Desloratadine/pseudoephedrine | Side Effects, Dosage & More
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Generic Name:

desloratadine-pseudoephedrine, Oral tablet

All Brands

  • Clarinex-D
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Highlights for desloratadine-pseudoephedrine

Oral tablet
1

Desloratadine/pseudoephedrine is used to help control the symptoms of seasonal allergic rhinitis. Symptoms include sneezing, stuffy nose, runny nose, and itchy nose. It’s used in adults and children 12 years of age and older.

2

This drug comes in the form of an extended-release tablet you take by mouth.

3

Desloratadine/pseudoephedrine is available as the brand-name drug called Clarinex-D. It isn’t available as a generic drug.

4

The more common side effects of this drug include insomnia (not being able to sleep), sore throat, headache, dizziness, and dry mouth. They also include nausea, tiredness, and loss of appetite.

5

This drug can increase your blood pressure and make your heart work harder. You shouldn’t take this drug if you have severe high blood pressure or heart disease.

IMPORTANT INFORMATION

Other allergy drugs

Using this drug with other allergy drugs may cause you to have more side effects. You shouldn’t use other antihistamines and decongestants while taking this drug.

Monoamine oxidase inhibitor (MAOI) use

You shouldn’t take this drug if you take a depression drug called a monoamine oxidase inhibitor (MAOI) or if you stopped taking an MAOI within the last 2 weeks. Ask your doctor or pharmacist if you’re not sure if you take an MAOI drug.

Central nervous system effects

This drug can affect your cardiovascular or central nervous system. Symptoms may include insomnia (not being able to sleep), dizziness, weakness, tremors (uncontrollable rhythmic movements in one part of your body), or arrhythmia (irregular heartbeat).

Drug features

This drug is a prescription drug. It’s available as an oral extended-release tablet.

This drug isn’t available as a generic drug. It’s only available as the brand-name drug called Clarinex-D.

This medication is a combination of two drugs in a single form: desloratadine and pseudoephedrine. It is important to know about all the drugs in the combination because each drug may affect you in a different way.

Why it's used

This drug is used to help control the symptoms of seasonal allergic rhinitis. Symptoms include sneezing, stuffy nose, runny nose, and itchy nose. It’s used in adults and children 12 years of age and older.

How it works

Desloratadine belongs to a class of drugs called antihistamines. Pseudoephedrine belongs to a class of drugs called decongestants.

More Details

How it works

Desloratadine belongs to a class of drugs called antihistamines. Pseudoephedrine belongs to a class of drugs called decongestants. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Desloratadine works to relieve runny nose, itchy eyes, and sneezing. It does this by blocking receptors that release chemicals that causes these symptoms.

Pseudoephedrine works to relieve stuffy nose. It does this by causing the vessels in your nose to constrict or tighten. This makes it easier for you to breathe.

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desloratadine-pseudoephedrine Side Effects

Oral tablet

More Common Side Effects

Some of the more common side effects of desloratadine/pseudoephedrine include:

  • insomnia (not being able to sleep)

  • sore throat

  • headache

  • dizziness

  • dry mouth

  • nausea

  • tiredness

  • loss of appetite

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

Call your doctor right away if you have serious side effects. Call 9-1-1 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • weakness

  • tremors (uncontrollable rhythmic movements in one part of your body)

  • irregular heart rate

  • trouble passing urine

  • shortness of breath

  • shakiness

  • changes in vision

  • seizures

  • low blood pressure. Symptoms may include:

    • lightheadedness
    • fainting
Pharmacist's Advice
Healthline Pharmacist Editorial Team

This drug may cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
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desloratadine-pseudoephedrine May Interact with Other Medications

Oral tablet

Desloratadine/pseudoephedrine can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Medications that might interact with this drug

Depression drugs

You shouldn’t take this drug if you take a depression drug called a monoamine oxidase inhibitor (MAOI). You also shouldn’t take it if you stopped taking an MAOI within the last 2 weeks. Taking these drugs together can make your blood pressure increase to a dangerous level. 

These drugs include:

  • isocarboxazid
  • phenelzine
  • tranylcypromine

Blood pressure drugs

Using desloratadine/pseudoephedrine while taking certain blood pressure drugs can reverse the blood pressuring-lowering effects of your medication.

These drugs include:

  • atenolol
  • bisoprolol
  • methyldopa
  • reserpine

Digoxin

Using desloratadine/pseudoephedrine while taking digoxin may cause dangerous changes in your heart rate.

Allergy drugs

Using desloratadine/pseudoephedrine with other allergy drugs may cause more side effects. You shouldn’t use other antihistamines and decongestants while taking this drug.

These drugs include:

  • diphenhydramine
  • loratadine
  • desloratadine
  • fexofenadine

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with diabetes

This drug may cause changes in your blood sugar. Your doctor may ask you to test your blood sugar level more often to make sure it’s near goal.

People with hyperthyroidism

This drug may affect your thyroid levels. Your doctor may check your thyroid levels if you are taking this drug long-term.

People with benign prostatic hypertrophy (BPH)

This drug may cause increased trouble urinating. You shouldn’t take this drug if you have problems urinating.

People with increased eye pressure

This drug may cause an even higher increase in your eye pressure. This added pressure may cause narrow-angle glaucoma. This is an eye condition that will change your eye sight. Talk to your doctor if you have any changes in your vision. If you already have narrow-angle glaucoma, you shouldn’t take this drug. This could make your vision worse and lead to blindness.

People with kidney disease

If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well. This may cause the drug to build up in your body, which may cause more side effects.

People with liver disease

If you have liver problems, you may not be able to process this drug well. This may increase the levels of this drug in your body. This can cause more side effects.

People with high blood pressure or heart disease

This drug use can increase your blood pressure and make your heart work harder. You shouldn’t take this drug if you have severe high blood pressure or heart disease.

Pregnant women

This drug is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus. 

Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should be used only if the potential benefit justifies the potential risk to the fetus. 

Women who are breast-feeding

This drug passes into breast milk and may cause side effects in a child who is breast-fed. 

Talk to your doctor if you breast-feed your baby. You may need to decide whether to stop breast-feeding or stop taking this medication.

For children

This drug shouldn’t be used in children younger than 12 years.

Allergies

This drug can cause a severe allergic reaction. Symptoms can include: 

  • skin rash
  • itching
  • hives
  • swelling of your lips, tongue, face, and throat
  • shortness of breath or trouble breathing 

Call 9-1-1 or go to the nearest emergency room if you develop these symptoms.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

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How to Take desloratadine-pseudoephedrine (Dosage)

Oral tablet

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Seasonal allergic rhinitis

Brand: Clarinex-D

Form: Oral extended-release tablet
Strengths: 2.5 mg desloratadine/120 mg pseudoephedrine
Adult dosage (ages 18–64 years)

Take 2.5 mg desloratadine/120 mg pseudoephedrine two times per day 12 hours apart.

Child dosage (ages 12–17 years)

Take 2.5 mg desloratadine/120 mg pseudoephedrine two times per day 12 hours apart.

Child dosage (ages 0–11 years)

It hasn’t been confirmed that this drug is safe and effective for use in people younger than 12 years. It shouldn’t be used in people younger than 12 years.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to work. This can cause your body to process drugs more slowly. As a result, more of the drug stays in your body for a longer time. This increases your risk of side effects.

Your doctor may start you on a lower dose or a different medication schedule. This can help keep levels of this drug from building up too much in your body.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

This drug comes with risks if you don’t take it as prescribed.

If you stop taking the drug or don’t take it at all

Your allergy symptoms won’t get better or will return.

If you miss doses or don’t take the drug on schedule

Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much

You could have dangerous levels of the drug in your body. Higher doses of this drug will cause more side effects. These include:

  • headache
  • nausea
  • vomiting
  • sweating
  • thirst
  • tachycardia (a fast heartbeat)
  • chest pain
  • palpitations (a fast or irregular heartbeat)
  • muscle weakness and tenseness
  • anxiety
  • restlessness
  • insomnia (not being able to sleep)

If you think you’ve taken too much of the drug, act right away. Call your doctor or local poison control center, or go to the nearest emergency room.

What to do if you miss a dose

Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working

Your allergy symptoms and stuffy nose symptoms will go away or get better.

This drug is used for short-term treatment. 

Important considerations for taking this drug
take with or without food You can take this drug with or without food. Taking it with food may help to reduce upset stomach
Don’t cut or crush Don’t cut or crush the tablet
storage Store this drug at room temperature See Details
medication is not refillable A prescription for this medication is not refillable See Details
travel Travel See Details

Store this drug at room temperature

Keep it from 59°F to 86°F (15°C to 30°C). Keep it away from high temperatures.

Don’t store this medication in moist or damp areas, such as bathrooms.

A prescription for this medication is not refillable

You or your pharmacy will have to contact your doctor for a new prescription if you need this medication refilled.

Travel

When traveling with your medication:

  • Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

What does the pill look like?

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on November 17, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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