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Generic Name:

captopril-hydrochlorothiazide, Oral tablet

All Brands

  • Capozide (Discontinued)
A discontinued drug is a drug that has been taken off the market due to safety issues, shortage of raw materials, or low market demand.
SECTION 1 of 4

Highlights for captopril-hydrochlorothiazide

Oral tablet
1

Captopril/hydrochlorothiazide is a combination of two drugs in a single form that work in different ways to treat high blood pressure.

2

The standard starting dose for adults is one 25-mg captopril/15-mg hydrochlorothiazide tablet taken by mouth once per day.

3

You shouldn’t take this drug if you’re pregnant or plan to become pregnant. It can harm or be fatal to your unborn baby.

4

Captopril/hydrochlorothiazide can cause sudden swelling of your face, arms, legs, lips, tongue, throat, and intestines. Tell your doctor right away if you have swelling or abdominal pain.

5

Common side effects include dizziness, headache, minor skin rash, and cough.

IMPORTANT INFORMATION

FDA warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

Use during pregnancy warning. You shouldn’t take this drug if you’re pregnant or plan to become pregnant. It can harm or be fatal to your unborn baby. If you get pregnant while taking captopril/hydrochlorothiazide, tell your doctor right away.

Swelling

Captopril/hydrochlorothiazide can cause severe, sudden swelling of your face, arms, legs, lips, tongue, throat, and intestines (angioedema). This swelling can even be fatal. Tell your doctor right away if you have swelling or stomach pain. You may need to stop taking this drug, and you may need a medication for the swelling. This can happen at any time during treatment with captopril/hydrochlorothiazide.

Low blood pressure

Captopril/ hydrochlorothiazide can cause low blood pressure, especially during the first few days of starting treatment. Tell your doctor if you feel lightheaded or faint. Your risk may be higher if you:

  • aren’t drinking enough fluids
  • sweat heavily
  • have diarrhea or vomiting
  • have heart failure
  • are on dialysis
  • take water pills (diuretics)

Cough

Captopril/hydrochlorothiazide may make you have a dry cough. It will go away once you stop taking the medication.

What is captopril/hydrochlorothiazide?

Captopril/hydrochlorothiazide is a prescription drug. It’s available as an oral tablet.

Captopril/hydrochlorothiazide is available as a generic drug. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand. Talk to your healthcare provider to see if the generic will work for you. 

Captopril/hydrochlorothiazide is a combination of two drugs in a single form. It’s important to know about all the drugs in the combination because they each may have unique traits.

This drug may be used as part of a combination therapy. That means you need to take it with other drugs.

Why it's used

Captopril/hydrochlorothiazide is used to treat high blood pressure.

How it works

Captopril belongs to a class of drugs called angiotensin-converting enzyme (ACE) inhibitors.

More Details

How it works

Captopril belongs to a class of drugs called angiotensin-converting enzyme (ACE) inhibitors.  Hydrochlorothiazide belongs to a class of drugs called thiazide diuretics. A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

This medication works in different ways to lower your blood pressure:

  • Captopril works by helping your blood vessels relax and widen.
  • Hydrochlorothiazide works to remove excess salt and water from your body. This keeps your heart from working as hard to pump blood.

These actions together help to lower your blood pressure.

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SECTION 2 of 4

captopril-hydrochlorothiazide Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with captopril/hydrochlorothiazide include:

  • dizziness

  • headache

  • skin rash

  • dry cough

  • changes in how foods taste

  • itching

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

  • severe allergic reactions. Symptoms include:

    • trouble breathing or swallowing
    • chest tightness
    • hives
    • skin rash
    • swelling
    • itching
    • dizziness
    • vomiting
    • stomach pain
  • severe swelling. Symptoms include:

    • swelling of your face, lips, tongue, throat, arms, legs, or your whole body
  • low blood pressure. Symptoms include:

    • feeling faint or dizzy
    • lightheadedness
    • tiredness
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Captopril/hydrochlorothiazide doesn’t cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

captopril-hydrochlorothiazide May Interact with Other Medications

Oral tablet

Captopril-hydrochlorothiazide can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Alcohol interaction

The use of drinks that contain alcohol can increase your risk of a drop in blood pressure when you stand up from a sitting or lying position (orthostatic hypotension) caused by this drug. If you drink alcohol, talk to your doctor.

Medications that might interact with this drug

Barbiturates

These drugs can increase the effect of captopril/hydrochlorothiazide. You may have a higher risk of having low blood pressure when standing up from a sitting or lying position (orthostatic hypotension).

These drugs include:

  • amobarbital
  • butabarbital
  • butalbital
  • methohextal
  • pentobarbital
  • phenobarbital
  • secobarbital
  • thiopental

Blood pressure medications

These drugs can increase the effect of captopril/hydrochlorothiazide. This means that it may lower your blood pressure more. You may also have more side effects. Some blood pressure medications may also increase your potassium levels too much.

These drugs include:

  • aliskiren
  • angiotensin-converting enzyme (ACE) inhibitors, such as:  
    • benazepril
    • captopril
    • clizapril
    • enalapril
    • enalaprilat
    • fosniopril
    • imidapril
    • moexipril
    • perindopril
    • qunapril
    • ramipril
    • trandolapril
  • angiotensin receptor blockers (ARBs), such as:
    • irbesartan
    • losartan
    • olmesartan
    • telmisatan
    • valsartan
  • beta blockers, such as:
    • acebutolol
    • arotinolol
    • atenolol
    • betaxolol
    • bisoprolol
    • esmolol
    • metoprolol
    • nadolol
    • nebivolol
    • penbutolol
    • pindolol
    • propranolol
    • timolol (systemic)
  • calcium channel blockers, such as:
    • amlodipine
    • felodipine
    • nicardipine
    • nifedipine
  • loop diuretics, such as:
    • bumetanide
    • furosemide
    • indapamide
    • torsemide
  • potassium-sparing diuretics, such as:
    • eplerenone
    • spironolactone
    • triamterene
    • amiloride
  • thiazide diuretics, such as:
    • chlorothiazide
    • chlorthalidone
    • hydrochlorothiazide
    • methylclothiazide
    • metolazone

Cholesterol medications

These drugs can decrease how well captopril/hydrochlorothiazide is absorbed by your body. This means that it may not work as well to lower your blood pressure.

These drugs include:

  • cholestyramine
  • colestipol resins

Mood stabilizers

Taking these drugs with captopril/hydrochlorothiazide can increase your potassium levels too much.

These drugs include:

  • lithium

Narcotics

These drugs can increase the effect of captopril/hydrochlorothiazide. This means that you may have more side effects.

  • codeine
  • dihydrocodeine
  • fentanyl
  • hydrocodone
  • hydromorphone
  • levorphanol
  • mepiridine
  • methadone
  • morphine
  • opium
  • oxycodone
  • oxymorphone
  • tramadol

Pain medications

These drugs can decrease the effect of captopril/hydrochlorothiazide. This means that it may not work as well to lower your blood pressure. Taking these drugs together may also increase your risk of kidney damage.

These drugs include:

  • nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
    • ibuprofen
    • naproxen
    • celecoxib
    • diclofenac
    • indomethacin
    • ketoprofen
    • ketorolac
    • meloxicam
    • nabumetone
    • piroxicam

Potassium supplements and potassium-based salts

Taking these drugs with captopril/hydrochlorothiazide can increase your potassium levels too much.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Captopril/hydrochlorothiazide warnings
sulfonamide allergy
People with a sulfonamide allergy

Hydrochlorothiazide is a sulfonamide drug. If you’re allergic to sulfonamides, don’t take this drug. Tell your doctor about all of your allergies.

congestive heart failure
People with congestive heart failure (CHF)

If you have congestive heart failure, you have a higher risk of your blood pressure dropping to a dangerously low level. 

kidney disease
People with kidney disease

If you have kidney disease, you have a higher risk of having serious side effects from this drug. Your doctor will monitor your kidney function. If you have severe kidney disease, your doctor may prescribe a lower dose of the medication or have you take it on a different schedule.

liver disease
People with liver disease

This drug can affect your electrolyte levels. Use this drug with caution if you have liver disease.

lupus
People with lupus

Captopril/hydrochlorothiazide can cause new or worsening symptoms of lupus. Call your doctor right way if this happens.

autoimmune disease
People with autoimmune disease

If you have an autoimmune disorder, you may be more likely to have low white blood cells while taking this drug. This means that you may be more likely to get an infection and it may be harder for your body to recover from an infection. Talk to your doctor if you get sick while taking this drug.

diabetes
People with diabetes

Your doctor may need to adjust your diabetes drugs while you’re taking captopril/hydrochlorothiazide. Your doctor will tell you how often to test your blood sugar.

pregnant women
Pregnant women

Captopril/hydrochlorothiazide is a category C pregnancy drug when taken in the first trimester and a category D pregnancy drug when taken in the second and third trimesters of pregnancy. That means two things:

  1. Research in humans has shown adverse effects to the fetus when the mother takes the drug.
  2. This drug should only be used during pregnancy in serious cases where it's needed to treat a dangerous condition in the mother.

Talk to your doctor if you’re pregnant or planning to become pregnant. Ask your doctor to tell you about the specific harm that may be done to the fetus. This drug should be only used if the potential risk to the fetus is acceptable given the drug’s potential benefit.

breastfeeding
Women who are breast-feeding

It isn’t known if captopril/hydrochlorothiazide passes into breast milk. If it does, it may cause side effects in a child who is breast-fed.

Talk to your doctor if you breast-feed your baby. You may need to decide whether to stop breast-feeding or stop taking this medication.

for seniors
For seniors

Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule.

for children
For children

This medicine hasn’t been studied in children and shouldn’t be used in children under the age of 18 years.

call doctor
When to call the doctor

If you get pregnant while taking captopril/hydrochlorothiazide, tell your doctor right away. This drug can harm or be fatal to your unborn baby.

allergies
Allergies

Captopril/hydrochlorothiazide can cause a severe allergic reaction. Symptoms include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives

Call 9-1-1 or go to the nearest emergency room if you develop these symptoms.

Don’t take this drug again if you’ve ever had an allergic reaction to it or any sulfonamide drugs. Taking it again could be fatal (cause death).

SECTION 4 of 4

How to Take captopril-hydrochlorothiazide (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

High blood pressure

Generic: captopril/hydrochlorothiazide

Form: Oral tablet
Strengths:
  • 25 mg captopril/15 mg hydrochlorothiazide
  • 25 mg captopril/25 mg hydrochlorothiazide
  • 50 mg captopril/15mg hydrochlorothiazide
  • 50 mg captopril/25mg hydrochlorothiazide
Adult dosage (ages 18–64 years)

The starting dose is 25 mg captopril/15 mg hydrochlorothiazide taken by mouth once per day. Your doctor may adjust your dose every 6 weeks until you find a dose that works for you. The maximum dose is 150 mg captopril/50 mg hydrochlorothiazide per day.

Child dosage (ages 0–17 years)

This medicine hasn’t been studied in children and shouldn’t be used in children under the age of 18 years.

Senior dosage (ages 65 years and older)

There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Captopril/hydrochlorothiazide comes with serious risks if you don't take it as prescribed.

If you don’t take it at all

Your blood pressure will stay high. This increases your risk for serious complications, such as heart attack and stroke.

If you stop taking it suddenly

Your blood pressure may suddenly increase. This can cause anxiety, sweating, and a fast heart rate.

If you don’t take it on schedule

You may not feel any different, but your blood pressure may not be controlled. This can put you at higher risk for heart attack and stroke.

If you take too much

If you take too much captopril/hydrochlorothiazide, call your doctor or poison control center, or go to the emergency room right away.

What to do if you miss a dose

If you forget to take your dose, take it as soon as you remember. If it’s just a few hours until the time for your next dose, then wait and only take one dose at that time.

Never try to catch up by taking two doses at once. This could cause serious side effects.

How to tell if the drug is working

You’ll know that this drug is working when you check your blood pressure at home. If your blood pressure is at or below the goal your doctor set for you, the drug is working.

Captopril/hydrochlorothiazide is used for long-term treatment.

Important considerations for taking captopril/hydrochlorothiazide
take before meals
Captopril/hydrochlorothiazide tablets should be taken one hour before meals
timing
This medication should be taken one hour before the same meal each day
can crush or cut
You can crush or cut the tablet
storage
Store this medication at room temperature
See Details
refillable
Prescription is refillable
travel
Travel
See Details
self-management
Self-management
See Details
clinical monitoring
Clinical monitoring
See Details
hidden costs
Hidden costs
See Details

Store this medication at room temperature

Keep it from 68–77°F (20–25°C). 

Keep its container tightly closed. 

Keep this drug away from light and high temperature.

Keep your drugs away from areas where they could get wet, such as bathrooms. Store this drug away from moisture and damp locations.

Travel

When traveling with your medication:

  • Always carry your medication with you, such as in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Self-management

You may need to check your blood pressure at home. You should keep a log with the date, time of day, and your blood pressure readings. Bring this diary with you to your doctor appointments.

You may need to buy your own blood pressure monitoring machine. These are available at most pharmacies.

Clinical monitoring

Before starting and during treatment with captopril/hydrochlorothiazide, your doctor will check your:

  • kidney function
  • liver function
  • white blood cell count (immune function)
  • electrolytes levels (the salts in your body, such as potassium)
  • blood pressure
  • heart rate

Hidden costs

You may need to buy your own blood pressure monitoring machine.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.


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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on September 10, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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