorb vitamin B-12. This drug can cause a vitamin B-12 deficiency. If you already have a vitamin B-12 deficiency, your risk for a severe deficiency may be higher.

People with osteoporosis
People with osteoporosis

People who have taken multiple doses per day for a year or longer may have an increased risk of bone fractures. If you already have osteoporosis, your risk is even higher.   

People with low magnesium levels in the blood
People with low magnesium levels in the blood

This drug can cause low magnesium levels if you’ve been taking it for 3 months or longer. If you already have low magnesium levels, your risk for severely low levels may be higher.

Pregnant women
Pregnant women

Dexlansoprazole is a category B pregnancy drug. That means two things:

  1. Research in animals has not shown a risk to the fetus when the mother takes the drug.
  2. There aren’t enough studies done in humans to show if the drug poses a risk to the fetus.

Talk to your doctor if you’re pregnant or planning to become pregnant. Animal studies do not always predict the way humans would respond. Therefore, this drug should only be used in pregnancy if clearly needed.

Women who are breast-feeding
Women who are breast-feeding

It isn’t known if dexlansoprazole passes into breast milk. If it does, it may cause side effects in a child who is breastfed.

Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For children
For children

This drug hasn’t been studied in children. It shouldn’t be used in people younger than 18 years.

Allergies
Allergies

Dexlansoprazole can cause a severe allergic reaction called anaphylaxis. Symptoms can include:

  • rash
  • swelling of your face
  • throat tightness
  • trouble breathing

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

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How to Take dexlansoprazole (Dosage)

Oral capsule

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Gastroesophageal reflux disease (GERD)

Brand: Dexilant

Form: Delayed-release oral capsule
Strengths: 30 mg, 60 mg

Brand: Dexilant SoluTab

Form: Delayed-release orally disintegrating tablet
Strength: 30 mg
Adult dosage (ages 18 years and older)
  • Typical dose: 30 mg taken once per day
  • Maximum dose: 60 mg taken once per day
  • Length of therapy: 4 weeks or longer
Child dosage (ages 0–17 years)

This drug hasn’t been studied in children. It shouldn’t be used in people younger than 18 years.

Warnings

Moderate liver disease: The maximum dose for people with moderate liver disease shouldn’t be more than 30 mg per day.

Erosive esophagitis

Brand: Dexilant

Form: Delayed-release oral capsule
Strengths: 30 mg, 60 mg

Brand: Dexilant SoluTab

Form: Delayed-release orally disintegrating tablet
Strength: 30 mg
Adult dosage (ages 18 years and older)
  • Typical dose: 
    • To heal acid-related damage to the lining of the esophagus (erosive esophagitis): 60 mg taken once per day
    • Maintenance dose to prevent ulceration from coming back: 30 mg taken once per day
  • Maximum dose: 60 mg taken once per day
  • Length of therapy: 8 weeks or longer
Child dosage (ages 0–17 years)

This drug hasn’t been studied in children. It shouldn’t be used in people younger than 18 years.

Warnings

Moderate liver disease: The maximum dose for people with moderate liver disease shouldn’t be more than 30 mg per day.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Dexlansoprazole comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all

The damage to your esophagus from the acid may not heal. Also, your symptoms of heartburn or erosive esophagitis won’t improve. Symptoms of heartburn can include a burning feeling in your chest or throat, a sour taste in your mouth, or burping. Symptoms of erosive esophagitis can include trouble or pain when swallowing, sore throat, or hoarse voice.

If you miss doses or don’t take the drug on schedule

Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much

You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

  • high blood pressure
  • hot flashes
  • bruising
  • pain in your throat area
  • weight loss

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room right away.   

What to do if you miss a dose

Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working

Your symptoms of heartburn or erosive esophagitis should get better.

Dexlansoprazole is used for short-term treatment.

Don’t chew dexlansoprazole capsules. Swallow them whole

You can open the capsules and sprinkle them onto a small amount of soft food or liquid. Swallow the drug mixture right away. Don’t chew the granules.

Can I crush or cut the tablet?

Don’t break or cut the disintegrating tablet. Place it on your tongue, let it dissolve, and swallow without water.

Store this drug carefully

  • Store this drug at room temperature. Keep it between 68°F and 77°F (20°C and 25°C).
  • Don’t store this medication in moist or damp areas, such as bathrooms.

A prescription for this medication is refillable

You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

  • Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

You and your doctor should monitor certain health issues. This can help make sure you stay safe while you take this drug. These issues include:

  • Liver function. Your doctor may do blood tests to check how well your liver is working. If you have liver disease, your doctor may reduce your dose of this drug.  
  • Diarrhea. Tell your doctor if you have severe diarrhea that’s not going away. Your doctor may check to see if you have an infection caused by Clostridium difficile.
  • Magnesium levels. This drug may decrease the level of magnesium in your blood. Your doctor may check your magnesium blood levels during treatment. You may need to take magnesium supplements.
  • Vitamin B-12. This drug may decrease the levels of vitamin B-12 in your body. Your doctor may check your vitamin B-12 levels. You may need to take vitamin B-12 injections.
  • Bone strength. Your doctor may do tests to see if you have osteoporosis. This drug may increase your risk of osteoporosis-related bone fractures.

Your diet

This drug may decrease the acidity in your stomach. This effect may change how your stomach absorbs certain foods. However, you don’t need to change your diet.

Insurance

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

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How Much Does dexlansoprazole Cost?

Oral capsule

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These prices represent the lowest priced national pharmacies for dexlansoprazole on GoodRx. They may be lower than your insurance.

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on April 24, 2016

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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