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Generic Name:

canagliflozin, Oral tablet

All Brands

  • Invokana
SECTION 1 of 4

Highlights for canagliflozin

Oral tablet
1

Canagliflozin is used with diet and exercise to help control blood sugar levels in people with type 2 diabetes.

2

The starting dose of canagliflozin is 100 mg, taken before the first meal of the day.

3

The most common side effects that occur with canagliflozin include yeast infections, urinary tract infections, and the need to urinate more often and more frequently at night.

4

Canagliflozin increases the risk of genital yeast or fungal infections. If you have a history of genital yeast or fungal infections or are an uncircumcised male, you’re more likely to develop genital yeast or fungal infections.

5

Canagliflozin can cause dehydration. Dehydration may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand.

IMPORTANT INFORMATION

Fungal infections

This drug increases your risk of fungal infections. If you have a history of fungal infections or are an uncircumcised male, you’re more likely to develop fungal infections.

Severe low blood pressure

This drug can cause severe low blood pressure. You’re at higher risk of having low blood pressure while taking this drug if you’re a senior, are on certain blood pressure medications, have kidney disease, or have existing low blood pressure.

Very low blood sugar levels

This drug can cause hypoglycemia (low blood sugar levels) when used with certain other diabetes drugs that boost your insulin level. Symptoms include nervousness, weakness, hunger, nausea, headache, and blurred vision.

Kidney damage warning

This drug can cause kidney damage. Call your doctor if you’re eating and drinking less than usual, such as from fasting or illness. Also call if you’re losing fluids, such as if you have vomiting or diarrhea, or have been out in the sun for too long. These factors may make kidney damage more likely.

What is canagliflozin?

This drug is a prescription drug. It’s available as an oral tablet.

This drug is only available as the brand-name drug Invokana. It isn’t available as a generic drug.

This drug may be used a part of a combination therapy. That means you may need to take it with other drugs, such as metformin.

Why it's used

This drug is used along with diet and exercise to lower blood sugar levels in adults with type 2 diabetes.

How it works

This drug belongs to a class of drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors.

More Details

How it works

This drug belongs to a class of drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors. A class of drugs refers to medications that work similarly. They’re often used to treat similar conditions. This drug works by removing sugar from your blood and getting rid of it through your urine.

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SECTION 2 of 4

canagliflozin Side Effects

Oral tablet

More Common Side Effects

The most common side effects that occur with canagliflozin include:

  • vaginal yeast infection. Symptoms may include:

    • vaginal odor
    • white or yellowish vaginal discharge
    • vaginal itching
  • yeast infection of the penis. Symptoms may include:

    • redness
    • itching
    • swelling
    • rash
    • foul smelling discharge
    • pain
  • urinary tract infection. Symptoms can include:

    • a burning sensation when you urinate
    • cloudy urine
    • pain in your pelvis or back changes in urination. Symptoms can include: urgent need to urinate
    • urinating more often
    • urinating at night more often
    • larger amounts of urination
  • changes in urination

    • urgent need to urinate
    • urinating more often
    • urinating at night more often
    • larger amounts of urination

If these effects are mild, they may disappear within a few days or a couple of weeks. If they’re more severe or don’t disappear, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • dehydration. Symptoms may include:

    • dizziness
    • fainting
    • lightheadedness
    • weakness
  • kidney problems. Symptoms may include:

    • tiredness
    • weakness
    • shortness of breath
  • increased potassium in your blood. Symptoms may include:

    • abnormal heartbeat
  • low blood sugar. Symptoms may include:

    • sweating
    • nervousness
    • shakiness
    • weakness
    • hunger
    • nausea
    • dizziness
    • headache
    • blurred vision
  • diabetic ketoacidosis. Symptoms may include:

    • excessive thirst
    • urinating more often than normal
    • nausea
    • vomiting
    • stomach pain
    • weakness
    • shortness of breath
    • fruity breath
    • confusion
  • allergic reaction. Symptoms may include:

    • rash
    • hives
    • swelling of your face, lips, tongue, and throat
    • difficulty breathing or swallowing
  • broken bones

Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug doesn’t cause drowsiness.

Mild side effects may disappear within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

canagliflozin May Interact with Other Medications

Oral tablet

Canagliflozin can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications that might interact with this drug

Tuberculosis drugs
  • rifampin

This drug can decrease the amount of canagliflozin in your body. You may need to increase your dose of canagliflozin while taking this medication.

Seizure drugs
  • phenobarbital
  • phenytoin

These drugs can decrease the amount of canagliflozin in your body. You may need to increase your dose of canagliflozin while taking these medications.

Human immunodeficiency virus (HIV) drugs
  • ritonavir

This drug can decrease the amount of canagliflozin in your body. You may need to increase your dose of canagliflozin while taking this medication.

Heart failure drugs
  • digoxin

Canagliflozin increases the amount of digoxin in your body when the drugs are taken together. Your doctor may monitor you more closely if you take these drugs together.

Insulin or drugs that cause the release of insulin
  • chlorpropamide
  • glipizide
  • glimepiride
  • glyburide
  • tolbutamide
  • tolazamide
  • repaglinide
  • nateglinide 

When you take canagliflozin with these drugs, your blood sugar level can get too low (hypoglycemia).

Blood pressure drugs
  • diuretics (water pills) such as chlorthalidone and furosemide
  • angiotensin-converting enzyme (ACE) inhibitors such as lisinopril and benazepril
  • angiotensin receptor blockers (ARBs) such as losartan and olmesartan

When you take Invokana with any of these drugs, you increase your risk of low blood pressure.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
kidney damage
People with kidney damage

This drug can decrease how well your kidneys work. If you have kidney damage, your doctor may have to monitor your kidneys more often while you take this drug.

yeast infection
People with a history of yeast infections

This drug increases your risk of genital yeast or fungal infections. If you have a history of genital yeast or fungal infections or are an uncircumcised male, you’re more likely to develop genital yeast or fungal infections while taking this drug.

high cholesterol
People with high cholesterol

This drug can raise your cholesterol levels. If you already have high cholesterol levels, your doctor will monitor your cholesterol levels more frequently while you take this drug and treat it if necessary.

pregnant women
Pregnant women

Invokana is not recommended during your second and third trimesters of pregnancy. Research in animals has shown adverse effects to the fetus when the mother takes the drug. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

breastfeeding
Women who are breast-feeding

It isn’t known if this drug passes through breast milk. Tell your doctor if you’re breastfeeding or plan to breastfeed. You should talk to your doctor about whether you should stop breastfeeding or stop taking this drug.

for seniors
For seniors

If you’re 65 years or older, your body may process this drug more slowly. Your doctor may start you on a lower dose so that too much of this drug doesn’t build up in your body. Too much of the drug in your body can be toxic.

for children
For children

The safety and effectiveness of this drug haven’t been established in children younger than 18 years old.

allergies
Allergies

Symptoms of allergic reaction to this drug may include:

  • rash
  • raised red patches on your skin (hives)
  • swelling of your face, lips, tongue, and throat (may cause difficulty in breathing or swallowing)

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal.

SECTION 4 of 4

How to Take canagliflozin (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Type 2 diabetes

Brand: Invokana

Form: Oral tablet
Strengths: 100 mg, 300 mg
Adult dosage (ages 18–64 years)
  • Starting dose: 100 mg, taken once per day before the first meal of the day.
  • Dose increases: The dose can be increased to 300 mg, taken once daily.
Child dosage (ages 0–17 years)

Dosage for people younger than 18 years hasn’t been established.

Senior dosage (ages 65 years and older)

Your body may process this drug more slowly. Your doctor may start you on a lower dose so that too much of this drug doesn’t build up in your body. Too much of the drug in your body can be toxic.

Special considerations

People with moderate kidney disease: If you have moderate kidney damage, your dose is limited to 100 mg per day. If you have severe kidney damage, you shouldn’t take this drug.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with serious risks if you don't take it as prescribed.

If you don't take it at all

If you don’t take this drug, your blood sugar will be too high and your diabetes may cause serious problems, such as kidney failure and blindness.

If you take too much

If you take too much of this drug, call your doctor or go to the nearest hospital emergency room right away.

What to do if you miss a dose

If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time.

Don’t take two doses of this drug at the same time. Talk to your doctor if you have questions about a missed dose.

How to tell if the drug is working

If this drug is working, you’ll have lower blood sugar levels and your symptoms of diabetes (increased urination, increased thirst, and decreased hunger) might go away.

This drug is used for long-term treatment.

Important considerations for taking this drug
take with food
You should take this drug before the first meal of the day
can crush or cut
You can crush or cut the tablet
storage
Store this drug at room temperature between 68°F and 77°F (20°C and 25°C)
See Details
refillable
Prescription is refillable
See Details
travel
Travel
See Details
clinical monitoring
Clinical monitoring
See Details
not usually stocked
Not every pharmacy stocks this drug, so call ahead
prior authorization
Insurance
See Details

Store this drug at room temperature between 68°F and 77°F (20°C and 25°C)

Storage temperatures from 59°F to 86°F (15°C to 30°C) are acceptable for short periods of time.

Store this drug away from light, high temperature, and areas where it could get wet, such as bathrooms. Store your drugs away from moisture and damp locations. As usual, keep it out of reach of children.

A prescription for this medication is refillable

You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

  • Always carry your medication with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines; they can’t hurt your medication.
  • You may need to produce your pharmacy’s preprinted label clearly identifying the medication. Keep the original pharmacy prescription-labeled box when traveling.
  • Don’t put this medicine in your glove compartment or leave it in the car, especially when the temperature is hot or freezing.

Clinical monitoring

Your doctor will check your diabetes with regular blood tests, including your blood sugar levels and your hemoglobin A1c levels. Your doctor will also monitor your kidney function because this drug can decrease how well your kidneys work, and check your potassium levels because this drug may cause your potassium levels to increase.

Your doctor may also check for possible complications of high blood sugar levels:

  • eye exam at least annually
  • foot exam at least annually
  • dental exam at least annually
  • tests for nerve damage
  • cholesterol level tests
  • blood pressure and heart rate exams

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for this drug.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.


Show Sources

  • Invokana (canagliflozin) tablets, for oral use. (2017). https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/204042s018lbl.pdf 

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on May 30, 2017

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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