Generic Name:

cisapride, Oral tablet

All Brands

  • Propulsid (Discontinued)
A discontinued drug is a drug that has been taken off the market due to safety issues, shortage of raw materials, or low market demand.
SECTION 1 of 4

Highlights for cisapride

Oral tablet
CISAPRIDE (SIS a pride) is used to treat heartburn in patients with gastroesophageal reflux disease (GERD). Because of the serious risks associated with this medicine it should only be used when lifestyle changes and other medicines have not worked. This medicine in only available from your doctor, who must register with the drug company and meet certain criteria for the use of this drug. Cisapride has not been available in pharmacies since August 2000. For information, the manufacturer has provided the following toll-free number (877) 795-4247.
This drug also comes in other forms, including Oral Suspension
3 4 5
Talk to your healthcare provider if you have any of these conditions.
Know what to watch for and get tips for reducing your risks while taking this drug.
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cisapride Side Effects

Oral tablet

Side effects that you should report to your doctor or health care professional as soon as possible:

  • breathing problems
  • fainting or falling spells
  • rapid or irregular heartbeat
  • unusually weak or tired
  • vomiting

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea or constipation
  • headache
  • nausea
  • stomach pain
  • stuffy nose
SECTION 3 of 4

cisapride May Interact with Other Medications

Oral tablet

Do not take this medicine with any of the following medications:

  • alfuzosin
  • antiviral medicines for HIV or AIDS
  • apomorphine
  • aprepitant
  • arsenic trioxide
  • certain antibiotics like ciprofloxacin, clarithromycin, dalfopristin;quinupristin, erythromycin, gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, norfloxacin, ofloxacin, pentamidine, sparfloxacin, telithromycin, troleandomycin
  • certain medicines for cancer like daunorubicin, doxorubicin, imatinib
  • certain medicines for depression, anxiety, or other psychotic disturbances like clozapine, haloperidol, pimozide, risperidone, ziprasidone
  • certain medicines for erectile dysfunction like sildenafil, tadalafil, vardenafil
  • certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole
  • certain medicines for irregular heart beat like amiodarone, disopyramide, bretylium, dofetilide, dronedarone, flecainide, ibutilide, procainamide, propafenone, quinidine, sotalol
  • chloroquine
  • cimetidine
  • conivaptan
  • cyclobenzaprine
  • cyclosporine
  • danazol
  • diltiazem
  • dolasetron
  • droperidol
  • ethinyl estradiol
  • general and local anesthetics
  • grapefruit juice
  • halofantrine
  • hawthorn
  • imatinib
  • isoniazid
  • methadone
  • mifepristone
  • nicardipine
  • octreotide
  • other medicines that prolong the QT interval (cause an abnormal heart rhythm)
  • palonosetron
  • phenothiazines like chlorpromazine, fluphenazine, mesoridazine, perphenazine, prochlorperazine, promethazine, thioridazine, trifluoperazine
  • quinine
  • ranolazine
  • sodium phosphates
  • tacrolimus
  • verapamil
  • zafirlukast
  • zileuton

This medicine may also interact with the following medications:

  • diuretics
  • insulin
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
SECTION 4 of 4

How to Use cisapride

Oral tablet

Take this medicine by mouth with a glass of water. Follow the directions on the label. Take this medicine on an empty stomach, at least 15 minutes before eating and at bedtime. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • eating disorder, like anorexia or bulimia
  • heart disease or heart failure
  • heart rhythm problems
  • heart valve problems
  • history of low levels of calcium, potassium, or magnesium
  • kidney disease
  • liver disease
  • lung disease
  • stomach bleeding, blockage, or ulceration
  • an unusual or allergic reaction to cisapride, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. For this medicine to work properly it is important to make lifestyle changes. Eat smaller meals, elevate the head of your bed 6 to 8 inches, avoid high-fat foods, chocolate, alcohol, smoking, caffeine and carbonated drinks.

If you have any fainting spells or rapid or irregular heartbeat, stop taking this drug immediately. Contact your health care professional right away for evaluation.

Do not drink grapefruit juice while you are taking this medicine. Grapefruit juice could increase your risk of having serious side effects from this medicine.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Throw away any unused medicine after the expiration date.

What does the pill look like?

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Last Updated: July 10, 2014

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