Generic Name: canagliflozin, Oral tablet

Generic Name:

canagliflozin, Oral tablet

Invokana

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  • Invokana
SECTION 1 of 5

Highlights for canagliflozin

Oral tablet
1

Invokana is used with diet and exercise to help control blood sugar levels in people with type 2 diabetes. 

2

The starting dose of Invokana is 100 mg, taken before the first meal of the day.

3

The most common side effects that occur with Invokana include yeast infections, urinary tract infections, and the need to urinate more often and more frequently at night.

4

Invokana increases the risk of genital yeast or fungal infections. If you have a history of genital yeast or fungal infections or are an uncircumcised male, you’re more likely to develop genital yeast or fungal infections.

5

Invokana can cause dehydration. Dehydration may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand.

IMPORTANT INFORMATION

Genital yeast infections

Invokana increases your risk of genital yeast infections. If you have a history of genital yeast infections or are an uncircumcised male, you’re more likely to develop genital yeast infections.

Fungal infections

Invokana increases your risk of fungal infections. If you have a history of fungal infections or are an uncircumcised male, you’re more likely to develop fungal infections.

Severe low blood pressure

Invokana can cause severe low blood pressure. You’re at higher risk of having low blood pressure while taking Invokana if you’re a senior, are on certain blood pressure medications, have kidney disease, or have existing low blood pressure.

Very low blood sugar levels (hypoglycemia)

Invokana can cause very low blood sugar levels (hypoglycemia) when used with certain other diabetes drugs, such as glyburide or glipizide. Symptoms include sweating, nervousness, shakiness, weakness, hunger, nausea, dizziness, headache and blurred vision.

Drug Features

Invokana is a prescription drug. It’s available as an oral tablet.

This drug may be used a part of a combination therapy. That means you may need to take it with other drugs.

Why It's Used

Invokana is used along with diet and exercise to lower blood sugar levels in adults with type 2 diabetes.

How It Works

Invokana belongs to a class of drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors.

More Details

How It Works

Invokana belongs to a class of drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors. A class of drugs refers to medications that work similarly. They’re often used to treat similar conditions. Invokana works by removing sugar from your blood and getting rid of it through your urine.

SECTION 2 of 5

canagliflozin Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with Invokana include:

  • vaginal yeast infection. Symptoms may include:

    • vaginal odor
    • white or yellowish vaginal discharge
    • vaginal itching
  • yeast infection of the penis. Symptoms may include:

    • redness
    • itching
    • swelling
    • rash
    • foul smelling discharge
    • pain
  • urinary tract infection

  • changes in urination

    • urgent need to urinate
    • urinating more often
    • urinating at night more often
    • larger amounts of urination

If these effects are mild, they may disappear within a few days or a couple of weeks. If they’re more severe or don’t disappear, talk to your doctor or pharmacist

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • dehydration. Symptoms may include:

    • dizziness
    • fainting
    • lightheadedness
    • weakness
  • kidney problems. Symptoms may include:

    • tiredness
    • weakness
    • shortness of breath
  • increased potassium in your blood. Symptoms may include:

    • abnormal heartbeat
  • low blood sugar. Symptoms may include:

    • sweating
    • nervousness
    • shakiness
    • weakness
    • hunger
    • nausea
    • dizziness
    • headache
    • blurred vision
  • allergic reaction. Symptoms may include:

    • rash
    • hives
    • swelling of your face, lips, tongue, and throat
    • difficulty breathing or swallowing
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Invokana doesn’t cause drowsiness.

Mild side effects may disappear within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

canagliflozin May Interact with Other Medications

Oral tablet

Invokana can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications That Might Interact with This Drug

Tuberculosis drugs
  • rifampin

This drug can decrease the amount of Invokana in your body. You may need to increase your dose of Invokana while taking this medication.

Seizure drugs
  • phenobarbital
  • phenytoin

These drugs can decrease the amount of Invokana in your body. You may need to increase your dose of Invokana while taking these medications.

Human immunodeficiency virus (HIV) drugs
  • ritonavir 

This drug can decrease the amount of Invokana in your body. You may need to increase your dose of Invokana while taking this medication.

Heart failure drugs
  • digoxin

Invokana increases the amount of digoxin in your body when they are taken together. You may need to adjust the dose of either Invokana or digoxin.

Insulin or drugs that cause the release of insulin
  • chlorpropamide
  • glipizide
  • glimepiride
  • glyburide
  • tolbutamide
  • tolazamide
  • repaglinide
  • nateglinide

When you take Invokana with these drugs, your blood sugar level can get too low (hypoglycemia).

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with kidney damage

Invokana can decrease how well your kidneys work. If you have kidney damage, your doctor may have to monitor your kidneys more often while you take Invokana.

People with a history of yeast infections

Invokana increases your risk of genital yeast or fungal infections. If you have a history of genital yeast or fungal infections or are an uncircumcised male, you’re more likely to develop genital yeast or fungal infections while taking Invokana.

People with high cholesterol

Invokana can raise your cholesterol levels. If you already have high cholesterol levels, your doctor will monitor your cholesterol levels more frequently while you take Invokana and treat it if necessary.

Pregnant women

Invokana is a category C pregnancy drug. That means two things: 

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Speak with your doctor if you’re pregnant or planning to become pregnant. Invokana should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Women who are nursing

It isn’t known if Invokana passes through breast milk. Tell your doctor if you’re breastfeeding or plan to breastfeed. You should talk to your doctor about whether you should stop breastfeeding or stop taking Invokana.

For Seniors

If you’re 65 years or older, your body may process this drug more slowly. Your doctor may start you on a lower dose so that too much of this drug doesn’t build up in your body. Too much of the drug in your body can be toxic.

For Children

The safety and effectiveness of Invokana haven’t been established in children younger than 18 years old.

Allergies

Symptoms of allergic reaction to Invokana may include:

  • rash
  • raised red patches on your skin (hives)
  • swelling of your face, lips, tongue, and throat (may cause difficulty in breathing or swallowing)

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal.

SECTION 4 of 5

How to Take canagliflozin (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Type 2 diabetes
Form: Oral tablet
Strengths: 100 mg and 300 mg
Adult Dosage (ages 18-64 years)
  • Starting dose: 100 mg, taken once per day before the first meal of the day
  • The dose can be increased to 300 mg, taken once daily.
Child Dosage (ages 0-17 years)

Dosage for people younger than 18 years hasn’t been established.

Senior Dosage (ages 65 years and older)

Your body may process this drug more slowly. Your doctor may start you on a lower dose so that too much of this drug doesn’t build up in your body. Too much of the drug in your body can be toxic.

Special Considerations

People with Moderate Kidney Disease: If you have moderate kidney damage, your dose is limited to 100 mg per day. If you have severe kidney damage, you shouldn’t take Invokana.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Invokana comes with serious risks if you don't take it as prescribed.

If You Don’t Take It at All

If you don’t take your Invokana, your blood sugar will be too high and your diabetes may cause serious problems, such as kidney failure and blindness.

If You Take Too Much

If you take too much Invokana, call your doctor or go to the nearest hospital emergency room right away.

What to Do If You Miss a Dose

If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time.

Don’t take two doses of Invokana at the same time. Talk to your doctor if you have questions about a missed dose.

How to Tell If the Drug Is Working

If Invokana is working, you’ll have lower blood sugar levels and your symptoms of diabetes (increased urination, increased thirst, and decreased hunger) might go away.

Invokana is a long-term drug treatment.

Important Considerations for Taking Invokana
take with food You should take Invokana before the first meal of the day
can crush or cut You can crush or cut the tablet
storage The ideal temperature for storing Invokana is 77°F (25°C) See Details
refillable Prescription is refillable
travel Travel See Details
clinical monitoring Clinical Monitoring See Details
not usually stocked Not every pharmacy stocks this drug, so call ahead
prior authorization Insurance See Details

The ideal temperature for storing Invokana is 77°F (25°C)

Storage temperatures from 59–86°F (15–30°C) are acceptable for short periods of time.

Keep it away from light and high temperature.

Keep your drugs away from areas where they could get wet, such as bathrooms. Store your drugs away from moisture and damp locations.

Keep Invokana out of the reach of children.

Travel

When traveling with your medication:

  • Always carry your medication with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines; they can’t hurt your medication.
  • You may need to produce your pharmacy’s preprinted label clearly identifying the medication. Keep the original pharmacy prescription-labeled box when traveling.
  • Don’t put this medicine in your glove compartment or leave it in the car, especially when the temperature is hot or freezing.

Clinical Monitoring

Your doctor will check your diabetes with regular blood tests, including your blood sugar levels and your hemoglobin A1c levels. Your doctor will also monitor your kidney function because Invokana can decrease how well your kidneys work, and check your potassium levels because Invokana may cause your potassium levels to increase.

Your doctor may also check for possible complications of high blood sugar levels:

  • eye exam at least annually
  • foot exam at least annually
  • dental exam at least annually
  • tests for nerve damage
  • cholesterol level tests
  • blood pressure and heart rate exams

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for Invokana.

Are There Any Alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

What does the pill look like?

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SECTION 5 of 5

How Much Does canagliflozin Cost?

Oral tablet
We've partnered with GoodRX so you can compare prices and save money on your next prescription. Check out the lowest cash prices below and enter your zip code to find the best deal near you.

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Lowest price for canagliflozin

Membership warehouse $354.37
Publix $355.72
Kroger Pharmacy $355.74
These represent the lowest cash prices for canagliflozin and may be lower than your insurance.

Find the lowest prices of canagliflozin near you

These represent the lowest cash prices for canagliflozin and may be lower than your insurance.

Show Sources

  • Janssen Pharmaceuticals, Inc. (2015, March). Invokana (canagliflozin) tablets, for oral use. Titusville, NJ.

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on July 8, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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