Generic Name: dasatinib, Oral tablet

Sprycel

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  • Sprycel
SECTION 1 of 4

Highlights for dasatinib

Oral tablet
1
DASATINIB (da SA ti nib) is a chemotherapy drug. It targets specific proteins within cancer cells and stops the cancer cells from growing. It is used to treat some kinds of leukemia.
2 3 4
Talk to your healthcare provider if you have any of these conditions.
5
Know what to watch for and get tips for reducing your risks while taking this drug.
SECTION 2 of 4

dasatinib Side Effects

Oral tablet

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • low blood counts - this medicine may decrease the number of white blood cells, red blood cells, and platelets.

You may be at increased risk for infections and bleeding.

  • signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine
  • signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine, nosebleeds
  • signs of decreased red blood cells - unusual weakness or tiredness, fainting spells, lightheadedness
  • breathing problems
  • dry cough
  • fast, irregular heartbeat
  • swelling of the legs or ankles, or other parts of the body
  • sores or white patches in your mouth or throat
  • sudden weight gain

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • diarrhea
  • headache
  • nausea, vomiting
  • weak or tired
SECTION 3 of 4

dasatinib May Interact with Other Medications

Oral tablet

Do not take this medicine with any of the following medications:

-certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole

-certain medicines for stomach problems like cimetidine, famotidine, ranitidine, omeprazole

-cisapride

-dofetilide

-dronedarone

-ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine

-pimozide

-St. John's Wort

-thioridazine

-ziprasidone

This medicine may also interact with the following medications:

-acetaminophen

-alfentanil

-antiviral medicines for HIV or AIDS

-aspirin

-carbamazepine

-certain antibiotics like clarithromycin, erythromycin, rifampin, rifabutin, rifapentine, telithromycin, troleandomycin

-certain medicines for cholesterol like atorvastatin

-certain medicines that treat or prevent blood clots like warfarin

-cyclosporine

-dexamethasone

-fentanyl

-NSAIDS, medicines for pain and inflammation, like ibuprofen, ketoprofen, naproxen

-other medicines that prolong the QT interval (cause an abnormal heart rhythm)

-phenobarbital

-phenytoin

-sirolimus

-tacrolimus

SECTION 4 of 4

How to Use dasatinib

Oral tablet

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take it with or without food. Do not cut, crush or chew this medicine. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Avoid taking antacids containing aluminum, calcium, or magnesium within 2 hours of taking this medicine. You can take such antacids up to 2 hours before or 2 hours after this medicine. Avoid taking all other medicines that reduce stomach acid.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • bleeding problems
  • heart disease
  • heart failure
  • infection (especially a virus infection such as chickenpox, cold sores, or herpes)
  • irregular heartbeat
  • liver disease
  • low blood counts, like low white cell, platelet, or red cell counts
  • take medicines that treat or prevent blood clots
  • an unusual or allergic reaction to dasatinib, lactose, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
What if I miss a dose?

If you miss a dose, take your next scheduled dose at its regular time. Do not take double or extra doses. Talk to your doctor if you are not sure what to do.

What should I watch for while using this medicine?

Visit your doctor for regular check ups. Report any side effects. Continue your course of treatment unless your doctor tells you to stop. You will need blood work done while you are taking this medicine.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine. Males who take this medicine should use a condom to avoid pregnancy in their partner.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep tightly closed. Throw away any unused medicine after the expiration date.

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Last Updated: January 11, 2014

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