Generic Name: clozapine, Oral tablet

Clozaril

All Brands

  • Clozaril
SECTION 1 of 4

Highlights for clozapine

Oral tablet
1
CLOZAPINE (KLOE za peen) is used to treat schizophrenia. This medicine is only used when others have not worked. It has a risk of serious side effects and is only available through a monitoring and dispensing system that includes special doctors, pharmacists, and laboratories. For the first few months of treatment, you will be required to have routine blood testing before your prescription can be refilled.
2
This drug also comes in other forms, including Oral SuspensionOrally disintegrating solid
3 4 5
Talk to your healthcare provider if you have any of these conditions.
6
Know what to watch for and get tips for reducing your risks while taking this drug.
SECTION 2 of 4

clozapine Side Effects

Oral tablet

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • changes in vision
  • chest pain, fast or irregular heartbeat
  • confusion
  • difficulty sleeping, nightmares
  • excessive thirst and/or hunger
  • feeling faint or lightheaded, falls
  • fever, chills, sore throat, or mouth sores
  • muscle and joint aches and pains
  • nausea, vomiting, or severe loss of appetite
  • restlessness
  • seizures
  • shortness of breath, chest pain, swelling in a leg
  • stiffness, spasms, trembling
  • trouble passing urine or change in the amount of urine
  • trouble with balance, talking, walking
  • uncontrollable tongue or chewing movements, smacking lips or puffing cheeks
  • unusually weak or tired
  • yellowing of the eyes, skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation
  • dry mouth
  • headache
  • increased watering of the mouth, drooling
  • weight gain
SECTION 3 of 4

clozapine May Interact with Other Medications

Oral tablet

Do not take this medicine with any of the following medications:

  • certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole
  • certain medicines for cancer
  • cisapride
  • dofetilide
  • dronedarone
  • medicines that lower your chance of fighting infection
  • mesoridazine
  • metoclopramide
  • pimozide
  • quinidine
  • thioridazine
  • ziprasidone

This medicine may also interact with the following medications:

  • alcohol
  • antihistamines for allergy, cough, and cold
  • atropine
  • birth control pills
  • caffeine
  • certain antibiotics like ciprofloxacin, erythromycin, mefloquine, moxifloxacin, pentamidine, rifabutin, rifampin
  • certain medicines for bladder problems like oxybutynin, tolterodine
  • certain medicines for blood pressure
  • certain medicines for depression, anxiety, or psychotic disturbances
  • certain medicines for irregular heart beat like amiodarone, encainide, flecainide, propafenone, sotalol
  • certain medicines for Parkinson's disease like benztropine, trihexyphenidyl
  • certain medicines for seizures
  • certain medicines for sleep
  • certain medicines for stomach problems like cimetidine, dicyclomine, dolasetron, hyoscyamine
  • certain medicines for travel sickness like scopolamine
  • ipratropium
  • lithium
  • methadone
  • nicotine
  • other medicines that prolong the QT interval (cause an abnormal heart rhythm)
  • skeletal muscle relaxants
  • St. John's Wort
  • tacrolimus
  • terbinafine
SECTION 4 of 4

How to Use clozapine

Oral tablet

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. This medicine may be taken with or without food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not suddenly stop taking this medicine. You may need to gradually reduce the dose. Only stop taking this medicine on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • being treated for cancer
  • blood disease or disorder, like leukemia
  • cigarette smoker
  • constipation, fecal impaction, or a history of an obstruction of the intestine
  • dementia
  • diabetes
  • heart disease
  • history of irregular heartbeat
  • kidney disease
  • liver disease
  • low blood counts, like low white cell, platelet, or red cell counts
  • low levels of potassium or magnesium in the blood
  • lung or breathing disease, like asthma
  • Parkinson's disease
  • seizures
  • an unusual or allergic reaction to clozapine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. If you miss your medicine for more than 2 days, you should not restart your medicine at the same dose. Contact your doctor for instructions.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. It may be several weeks before you see the full effects of this medicine. Contact your doctor or health care professional if your symptoms get worse or if you have new symptoms.

You must have a weekly blood test when you first begin this medicine. If your blood counts stay in the right range, your tests may be reduced after 6 months to every other week. Your name will go on a national registry of patients that take this medicine, to make sure that you have never had a serious reaction to it.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.

Do not treat yourself for colds, fever, diarrhea or allergies. Ask your doctor or health care professional for advice, some nonprescription medicines may increase possible side effects.

If you notice an increased hunger or thirst, different from your normal hunger or thirst, or if you find that you have to urinate more frequently, you should contact your health care provider as soon as possible. You may need to have your blood sugar monitored. This medicine may cause changes in your blood sugar levels. You should monitor you blood sugar frequently if you have diabetes.

If you smoke, tell your doctor if you notice this medicine is not working well for you. Talk to your doctor if you are a smoker or if you decide to stop smoking.

If you are going to have surgery tell your doctor or health care professional that you are taking this medicine.

This medicine can reduce the response of your body to heat or cold. Dress warm in cold weather and stay hydrated in hot weather. If possible, avoid extreme temperatures like saunas, hot tubs, very hot or cold showers, or activities that can cause dehydration such as vigorous exercise.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature below 30 degrees C (86 degrees F). Throw away any unused medicine after the expiration date.

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Last Updated: July 11, 2014

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