Generic Name: cyclophosphamide, Oral tablet

Generic Name:

cyclophosphamide, Oral tablet

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SECTION 1 of 5

Highlights for cyclophosphamide

Oral tablet
1
CYCLOPHOSPHAMIDE (sye kloe FOSS fa mide) is a chemotherapy drug. It slows the growth of cancer cells. This medicine is used to treat many types of cancer like lymphoma, myeloma, leukemia, breast cancer, and ovarian cancer, to name a few. It is also used to treat nephrotic syndrome in children.
2 3 4
Talk to your healthcare provider if you have any of these conditions.
5
Know what to watch for and get tips for reducing your risks while taking this drug.
SECTION 2 of 5

cyclophosphamide Side Effects

Oral tablet

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • low blood counts - this medicine may decrease the number of white blood cells, red blood cells and platelets. You may be at increased risk for infections and bleeding.
  • signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine
  • signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine
  • signs of decreased red blood cells - unusually weak or tired, fainting spells, lightheadedness
  • breathing problems
  • dark urine
  • dizziness
  • palpitations
  • swelling of the ankles, feet, hands
  • trouble passing urine or change in the amount of urine
  • weight gain
  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • changes in nail or skin color
  • hair loss
  • missed menstrual periods
  • mouth sores
  • nausea, vomiting
SECTION 3 of 5

cyclophosphamide May Interact with Other Medications

Oral tablet

This medicine may interact with the following medications:

  • amiodarone
  • amphotericin B
  • azathioprine
  • certain antiviral medicines for HIV or AIDS such as protease inhibitors (e.g., indinavir, ritonavir) and zidovudine
  • certain blood pressure medications such as benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, monopril, perindopril, quinapril, ramipril, trandolapril
  • certain cancer medications such as anthracyclines (e.g., daunorubicin, doxorubicin), busulfan, cytarabine, paclitaxel, pentostatin, tamoxifen, trastuzumab
  • certain diuretics such as chlorothiazide, chlorthalidone, hydrochlorothiazide, indapamide, metolazone
  • certain medicines that treat or prevent blood clots like warfarin
  • certain muscle relaxants such as succinylcholine
  • cyclosporine
  • etanercept
  • indomethacin
  • medicines to increase blood counts like filgrastim, pegfilgrastim, sargramostim
  • medicines used as general anesthesia
  • metronidazole
  • natalizumab
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
SECTION 4 of 5

How to Use cyclophosphamide

Oral tablet

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush or chew this medicine. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • blood disorders
  • infection
  • kidney disease
  • liver disease
  • recent or ongoing radiation therapy
  • an unusual or allergic reaction to cyclophosphamide, other chemotherapy, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What should I watch for while using this medicine?

Visit your doctor for checks on your progress. This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Drink water or other fluids as directed. Urinate often, even at night.

In some cases, you may be given additional medicines to help with side effects. Follow all directions for their use.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you.

Do not become pregnant while taking this medicine or for 1 year after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 4 months after stopping it. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

This medicine may interfere with the ability to have a child. This medicine has caused ovarian failure in some women. This medicine has caused reduced sperm counts in some men. You should talk with your doctor or health care professional if you are concerned about your fertility.

If you are going to have surgery, tell your doctor or health care professional that you have taken this medicine.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature at or below 25 degrees C (77 degrees F). This medicine can be stored at room temperatures of up to 30 degrees C (86 degrees F) for a short time. Protect from temperatures above 30 degrees C (86 degrees F). Throw away any unused medicine after the expiration date.

SECTION 5 of 5

How Much Does cyclophosphamide Cost?

Oral tablet
We've partnered with GoodRX so you can compare prices and save money on your next prescription. Check out the lowest cash prices below and enter your zip code to find the best deal near you.

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Lowest price for cyclophosphamide

Walmart $330.05
Sams Club $330.05
Membership warehouse $331.30
These represent the lowest cash prices for cyclophosphamide and may be lower than your insurance.

Find the lowest prices of cyclophosphamide near you

These represent the lowest cash prices for cyclophosphamide and may be lower than your insurance.

Last Updated: November 1, 2013

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