Generic Name: delavirdine, Oral tablet

Generic Name:

delavirdine, Oral tablet

Rescriptor

All Brands

  • Rescriptor
SECTION 1 of 5

Highlights for delavirdine

Oral tablet
1

Rescriptor is used to treat human immunodeficiency virus (HIV) infection. It can’t control HIV on its own, so it’s always used in combination with other antiretroviral drugs.

2

Rescriptor may not be as effective as other HIV drugs. Talk to your doctor about the best treatment for your HIV infection.

3

A typical dose is often 400 mg taken three times per day in evenly spaced doses.

4

Most side effects are mild to moderate. They can include headache, nausea or vomiting, fever, and depression.

5

Severe side effects can include serious skin rashes. Symptoms may include blisters, mouth sores, fever, and muscle or joint aches.

IMPORTANT INFORMATION

May cause dangerous rash

Rescriptor can cause a rash in many people. The rash most often affects the upper body and arms. In rare cases, it can lead to infection, loss of body fluids, and organ damage. These complications can be life threatening. Call your doctor right away if you have a severe skin rash or a rash along with any of these symptoms:

  • fever
  • blistering
  • mouth sores
  • redness or swelling of your eyes
  • muscle or joint aches

May cause HIV drug resistance

This medication may lead to HIV drug resistance. That means this drug and similar drugs may not work well for you any longer. It’s important to take your HIV medications as directed. Missing doses or stopping therapy without your doctor’s approval could increase your chances of medication resistance.

Drug Features

Rescriptor is a prescription medication. It’s available as an oral tablet.

This drug is used as part of a combination therapy. That means you’ll need to take it in combination with other drugs.

Why It's Used

Rescriptor is used to treat HIV infection. It’s always used in combination with other antiretroviral drugs. Rescriptor can’t cure HIV, but it may slow its progression.

How It Works

Rescriptor works by blocking an enzyme called reverse transcriptase. HIV needs this enzyme to make copies of itself.

More Details

How It Works

Rescriptor works by blocking an enzyme called reverse transcriptase. HIV needs this enzyme to make copies of itself. By blocking the enzyme, this drug helps to reduce HIV’s ability to spread in your body. 

Rescriptor belongs to a class of drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs).

SECTION 2 of 5

delavirdine Side Effects

Oral tablet

Most Common Side Effects

Most side effects from Rescriptor are mild or moderate. The most common side effects include:

  • rash

  • headache

  • depression

  • nausea

  • vomiting

  • fever

  • anxiety

  • a buildup of body fat, including on the back of your neck

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • severe rash. In rare cases, this rash can be life threatening because it can lead to infection, loss of body fluids, and organ damage. Call your doctor right away if you have a severe skin rash, or a skin rash with any of these symptoms:

    • fever
    • blistering
    • mouth sores
    • redness or swelling of your eyes
    • muscle or joint aches
  • immune reconstitution syndrome. In this condition, your recovering immune system causes infections you’ve had in the past to return. Examples include fungal infections, pneumonia, or tuberculosis. Watch for symptoms of returning infections.

Pharmacist's Advice
Healthline Pharmacist Editorial Team

Rescriptor does not cause drowsiness.

Most of the common side effects will disappear. Call your doctor if they don’t go away or if they’re bothersome.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

delavirdine May Interact with Other Medications

Oral tablet

Rescriptor can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications That Might Interact with This Drug

Antacids

These include H2 blockers and proton pump inhibitors. These drugs can interact with Rescriptor, but you may still be able to take them with dose adjustments. Tell your doctor if you’re taking any of these drugs before taking Rescriptor: 

  • calcium, magnesium/aluminum, or magnesium calcium antacids
  • cimetidine (Tagamet)
  • famotidine (Pepcid)
  • nizatidine (Axid)
  • ranitidine (Zantac)
  • omeprazole (Prilosec)
  • lansoprazole (Prevacid)

Antibiotics and other drugs to treat infections
  • Don’t take these medications with Rescriptor:
    • rifabutin (Mycobutin)
    • rifampin (Rifadin)
  • The below drug can interact with Rescriptor, but you may still be able to take it with dose adjustments. Tell your doctor if you’re taking this drug before taking Rescriptor:
    • clarithromycin (Biaxin)

Anticoagulant (blood thinner)
  • warfarin (Coumadin) 

This drug can interact with Rescriptor, but you may still be able to take it with dose adjustments. Tell your doctor if you’re taking this drug before taking Rescriptor.

Antidepressants
  • fluoxetine (Prozac)
  • trazodone (Desyrel) 

These drugs can interact with Rescriptor, but you may still be able to take them with dose adjustments. Tell your doctor if you’re taking any of these drugs before taking Rescriptor.

Asthma/allergy drug (inhaled)
  • fluticasone (Flonase) 

This drug can interact with Rescriptor, but you may still be able to take it with dose adjustments. Tell your doctor if you’re taking this drug before taking Rescriptor.

Cholesterol-lowering drugs
  • Don’t take these medications with Rescriptor:
    • lovastatin (Mevacor)
    • simvastatin (Zocor)
  • The below drugs can interact with Rescriptor, but you may still be able to take them with dose adjustments. Tell your doctor if you’re taking any of these drugs before taking Rescriptor:
    • atorvastatin (Lipitor)
    • fluvastatin (Lescol)

Epilepsy drugs

Don’t take these medications with Rescriptor:

  • phenytoin (Dilantin)
  • phenobarbital
  • carbamazepine (Tegretol)

Erectile dysfunction drug
  • sildenafil (Viagra)

This drug can interact with Rescriptor, but you may still be able to take it with dose adjustments. Tell your doctor if you’re taking this drug before taking Rescriptor.

Drug to increase stomach emptying

Don’t take this medication with Rescriptor: 

  • cisapride (Propulsid)

Heart drugs

These include drugs for high blood pressure or arrhythmias. These drugs can interact with Rescriptor, but you may still be able to take them with dose adjustments. Tell your doctor if you’re taking any of these drugs before taking Rescriptor:

  • amiodarone (Cordarone)
  • amlodipine (Norvasc)
  • diltiazem (Cardizem)
  • felodipine (Plendil)
  • isradipine    
  • lidocaine (when given intravenously)
  • nifedipine (Adalat, Procardia)
  • nicardipine (Cardene)
  • nimodipine (Nymalize)
  • quinidine
  • propafenone (Rythmol)
  • verapamil (Calan, Isoptin, Verelan)

Herbal drug

Don’t take this medication with Rescriptor:

  • St. John's wort (Hypericum perforatum)

Hormone
  • ethinyl estradiol

This drug can interact with Rescriptor, but you may still be able to take it with dose adjustments. Tell your doctor if you’re taking this drug before taking Rescriptor.

Human immunodeficiency virus (HIV) drugs

These drugs can interact with Rescriptor, but you may still be able to take them with dose adjustments. Tell your doctor if you’re taking any of these drugs before taking Rescriptor:

  • didanosine (Videx)
  • indinavir (Crixivan)
  • lopinavir/ritonavir (Kaletra)
  • nelfinavir (Viracept)
  • ritonavir (Norvir)
  • saquinavir (Invirase)

Migraine headache drugs

Don’t take these medications with Rescriptor:

  • dihydroergotamine
  • ergonovine
  • ergotamine
  • methylergonovine

Pain drug
  • methadone

This drug can interact with Rescriptor, but you may still be able to take it with dose adjustments. Tell your doctor if you’re taking this drug before taking Rescriptor.

Post-transplant drugs

These drugs can interact with Rescriptor, but you may still be able to take them with dose adjustments. Tell your doctor if you’re taking any of these drugs before taking Rescriptor:

  • cyclosporine (Gengraf, Neoral)
  • tacrolimus (Prograf)
  • sirolimus (Rapamune)

Sleeping pills and sedatives

Don’t take these medications with Rescriptor: 

  • alprazolam (Xanax)
  • Midazolam (Versed, IV drug)
  • triazolam (Halcion)

Steroid
  • dexamethasone (Decadron)

This drug can interact with Rescriptor, but you may still be able to take it with dose adjustments. Tell your doctor if you’re taking this drug before taking Rescriptor.

Stimulant (used for ADHD)
  • amphetamines (Dexedrine, Adderall)

Tourette’s syndrome drug

Don’t take this medication with Rescriptor:

  • pimozide (Orap)

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with liver disease

If you have liver disease, your body may process Rescriptor more slowly. This could lead to a buildup of the drug in your body and increase your chance of negative side effects. Your doctor will monitor your liver function very closely.

Pregnant women

Rescriptor is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans.

Rescriptor should be used during pregnancy only if the potential benefits outweigh the potential risk to the fetus.

Women who are nursing

According to the U.S. Department of Health and Human Services, you shouldn’t breastfeed your infant if you have HIV. There is a risk of passing HIV to your baby.

Additionally, it isn’t known if this drug passes through breast milk.

When to call the doctor

Call your doctor if you experience: 

  • fever
  • weakness
  • chills
  • night sweats
  • sore throat
  • joint pain

These symptoms may be a sign the drug isn’t working, and you may need a different treatment.

Allergies

Rescriptor can cause a rash in many people. The rash most often affects the upper body and arms. In rare cases, it can lead to infection, loss of body fluids, and organ damage. These complications can be life threatening. Call your doctor right away if you have a rash with any of these symptoms:

  • fever
  • blistering
  • mouth sores
  • redness or swelling of your eyes
  • muscle or joint aches
SECTION 4 of 5

How to Take delavirdine (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Human immunodeficiency virus (HIV) infection

Brand: Rescriptor

Form: Oral Tablet
Strengths: 100 mg and 200 mg
Adult Dosage (ages 18 years and older)

400 mg taken 3 times per day in evenly spaced doses. You may take the dose as four 100-mg tablets or two 200-mg tablets.

Child Dosage (ages 16-17 years)

400 mg taken 3 times per day in evenly spaced doses

Child Dosage (ages 0-15 years)

Dosage hasn’t been established for this age group.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Keeping HIV under control requires lifelong treatment. There can be serious health consequences if you don’t take this drug exactly how your doctor tells you.

If You Don’t Take It at All

If you don’t take it at all, your HIV infection may reduce your immunity to a point where you won’t be able to defend against many types of infections. You may not be able to fight infections that are commonly cured in people who don’t have HIV.

If You Stop or Miss Doses

If you stop taking this medication, miss doses, or don’t take it on schedule, the amount of medication in your body fluctuates. This can allow the HIV in your body to become resistant to the drug, which means the drug stops working.

If You Don’t Take It on Schedule

Taking this drug at the same time every day keeps a constant amount of the drug in your body. This helps make the drug as effective as possible at keeping the virus under control.

What to Do If You Miss a Dose

If you’re just a few hours late for your daily dose, take it as soon as you can. If it's just a few hours until your next dose, only take a single dose.

Never try to catch up by taking a double dose. This could result in toxic side effects.

How to Tell If the Drug Is Working

To see how well the drug is working, your doctor will check your:

  • virus count. A virus count measures the number of copies of HIV in your body. A decreased virus count is a sign that your treatment is working.
  • CD4 count. A CD4 count measures the amount of CD4 cells in your body. CD4 cells are white blood cells that fight infection. An increased CD4 count is a sign that your treatment is working. 

Rescriptor is a long-term drug treatment.

Important Considerations for Taking Rescriptor

Don’t cut or crush the oral tablets

However, if you can’t swallow the 100-mg tablet, you can dissolve it in water. 

For a 400-mg dose, add 4 tablets to at least 3 ounces of water. Let the tablets sit in the water for a few minutes. Stir the water until the tablets dissolve and then drink the mixture right away. Refill the glass with more water and swallow all of it to make sure you get the whole dose.

Store at room temperature: 68–77°F (20–25°C)

Keep the bottle tightly closed and protect it from high humidity.

Note: Be careful of moist environments, including bathrooms. To keep drugs away from moisture, store them somewhere other than your bathroom and any other damp location.

Clinical Monitoring

To see how well your treatment is working, your doctor may check your:

  • virus count. The virus count measures the number of copies of HIV in your body. A decrease in the number of copies is a sign that your treatment is working.
  • CD4 count. A CD4 count measures the amount of CD4 cells in your body. CD4 cells are white blood cells that fight infection. An increased CD4 count is a sign that your treatment is working.

Not every pharmacy stocks this drug, so call ahead

If you only need a few tablets, you should call and ask if your pharmacy dispenses only a small number of tablets. Some pharmacies can't dispense only part of a bottle.

This drug is often available from specialty pharmacies through your insurance plan. These pharmacies operate like mail order pharmacies and ship the drug to you.

In larger cities, there will often be HIV pharmacies where you can have your prescriptions filled. Ask your doctor if there's a HIV pharmacy in your area.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for Rescriptor. Your doctor may need to do paperwork for you, which could take a week or two.

Are There Any Alternatives?

There are other drugs and combinations that can treat HIV. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

What does the pill look like?

Showing - out of 6
SECTION 5 of 5

How Much Does delavirdine Cost?

Oral tablet
We've partnered with GoodRX so you can compare prices and save money on your next prescription. Check out the lowest cash prices below and enter your zip code to find the best deal near you.

Compare prices and save money on your next refill!

Lowest price for delavirdine

Kroger Pharmacy $37.83
Kmart $37.83
Target $37.83
These represent the lowest cash prices for delavirdine and may be lower than your insurance.

Find the lowest prices of delavirdine near you

These represent the lowest cash prices for delavirdine and may be lower than your insurance.

Show Sources

Content developed in collaboration with Susan J. Bliss, RPh, MBA

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on April 24, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Read This Next

Does Apple Cider Vinegar Help with Psoriasis?
Does Apple Cider Vinegar Help with Psoriasis?
What to Do When Your Friend Has Breast Cancer
What to Do When Your Friend Has Breast Cancer
Positive Parenting in 20 Steps
Positive Parenting in 20 Steps
Advertisement
Advertisement
Advertisement