Darifenacin | Side Effects, Dosage, Uses & More
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Generic Name:

darifenacin, Oral tablet

All Brands

  • Enablex
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Highlights for darifenacin

Oral tablet
1

Darifenacin is an oral drug that’s used to treat the symptoms of overactive bladder. It is an extended-release drug. That means the drug is released slowly into your bloodstream over time.

2

The recommended adult starting dose is 7.5 mg taken by mouth once per day. If this dose isn’t working well enough to decrease your symptoms after 2 weeks, your doctor may increase your dose to 15 mg taken once per day.

3

You shouldn’t take this drug if you have certain conditions. Tell your doctor if you have trouble emptying your bladder, a weak urine stream, stomach problems, narrow-angle glaucoma, or severe liver problems.

4

Darifenacin can cause blurred vision or dizziness. You shouldn’t drive, use machinery, or do other tasks that require alertness until you know how this drug affects you.

5

Other common side effects include constipation, dry mouth, heartburn, urinary tract infection, and heat exhaustion or heat stroke.

IMPORTANT INFORMATION

Other conditions

You shouldn’t take this drug if you’re unable to empty your bladder (urinary retention), have delayed or slowed emptying of your stomach (gastric retention), or have an eye problem called narrow-angle glaucoma that’s not controlled.

Driving

This drug can cause blurred vision or dizziness. You shouldn’t drive, use machinery, or do other tasks that require alertness until you know how this drug affects you.

Drug features

This drug is a prescription drug. It’s available as an oral extended-release tablet. 

This drug is only available as the brand Enablex. It isn’t available as a generic drug.

Why it's used

This drug is used to treat the following symptoms caused by overactive bladder (OAB):

  • urge urinary incontinence: a strong need to urinate, with leaking or wetting accidents
  • urgency: a strong need to urinate right away
  • frequency: urinating more often than normal

How it works

This drug belongs to a class of drugs called urinary anticholinergics / muscarinic antagonists. A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

More Details

How it works

This drug belongs to a class of drugs called urinary anticholinergics / muscarinic antagonists. A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

Overactive bladder is a condition where your bladder muscles contract involuntarily even when your bladder isn’t full. When they contract, you’ll feel the need to urinate right away. This drug works by preventing these involuntary bladder contractions or spasms.

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darifenacin Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with darifenacin include:

  • constipation

  • dry mouth

  • headache

  • heartburn

  • nausea

  • urinary tract infection

  • blurred vision

  • heat exhaustion or heat stroke. This can happen when darifenacin is used in hot weather. Symptoms include:

    • sweating less
    • dizziness
    • tiredness
    • nausea
    • increased body temperature

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • serious allergic reaction. Symptoms include:

    • hives, skin rash, or swelling
    • severe itching
    • swelling of your face, mouth, or tongue
    • trouble breathing
  • urinary retention. Symptoms include:

    • not being able to urinate
    • painful urge to urinate
    • pain in the lower part of the abdomen (stomach area)
    • bloating
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
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darifenacin May Interact with Other Medications

Oral tablet

Darifenacin can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications that might interact with this drug

Antifungal drugs
  • ketoconazole (Nizoral)
  • itraconazole (Sporanox)

These drugs may increase the level of darifenacin in your body. This can raise your risk for side effects. If you’re on these medications, your maximum dose of darifenacin should be 7.5 mg to lower your risk for side effects.

Drugs used to treat human immunodeficiency virus (HIV)
  • ritonavir (Norvir)
  • nelfinavir (Viracept)

These drugs may increase the level of darifenacin in your body. This can raise your risk of side effects. If you’re on these medications, your maximum dose of darifenacin should be 7.5 mg to lower your risk of side effects.

Antibiotics
  • clarithromycin (Biaxin)

This drug may increase the level of darifenacin in your body. This can raise your risk of side effects. If you’re on this medication, your maximum dose of darifenacin should be 7.5 mg to lower your risk of side effects.

Drug used to treat depression
  • nefazodone

This drug may increase the level of darifenacin in your body. This can raise your risk of side effects. If you’re on this medication, your maximum dose of darifenacin should be 7.5 mg to lower your risk of side effects.

Drugs used to treat an abnormal heart rate
  • flecainide 

Darifenacin increases the levels of this drug in your body. This can cause toxic side effects. Your doctor may check your blood levels of this drug and reduce your dose if needed.

Antipsychotics
  • thioridazine (Mellaril)

Darifenacin increases the levels of this drug in your body. This can cause toxic side effects. Your doctor may check your blood levels of this drug and reduce your dose if needed.

Tricyclic antidepressants
  • desipramine (Norpramin)
  • imipramine (Tofranil)

Darifenacin increases the levels of these drugs in your body. This can cause toxic side effects. Your doctor may check your blood levels of these drugs and reduce your dose if needed.

Other drugs
  • amitriptyline (Elavil)
  • benztropine (Cogentin)
  • chlorpromazine
  • clomipramine (Anafranil)
  • clozapine (Clozaril)
  • cyclobenzaprine (Flexeril)
  • cyproheptadine (Periactin)
  • desipramine (Norpramin)
  • dicyclomine (Bentyl)
  • diphenhydramine (Benadryl)
  • doxepin (Silenor)
  • fesoterodine (Toviaz)
  • hydroxyzine (Atarax, Vistaril)
  • hyoscyamine (Anaspaz, Levbid, Levsin)
  • imipramine (Tofranil)
  • meclizine (Antivert)
  • nortriptyline (Pamelor)
  • olanzapine (Zyprexa)
  • orphenadrine (Norflex)
  • oxybutynin (Ditropan, Oxytrol)
  • paroxetine (Brisdelle, Paxil, Pexeva)
  • perphenazine
  • prochlorperazine (Compazine)
  • promethazine (Phenergan)
  • solifenacin (Vesicare)
  • trospium
  • tolterodine (Detrol)
  • glycopyrrolate (Robinul)
  • scopolamine (Transderm-Scop)
  • atropine

Taking these drugs with darifenacin may raise your risk of side effects. These include dry mouth, constipation, urinary retention, and blurred vision.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
urination problems
People with urination problems

If you have trouble emptying your bladder or if you have a weak urine stream (urinary retention), this drug may make your condition worse. You shouldn’t take this drug if you have urinary retention.

delayed emptying of the stomach
People with delayed emptying of the stomach

If you have gastric retention (also called gastroparesis), you should not use this drug.

eating or digestion problems
People with certain eating or digestion problems

If you have any stomach or intestinal problems, this drug may make your condition worse. You should talk to your doctor before using this drug if you have severe constipation, ulcerative colitis, or myasthenia gravis.

glaucoma
People with narrow-angle glaucoma

If you have an eye problem called narrow-angle glaucoma, this drug may make your condition worse. You shouldn’t use this drug if you have uncontrolled glaucoma.

liver problems
People with liver problems

This drug is processed by your liver. If you have liver problems, more of the drug may stay in your body longer, putting you at risk for side effects. If your liver problems are severe, you shouldn’t take this drug.

pregnant women
Pregnant women

This drug is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Tell your doctor if you’re pregnant or plan to become pregnant. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

breastfeeding
Women who are breast-feeding

It isn’t known if this drug passes into breast milk. If it does, it may cause negative effects in a child who is breastfed.  

You and your doctor may need to decide if you’ll take this drug or breastfeed.

for children
For children

The safety and effectiveness of this drug in children under 18 years of age hasn’t been established.

call doctor
When to call the doctor

If your symptoms (such as a strong need to urinate right away or often) don’t improve after 2 weeks of taking this drug, call your doctor. They may increase your dose.

allergies
Allergies

This drug may cause serious allergic reaction. Symptoms include:

  • swelling of your face, mouth, or tongue
  • trouble breathing

Don’t take this drug again if you’ve ever had an allergic reaction to it before. Taking it a second time after an allergic reaction to it could be fatal.

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How to Take darifenacin (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Overactive bladder

Brand: Enablex

Form: Oral extended-release tablet
Strengths: 7.5 mg, 15 mg
Adult dosage (ages 18 years and older)

The recommended starting dose is 7.5 mg taken by mouth once per day. If this dose isn’t working well enough to decrease your symptoms after 2 weeks, your doctor may increase your dose to 15 mg taken once per day.

Child dosage (ages 0-17 years)

This medicine hasn’t been studied in children and shouldn’t be used in children under the age of 18 years.

Special considerations

Liver problems: If you have moderate liver disease, your dose shouldn’t be greater than 7.5 mg taken once per day. If you have severe liver disease, you shouldn’t take this drug at all.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with serious risks if you don’t take it as prescribed.

If you don’t take it at all or if you skip or miss doses

If you don’t take this drug at all or skip or miss doses, your overactive bladder symptoms may get worse. You may have a strong need to urinate, with leaking or wetting accidents, or a need to urinate more often.

What to do if you miss a dose

If you forget to take your dose, take it as soon as you remember. If it’s just a few hours before the time for your next dose, wait and only take one dose at that time. Never try to catch up by taking two doses at once. This could cause toxic side effects.

If you take too much

You may have the following symptoms:

  • feelings of warmth and reddening of your face (flushing)
  • a very fast heart rate
  • being unable to urinate
  • extreme sleepiness
  • severe confusion
  • hallucinations

If you think that you’ve taken too much of this drug, call your doctor or go to the emergency room right away.

How to tell the drug is working

You can tell if this drug is working if your symptoms of overactive bladder improve. You may no longer have a strong need to urinate or a need to urinate more often.

This drug is used for long-term treatment.

Store this drug at room temperature at 77°F (25°C)

It can be kept at a range between 59°F (15°C) and 86°F (30°C) for short periods.

Keep this drug away from light.

Keep your drugs away from areas where they could get wet, such as bathrooms. Store this drug away from moisture and damp locations.

A prescription for this medication is refillable

You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

  • Always carry your medication with you in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt this medication.
  • You may need to show airport staff your pharmacy’s label to clearly identify this medication. Keep the original prescription label with you when traveling.
  • Don’t leave this medicine in the car, especially when the temperature is hot or freezing.

Clinical monitoring

Before starting and during your treatment with this drug, your doctor may check your:

  • liver function. These blood tests will help your doctor decide if this drug is safe for you to start and if you need a lower dose.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for this drug.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.


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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on August 10, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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