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Generic Name:

cobicistat, Oral tablet

All Brands

  • TYBOST
SECTION 1 of 5

Highlights for cobicistat

Oral tablet
1

Cobicistat is an oral tablet used to increase the effectiveness of the human immunodeficiency virus (HIV) drugs atazanavir and darunavir. It slows down how fast these drugs leave your body.

2

Cobicistat comes in a 150-mg tablet. A dose of cobicistat is usually taken once per day with food.

3

Cobicistat can lead to many possible drug interactions. Always talk to your doctor and pharmacist about all of the drugs you take.

4

If you have reduced kidney function, it’s recommended that you not take cobicistat with the HIV medication tenofovir disoproxil fumarate. If you currently take tenofovir, talk to your doctor before taking cobicistat.

5

Common side effects include nausea and yellowing of your skin or whites of your eyes.

IMPORTANT INFORMATION

Drug combination warning

Cobicistat isn’t safe to use with all human immunodeficiency virus (HIV) combination drugs or drug combination therapies. This is because it slows down how fast your body can remove these drugs. This could lead to a buildup of the drugs in your body, which could be harmful.

Tenofovir disoproxil fumarate warning

It’s not recommended to take this drug with tenofovir disoproxil fumarate if you have decreased kidney function. Taking the two drugs together can lead to a buildup of the drug in your body and increase your risk of kidney failure. Symptoms of kidney failure include swelling of your feet and legs, reduced urination, shortness of breath, and confusion.

What is cobicistat?

Cobicistat is a prescription drug. It is available in these forms: oral tablet.

Cobicistat is used as part of a combination therapy. That means you will need to take it in combination with other drugs.

Why it's used

Cobicistat is used in combination with the HIV drugs atazanavir (Reyataz) and darunavir (Prezista).

More Details

How it works

Cobicistat is used to extend the amount of time certain HIV drugs stay in your body.

More Details

Why it's used

Cobicistat is used in combination with the HIV drugs atazanavir (Reyataz) and darunavir (Prezista). It works to slow down how fast your body removes these drugs. This makes it so that you only have to take the drugs once per day rather than twice per day.

How It Works

Cobicistat is used to extend the amount of time certain HIV drugs stay in your body.

Cobicistat is a CYP3A inhibitor. CYP3A is an enzyme in your body that breaks down cobicistat and certain HIV drugs. When the enzyme breaks down cobicistat, it doesn’t break down the other HIV drugs as well. This causes the HIV drugs to stay in your body longer, which can make them more effective.

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SECTION 2 of 5

cobicistat Side Effects

Oral tablet

More Common Side Effects

The most common side effects that occur with cobicistat include:

  • yellowing skin

  • yellow whites of your eyes

  • nausea

These side effects should disappear within a week or two. Call your doctor if they don’t go away or become more severe.

Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Cobicistat does not cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

cobicistat May Interact with Other Medications

Oral tablet

Cobicistat can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications that might interact with this drug

Acid-reducing drugs

These drugs are sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking these drugs before you take cobicistat:

  • famotidine (Pepcid)
  • omeprazole (Prilosec)

Angina drug

Be sure to tell your doctor if you’re taking this drug before you take cobicistat:

  • ranolazine (Ranexa)

Antacid

This drug is sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking this drug before you take cobicistat:

  • aluminum and magnesium hydroxide

Antibiotics

This drug should not be taken with cobicistat:

  • rifampin (Rifadin, Rifamate)

These drugs are sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking these drugs before you take cobicistat:

  • clarithromycin (Biaxin)
  • erythromycin
  • rifabutin (Mycobutin)
  • telithromycin (Ketek)

Antidepressants

These drugs are sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking these drugs before you take cobicistat:

  • amitriptyline (Elavil)
  • desipramine  
  • imipramine (Tofranil)
  • nortriptyline
  • paroxetine (Paxil)
  • trazodone (Desyrel)

Antifungal drugs

These drugs are sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking these drugs before you take cobicistat:

  • ketoconazole
  • itraconazole (Sporanox)
  • voriconazole (Vfend)

Antipsychotic drug

Be sure to tell your doctor if you’re taking this drug before you take cobicistat:

  • lurasidone (Latuda)

Asthma and allergy drugs (inhaled)

These drugs are sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking these drugs before you take cobicistat:

  • budesonide (Pulmocort)
  • fluticasone (Flonase, Flovent, Veramyst))
  • salmeterol (Serevent)

Blood thinner (anticoagulant)

These drugs are sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking these drugs before you take cobicistat:

  • rivaroxaban (Xarelto)
  • warfarin (Coumadin)

Chemotherapy drugs (to treat cancer)

This drug should not be taken with cobicistat:

  • Irinotecan (Camptosar). Do not take Irinotecan if you are taking atazanavir along with cobicistat.

These drugs are sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking these drugs before you take cobicistat:

  • dasatinib
  • nilotinib
  • vinblastine
  • vincristine

Cholesterol-lowering drugs

These drugs should not be taken with cobicistat:

  • lovastatin (Mevacor)
  • simvastatin (Zocor)

These drugs are sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking these drugs before you take cobicistat:

  • atorvastatin (Lipitor)
  • rosuvastatin (Crestor)

Enlarged prostate (BPH) drug

This drug should not be taken with cobicistat:

  • alfuzosin (Uroxatral)

Epilepsy drugs

These drugs are sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking these drugs before you take cobicistat:

  • carbamazepine (Tegretol)
  • clonazepam (Klonopin)
  • oxcarbazepine (Trileptal)
  • phenobarbital    
  • phenytoin (Dilantin)

Erectile dysfunction drugs

These drugs are sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking these drugs before you take cobicistat:

  • avanafil (Stendra)
  • sildenafil (Viagra)
  • tadalafil (Cialis)
  • vardenafil (Levitra)

Gastrointestinal motility drug (increase stomach emptying)

This drug should not be taken with cobicistat:

  •  cisapride (Propulsid)

Gout drug

This drug is sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking this drug before you take cobicistat:

  • colchicine (Colcrys)

Heart drugs

This arrhythmia drug should not be taken with cobicistat:

  • dronedarone (Multaq)

These drugs are sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking these drugs before you take cobicistat:

  • amiodarone (Cordarone)
  • amlodipine (Norvasc)
  • digoxin (Lanoxin)
  • diltiazem (Cardizem)
  • disopyramide
  • felodipine (Plendil)
  • flecainide
  • mexiletine
  • nifedipine
  • propafenone (Rythmol)
  • quinidine
  • verapamil

Hepatitis C drugs

These drugs are sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking these drugs before you take cobicistat:

  • boceprevir (Victrelis)
  • simeprevir (Olysio)
  • telaprevir (Incivek)

Herbal supplement

This supplement should not be taken with cobicistat:

  • St. John’s wort

Human immunodeficiency virus (HIV) drugs

These drugs should not be taken with cobicistat:

  • indinavir (Crixivan). Do not take Indinavir if you’re taking atazanavir along with cobicistat.
  • nevirapine (Viramune). Do not take nevirapine if you’re taking atazanavir along with cobicistat.

These drugs are sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking these drugs before you take cobicistat:

  • efavirenz (Sustiva)
  • etravirine (Intelence)
  • maraviroc (Selzentry)
  • nevirapine (Viramune)

It is not recommended to take cobicistat with:

  • more than one HIV protease inhibitor or an HIV protease inhibitor and elvitegravir (Vitekta)
  • protease inhibitor medicines, except for atazanavir (Reyataz) or darunavir (Prezista) when taken once a day. Do not take with:
    • fosamprenavir (Lexiva)
    • indinavir (Crixivan)
    • nelfinavir (Viracept)
    • ritonavir (Norvir)
    • saquinavir (Invirase)
  • other medicines that contain cobicistat (Stribild)
  • ritonavir (Norvir) or medicines that contain ritonavir, such as lopinavir/ritonavir (Kaletra)

Hormones

These drugs are sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking these drugs before you take cobicistat:

  • progestin/estrogen and other hormone-based oral contraceptives, hormonal intrauterine device, skin patches, or vaginal rings

Hypertension drugs (beta blockers)

These drugs are sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking these drugs before you take cobicistat:

  • metoprolol (Toprol)
  • carvedilol
  • timolol

Migraine drugs with ergotamine

These drugs should not be taken with cobicistat:

  • dihydroergotamine (D.H.E. 45, Migranal)
  • ergotamine (Cafergot, Ergomar)
  • methylergonovine

Neuroleptics (used to treat mental health problems)

These drugs are sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking these drugs before you take cobicistat:

  • perphenazine
  • risperidone (Risperdal)
  • thioridazine

Pain drugs

These drugs are sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking these drugs before you take cobicistat:

  • buprenorphine
  • buprenorphine/naloxone
  • fentanyl
  • methadone
  • tramadol

Post-transplant drugs (immunosuppressants)

These drugs are sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking these drugs before you take cobicistat:

  • cyclosporine (Gengraf, Neoral)
  • everolimus (Afinitor)
  • tacrolimus (Prograf)
  • sirolimus (rapamycin)

Pulmonary arterial hypertension drug

This drug should not be taken with cobicistat:

  • sildenafil (Revatio) Note: This is the 5-mg or 20-mg sildenafil strength, which is taken 3 times per day.

This drug is sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking this drug before you take cobicistat:

  • bosentan (Tracleer)

Sleeping medications

These drugs should not be taken with cobicistat:

  • oral midazolam (Versed)
  • triazolam (Halcion)

These drugs are sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking these drugs before you take cobicistat:

  • buspirone (Buspar)
  • diazepam (Valium)
  • midazolam—when given intravenously

Steroid

This drug is sometimes taken with cobicistat with dose adjustments. Tell your doctor if you’re taking this drug before you take cobicistat:

  • dexamethasone (Decadron)

Tourette syndrome drug

This drug should not be taken with cobicistat:

  • pimozide (Orap) 

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
pregnant women
Pregnant women

Cobicistat is a pregnancy category B drug. That means two things:

  1. Studies of the drug in pregnant animals have not shown risk to the fetus.
  2. There aren’t enough studies done in pregnant women to show the drug poses a risk to the fetus.

This drug should be used in pregnancy only if the potential benefit outweighs the potential risk to the fetus.

breastfeeding
Women who are nursing

According to the U.S. Department of Health and Human Services, you shouldn’t breastfeed your infant if you have an HIV infection. There’s a risk of passing HIV to your baby. Additionally, It isn’t known if this drug passes through breast milk.

seniors
For Seniors

Seniors are more likely to have reduced kidney or liver function. If you’re an older adult, your doctor may monitor you more closely while you take this drug.

telephone
When to call the doctor

Call your doctor if you experience:

  • fever
  • weakness
  • chills
  • night sweats
  • sore throat
  • joint pain

These symptoms may be a sign the drug isn’t working, and you may need a different treatment.

Allergies
Allergies

Allergic reactions to this drug are usually limited to a rash. See a doctor right away if you experience a severe rash, breathing problems, hives, or a fever.

SECTION 4 of 5

How to Take cobicistat (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Human immunodeficiency virus (HIV) infection

Brand: Tybost

Form: Oral Tablet
Strength: 150 mg
Adult Dosage (ages 18-64 years)
  • The dose is 150 mg taken once per day.
  • This medication is always taken in combination with certain human immunodeficiency virus (HIV) medications when they’re taken once per day.
Child Dosage (ages 0-17 years)

Dosage for people younger than 17 years hasn’t been established.

Senior Dosage (ages 65 years and older)

There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of the drug to be higher than normal. If you’re a senior, you may need a lower dose or you may need a different schedule.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Keeping an HIV infection under control requires lifelong treatment. There can be serious health consequences if you don’t take this drug exactly how your doctor tells you.

If You Don’t Take It at All

If you don’t take it at all, your HIV infection will eventually reduce your immunity so much that won’t be able to defend itself against many types of infections. You may not be able to defend against infections that are commonly cured in people who don’t have HIV infection.

If You Stop or Miss Doses

If you stop taking this medication, miss doses, or don’t take it on schedule, the amount of medication in your body fluctuates. This can allow the HIV in your body to become resistant to the drug, which means the drug stops working.

If You Don’t Take It on Schedule

Taking your drug at the same time every day keeps a constant amount of the drug in your body. This helps make the drug as effective as possible at keeping the virus under control.

What to Do if You Miss a Dose

In most cases, if you miss a dose, take it as soon as you remember. However, if it's just a few hours until your next dose, wait and take a single dose at the usual time.

Take just one dose at a time. Never try to catch up by taking two tablets at once. This could result in toxic side effects.

How Can I Tell if the Drug Is Working?

To see how well your treatment is working, your doctor will check your:

  • virus count. The virus count measures the number of copies of HIV in your body. A decreased virus count is a sign that your treatment is working.
  • CD4 cell count. A CD4 cell count measures the number of CD4 cells in your body. CD4 cells are white blood cells that fight infection. An increased CD4 cell count is a sign that your treatment is working.

Cobicistat is a long-term drug treatment.

Important considerations for taking this drug
take with food
Cobicistat should be taken with food
clock
Take this drug at the same time every day for the best effect
do not crush
The tablets are film-coated and can’t be cut or crushed
storage
Store cobicistat at 77°F (25°C)
See Details
not refillable prescription
Product is not refillable
clinical monitoring
Clinical Monitoring
See Details
not usually stocked
Not every pharmacy stocks this drug, so call ahead
See Details
prior authorization needed
Insurance
See Details

Store cobicistat at 77°F (25°C)

You can store it briefly in temperatures as low as 59°F (15°C) and as high as 86°F (30°C).

Keep this drug in its original container and keep it tightly closed. Don’t use it if the seal over the bottle is broken or missing.

Note: Be careful of moist environments, including bathrooms. To keep drugs away from moisture, store them somewhere other than your bathroom and any other damp location.

Clinical Monitoring

Your doctor may check your kidney function with urine and blood tests before you start taking cobicistat. They may decide not to give you cobicistat if you have reduced kidney function.

If you take cobicistat with tenofovir disoproxil fumarate, you may need extra urine tests to check your glucose and protein levels before you start taking tenofovir. Your doctor may occasionally check your kidney function and do these additional urine tests while you take the two drugs together. You may also have a blood test for phosphorus while taking this combination.

Not every pharmacy stocks this drug, so call ahead

If you run out of it or are traveling and need just a few tablets, you may not be able to have a partial prescription filled. Call the pharmacy and ask before you go.

This drug is often available from specialty pharmacies through your insurance plan. These pharmacies operate like mail order pharmacies and ship the drug to you.

In larger cities, there will often be HIV pharmacies where you can have your prescriptions filled. Ask your doctor if there's an HIV pharmacy in your area.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for cobicistat.

SECTION 5 of 5

How Much Does cobicistat Cost?

Oral tablet

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Lowest price for cobicistat

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Kroger Pharmacy $200.22
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These prices represent the lowest priced national pharmacies for cobicistat on GoodRx. They may be lower than your insurance.

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These prices represent the lowest priced national pharmacies for cobicistat on GoodRx. They may be lower than your insurance.

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Content developed in collaboration with Susan J. Bliss, RPh, MBA

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on September 15, 2016

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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