Generic Name: desvenlafaxine, Oral tablet

Generic Name:

desvenlafaxine, Oral tablet


All Brands

  • Khedezla
  • Pristiq
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Highlights for desvenlafaxine

Oral tablet
DESVENLAFAXINE (des VEN la FAX een) is used to treat depression.
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Talk to your healthcare provider if you have any of these conditions.
Know what to watch for and get tips for reducing your risks while taking this drug.
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desvenlafaxine Side Effects

Oral tablet

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • hallucination, loss of contact with reality
  • mania (over-active behavior)
  • increase in blood pressure
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • seizures
  • sexual difficulties (abnormal ejaculation or orgasm)
  • unusual bleeding or bruising
  • vomiting

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation
  • difficulty sleeping
  • dizziness, drowsiness
  • dry mouth
  • increased sweating
  • loss of appetite
  • nausea
  • tremor
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desvenlafaxine May Interact with Other Medications

Oral tablet

Do not take this medicine with any of the following medications:

  • duloxetine
  • linezolid
  • MAOIs like Azilect, Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • methylene blue (injected into a vein)
  • venlafaxine

This medicine may also interact with the following medications:

  • alcohol
  • amphetamine
  • aspirin and aspirin-like medicines
  • certain migraine headache medicines (almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan)
  • dexfenfluramine or fenfluramine
  • dextroamphetamine
  • furazolidone
  • isoniazid
  • lithium
  • medicines for heart rhythm or blood pressure
  • medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin
  • methylphenidate
  • metoclopramide
  • NSAIDS, medicines for pain and inflammation, like ibuprofen or naproxen
  • pentazocine
  • phentermine
  • procarbazine
  • protriptyline
  • sibutramine
  • St. John's wort, Hypericum perforatum
  • tramadol
  • tryptophan
  • zolpidem
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
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How to Use desvenlafaxine

Oral tablet

Take this medicine by mouth with a drink of water. Do not crush, cut or chew. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly except upon the advice of your doctor. Stopping this medicine too quickly may cause serious side effects or your condition may worsen.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • glaucoma
  • high blood pressure
  • kidney disease
  • liver disease
  • mania or bipolar disorder
  • suicidal thoughts or a previous suicide attempt
  • an unusual reaction to desvenlafaxine, venlafaxine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What should I watch for while using this medicine?

Tell your doctor if your symptoms do not get better or if they get worse. Visit your doctor or health care professional for regular checks on your progress. Because it may take several weeks to see the full effects of this medicine, it is important to continue your treatment as prescribed by your doctor.

Patients and their families should watch out for new or worsening thoughts of suicide or depression. Also watch out for sudden changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your health care professional.

This medicine can cause an increase in blood pressure. Check with your doctor for instructions on monitoring your blood pressure while taking this medicine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

Your mouth may get dry. Chewing sugarless gum, sucking hard candy and drinking plenty of water will help. Contact your doctor if the problem does not go away or is severe.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

What does the pill look like?

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Last Updated: April 20, 2015

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