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Generic Name:

dapagliflozin, Oral tablet

All Brands

  • Farxiga
SECTION 1 of 5

Highlights for dapagliflozin

Oral tablet
1

Dapagliflozin propanediol is an oral medication used with diet and exercise to treat type 2 diabetes.

2

Dapagliflozin propanediol may cause dehydration. Symptoms of dehydration include dizziness, feeling faint, lightheadedness, or weakness, especially when you stand up.

3

Some people who have taken dapagliflozin propanediol have developed bladder cancer. There isn’t enough information to know if this drug is the cause. It also isn’t known how this drug might affect people with existing bladder cancer. Until more is known, don’t take this drug if you have bladder cancer.

4

Use of dapagliflozin propanediol with insulin and medications that boost your insulin level can increase your risk of low blood sugar levels (hypoglycemia). Your doctor may lower your dose of other diabetes medications if you add dapagliflozin propanediol.

5

Common side effects of this drug include increased risk of genital infections, urinary tract infection, and increased urination.

IMPORTANT INFORMATION

Dehydration

This drug may cause you to become dehydrated. Symptoms of dehydration include:

  • dizziness
  • feeling faint
  • lightheadedness
  • weakness, especially when you stand up

Genital infections

Use of this drug can increase your risk of genital infections. You’re at a greater risk if you have a history of these infections or if you’re an uncircumcised male.

Bladder cancer

Don’t take this drug if you have bladder cancer. This drug may make it worse. This drug may also increase your risk of bladder cancer. Tell your doctor right away if you’re taking this drug and have any of the following symptoms:

  • blood or red color in your urine
  • pain while you urinate

Ketoacidosis

This drug may cause diabetic ketoacidosis. This is a serious complication of diabetes. It happens when your body makes high levels of the blood acids called ketones. This condition should be treated with insulin. If you develop ketoacidosis, your doctor may have you stop taking this drug temporarily or permanently.

What is dapagliflozin/propanediol?

This drug is a prescription drug. It’s available as an oral tablet.

This drug is only available as the brand-name drug Farxiga. It isn’t available as a generic drug.

This drug may be used as part of a combination therapy. That means you need to take it with other drugs.

Why it's used

This drug, when combined with lifestyle changes (diet, exercise, quitting smoking) and sometimes other medications, can help lower your blood sugar level. This helps to control your type 2 diabetes.

How it works

This drug belongs to a class of drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors. A class of drugs refers to medications that work similarly. They’re often used to treat similar conditions. This drug lowers your blood sugar level by causing the kidneys to get rid of excess sugar through your urine.

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SECTION 2 of 5

dapagliflozin Side Effects

Oral tablet

More Common Side Effects

The most common side effects that occur with dapagliflozin propanediol include:

  • infections

    • yeast infections of the vagina
    • yeast infections of the penis
    • infections of the urinary tract
  • changes in urination

    • urge to urinate often
    • urge to urinate at night
  • stuffy or runny nose and sore throat

If these effects are mild, they may disappear within a few days or a couple of weeks. If they’re more severe or don’t disappear, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • dehydration. Symptoms may include:

    • dizziness
    • feeling faint
    • lightheadedness
    • weakness, especially when you stand up
  • yeast infection. Symptoms in women may include:

    • vaginal odor
    • white or yellowish vaginal discharge
    • vaginal itching

    Symptoms in men may include:

    • redness, itching, or swelling of the penis
    • rash of the penis
    • foul-smelling discharge from the penis
    • pain in the skin around the penis
  • low blood sugar (hypoglycemia). Symptoms may include:

    • drowsiness
    • headache
    • confusion
    • weakness
    • hunger
    • irritability
    • sweating
    • feeling jittery
    • fast heartbeat
  • kidney problems

  • increased cholesterol levels. If you already have high cholesterol, your doctor will monitor your cholesterol closely.

Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug doesn’t cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

dapagliflozin May Interact with Other Medications

Oral tablet

Dapagliflozin propanediol can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist. 

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Alcohol interaction

Avoid drinking too much alcohol. Alcohol can change blood sugar levels and result in increased risk of low blood sugar.

Medications that might interact with this drug

Insulin or drugs that cause the release of insulin
  • chlorpropamide
  • glipizide
  • glimepiride
  • glyburide
  • tolbutamide
  • tolazamide
  • repaglinide
  • nateglinide

When you take dapagliflozin propanediol with these drugs, your blood sugar level can get too low (hypoglycemia). 

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
kidney disease
People with kidney disease

This medication could cause kidney damage. If your kidney function decreases, your doctor may have you stop taking this drug. Don’t take this medication if you have severe kidney disease or if you’re on dialysis.

bladder cancer
People with bladder cancer

Some people who have taken this drug have developed bladder cancer. There isn’t enough information to know if this drug is the cause. It also isn’t known if it affects existing bladder cancer. Until more is known, don’t take this drug if you have bladder cancer.

high cholesterol
People with high cholesterol

This medication can increase your cholesterol levels. If you already have high cholesterol, your doctor will monitor your cholesterol closely.

pregnant women
Pregnant women

This drug is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

If you’re pregnant, talk with your doctor about the best way to control your blood sugar while you’re pregnant. Tell your doctor right away if you become pregnant during treatment with this drug.

breastfeeding
Women who are breast-feeding

It isn’t known if this drug passes through breast milk. You and your doctor should decide if you’ll take this drug or breastfeed.

for seniors
For seniors

People aged 65 years or older may be at an increased risk of low blood pressure, low blood pressure when standing, dizziness, fainting, dehydration, and kidney problems if you take this drug.

allergies
Allergies

This drug can cause a severe allergic reaction. Symptoms may include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal.

SECTION 4 of 5

How to Take dapagliflozin (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Type 2 diabetes

Brand: Farxiga

Form: Oral tablet
Strengths: 5 mg, 10 mg
Adult dosage (ages 18–64 years)
  • Typical starting dose: Your initial dose is 5 mg taken once per day in the morning.
  • Dose increases: Your dose may be increased to 10 mg per day if your blood sugar level is still not controlled with the 5-mg dose.
Child dosage (ages 0–17 years)

Dosage for people younger than 18 years old hasn’t been established.

Senior dosage (ages 65 years and older)

Your body may process this drug more slowly. Your doctor may start you on a lower dose so that too much of this drug doesn’t build up in your body. Too much of the drug in your body can be toxic.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with serious risks if you don't take it as prescribed.

If you don't take it at all

If you don’t take it, your blood sugar levels may not be controlled.

If you stop taking it suddenly

If your condition improved while taking the medication regularly and you stop taking this drug suddenly, your symptoms of type 2 diabetes may return.

If you don't take it on schedule

You may not get the full benefit of this medication.

If you take too much

If you take too much, your blood sugar levels may drop too low.

What to do if you miss a dose

If you forget to take your dose, take it as soon as you remember, unless you remember just a few hours before your next dose. Then only take one dose. Never try to catch up by taking two doses at once. This could result in toxic side effects.

How to tell if the drug is working

Your blood sugar level will decrease and stay in the normal range.

This drug is used for long-term treatment.

Important considerations for taking this drug

Store this drug in temperatures from 68–77°F (20–25ºC)

When travelling, this medication can be stored in temperatures from 59–86°F (15–30ºC).

Keep it away from light and high temperature.

Keep your drugs away from areas where they could get wet, such as bathrooms. Store these drugs away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry your medication with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines; they can’t hurt your medication.
  • You may need to produce your pharmacy’s preprinted label clearly identifying the medication. Keep the original pharmacy prescription-labeled box when traveling.
  • Don’t put this medicine in your glove compartment or leave it in the car, especially when the temperature is hot or freezing.

Self-management

You may need to check your blood sugar level at home.

You may need to learn how to use a blood sugar level monitoring system.

Clinical monitoring

Your doctor may do tests during treatment to check your:

  • blood sugar level
  • hemoglobin A1c level. This shows how well controlled your blood sugar levels have been over the past 3 months.
  • cholesterol level
  • electrolyte level
  • red blood cell count
  • kidney function

Your doctor may also monitor your blood pressure level and check for signs of a genital infection.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for this drug.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

SECTION 5 of 5

How Much Does dapagliflozin Cost?

Oral tablet

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These prices represent the lowest priced national pharmacies for dapagliflozin on GoodRx. They may be lower than your insurance.

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on July 8, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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